Analysis of information sources in references of the Wikipedia article "Nancy Bonini" in English language version.
The recently developed Drosophila wing injury assay is an elegant approach to study axonal degeneration and regeneration in vivo (Fang et al., 2012). The goal of these studies is to identify genes that are required for axonal degeneration and regeneration, and to identify the regulatory processes that are involved in spinal cord and nerve injuries.
As part of Charlie's Brain Series, a panel of experts gives insight into disorders of the brain, such as Parkinson's disease, stroke, and paralysis, and describes the latest cutting-edge treatments.
The recently developed Drosophila wing injury assay is an elegant approach to study axonal degeneration and regeneration in vivo (Fang et al., 2012). The goal of these studies is to identify genes that are required for axonal degeneration and regeneration, and to identify the regulatory processes that are involved in spinal cord and nerve injuries.
"… present evidence on page 1069 of this issue that short expansions of glutamine (Q) amino-acid residues — a polyglutamine, or polyQ tract — in the ataxin-2 protein are associated with increased risk of ALS. This unexpected finding comes 15 years after the discovery that long polyQ expansions in ataxin-2 cause spinocerebellar ataxia type 2, a neurodegenerative disorder involving abnormalities of gait.
In 1998, however, Bonini authored an idea that radically extended the scientific reach of the humble insect. She mused that inserting genes related to human brain diseases might yield critical insights into poorly understood neurodegenerative conditions, including Huntington's disease, Parkinson's disease, and ALS. "I saw it as, 'there are all these terrible diseases and nobody is really studying them in model organisms,'" Bonini says. "I knew it was a high-risk thing."
The recently developed Drosophila wing injury assay is an elegant approach to study axonal degeneration and regeneration in vivo (Fang et al., 2012). The goal of these studies is to identify genes that are required for axonal degeneration and regeneration, and to identify the regulatory processes that are involved in spinal cord and nerve injuries.
"… present evidence on page 1069 of this issue that short expansions of glutamine (Q) amino-acid residues — a polyglutamine, or polyQ tract — in the ataxin-2 protein are associated with increased risk of ALS. This unexpected finding comes 15 years after the discovery that long polyQ expansions in ataxin-2 cause spinocerebellar ataxia type 2, a neurodegenerative disorder involving abnormalities of gait.
The recently developed Drosophila wing injury assay is an elegant approach to study axonal degeneration and regeneration in vivo (Fang et al., 2012). The goal of these studies is to identify genes that are required for axonal degeneration and regeneration, and to identify the regulatory processes that are involved in spinal cord and nerve injuries.
"… present evidence on page 1069 of this issue that short expansions of glutamine (Q) amino-acid residues — a polyglutamine, or polyQ tract — in the ataxin-2 protein are associated with increased risk of ALS. This unexpected finding comes 15 years after the discovery that long polyQ expansions in ataxin-2 cause spinocerebellar ataxia type 2, a neurodegenerative disorder involving abnormalities of gait.
