Methotrexate (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Methotrexate" in English language version.

refsWebsite

Global rank English rank

52nih.gov

4^th place

35doi.org

2^nd place

8semanticscholar.org

11^th place

8^th place

5web.archive.org

1^st place

2books.google.com

3^rd place

2clincalc.com

3,912^th place

2,496^th place

2nihr.ac.uk

low place

6,693^rd place

1oxforddictionaries.com

710^th place

648^th place

1merriam-webster.com

209^th place

191^st place

1dictionary.com

794^th place

588^th place

1drugs.com

399^th place

333^rd place

1europa.eu

68^th place

117^th place

1medscape.com

719^th place

636^th place

1economist.com

254^th place

236^th place

1handle.net

102^nd place

76^th place

1medicines.org.uk

3,823^rd place

2,387^th place

1hu-berlin.de

2,869^th place

4,557^th place

1archive.org

6^th place

1versusarthritis.org

low place

1nras.org.uk

low place

1mayoclinic.org

1,610^th place

1,279^th place

1nice.org.uk

3,258^th place

2,666^th place

1medicinescomplete.com

low place

1harvard.edu

18^th place

17^th place

1psu.edu

207^th place

136^th place

archive.org (Global: 6^th place; English: 6^th place)

Joint Formulary Committee (2013). British National Formulary (BNF) (65 ed.). London, UK: Pharmaceutical Press. ISBN 978-0-85711-084-8.

books.google.com (Global: 3^rd place; English: 3^rd place)

Sneader W (2005). Drug Discovery: A History. John Wiley & Sons. p. 251. ISBN 9780470015520. Archived from the original on 16 February 2017.
Bertino JR (2000). "Methotrexate: historical aspects". In Cronstein BN, Bertino JR (eds.). Methotrexate. Basel: Birkhäuser. ISBN 978-3-7643-5959-1.^{[page needed]}

clincalc.com (Global: 3,912^th place; English: 2,496^th place)

"Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
"Methotrexate Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.

dictionary.com (Global: 794^th place; English: 588^th place)

"methotrexate". Dictionary.com Unabridged (Online). n.d.

doi.org (Global: 2^nd place; English: 2^nd place)

Bannwarth B, Labat L, Moride Y, Schaeverbeke T (January 1994). "Methotrexate in rheumatoid arthritis. An update". Drugs. 47 (1): 25–50. doi:10.2165/00003495-199447010-00003. PMID 7510620. S2CID 46974070.
Lee YS, Joo MW, Shin SH, Hong S, Chung YG (January 2024). "Current Treatment Concepts for Extra-Abdominal Desmoid-Type Fibromatosis: A Narrative Review". Cancers. 16 (2): 273. doi:10.3390/cancers16020273. PMC 10813957. PMID 38254764.
Herfarth HH, Long MD, Isaacs KL (2012). "Methotrexate: underused and ignored?". Digestive Diseases. 30 (Suppl 3): 112–8. doi:10.1159/000342735. PMC 4629813. PMID 23295701.
Boehm IB, Boehm GA, Bauer R (1998). "Management of cutaneous lupus erythematosus with low-dose methotrexate: indication for modulation of inflammatory mechanisms". Rheumatol Int. 18 (2): 59–62. doi:10.1515/cclm.1993.31.10.667. PMID 9782534. S2CID 25311594.
Lopez-Olivo MA, Siddhanamatha HR, Shea B, Tugwell P, Wells GA, Suarez-Almazor ME (June 2014). "Methotrexate for treating rheumatoid arthritis". The Cochrane Database of Systematic Reviews. 2014 (6): CD000957. doi:10.1002/14651858.CD000957.pub2. PMC 7047041. PMID 24916606.{{cite journal}}: CS1 maint: article number as page number (link)
Cronstein BN (June 2005). "Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis". Pharmacological Reviews. 57 (2): 163–72. doi:10.1124/pr.57.2.3. PMID 15914465. S2CID 1643606.
American Rheumatoid Arthritis Guidelines (February 2002). "Guidelines for the management of rheumatoid arthritis: 2002 Update". Arthritis and Rheumatism. 46 (2): 328–46. doi:10.1002/art.10148. PMID 11840435.
Colebatch AN, Marks JL, Edwards CJ (November 2011). "Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)". The Cochrane Database of Systematic Reviews (11): CD008872. doi:10.1002/14651858.CD008872.pub2. PMID 22071858.{{cite journal}}: CS1 maint: article number as page number (link)
Marks JL, Edwards CJ (June 2012). "Protective effect of methotrexate in patients with rheumatoid arthritis and cardiovascular comorbidity". Therapeutic Advances in Musculoskeletal Disease. 4 (3): 149–57. doi:10.1177/1759720X11436239. PMC 3400102. PMID 22850632.
Donahue KE, Schulman ER, Gartlehner G, Jonas BL, Coker-Schwimmer E, Patel SV, et al. (October 2019). "Comparative Effectiveness of Combining MTX with Biologic Drug Therapy Versus Either MTX or Biologics Alone for Early Rheumatoid Arthritis in Adults: a Systematic Review and Network Meta-analysis". Journal of General Internal Medicine. 34 (10): 2232–2245. doi:10.1007/s11606-019-05230-0. PMC 6816735. PMID 31388915.
Herfarth HH (1 January 2016). "Methotrexate for Inflammatory Bowel Diseases - New Developments". Digestive Diseases. 34 (1–2): 140–6. doi:10.1159/000443129. PMC 4820247. PMID 26981630.
Tsang-A-Sjoe MW, Bultink IE (2015). "Systemic lupus erythematosus: review of synthetic drugs". Expert Opinion on Pharmacotherapy. 16 (18): 2793–806. doi:10.1517/14656566.2015.1101448. PMID 26479437. S2CID 36049926. ] To date, three small [86–88] RCTs in SLE patients have been published, including in total 76 patients in the active arm
Paolino A, Alexander H, Broderick C, Flohr C (May 2023). "Non-biologic systemic treatments for atopic dermatitis: Current state of the art and future directions". Clinical and Experimental Allergy. 53 (5): 495–510. doi:10.1111/cea.14301. PMID 36949024.
Flohr C, Rosala-Hallas A, Jones AP, Beattie P, Baron S, Browne F, et al. (November 2023). "Efficacy and safety of ciclosporin versus methotrexate in the treatment of severe atopic dermatitis in children and young people (TREAT): a multicentre parallel group assessor-blinded clinical trial". The British Journal of Dermatology. 189 (6): 674–684. doi:10.1093/bjd/ljad281. PMID 37722926.
Eczema in children: uncertainties addressed (Report). NIHR Evidence. 19 March 2024. doi:10.3310/nihrevidence_62438.
Mol F, Mol BW, Ankum WM, van der Veen F, Hajenius PJ (2008). "Current evidence on surgery, systemic methotrexate and expectant management in the treatment of tubal ectopic pregnancy: a systematic review and meta-analysis". Human Reproduction Update. 14 (4): 309–19. doi:10.1093/humupd/dmn012. PMID 18522946.
Oliff A, Bleyer WA, Poplack DG (1 September 1979). "Methotrexate-induced oral mucositis and salivary methotrexate concentrations". Cancer Chemotherapy and Pharmacology. 2 (3): 225–226. doi:10.1007/BF00258300. PMID 313282. S2CID 6273303.
Fragoulis GE, Nikiphorou E, Larsen J, Korsten P, Conway R (2019). "Methotrexate-Associated Pneumonitis and Rheumatoid Arthritis-Interstitial Lung Disease: Current Concepts for the Diagnosis and Treatment". Frontiers in Medicine. 6 238. doi:10.3389/fmed.2019.00238. PMC 6819370. PMID 31709258.
Russell MD, Dey M, Flint J, Davie P, Allen A, Crossley A, et al. (BSR Standards, Audit and Guidelines Working Group) (November 2022). "Executive Summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids". Rheumatology. 62 (4): 1370–1387. doi:10.1093/rheumatology/keac558. PMC 10070067. PMID 36318965.
Scheinfeld N (December 2006). "Three cases of toxic skin eruptions associated with methotrexate and a compilation of methotrexate-induced skin eruptions". Dermatology Online Journal. 12 (7): 15. doi:10.5070/D30NQ2C0BX. PMID 17459301.
Hafner DL (August 2009). "Lost in the fog: understanding "chemo brain"". Nursing. 39 (8): 42–5. doi:10.1097/01.nurse.0000358574.56241.2f. PMID 19633502. S2CID 9456346.
Wroński J, Ciechomska M, Kuca-Warnawin E (September 2023). "Impact of methotrexate treatment on vaccines immunogenicity in adult rheumatological patients - Lessons learned from the COVID-19 pandemic". Biomedicine & Pharmacotherapy. 165 115254. doi:10.1016/j.biopha.2023.115254. PMID 37542854.
Bass AR, Chakravarty E, Akl EA, Bingham CO, Calabrese L, Cappelli LC, et al. (March 2023). "2022 American College of Rheumatology Guideline for Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases". Arthritis Care & Research. 75 (3): 449–464. doi:10.1002/acr.25045. PMC 10291822. PMID 36597813.
Al-Haideri MT, Mannani R, Kaboli R, Gharebakhshi F, Darvishzadehdeldari S, Tahmasebi S, et al. (August 2023). "The effects of methotrexate on the immune responses to the COVID-19 vaccines in the patients with immune-mediated inflammatory disease: A systematic review of clinical evidence". Transplant Immunology. 79 101858. doi:10.1016/j.trim.2023.101858. PMC 10205646. PMID 37236514.
"A pause in methotrexate treatment boosted the immune response to the COVID-19 vaccine". NIHR Evidence. National Institute for Health and Care Research. 26 January 2023. doi:10.3310/nihrevidence_56391.
Imran M, Ali S, Ibrahim AA, Amjad A, Tanveer A, Khalil S, et al. (July 2024). "Effect of methotrexate hold on COVID-19 vaccine response in the patients with autoimmune inflammatory disorders: a systematic review and meta-analysis". Clinical Rheumatology. 43 (7): 2203–2214. doi:10.1007/s10067-024-07013-3. PMID 38802670.
Abhishek A, Peckham N, Pade C, Gibbons JM, Cureton L, Francis A, et al. (February 2024). "Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial". The Lancet. Rheumatology. 6 (2): e92 – e104. doi:10.1016/S2665-9913(23)00298-9. PMID 38267107.
Rajagopalan PT, Zhang Z, McCourt L, Dwyer M, Benkovic SJ, Hammes GG (October 2002). "Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics". Proceedings of the National Academy of Sciences of the United States of America. 99 (21): 13481–6. Bibcode:2002PNAS...9913481R. doi:10.1073/pnas.172501499. PMC 129699. PMID 12359872.
Goodsell DS (August 1999). "The molecular perspective: methotrexate". The Oncologist. 4 (4): 340–1. doi:10.1634/theoncologist.4-4-340. PMID 10476546.
Wessels JA, Huizinga TW, Guchelaar HJ (March 2008). "Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis". Rheumatology. 47 (3): 249–55. doi:10.1093/rheumatology/kem279. PMID 18045808.
Böhm I (June 2004). "Increased peripheral blood B-cells expressing the CD5 molecules in association to autoantibodies in patients with lupus erythematosus and evidence to selectively down-modulate them". Biomedicine & Pharmacotherapy. 58 (5): 338–43. doi:10.1016/j.biopha.2004.04.010. PMID 15194170.
Brody M, Böhm I, Bauer R (October 1993). "Mechanism of action of methotrexate: experimental evidence that methotrexate blocks the binding of interleukin 1 beta to the interleukin 1 receptor on target cells". European Journal of Clinical Chemistry and Clinical Biochemistry. 31 (10): 667–74. CiteSeerX 10.1.1.633.8921. doi:10.1515/cclm.1993.31.10.667. PMID 8292668. S2CID 25311594.
Meyer LM, Miller FR, Rowen MJ, Bock G, Rutzky J (September 1950). "Treatment of acute leukemia with amethopterin (4-amino, 10-methyl pteroyl glutamic acid)". Acta Haematologica. 4 (3): 157–67. doi:10.1159/000203749. PMID 14777272.
Hertz R, Li MC, Spencer DB (November 1956). "Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma". Proceedings of the Society for Experimental Biology and Medicine. 93 (2): 361–6. doi:10.3181/00379727-93-22757. PMID 13379512. S2CID 22939197.
Wright JC, Lyons MM, Walker DG, Golomb FM, Gumport SL, Medrek TJ (August 1964). "Observations on the Use of Cancer Chemotherapeutic Agents in Patients With Mycosis Fungoides". Cancer. 17 (8): 1045–62. doi:10.1002/1097-0142(196408)17:8<1045::AID-CNCR2820170811>3.0.CO;2-S. PMID 14202592.

drugs.com (Global: 399^th place; English: 333^rd place)

"Methotrexate". The American Society of Health-System Pharmacists. Archived from the original on 8 October 2016. Retrieved 22 August 2016.

economist.com (Global: 254^th place; English: 236^th place)

"Today's anti-cancer tools are ever better wielded". The Economist. 14 September 2017. Retrieved 16 September 2017.

europa.eu (Global: 68^th place; English: 117^th place)

ema.europa.eu

"Jylamvo EPAR". European Medicines Agency. 29 March 2017. Retrieved 25 June 2024.

handle.net (Global: 102^nd place; English: 76^th place)

hdl.handle.net

World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.

harvard.edu (Global: 18^th place; English: 17^th place)

ui.adsabs.harvard.edu

Rajagopalan PT, Zhang Z, McCourt L, Dwyer M, Benkovic SJ, Hammes GG (October 2002). "Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics". Proceedings of the National Academy of Sciences of the United States of America. 99 (21): 13481–6. Bibcode:2002PNAS...9913481R. doi:10.1073/pnas.172501499. PMC 129699. PMID 12359872.

hu-berlin.de (Global: 2,869^th place; English: 4,557^th place)

edoc.hu-berlin.de

Boehm IB, Boehm GA, Bauer R (1998). "Management of cutaneous lupus erythematosus with low-dose methotrexate: indication for modulation of inflammatory mechanisms". Rheumatol Int. 18 (2): 59–62. doi:10.1515/cclm.1993.31.10.667. PMID 9782534. S2CID 25311594.

mayoclinic.org (Global: 1,610^th place; English: 1,279^th place)

"Medical abortion". Mayo Clinic. Retrieved 10 July 2022.

medicines.org.uk (Global: 3,823^rd place; English: 2,387^th place)

"Methotrexate 2.5 mg Tablets - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Retrieved 19 February 2023.

medicinescomplete.com (Global: low place; English: low place)

Brayfield A, ed. (6 January 2014). "Methotrexate". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 12 April 2014.

medscape.com (Global: 719^th place; English: 636^th place)

reference.medscape.com

"Trexall, Rheumatrex (methotrexate) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 8 February 2014. Retrieved 12 April 2014.

merriam-webster.com (Global: 209^th place; English: 191^st place)

"methotrexate". Merriam-Webster.com Dictionary. Merriam-Webster.

nice.org.uk (Global: 3,258^th place; English: 2,666^th place)

"BNF is only available in the UK". NICE. Retrieved 19 February 2023.

nih.gov (Global: 4^th place; English: 4^th place)

pubmed.ncbi.nlm.nih.gov

Bannwarth B, Labat L, Moride Y, Schaeverbeke T (January 1994). "Methotrexate in rheumatoid arthritis. An update". Drugs. 47 (1): 25–50. doi:10.2165/00003495-199447010-00003. PMID 7510620. S2CID 46974070.
Lee YS, Joo MW, Shin SH, Hong S, Chung YG (January 2024). "Current Treatment Concepts for Extra-Abdominal Desmoid-Type Fibromatosis: A Narrative Review". Cancers. 16 (2): 273. doi:10.3390/cancers16020273. PMC 10813957. PMID 38254764.
Donahue KE, Gartlehner G, Schulman ER, Jonas B, Coker-Schwimmer E, Patel SV, et al. (2018). Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update. AHRQ Comparative Effectiveness Reviews. Rockville (MD): Agency for Healthcare Research and Quality (US). PMID 30199187.
Herfarth HH, Long MD, Isaacs KL (2012). "Methotrexate: underused and ignored?". Digestive Diseases. 30 (Suppl 3): 112–8. doi:10.1159/000342735. PMC 4629813. PMID 23295701.
Boehm IB, Boehm GA, Bauer R (1998). "Management of cutaneous lupus erythematosus with low-dose methotrexate: indication for modulation of inflammatory mechanisms". Rheumatol Int. 18 (2): 59–62. doi:10.1515/cclm.1993.31.10.667. PMID 9782534. S2CID 25311594.
Lopez-Olivo MA, Siddhanamatha HR, Shea B, Tugwell P, Wells GA, Suarez-Almazor ME (June 2014). "Methotrexate for treating rheumatoid arthritis". The Cochrane Database of Systematic Reviews. 2014 (6): CD000957. doi:10.1002/14651858.CD000957.pub2. PMC 7047041. PMID 24916606.{{cite journal}}: CS1 maint: article number as page number (link)
Cronstein BN (June 2005). "Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis". Pharmacological Reviews. 57 (2): 163–72. doi:10.1124/pr.57.2.3. PMID 15914465. S2CID 1643606.
American Rheumatoid Arthritis Guidelines (February 2002). "Guidelines for the management of rheumatoid arthritis: 2002 Update". Arthritis and Rheumatism. 46 (2): 328–46. doi:10.1002/art.10148. PMID 11840435.
Colebatch AN, Marks JL, Edwards CJ (November 2011). "Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)". The Cochrane Database of Systematic Reviews (11): CD008872. doi:10.1002/14651858.CD008872.pub2. PMID 22071858.{{cite journal}}: CS1 maint: article number as page number (link)
Weinblatt ME (2013). "Methotrexate in rheumatoid arthritis: a quarter century of development". Transactions of the American Clinical and Climatological Association. 124: 16–25. PMC 3715949. PMID 23874006.
Marks JL, Edwards CJ (June 2012). "Protective effect of methotrexate in patients with rheumatoid arthritis and cardiovascular comorbidity". Therapeutic Advances in Musculoskeletal Disease. 4 (3): 149–57. doi:10.1177/1759720X11436239. PMC 3400102. PMID 22850632.
Donahue KE, Schulman ER, Gartlehner G, Jonas BL, Coker-Schwimmer E, Patel SV, et al. (October 2019). "Comparative Effectiveness of Combining MTX with Biologic Drug Therapy Versus Either MTX or Biologics Alone for Early Rheumatoid Arthritis in Adults: a Systematic Review and Network Meta-analysis". Journal of General Internal Medicine. 34 (10): 2232–2245. doi:10.1007/s11606-019-05230-0. PMC 6816735. PMID 31388915.
Herfarth HH (1 January 2016). "Methotrexate for Inflammatory Bowel Diseases - New Developments". Digestive Diseases. 34 (1–2): 140–6. doi:10.1159/000443129. PMC 4820247. PMID 26981630.
Tsang-A-Sjoe MW, Bultink IE (2015). "Systemic lupus erythematosus: review of synthetic drugs". Expert Opinion on Pharmacotherapy. 16 (18): 2793–806. doi:10.1517/14656566.2015.1101448. PMID 26479437. S2CID 36049926. ] To date, three small [86–88] RCTs in SLE patients have been published, including in total 76 patients in the active arm
Paolino A, Alexander H, Broderick C, Flohr C (May 2023). "Non-biologic systemic treatments for atopic dermatitis: Current state of the art and future directions". Clinical and Experimental Allergy. 53 (5): 495–510. doi:10.1111/cea.14301. PMID 36949024.
Flohr C, Rosala-Hallas A, Jones AP, Beattie P, Baron S, Browne F, et al. (November 2023). "Efficacy and safety of ciclosporin versus methotrexate in the treatment of severe atopic dermatitis in children and young people (TREAT): a multicentre parallel group assessor-blinded clinical trial". The British Journal of Dermatology. 189 (6): 674–684. doi:10.1093/bjd/ljad281. PMID 37722926.
Mol F, Mol BW, Ankum WM, van der Veen F, Hajenius PJ (2008). "Current evidence on surgery, systemic methotrexate and expectant management in the treatment of tubal ectopic pregnancy: a systematic review and meta-analysis". Human Reproduction Update. 14 (4): 309–19. doi:10.1093/humupd/dmn012. PMID 18522946.
Oliff A, Bleyer WA, Poplack DG (1 September 1979). "Methotrexate-induced oral mucositis and salivary methotrexate concentrations". Cancer Chemotherapy and Pharmacology. 2 (3): 225–226. doi:10.1007/BF00258300. PMID 313282. S2CID 6273303.
Fragoulis GE, Nikiphorou E, Larsen J, Korsten P, Conway R (2019). "Methotrexate-Associated Pneumonitis and Rheumatoid Arthritis-Interstitial Lung Disease: Current Concepts for the Diagnosis and Treatment". Frontiers in Medicine. 6 238. doi:10.3389/fmed.2019.00238. PMC 6819370. PMID 31709258.
Gromnica-Ihle E, Krüger K (1 September 2010). "Use of methotrexate in young patients with respect to the reproductive system". Clinical and Experimental Rheumatology. 28 (5 Suppl 61): S80-4. PMID 21044438.
Russell MD, Dey M, Flint J, Davie P, Allen A, Crossley A, et al. (BSR Standards, Audit and Guidelines Working Group) (November 2022). "Executive Summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids". Rheumatology. 62 (4): 1370–1387. doi:10.1093/rheumatology/keac558. PMC 10070067. PMID 36318965.
Scheinfeld N (December 2006). "Three cases of toxic skin eruptions associated with methotrexate and a compilation of methotrexate-induced skin eruptions". Dermatology Online Journal. 12 (7): 15. doi:10.5070/D30NQ2C0BX. PMID 17459301.
Hafner DL (August 2009). "Lost in the fog: understanding "chemo brain"". Nursing. 39 (8): 42–5. doi:10.1097/01.nurse.0000358574.56241.2f. PMID 19633502. S2CID 9456346.
Wroński J, Ciechomska M, Kuca-Warnawin E (September 2023). "Impact of methotrexate treatment on vaccines immunogenicity in adult rheumatological patients - Lessons learned from the COVID-19 pandemic". Biomedicine & Pharmacotherapy. 165 115254. doi:10.1016/j.biopha.2023.115254. PMID 37542854.
Bass AR, Chakravarty E, Akl EA, Bingham CO, Calabrese L, Cappelli LC, et al. (March 2023). "2022 American College of Rheumatology Guideline for Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases". Arthritis Care & Research. 75 (3): 449–464. doi:10.1002/acr.25045. PMC 10291822. PMID 36597813.
Al-Haideri MT, Mannani R, Kaboli R, Gharebakhshi F, Darvishzadehdeldari S, Tahmasebi S, et al. (August 2023). "The effects of methotrexate on the immune responses to the COVID-19 vaccines in the patients with immune-mediated inflammatory disease: A systematic review of clinical evidence". Transplant Immunology. 79 101858. doi:10.1016/j.trim.2023.101858. PMC 10205646. PMID 37236514.
Imran M, Ali S, Ibrahim AA, Amjad A, Tanveer A, Khalil S, et al. (July 2024). "Effect of methotrexate hold on COVID-19 vaccine response in the patients with autoimmune inflammatory disorders: a systematic review and meta-analysis". Clinical Rheumatology. 43 (7): 2203–2214. doi:10.1007/s10067-024-07013-3. PMID 38802670.
Abhishek A, Peckham N, Pade C, Gibbons JM, Cureton L, Francis A, et al. (February 2024). "Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial". The Lancet. Rheumatology. 6 (2): e92 – e104. doi:10.1016/S2665-9913(23)00298-9. PMID 38267107.
Rajagopalan PT, Zhang Z, McCourt L, Dwyer M, Benkovic SJ, Hammes GG (October 2002). "Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics". Proceedings of the National Academy of Sciences of the United States of America. 99 (21): 13481–6. Bibcode:2002PNAS...9913481R. doi:10.1073/pnas.172501499. PMC 129699. PMID 12359872.
Goodsell DS (August 1999). "The molecular perspective: methotrexate". The Oncologist. 4 (4): 340–1. doi:10.1634/theoncologist.4-4-340. PMID 10476546.
Wessels JA, Huizinga TW, Guchelaar HJ (March 2008). "Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis". Rheumatology. 47 (3): 249–55. doi:10.1093/rheumatology/kem279. PMID 18045808.
Böhm I (June 2004). "Increased peripheral blood B-cells expressing the CD5 molecules in association to autoantibodies in patients with lupus erythematosus and evidence to selectively down-modulate them". Biomedicine & Pharmacotherapy. 58 (5): 338–43. doi:10.1016/j.biopha.2004.04.010. PMID 15194170.
Brody M, Böhm I, Bauer R (October 1993). "Mechanism of action of methotrexate: experimental evidence that methotrexate blocks the binding of interleukin 1 beta to the interleukin 1 receptor on target cells". European Journal of Clinical Chemistry and Clinical Biochemistry. 31 (10): 667–74. CiteSeerX 10.1.1.633.8921. doi:10.1515/cclm.1993.31.10.667. PMID 8292668. S2CID 25311594.
Meyer LM, Miller FR, Rowen MJ, Bock G, Rutzky J (September 1950). "Treatment of acute leukemia with amethopterin (4-amino, 10-methyl pteroyl glutamic acid)". Acta Haematologica. 4 (3): 157–67. doi:10.1159/000203749. PMID 14777272.
Wright JC, Prigot A, Wright B, Weintraub S, Wright LT (July 1951). "An evaluation of folic acid antagonists in adults with neoplastic diseases: a study of 93 patients with incurable neoplasms". Journal of the National Medical Association. 43 (4): 211–40. PMC 2616951. PMID 14850976.
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nihr.ac.uk (Global: low place; English: 6,693^rd place)

evidence.nihr.ac.uk

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