NLRP3 (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "NLRP3" in English language version.

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alzdiscovery.org

Alzheimer's Drug Discovery Foundation D. "Dapansutrile" (PDF).

doi.org

Hoffman HM, Wright FA, Broide DH, et al. (May 2000). "Identification of a locus on chromosome 1q44 for familial cold urticaria". American Journal of Human Genetics. 66 (5): 1693–8. doi:10.1086/302874. PMC 1378006. PMID 10741953.
Tao JH, Zhang Y, Li XP (Dec 2013). "P2X7R: a potential key regulator of acute gouty arthritis". review. Seminars in Arthritis and Rheumatism. 43 (3): 376–80. doi:10.1016/j.semarthrit.2013.04.007. PMID 23786870.
Lu A, Wu H (Feb 2015). "Structural mechanisms of inflammasome assembly". review. The FEBS Journal. 282 (3): 435–44. doi:10.1111/febs.13133. PMC 6400279. PMID 25354325.
Koonin EV, Aravind L (May 2000). "The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation". Trends in Biochemical Sciences. 25 (5): 223–4. doi:10.1016/S0968-0004(00)01577-2. PMID 10782090.
Pueyo I, Jiménez JR, Hernández J, et al. (Sep 1978). "Carcinoid syndrome treated by hepatic embolization". AJR. American Journal of Roentgenology. 131 (3): 511–3. doi:10.2214/ajr.131.3.511. PMID 99001.
Jha S, Ting JP (Dec 2009). "Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases". Journal of Immunology. 183 (12): 7623–9. doi:10.4049/jimmunol.0902425. PMC 3666034. PMID 20007570.
Bertin J, DiStefano PS (Dec 2000). "The PYRIN domain: a novel motif found in apoptosis and inflammation proteins". review. Cell Death and Differentiation. 7 (12): 1273–4. doi:10.1038/sj.cdd.4400774. PMID 11270363.
Martinon F (Mar 2008). "Detection of immune danger signals by NALP3". review. Journal of Leukocyte Biology. 83 (3): 507–11. doi:10.1189/jlb.0607362. PMID 17982111.
Tapia-Abellán A, Angosto-Bazarra D, Alarcón-Vila C, et al. (2021-09-17). "Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation". Science Advances. 7 (38): eabf4468. Bibcode:2021SciA....7.4468T. doi:10.1126/sciadv.abf4468. ISSN 2375-2548. PMC 8443177. PMID 34524838.
Hari A, Zhang Y, Tu Z, et al. (2014). "Activation of NLRP3 inflammasome by crystalline structures via cell surface contact". Scientific Reports. 4: 7281. Bibcode:2014NatSR...4E7281H. doi:10.1038/srep07281. PMC 4250918. PMID 25445147.
Haneklaus M, O'Neill LA, Coll RC (Feb 2013). "Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments". review. Current Opinion in Immunology. 25 (1): 40–45. doi:10.1016/j.coi.2012.12.004. hdl:2262/72554. PMID 23305783.
Fang R, Uchiyama R, Sakai S, et al. (September 2019). "ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism". Mucosal Immunology. 12 (5): 1092–1103. doi:10.1038/s41385-019-0181-1. PMID 31278375.
Molina-López C, Hurtado-Navarro L, García CJ, et al. (2024-02-06). "Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production". Nature Communications. 15 (1): 1096. Bibcode:2024NatCo..15.1096M. doi:10.1038/s41467-024-44990-0. ISSN 2041-1723. PMC 10847128. PMID 38321014.
Turunen JA, Wedenoja J, Repo P, et al. (Jan 2018). "Keratoendotheliitis Fugax Hereditaria: A Novel Cryopyrin-Associated Periodic Syndrome Caused by a Mutation in the Nucleotide-Binding Domain, Leucine-Rich Repeat Family, Pyrin Domain-Containing 3 (NLRP3) Gene". American Journal of Ophthalmology. 184: 41–50. doi:10.1016/j.ajo.2018.01.017. PMID 29366613.
Church LD, Cook GP, McDermott MF (Jan 2008). "Primer: inflammasomes and interleukin 1beta in inflammatory disorders". review. Nature Clinical Practice Rheumatology. 4 (1): 34–42. doi:10.1038/ncprheum0681. PMID 18172447. S2CID 19986204.
Ren H, Han R, Chen X, et al. (May 2020). "Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update". J Cereb Blood Flow Metab. 40 (9): 1752–1768. doi:10.1177/0271678X20923551. PMC 7446569. PMID 32423330.
Liu-Bryan R (Jan 2010). "Intracellular innate immunity in gouty arthritis: role of NALP3 inflammasome". review. Immunology and Cell Biology. 88 (1): 20–3. doi:10.1038/icb.2009.93. PMC 4337950. PMID 19935768.
Heneka MT, Kummer MP, Stutz A, et al. (Jan 2013). "NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice". Nature. 493 (7434): 674–8. Bibcode:2013Natur.493..674H. doi:10.1038/nature11729. PMC 3812809. PMID 23254930.
Shi F, Kouadir M, Yang Y (Aug 2015). "NALP3 inflammasome activation in protein misfolding diseases". review. Life Sciences. 135: 9–14. doi:10.1016/j.lfs.2015.05.011. PMID 26037399.
Levy M, Thaiss CA, Elinav E (2015). "Taming the inflammasome". Nature Medicine. 21 (3): 213–215. doi:10.1038/nm.3808. PMID 25742454. S2CID 6659540.
Youm YH, Nguyen KY, Grant RW, et al. (2015). "The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease". Nature Medicine. 21 (3): 263–269. doi:10.1038/nm.3804. PMC 4352123. PMID 25686106.
Wei Q, Mu K, Li T, et al. (Jan 2014). "Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression". Laboratory Investigation. 94 (1): 52–62. doi:10.1038/labinvest.2013.126. PMID 24166187.
Coll RC, Robertson AA, Chae JJ, et al. (March 2015). "A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases". Nature Medicine. 21 (3): 248–55. doi:10.1038/nm.3806. PMC 4392179. PMID 25686105.
Tapia-Abellán A, Angosto-Bazarra D, Martínez-Banaclocha H, et al. (June 2019). "MCC950 closes the active conformation of NLRP3 to an inactive state". Nature Chemical Biology. 15 (6): 560–564. doi:10.1038/s41589-019-0278-6. ISSN 1552-4450. PMC 7116292. PMID 31086329.

ensembl.org

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000162711 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032691 – Ensembl, May 2017

handle.net

hdl.handle.net

Haneklaus M, O'Neill LA, Coll RC (Feb 2013). "Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments". review. Current Opinion in Immunology. 25 (1): 40–45. doi:10.1016/j.coi.2012.12.004. hdl:2262/72554. PMID 23305783.

harvard.edu

ui.adsabs.harvard.edu

Tapia-Abellán A, Angosto-Bazarra D, Alarcón-Vila C, et al. (2021-09-17). "Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation". Science Advances. 7 (38): eabf4468. Bibcode:2021SciA....7.4468T. doi:10.1126/sciadv.abf4468. ISSN 2375-2548. PMC 8443177. PMID 34524838.
Hari A, Zhang Y, Tu Z, et al. (2014). "Activation of NLRP3 inflammasome by crystalline structures via cell surface contact". Scientific Reports. 4: 7281. Bibcode:2014NatSR...4E7281H. doi:10.1038/srep07281. PMC 4250918. PMID 25445147.
Molina-López C, Hurtado-Navarro L, García CJ, et al. (2024-02-06). "Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production". Nature Communications. 15 (1): 1096. Bibcode:2024NatCo..15.1096M. doi:10.1038/s41467-024-44990-0. ISSN 2041-1723. PMC 10847128. PMID 38321014.
Heneka MT, Kummer MP, Stutz A, et al. (Jan 2013). "NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice". Nature. 493 (7434): 674–8. Bibcode:2013Natur.493..674H. doi:10.1038/nature11729. PMC 3812809. PMID 23254930.

nature.com

Levy M, Thaiss CA, Elinav E (2015). "Taming the inflammasome". Nature Medicine. 21 (3): 213–215. doi:10.1038/nm.3808. PMID 25742454. S2CID 6659540.

nih.gov

pubmed.ncbi.nlm.nih.gov

Hoffman HM, Wright FA, Broide DH, et al. (May 2000). "Identification of a locus on chromosome 1q44 for familial cold urticaria". American Journal of Human Genetics. 66 (5): 1693–8. doi:10.1086/302874. PMC 1378006. PMID 10741953.
Tao JH, Zhang Y, Li XP (Dec 2013). "P2X7R: a potential key regulator of acute gouty arthritis". review. Seminars in Arthritis and Rheumatism. 43 (3): 376–80. doi:10.1016/j.semarthrit.2013.04.007. PMID 23786870.
Lu A, Wu H (Feb 2015). "Structural mechanisms of inflammasome assembly". review. The FEBS Journal. 282 (3): 435–44. doi:10.1111/febs.13133. PMC 6400279. PMID 25354325.
Koonin EV, Aravind L (May 2000). "The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation". Trends in Biochemical Sciences. 25 (5): 223–4. doi:10.1016/S0968-0004(00)01577-2. PMID 10782090.
Pueyo I, Jiménez JR, Hernández J, et al. (Sep 1978). "Carcinoid syndrome treated by hepatic embolization". AJR. American Journal of Roentgenology. 131 (3): 511–3. doi:10.2214/ajr.131.3.511. PMID 99001.
Jha S, Ting JP (Dec 2009). "Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases". Journal of Immunology. 183 (12): 7623–9. doi:10.4049/jimmunol.0902425. PMC 3666034. PMID 20007570.
Bertin J, DiStefano PS (Dec 2000). "The PYRIN domain: a novel motif found in apoptosis and inflammation proteins". review. Cell Death and Differentiation. 7 (12): 1273–4. doi:10.1038/sj.cdd.4400774. PMID 11270363.
Martinon F (Mar 2008). "Detection of immune danger signals by NALP3". review. Journal of Leukocyte Biology. 83 (3): 507–11. doi:10.1189/jlb.0607362. PMID 17982111.
Tapia-Abellán A, Angosto-Bazarra D, Alarcón-Vila C, et al. (2021-09-17). "Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation". Science Advances. 7 (38): eabf4468. Bibcode:2021SciA....7.4468T. doi:10.1126/sciadv.abf4468. ISSN 2375-2548. PMC 8443177. PMID 34524838.
Hari A, Zhang Y, Tu Z, et al. (2014). "Activation of NLRP3 inflammasome by crystalline structures via cell surface contact". Scientific Reports. 4: 7281. Bibcode:2014NatSR...4E7281H. doi:10.1038/srep07281. PMC 4250918. PMID 25445147.
Haneklaus M, O'Neill LA, Coll RC (Feb 2013). "Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments". review. Current Opinion in Immunology. 25 (1): 40–45. doi:10.1016/j.coi.2012.12.004. hdl:2262/72554. PMID 23305783.
Fang R, Uchiyama R, Sakai S, et al. (September 2019). "ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism". Mucosal Immunology. 12 (5): 1092–1103. doi:10.1038/s41385-019-0181-1. PMID 31278375.
Molina-López C, Hurtado-Navarro L, García CJ, et al. (2024-02-06). "Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production". Nature Communications. 15 (1): 1096. Bibcode:2024NatCo..15.1096M. doi:10.1038/s41467-024-44990-0. ISSN 2041-1723. PMC 10847128. PMID 38321014.
Turunen JA, Wedenoja J, Repo P, et al. (Jan 2018). "Keratoendotheliitis Fugax Hereditaria: A Novel Cryopyrin-Associated Periodic Syndrome Caused by a Mutation in the Nucleotide-Binding Domain, Leucine-Rich Repeat Family, Pyrin Domain-Containing 3 (NLRP3) Gene". American Journal of Ophthalmology. 184: 41–50. doi:10.1016/j.ajo.2018.01.017. PMID 29366613.
Church LD, Cook GP, McDermott MF (Jan 2008). "Primer: inflammasomes and interleukin 1beta in inflammatory disorders". review. Nature Clinical Practice Rheumatology. 4 (1): 34–42. doi:10.1038/ncprheum0681. PMID 18172447. S2CID 19986204.
Ren H, Han R, Chen X, et al. (May 2020). "Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update". J Cereb Blood Flow Metab. 40 (9): 1752–1768. doi:10.1177/0271678X20923551. PMC 7446569. PMID 32423330.
Liu-Bryan R (Jan 2010). "Intracellular innate immunity in gouty arthritis: role of NALP3 inflammasome". review. Immunology and Cell Biology. 88 (1): 20–3. doi:10.1038/icb.2009.93. PMC 4337950. PMID 19935768.
Heneka MT, Kummer MP, Stutz A, et al. (Jan 2013). "NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice". Nature. 493 (7434): 674–8. Bibcode:2013Natur.493..674H. doi:10.1038/nature11729. PMC 3812809. PMID 23254930.
Shi F, Kouadir M, Yang Y (Aug 2015). "NALP3 inflammasome activation in protein misfolding diseases". review. Life Sciences. 135: 9–14. doi:10.1016/j.lfs.2015.05.011. PMID 26037399.
Levy M, Thaiss CA, Elinav E (2015). "Taming the inflammasome". Nature Medicine. 21 (3): 213–215. doi:10.1038/nm.3808. PMID 25742454. S2CID 6659540.
Youm YH, Nguyen KY, Grant RW, et al. (2015). "The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease". Nature Medicine. 21 (3): 263–269. doi:10.1038/nm.3804. PMC 4352123. PMID 25686106.
Wei Q, Mu K, Li T, et al. (Jan 2014). "Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression". Laboratory Investigation. 94 (1): 52–62. doi:10.1038/labinvest.2013.126. PMID 24166187.
Coll RC, Robertson AA, Chae JJ, et al. (March 2015). "A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases". Nature Medicine. 21 (3): 248–55. doi:10.1038/nm.3806. PMC 4392179. PMID 25686105.
Tapia-Abellán A, Angosto-Bazarra D, Martínez-Banaclocha H, et al. (June 2019). "MCC950 closes the active conformation of NLRP3 to an inactive state". Nature Chemical Biology. 15 (6): 560–564. doi:10.1038/s41589-019-0278-6. ISSN 1552-4450. PMC 7116292. PMID 31086329.

ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Anon. (2015). "Entrez Gene: NLRP3 NLR family, pyrin domain containing 3 [Homo sapiens (human)], Gene ID: 114548 (updated on 13-Nov-2015)". Bethesda, MD, USA: National Center for Biotechnology Information, National Library of Medicine. Retrieved 13 November 2015.
Hoffman HM, Wright FA, Broide DH, et al. (May 2000). "Identification of a locus on chromosome 1q44 for familial cold urticaria". American Journal of Human Genetics. 66 (5): 1693–8. doi:10.1086/302874. PMC 1378006. PMID 10741953.
Lu A, Wu H (Feb 2015). "Structural mechanisms of inflammasome assembly". review. The FEBS Journal. 282 (3): 435–44. doi:10.1111/febs.13133. PMC 6400279. PMID 25354325.
Jha S, Ting JP (Dec 2009). "Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases". Journal of Immunology. 183 (12): 7623–9. doi:10.4049/jimmunol.0902425. PMC 3666034. PMID 20007570.
Tapia-Abellán A, Angosto-Bazarra D, Alarcón-Vila C, et al. (2021-09-17). "Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation". Science Advances. 7 (38): eabf4468. Bibcode:2021SciA....7.4468T. doi:10.1126/sciadv.abf4468. ISSN 2375-2548. PMC 8443177. PMID 34524838.
Hari A, Zhang Y, Tu Z, et al. (2014). "Activation of NLRP3 inflammasome by crystalline structures via cell surface contact". Scientific Reports. 4: 7281. Bibcode:2014NatSR...4E7281H. doi:10.1038/srep07281. PMC 4250918. PMID 25445147.
Molina-López C, Hurtado-Navarro L, García CJ, et al. (2024-02-06). "Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production". Nature Communications. 15 (1): 1096. Bibcode:2024NatCo..15.1096M. doi:10.1038/s41467-024-44990-0. ISSN 2041-1723. PMC 10847128. PMID 38321014.
Ren H, Han R, Chen X, et al. (May 2020). "Potential therapeutic targets for intracerebral hemorrhage-associated inflammation: An update". J Cereb Blood Flow Metab. 40 (9): 1752–1768. doi:10.1177/0271678X20923551. PMC 7446569. PMID 32423330.
Liu-Bryan R (Jan 2010). "Intracellular innate immunity in gouty arthritis: role of NALP3 inflammasome". review. Immunology and Cell Biology. 88 (1): 20–3. doi:10.1038/icb.2009.93. PMC 4337950. PMID 19935768.
Heneka MT, Kummer MP, Stutz A, et al. (Jan 2013). "NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice". Nature. 493 (7434): 674–8. Bibcode:2013Natur.493..674H. doi:10.1038/nature11729. PMC 3812809. PMID 23254930.
Youm YH, Nguyen KY, Grant RW, et al. (2015). "The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease". Nature Medicine. 21 (3): 263–269. doi:10.1038/nm.3804. PMC 4352123. PMID 25686106.
Coll RC, Robertson AA, Chae JJ, et al. (March 2015). "A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases". Nature Medicine. 21 (3): 248–55. doi:10.1038/nm.3806. PMC 4392179. PMID 25686105.
Tapia-Abellán A, Angosto-Bazarra D, Martínez-Banaclocha H, et al. (June 2019). "MCC950 closes the active conformation of NLRP3 to an inactive state". Nature Chemical Biology. 15 (6): 560–564. doi:10.1038/s41589-019-0278-6. ISSN 1552-4450. PMC 7116292. PMID 31086329.

semanticscholar.org

api.semanticscholar.org

Church LD, Cook GP, McDermott MF (Jan 2008). "Primer: inflammasomes and interleukin 1beta in inflammatory disorders". review. Nature Clinical Practice Rheumatology. 4 (1): 34–42. doi:10.1038/ncprheum0681. PMID 18172447. S2CID 19986204.
Levy M, Thaiss CA, Elinav E (2015). "Taming the inflammasome". Nature Medicine. 21 (3): 213–215. doi:10.1038/nm.3808. PMID 25742454. S2CID 6659540.

uniprot.org

Q96P20

worldcat.org

search.worldcat.org

Tapia-Abellán A, Angosto-Bazarra D, Alarcón-Vila C, et al. (2021-09-17). "Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation". Science Advances. 7 (38): eabf4468. Bibcode:2021SciA....7.4468T. doi:10.1126/sciadv.abf4468. ISSN 2375-2548. PMC 8443177. PMID 34524838.
Molina-López C, Hurtado-Navarro L, García CJ, et al. (2024-02-06). "Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production". Nature Communications. 15 (1): 1096. Bibcode:2024NatCo..15.1096M. doi:10.1038/s41467-024-44990-0. ISSN 2041-1723. PMC 10847128. PMID 38321014.
Tapia-Abellán A, Angosto-Bazarra D, Martínez-Banaclocha H, et al. (June 2019). "MCC950 closes the active conformation of NLRP3 to an inactive state". Nature Chemical Biology. 15 (6): 560–564. doi:10.1038/s41589-019-0278-6. ISSN 1552-4450. PMC 7116292. PMID 31086329.