S Sinha, DHJ Lopes, Z Du, ES Pang, A Shanmugam, A Lomakin, P Talbiersky, A Tennstaedt, K McDaniel, R Bakshi, P-Y Kuo, M Ehrmann, GB Benedek, JA Loo, F-G Klärner, T Schrader, C Wang, and G Bitan. Lysine-specific molecular tweezers are broad-spectrum inhibitor of aggregation and toxicity of amyloid proteins. J. Am. Chem. Soc. 2011; 133(42): 16958–16969.
S Sinha, Z Du, P Maiti, F-G Klärner, T Schrader, C Wang, and G Bitan. Comparison of Three Amyloid Assembly Inhibitors: The Sugar scyllo-Inositol, the Polyphenol Epigallocatechin Gallate, and the Molecular Tweezer CLR01. ACS Chem. Neurosci. 2012; 3(6): 451–458.
X Zheng, D-Y Liu, F-G Klärner, T Schrader, G Bitan, and MT Bowers. Amyloid β-protein Assembly: The Effect of Molecular Tweezer CLR01 and CLR03. J. Phys. Chem. B, 2015; 119: 4831–4841.
DHJ Lopes, A Attar, G Nair, EY Hayden, Z Du, K McDaniel, S Dutt, K Bravo-Rodriguez, S Mittal, F-G Klärner, C Wang, E Sanchez-Garcia, T Schrader, and G Bitan (2015) Molecular tweezers inhibit islet amyloid polypeptide assembly and toxicity by a new mechanism, ACS Chem. Biol. 2015; 10: 1555–1569.
G Herzog, MD Shmueli, L Levi, L Engel, E Gazit, F-G Klärner, T Schrader, G Bitan, and D Segal. The Lys-specific molecular tweezer, CLR01, modulates aggregation of mutant p53 DNA binding domain and inhibits its toxicity, Biochemistry, 2015; 54: 3729–3738.
F-G Klärner and T Schrader. Aromatic Interactions by Molecular Tweezers and Clips in Chemical and Biological Systems. Acc. Chem. Res. 2013; 46: 967–978.
biomedcentral.com
bmcpharmacoltoxicol.biomedcentral.com
A Attar, W-TC Chan, F-G Klärner, T Schrader, and G Bitan. Safety and pharmacological characterization of the molecular tweezer CLR01 – a broad-spectrum inhibitor of amyloid proteins' toxicity. BMC Pharm. Tox. 2014; 15(23): doi:10.1186/2050-6511-15-23.
doi.org
A. Petitjean; R. G. Khoury; N. Kyritsakas; J. M. Lehn (2004). "Dynamic Devices. Shape Switching and Substrate Binding in Ion-Controlled Nanomechanical Molecular Tweezers". J. Am. Chem. Soc.126 (21): 6637–6647. doi:10.1021/ja031915r. PMID15161291.
F.-G. Klärner & B. Kahlert (2003). "Molecular Tweezers and Clips as Synthetic Receptors. Molecular Recognition and Dynamics in Receptor-Substrate Complexes". Acc. Chem. Res.36 (12): 919–932. doi:10.1021/ar0200448. PMID14674783. S2CID29313731.
X. Huang; N. Fujioka; G. Pescitelli; F. Koehn; R. T. Williamson; K. Nakanishi; N. Berova (2002). "Absolute Configurational Assignments of Secondary Amines by CD-sensitive Dimeric Zinc Porphyrin Host". J. Am. Chem. Soc.124 (17): 10320–10335. doi:10.1021/ja020520p. PMID12197735. S2CID33852448.
P. Talbiersky; F. Bastkowski; F.-G. Klärner; T. Schrader (2008). "Molecular Clip and Tweezer Introduce New Mechanisms of Enzyme Inhibition". J. Am. Chem. Soc.130 (30): 9824–9828. doi:10.1021/ja801441j. PMID18605724.
J. Polkowska; F. Bastkowski; T. Schrader; F.-G. Klärner; J. Zienau; F. Koziol; C. Ochsenfeld (2009). "A combined experimental and theoretical study of the pH-dependent binding mode of NAD+ by water-soluble molecular clips". J. Phys. Org. Chem. 22 (30): 779–790. doi:10.1002/poc.1519.
M. Kirsch; P. Talbiersky; J. Polkowska; F. Bastkowski; T. Schaller; H. de Groot; F.-G. Klärner; T. Schrader (2009). "A Mechanism of Efficient G6PD Inhibition by a Molecular Clip". Angew. Chem. Int. Ed.48 (16): 2886–2890. doi:10.1002/anie.200806175. PMID19283805.
E Lump, LM Castellano, C Meier, J Seeliger, N Erwin, B Sperlich, CM Stürzel, S Usmani, RM Hammond, J von Einem, G Gerold, F Kreppel, K Bravo-Rodriguez, T Pietschmann, VM Holmes, D Palesch, O Zirafi, D Weissman, A Sowislok, B Wettig, C Heid, F Kirchhoff, T Weil, F-G Klärner, T Schrader, G Bitan, E Sanchez-Garcia, R Winter, J Shorter, and Jan Münch, A molecular tweezer antagonizes seminal amyloids and HIV infection, eLife, 2015; 4:e05397.
jbc.org
S Acharya, BM Safaie, P Wongkongkathep, MI Ivanova, A Attar, F-G Klärner, T Schrader, JA Loo, G Bitan, and LJ Lapidus. Molecular Basis for Preventing α-Synuclein Aggregation by a Molecular Tweezer. J. Biol. Chem. 2014; 289(15): 10727–10737.
nih.gov
pubmed.ncbi.nlm.nih.gov
A. Petitjean; R. G. Khoury; N. Kyritsakas; J. M. Lehn (2004). "Dynamic Devices. Shape Switching and Substrate Binding in Ion-Controlled Nanomechanical Molecular Tweezers". J. Am. Chem. Soc.126 (21): 6637–6647. doi:10.1021/ja031915r. PMID15161291.
F.-G. Klärner & B. Kahlert (2003). "Molecular Tweezers and Clips as Synthetic Receptors. Molecular Recognition and Dynamics in Receptor-Substrate Complexes". Acc. Chem. Res.36 (12): 919–932. doi:10.1021/ar0200448. PMID14674783. S2CID29313731.
X. Huang; N. Fujioka; G. Pescitelli; F. Koehn; R. T. Williamson; K. Nakanishi; N. Berova (2002). "Absolute Configurational Assignments of Secondary Amines by CD-sensitive Dimeric Zinc Porphyrin Host". J. Am. Chem. Soc.124 (17): 10320–10335. doi:10.1021/ja020520p. PMID12197735. S2CID33852448.
P. Talbiersky; F. Bastkowski; F.-G. Klärner; T. Schrader (2008). "Molecular Clip and Tweezer Introduce New Mechanisms of Enzyme Inhibition". J. Am. Chem. Soc.130 (30): 9824–9828. doi:10.1021/ja801441j. PMID18605724.
M. Kirsch; P. Talbiersky; J. Polkowska; F. Bastkowski; T. Schaller; H. de Groot; F.-G. Klärner; T. Schrader (2009). "A Mechanism of Efficient G6PD Inhibition by a Molecular Clip". Angew. Chem. Int. Ed.48 (16): 2886–2890. doi:10.1002/anie.200806175. PMID19283805.
SM Fogerson, AJ van Brummen, DJ Busch, SR Allen, R Roychaudhuri, S Banks, F-G Klärner, T Schrader, G Bitan, and JR Morgan, Reducing synuclein accumulation improves neuronal survival after spinal cord injury, Exp. Neurol. 2016; 278: 105–115.
A Attar and G Bitan. Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" – from the test tube to animal models, Curr. Pharm. Des. 2014; 20: 2469–2483.
T Schrader, G Bitan, and F-G Klärner, Molecular Tweezers for Lysine and Arginine – Powerful Inhibitors of Pathologic Protein Aggregation, Chem. Commun. 2016: 52: 11318–11334.
F.-G. Klärner & B. Kahlert (2003). "Molecular Tweezers and Clips as Synthetic Receptors. Molecular Recognition and Dynamics in Receptor-Substrate Complexes". Acc. Chem. Res.36 (12): 919–932. doi:10.1021/ar0200448. PMID14674783. S2CID29313731.
X. Huang; N. Fujioka; G. Pescitelli; F. Koehn; R. T. Williamson; K. Nakanishi; N. Berova (2002). "Absolute Configurational Assignments of Secondary Amines by CD-sensitive Dimeric Zinc Porphyrin Host". J. Am. Chem. Soc.124 (17): 10320–10335. doi:10.1021/ja020520p. PMID12197735. S2CID33852448.
springer.com
link.springer.com
S Prabhudesai*, S Sinha*, A Attar, A Kotagiri, AG Fitzmaurice, R Lakshmanan, MI Ivanova, JA Loo, F-G Klärner, T Schrader, M Stahl, G Bitan#, and JM Bronstein#. A Novel "Molecular Tweezer" Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo. Neurotherapeutics. 2012; 9(2): 464–476.
N Ferreira, A Pereira-Henriques, A Attar, F-G Klärner, T Schrader, G Bitan, L Gales, MJ Saraiva, and MR Almeida. Molecular Tweezers Targeting Transthyretin Amyloidosis. Neurotherapeutics. 2014; 11: 450–461.
A Attar, C Ripoli, E Riccardi, P Maiti, DD Li Puma, T Liu, J Hayes, MR Jones, K Lichti-Kaiser, F Yang, GD Gale, C-h Tseng, M Tan, C-W Xie, JL Straudinger, F-G Klärner, T Schrader, SA Frautschy, C Grassi and G Bitan. Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers. Brain. 2012; 135(Pt 12): 3735–3748.
