DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, et al. (March 2013). "A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine". The Journal of Pharmacology and Experimental Therapeutics. 344 (3): 708–717. doi:10.1124/jpet.112.201616. PMID23300227. S2CID8785003.
Chen XT, Pitis P, Liu G, Yuan C, Gotchev D, Cowan CL, et al. (October 2013). "Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain". Journal of Medicinal Chemistry. 56 (20): 8019–8031. doi:10.1021/jm4010829. PMID24063433.
Soergel DG, Subach RA, Sadler B, Connell J, Marion AS, Cowan CL, et al. (March 2014). "First clinical experience with TRV130: pharmacokinetics and pharmacodynamics in healthy volunteers". Journal of Clinical Pharmacology. 54 (3): 351–357. doi:10.1002/jcph.207. PMID24122908. S2CID25049515.
Waldman SA (July 2002). "Does potency predict clinical efficacy? Illustration through an antihistamine model". Annals of Allergy, Asthma & Immunology. 89 (1): 7–11, quiz 11–2, 77. doi:10.1016/S1081-1206(10)61904-7. PMID12141724.
DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, et al. (March 2013). "A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine". The Journal of Pharmacology and Experimental Therapeutics. 344 (3): 708–717. doi:10.1124/jpet.112.201616. PMID23300227. S2CID8785003.
Chen XT, Pitis P, Liu G, Yuan C, Gotchev D, Cowan CL, et al. (October 2013). "Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain". Journal of Medicinal Chemistry. 56 (20): 8019–8031. doi:10.1021/jm4010829. PMID24063433.
Soergel DG, Subach RA, Sadler B, Connell J, Marion AS, Cowan CL, et al. (March 2014). "First clinical experience with TRV130: pharmacokinetics and pharmacodynamics in healthy volunteers". Journal of Clinical Pharmacology. 54 (3): 351–357. doi:10.1002/jcph.207. PMID24122908. S2CID25049515.
Waldman SA (July 2002). "Does potency predict clinical efficacy? Illustration through an antihistamine model". Annals of Allergy, Asthma & Immunology. 89 (1): 7–11, quiz 11–2, 77. doi:10.1016/S1081-1206(10)61904-7. PMID12141724.
DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, et al. (March 2013). "A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine". The Journal of Pharmacology and Experimental Therapeutics. 344 (3): 708–717. doi:10.1124/jpet.112.201616. PMID23300227. S2CID8785003.