Methadone (English Wikipedia)

Toombs JD, Kral LA (April 2005). "Methadone treatment for pain states". American Family Physician. 71 (7): 1353–1358. PMID 15832538. Archived from the original on 5 September 2017.
Sadovsky R (15 July 2000). "Tips from Other Journals – Public Health Issue: Methadone Maintenance Therapy". American Family Physician. 62 (2): 428–432. Archived from the original on 4 September 2015.

about.com

alcoholism.about.com

"Methadone-Associated Mortality, Report of a National Assessment". Archived from the original on 1 January 2016.

asam.org

"Medicaid Coverage of Medications for the Treatment of Opioid Use Disorder" (PDF).

aspetjournals.org

jpet.aspetjournals.org

Codd EE, Shank RP, Schupsky JJ, Raffa RB (1995). "Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception". J. Pharmacol. Exp. Ther. 274 (3): 1263–70. PMID 7562497.
Xiao Y, Smith RD, Caruso FS, Kellar KJ (October 2001). "Blockade of rat alpha3beta4 nicotinic receptor function by methadone, its metabolites, and structural analogs". The Journal of Pharmacology and Experimental Therapeutics. 299 (1): 366–371. PMID 11561100. Archived from the original on 28 August 2021. Retrieved 21 June 2011.

atforum.com

Leavitt SB (September 2003). "Methadone Dosing & Safety in the Treatment of Opioid Addiction" (PDF). Addiction Treatment Forum.
Eap CB, Déglon JJ, Baumann P (1999). "Pharmacokinetics and pharmacogenetics of methadone: Clinical relevance" (PDF). Heroin Addiction and Related Clinical Problems. 1 (1): 19–34.

benefits.gov

"Veterans Alcohol and Drug Dependence Rehabilitation Program". 1 November 2018.

bmj.com

pmj.bmj.com

Brown R, Kraus C, Fleming M, Reddy S (November 2004). "Methadone: applied pharmacology and use as adjunctive treatment in chronic pain" (PDF). Postgraduate Medical Journal. 80 (949): 654–659. doi:10.1136/pgmj.2004.022988. PMC 1743125. PMID 15537850. Archived (PDF) from the original on 2 May 2014.

books.google.com

Bonewit-West K, Hunt SA, Applegate E (2012). Today's Medical Assistant: Clinical and Administrative Procedures. Elsevier Health Sciences. p. 571. ISBN 9781455701506.
Methadone Matters: Evolving Community Methadone Treatment of Opiate Addiction. CRC Press. 2003. p. 13. ISBN 9780203633090. Archived from the original on 23 December 2015.
Kleiman MA, Hawdon JE (2011). "Diphenypropylamine Derivatives". Encyclopedia of Drug Policy. SAGE Publications. ISBN 9781506338248. Archived from the original on 23 December 2015.
Browne-Miller A (2009). The Praeger International Collection on Addictions. ABC-CLIO. ISBN 978-0-275-99605-5.
Nordegren T (1 March 2002). The A-Z Encyclopedia of Alcohol and Drug Abuse. Universal-Publishers. p. 366. ISBN 978-1-58112-404-0. Archived from the original on 1 January 2014. Retrieved 16 May 2012.

cam.ac.uk

ccdc.cam.ac.uk

"CSD Entry METHAD01: (6R)-Dimethylamino-4,4-diphenyl-3-heptanone, L-Methadone". Cambridge Structural Database: Access Structures. Cambridge Crystallographic Data Centre. Retrieved 22 November 2020.

cdc.gov

"Data table for Figure 1. Age-adjusted drug-poisoning and opioid-analgesic poisoning death rates: United States, 1999–2011" (PDF). CDC. Archived (PDF) from the original on 23 November 2015. Retrieved 22 December 2015.
"Increases in Methadone-Related Deaths:1999–2004". 4 September 2018. Archived from the original on 11 April 2010.

cms.gov

"Medicare Coverage of Substance Abuse Services" (PDF).

cornell.edu

law.cornell.edu

"42 CFR § 8.12 – Federal opioid treatment standards". LII / Legal Information Institute. Retrieved 15 February 2021.

doi.org

Bye E (1974). "Crystal Structures of Synthetic Analgetics. II. l-Methadone". Acta Chem. Scand. 28b: 5–12. doi:10.3891/acta.chem.scand.28b-0005.
Fredheim OM, Moksnes K, Borchgrevink PC, Kaasa S, Dale O (August 2008). "Clinical pharmacology of methadone for pain". Acta Anaesthesiologica Scandinavica. 52 (7): 879–889. doi:10.1111/j.1399-6576.2008.01597.x. PMID 18331375. S2CID 25626479.
Brown R, Kraus C, Fleming M, Reddy S (November 2004). "Methadone: applied pharmacology and use as adjunctive treatment in chronic pain" (PDF). Postgraduate Medical Journal. 80 (949): 654–659. doi:10.1136/pgmj.2004.022988. PMC 1743125. PMID 15537850. Archived (PDF) from the original on 2 May 2014.
Anderson IB, Kearney TE (January 2000). "Use of methadone". The Western Journal of Medicine. 172 (1): 43–46. doi:10.1136/ewjm.172.1.43. PMC 1070723. PMID 10695444.
Volkow ND, Wargo EM (August 2018). "Overdose Prevention Through Medical Treatment of Opioid Use Disorders". Annals of Internal Medicine. 169 (3): 190–192. doi:10.7326/M18-1397. PMID 29913514. S2CID 49300767.
Rudd RA, Seth P, David F, Scholl L (December 2016). "Increases in Drug and Opioid-Involved Overdose Deaths - United States, 2010-2015". MMWR. Morbidity and Mortality Weekly Report. 65 (50–51): 1445–1452. doi:10.15585/mmwr.mm655051e1. PMID 28033313.
Chou R, Turner JA, Devine EB, Hansen RN, Sullivan SD, Blazina I, et al. (February 2015). "The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a National Institutes of Health Pathways to Prevention Workshop". Annals of Internal Medicine. 162 (4): 276–286. doi:10.7326/M14-2559. PMID 25581257. S2CID 207538295.
Mattick RP, Breen C, Kimber J, Davoli M (July 2009). Mattick RP (ed.). "Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence". The Cochrane Database of Systematic Reviews. 2009 (3): CD002209. doi:10.1002/14651858.CD002209.pub2. PMC 7097731. PMID 19588333.
Stotts AL, Dodrill CL, Kosten TR (August 2009). "Opioid dependence treatment: options in pharmacotherapy". Expert Opinion on Pharmacotherapy. 10 (11): 1727–1740. doi:10.1517/14656560903037168. PMC 2874458. PMID 19538000.
Connock M, Juarez-Garcia A, Jowett S, Frew E, Liu Z, Taylor RJ, et al. (March 2007). "Methadone and buprenorphine for the management of opioid dependence: a systematic review and economic evaluation". Health Technology Assessment. 11 (9): 1–171, iii–iv. doi:10.3310/hta11090. PMID 17313907.
Kraychete DC, Sakata RK (July 2012). "Use and rotation of opioids in chronic non-oncologic pain". Revista Brasileira de Anestesiologia. 62 (4): 554–562. doi:10.1016/S0034-7094(12)70155-1. PMID 22793972.
Mercadante S, Bruera E (March 2016). "Opioid switching in cancer pain: From the beginning to nowadays". Critical Reviews in Oncology/Hematology. 99: 241–248. doi:10.1016/j.critrevonc.2015.12.011. PMID 26806145.
Leppert W (July 2009). "The role of methadone in cancer pain treatment--a review". International Journal of Clinical Practice. 63 (7): 1095–1109. doi:10.1111/j.1742-1241.2008.01990.x. PMID 19570126. S2CID 205875314.
Nicholson AB, Watson GR, Derry S, Wiffen PJ (February 2017). "Methadone for cancer pain". The Cochrane Database of Systematic Reviews. 2 (3): CD003971. doi:10.1002/14651858.CD003971.pub4. PMC 6464101. PMID 28177515.
Nutt D, King LA, Saulsbury W, Blakemore C (March 2007). "Development of a rational scale to assess the harm of drugs of potential misuse". Lancet. 369 (9566): 1047–1053. doi:10.1016/s0140-6736(07)60464-4. PMID 17382831. S2CID 5903121.
John J, Amley X, Bombino G, Gitelis C, Topi B, Hollander G, et al. (December 2010). "Torsade de Pointes due to Methadone Use in a Patient with HIV and Hepatitis C Coinfection". Cardiology Research and Practice. 2010: 524764. doi:10.4061/2010/524764. PMC 3021856. PMID 21253542.
Graham CH, Meechan JG (October 2005). "Dental management of patients taking methadone". Dental Update. 32 (8): 477–8, 481–2, 485. doi:10.12968/denu.2005.32.8.477. PMID 16262036.
Tran PN, Sheng J, Randolph AL, Baron CA, Thiebaud N, Ren M, et al. (2020). "Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block". PLOS ONE. 15 (11): e0241362. Bibcode:2020PLoSO..1541362T. doi:10.1371/journal.pone.0241362. PMC 7647070. PMID 33157550.
Giacomuzzi SM, Ertl M, Vigl A, Riemer Y, Günther V, Kopp M, et al. (July 2005). "Driving capacity of patients treated with methadone and slow-release oral morphine". Addiction. 100 (7): 1027. doi:10.1111/j.1360-0443.2005.01148.x. PMID 15955021.
Reece AS (May 2008). "Experience of road and other trauma by the opiate dependent patient: a survey report". Substance Abuse Treatment, Prevention, and Policy. 3: 10. doi:10.1186/1747-597X-3-10. PMC 2396610. PMID 18454868.
Gorman AL, Elliott KJ, Inturrisi CE (February 1997). "The d- and l-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord". Neurosci. Lett. 223 (1): 5–8. doi:10.1016/S0304-3940(97)13391-2. PMID 9058409.
Bengt Danielsson, Julius Collin, Anastasia Nyman, Annica Bergendal, Natalia Borg, Maria State, et al. (12 March 2020). "Drug use and torsades de pointes cardiac arrhythmias in Sweden: a nationwide register-based cohort study". BMJ Open. 10 (3): e034560. doi:10.1136/bmjopen-2019-034560. PMC 7069257. PMID 32169926.
Schulze V, Stoetzer C, O'Reilly AO, Eberhardt E, Leffler A, et al. (January 2014). "The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na+ channel, Nav1.5". Br. J. Pharmacology. 171 (2): 427–437. doi:10.1111/bph.12465. PMC 3904262. PMID 24117196. Retrieved 1 May 2024. the clinical relevance of a Na+ channel blocker is probably better estimated from recordings on inactivated channels (IC50 ∼10 μM in our study).
Kell MJ (1994). "Utilization of plasma and urine methadone concentrations to optimize treatment in maintenance clinics: I. Measurement techniques for a clinical setting". Journal of Addictive Diseases. 13 (1): 5–26. doi:10.1300/J069v13n01_02. PMID 8018740.
Eap CB, Buclin T, Baumann P (2002). "Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence". Clinical Pharmacokinetics. 41 (14): 1153–1193. doi:10.2165/00003088-200241140-00003. PMID 12405865. S2CID 1396257.
Preston KL, Epstein DH, Davoudzadeh D, Huestis MA (September 2003). "Methadone and metabolite urine concentrations in patients maintained on methadone". Journal of Analytical Toxicology. 27 (6): 332–341. doi:10.1093/jat/27.6.332. PMID 14516485.
Hill AD, Toner ME, FitzGerald MX (May 1990). "Talc lung in a drug abuser". Irish Journal of Medical Science. 159 (5): 147–148. doi:10.1007/BF02937408. PMID 2397985. S2CID 41611298.
Cappola TP, Felker GM, Kao WH, Hare JM, Baughman KL, Kasper EK (April 2002). "Pulmonary hypertension and risk of death in cardiomyopathy: patients with myocarditis are at higher risk". Circulation. 105 (14): 1663–1668. doi:10.1161/01.CIR.0000013771.30198.82. PMID 11940544. S2CID 298931.
Humbert M (February 2005). "Improving survival in pulmonary arterial hypertension". The European Respiratory Journal. 25 (2): 218–220. doi:10.1183/09031936.05.00129604. PMID 15684283.
Lintzeris N, Lenné M, Ritter A (August 1999). "Methadone injecting in Australia: a tale of two cities". Addiction. 94 (8): 1175–1178. doi:10.1046/j.1360-0443.1999.94811757.x. PMID 10615732.
Bürgi HB, Dunitz JD, Shefter E (August 1973). "Pharmacological implications of the conformation of the methadone base". Nature. 244 (136): 186–187. doi:10.1038/newbio244186b0. PMID 4516455.
López-Muñoz F, Alamo C (April 2009). "The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice". Brain Research Bulletin. 79 (2): 130–141. doi:10.1016/j.brainresbull.2009.01.005. PMID 19186209. S2CID 7720401.
Bockmühl M, Ehrhart G (1949). "Über eine neue Klasse von spasmolytisch und analgetisch wirkenden Verbindungen, I" [On a new class of spasmolytic and analgesic compounds, I]. Justus Liebigs Annalen der Chemie (in German). 561 (1): 52–86. doi:10.1002/jlac.19495610107.
Defalque RJ, Wright AJ (October 2007). "The early history of methadone. Myths and facts". Bulletin of Anesthesia History. 25 (3): 13–16. doi:10.1016/S1522-8649(07)50035-1. PMID 20506765.
Dole VP, Nyswander ME (May 1976). "Methadone maintenance treatment. A ten-year perspective". JAMA. 235 (19): 2117–2119. doi:10.1001/jama.1976.03260450029025. PMID 946538.
Sullivan SG, Wu Z, Rou K, Pang L, Luo W, Wang C, et al. (January 2015). "Who uses methadone services in China? Monitoring the world's largest methadone programme". Addiction. 110 (Suppl 1): 29–39. doi:10.1111/add.12781. PMID 25533862.

drugabuse.gov

National Institute on Drug Abuse. "How Much Does Opioid Treatment Cost?". Retrieved 2 November 2018.
"Is drug addiction treatment worth its cost?". Archived from the original on 28 July 2020. Retrieved 29 December 2019.

international.drugabuse.gov

"Methadone Research Web Guide". NIDA. Archived from the original on 15 February 2010.

drugpolicy.org

"Methadone Maintenance Treatment". Drug Policy Alliance Lindesmith Library. Archived from the original on 11 May 2003.

drugs.com

"Methadone Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 23 December 2015. Retrieved 22 December 2015.
"Methadone". Drugs.com. Archived from the original on 29 July 2017.
"Methadone Black Box Warnings - Drugs.com". drugs.com. Retrieved 20 November 2018.

espn.com.br

"Caso Robson: Campanha pede justiça a ex-funcionário de Fernando preso há 562 dias na Rússia" [Robson case: Campaign calls for justice for former Fernando employee imprisoned 562 days in Russia]. ESPN Caso Robson (in Portuguese). 30 September 2020.

exchangesupplies.org

"Methadone Briefing". Archived from the original on 20 November 2003. Retrieved 9 July 2007.

fda.gov

nctr-crs.fda.gov

"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.

goodrx.com

Based on:
- "Methadone Prices and Methadone Coupons » 5 mg". GoodRx, Inc. Archived from the original on 11 September 2016. Retrieved 30 August 2016.^{[unreliable source?}

handle.net

hdl.handle.net

World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
World Health Organization (2009). "Methadone maintenance treatment". Clinical guidelines for withdrawal management and treatment of drug dependence in closed settings. Manila : WHO Regional Office for the Western Pacific. WHO Regional Office for the Western Pacific. hdl:10665/207032. ISBN 9789290614302.

harvard.edu

ui.adsabs.harvard.edu

Tran PN, Sheng J, Randolph AL, Baron CA, Thiebaud N, Ren M, et al. (2020). "Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block". PLOS ONE. 15 (11): e0241362. Bibcode:2020PLoSO..1541362T. doi:10.1371/journal.pone.0241362. PMC 7647070. PMID 33157550.

indro-online.de

Indro-Online.de Archived 13 January 2016 at the Wayback Machine (PDF format)

jaoa.org

Manfredonia JF (March 2005). "Prescribing methadone for pain management in end-of-life care". The Journal of the American Osteopathic Association. 105 (3 Suppl 1): S18–S21. PMID 18154194. Archived from the original on 20 May 2007.

lecturio.com

"Opioid Use Disorder". The Lecturio Medical Concept Library. Retrieved 25 June 2021.

medicinenet.com

"Methadone". MedicineNet. Archived from the original on 4 March 2016.

medlineplus.gov

"Methadone overdose". MedlinePlus. 3 October 2017.
"Methadone overdose: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 13 November 2021.

medsafe.govt.nz

https://www.medsafe.govt.nz/consumers/cmi/m/Methatabs.pdf

medscape.com

reference.medscape.com

Medscape Methadone Dosage. [1].

methadonesupport.org

"Methadone and Driving Article Abstracts: Brief Literature Review". Institute for Metropolitan Affairs, Roosevelt University. 14 February 2008. Archived from the original (DOC) on 3 November 2011.

mywaybettyford.de

"Polamidon: Wirkung, Legalität, Substitution, Erfolgschancen & Entzug". My Way Betty Ford Klinik (in German). Retrieved 2 March 2023.

nhtsa.gov

"National Highway Traffic Safety Administration. Methadone. Drugs and Human Performance Fact Sheets" (PDF). NHTSA.

nih.gov

pubmed.ncbi.nlm.nih.gov

Fredheim OM, Moksnes K, Borchgrevink PC, Kaasa S, Dale O (August 2008). "Clinical pharmacology of methadone for pain". Acta Anaesthesiologica Scandinavica. 52 (7): 879–889. doi:10.1111/j.1399-6576.2008.01597.x. PMID 18331375. S2CID 25626479.
Brown R, Kraus C, Fleming M, Reddy S (November 2004). "Methadone: applied pharmacology and use as adjunctive treatment in chronic pain" (PDF). Postgraduate Medical Journal. 80 (949): 654–659. doi:10.1136/pgmj.2004.022988. PMC 1743125. PMID 15537850. Archived (PDF) from the original on 2 May 2014.
Toombs JD, Kral LA (April 2005). "Methadone treatment for pain states". American Family Physician. 71 (7): 1353–1358. PMID 15832538. Archived from the original on 5 September 2017.
Anderson IB, Kearney TE (January 2000). "Use of methadone". The Western Journal of Medicine. 172 (1): 43–46. doi:10.1136/ewjm.172.1.43. PMC 1070723. PMID 10695444.
Volkow ND, Wargo EM (August 2018). "Overdose Prevention Through Medical Treatment of Opioid Use Disorders". Annals of Internal Medicine. 169 (3): 190–192. doi:10.7326/M18-1397. PMID 29913514. S2CID 49300767.
Joseph H, Stancliff S, Langrod J (2000). "Methadone maintenance treatment (MMT): a review of historical and clinical issues". The Mount Sinai Journal of Medicine, New York. 67 (5–6): 347–364. PMID 11064485.
Grissinger M (August 2011). "Keeping patients safe from methadone overdoses". P & T. 36 (8): 462–466. PMC 3171821. PMID 21935293.
Rudd RA, Seth P, David F, Scholl L (December 2016). "Increases in Drug and Opioid-Involved Overdose Deaths - United States, 2010-2015". MMWR. Morbidity and Mortality Weekly Report. 65 (50–51): 1445–1452. doi:10.15585/mmwr.mm655051e1. PMID 28033313.
Chou R, Turner JA, Devine EB, Hansen RN, Sullivan SD, Blazina I, et al. (February 2015). "The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a National Institutes of Health Pathways to Prevention Workshop". Annals of Internal Medicine. 162 (4): 276–286. doi:10.7326/M14-2559. PMID 25581257. S2CID 207538295.
Mattick RP, Breen C, Kimber J, Davoli M (July 2009). Mattick RP (ed.). "Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence". The Cochrane Database of Systematic Reviews. 2009 (3): CD002209. doi:10.1002/14651858.CD002209.pub2. PMC 7097731. PMID 19588333.
Stotts AL, Dodrill CL, Kosten TR (August 2009). "Opioid dependence treatment: options in pharmacotherapy". Expert Opinion on Pharmacotherapy. 10 (11): 1727–1740. doi:10.1517/14656560903037168. PMC 2874458. PMID 19538000.
Connock M, Juarez-Garcia A, Jowett S, Frew E, Liu Z, Taylor RJ, et al. (March 2007). "Methadone and buprenorphine for the management of opioid dependence: a systematic review and economic evaluation". Health Technology Assessment. 11 (9): 1–171, iii–iv. doi:10.3310/hta11090. PMID 17313907.
Kraychete DC, Sakata RK (July 2012). "Use and rotation of opioids in chronic non-oncologic pain". Revista Brasileira de Anestesiologia. 62 (4): 554–562. doi:10.1016/S0034-7094(12)70155-1. PMID 22793972.
Mercadante S, Bruera E (March 2016). "Opioid switching in cancer pain: From the beginning to nowadays". Critical Reviews in Oncology/Hematology. 99: 241–248. doi:10.1016/j.critrevonc.2015.12.011. PMID 26806145.
Leppert W (July 2009). "The role of methadone in cancer pain treatment--a review". International Journal of Clinical Practice. 63 (7): 1095–1109. doi:10.1111/j.1742-1241.2008.01990.x. PMID 19570126. S2CID 205875314.
Nicholson AB, Watson GR, Derry S, Wiffen PJ (February 2017). "Methadone for cancer pain". The Cochrane Database of Systematic Reviews. 2 (3): CD003971. doi:10.1002/14651858.CD003971.pub4. PMC 6464101. PMID 28177515.
Nutt D, King LA, Saulsbury W, Blakemore C (March 2007). "Development of a rational scale to assess the harm of drugs of potential misuse". Lancet. 369 (9566): 1047–1053. doi:10.1016/s0140-6736(07)60464-4. PMID 17382831. S2CID 5903121.
John J, Amley X, Bombino G, Gitelis C, Topi B, Hollander G, et al. (December 2010). "Torsade de Pointes due to Methadone Use in a Patient with HIV and Hepatitis C Coinfection". Cardiology Research and Practice. 2010: 524764. doi:10.4061/2010/524764. PMC 3021856. PMID 21253542.
Brondani M, Park PE (16 May 2011). "Methadone and oral health--a brief review". Journal of Dental Hygiene. 85 (2): 92–98. PMID 21619737.
Graham CH, Meechan JG (October 2005). "Dental management of patients taking methadone". Dental Update. 32 (8): 477–8, 481–2, 485. doi:10.12968/denu.2005.32.8.477. PMID 16262036.
Tran PN, Sheng J, Randolph AL, Baron CA, Thiebaud N, Ren M, et al. (2020). "Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block". PLOS ONE. 15 (11): e0241362. Bibcode:2020PLoSO..1541362T. doi:10.1371/journal.pone.0241362. PMC 7647070. PMID 33157550.
Giacomuzzi SM, Ertl M, Vigl A, Riemer Y, Günther V, Kopp M, et al. (July 2005). "Driving capacity of patients treated with methadone and slow-release oral morphine". Addiction. 100 (7): 1027. doi:10.1111/j.1360-0443.2005.01148.x. PMID 15955021.
Reece AS (May 2008). "Experience of road and other trauma by the opiate dependent patient: a survey report". Substance Abuse Treatment, Prevention, and Policy. 3: 10. doi:10.1186/1747-597X-3-10. PMC 2396610. PMID 18454868.
Codd EE, Shank RP, Schupsky JJ, Raffa RB (1995). "Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception". J. Pharmacol. Exp. Ther. 274 (3): 1263–70. PMID 7562497.
Gorman AL, Elliott KJ, Inturrisi CE (February 1997). "The d- and l-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord". Neurosci. Lett. 223 (1): 5–8. doi:10.1016/S0304-3940(97)13391-2. PMID 9058409.
Bengt Danielsson, Julius Collin, Anastasia Nyman, Annica Bergendal, Natalia Borg, Maria State, et al. (12 March 2020). "Drug use and torsades de pointes cardiac arrhythmias in Sweden: a nationwide register-based cohort study". BMJ Open. 10 (3): e034560. doi:10.1136/bmjopen-2019-034560. PMC 7069257. PMID 32169926.
Schulze V, Stoetzer C, O'Reilly AO, Eberhardt E, Leffler A, et al. (January 2014). "The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na+ channel, Nav1.5". Br. J. Pharmacology. 171 (2): 427–437. doi:10.1111/bph.12465. PMC 3904262. PMID 24117196. Retrieved 1 May 2024. the clinical relevance of a Na+ channel blocker is probably better estimated from recordings on inactivated channels (IC50 ∼10 μM in our study).
Xiao Y, Smith RD, Caruso FS, Kellar KJ (October 2001). "Blockade of rat alpha3beta4 nicotinic receptor function by methadone, its metabolites, and structural analogs". The Journal of Pharmacology and Experimental Therapeutics. 299 (1): 366–371. PMID 11561100. Archived from the original on 28 August 2021. Retrieved 21 June 2011.
Kell MJ (1994). "Utilization of plasma and urine methadone concentrations to optimize treatment in maintenance clinics: I. Measurement techniques for a clinical setting". Journal of Addictive Diseases. 13 (1): 5–26. doi:10.1300/J069v13n01_02. PMID 8018740.
Eap CB, Buclin T, Baumann P (2002). "Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence". Clinical Pharmacokinetics. 41 (14): 1153–1193. doi:10.2165/00003088-200241140-00003. PMID 12405865. S2CID 1396257.
Manfredonia JF (March 2005). "Prescribing methadone for pain management in end-of-life care". The Journal of the American Osteopathic Association. 105 (3 Suppl 1): S18–S21. PMID 18154194. Archived from the original on 20 May 2007.
Preston KL, Epstein DH, Davoudzadeh D, Huestis MA (September 2003). "Methadone and metabolite urine concentrations in patients maintained on methadone". Journal of Analytical Toxicology. 27 (6): 332–341. doi:10.1093/jat/27.6.332. PMID 14516485.
Murphy SB, Jackson WB, Pare JA (July 1978). "Talc retinopathy". Canadian Journal of Ophthalmology. Journal Canadien d'Ophtalmologie. 13 (3): 152–156. PMID 698886.
Hill AD, Toner ME, FitzGerald MX (May 1990). "Talc lung in a drug abuser". Irish Journal of Medical Science. 159 (5): 147–148. doi:10.1007/BF02937408. PMID 2397985. S2CID 41611298.
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