Omigapil (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Omigapil" in English language version.

refsWebsite

Global rank English rank

26nih.gov

4^th place

20doi.org

2^nd place

9semanticscholar.org

11^th place

8^th place

3web.archive.org

1^st place

1clinicaltrials.gov

5,225^th place

4,062^nd place

1mdausa.org

low place

1santhera.com

low place

1europa.eu

68^th place

117^th place

1muscular-dystrophy.org

low place

1harvard.edu

18^th place

17^th place

clinicaltrials.gov

Clinical trial number NCT00036413 for "A 12-Week, Multicenter, Safety and Dose-Ranging Study of 3 Oral Doses of TCH346 in Patients With Amyotrophic Lateral Sclerosis" at ClinicalTrials.gov

doi.org

Olanow CW, Schapira AH, LeWitt PA, Kieburtz K, Sauer D, Olivieri G, et al. (December 2006). "TCH346 as a neuroprotective drug in Parkinson's disease: a double-blind, randomised, controlled trial". The Lancet. Neurology. 5 (12): 1013–1020. doi:10.1016/S1474-4422(06)70602-0. PMID 17110281. S2CID 1562331.
Meinen S, Lin S, Thurnherr R, Erb M, Meier T, Rüegg MA (August 2011). "Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice". EMBO Molecular Medicine. 3 (8): 465–479. doi:10.1002/emmm.201100151. PMC 3377088. PMID 21674808.
Olanow CW, Schapira AH, LeWitt PA, Kieburtz K, Sauer D, Olivieri G, et al. (December 2006). "TCH346 as a neuroprotective drug in Parkinson's disease: a double-blind, randomised, controlled trial". The Lancet. Neurology. 5 (12): 1013–1020. doi:10.1016/S1474-4422(06)70602-0. PMID 17110281. S2CID 1562331.
Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M, Ozeki Y, et al. (July 2005). "S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding". Nature Cell Biology. 7 (7): 665–674. doi:10.1038/ncb1268. PMID 15951807. S2CID 1922911.
Sen N, Hara MR, Kornberg MD, Cascio MB, Bae BI, Shahani N, et al. (July 2008). "Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis". Nature Cell Biology. 10 (7): 866–873. doi:10.1038/ncb1747. PMC 2689382. PMID 18552833.
Hara MR, Thomas B, Cascio MB, Bae BI, Hester LD, Dawson VL, et al. (March 2006). "Neuroprotection by pharmacologic blockade of the GAPDH death cascade". Proceedings of the National Academy of Sciences of the United States of America. 103 (10): 3887–3889. Bibcode:2006PNAS..103.3887H. doi:10.1073/pnas.0511321103. PMC 1450161. PMID 16505364.
Jenkins JL, Tanner JJ (March 2006). "High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase". Acta Crystallographica. Section D, Biological Crystallography. 62 (Pt 3): 290–301. doi:10.1107/S0907444905042289. PMID 16510976.
Kragten E, Lalande I, Zimmermann K, Roggo S, Schindler P, Muller D, et al. (March 1998). "Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl". The Journal of Biological Chemistry. 273 (10): 5821–5828. doi:10.1074/jbc.273.10.5821. PMID 9488718.
Waldmeier P, Bozyczko-Coyne D, Williams M, Vaught JL (November 2006). "Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases". Biochemical Pharmacology. 72 (10): 1197–1206. doi:10.1016/j.bcp.2006.06.031. PMID 16901468.
Waldmeier PC, Boulton AA, Cools AR, Kato AC, Tatton WG (2000). "Neurorescuing effects of the GAPDH ligand CGP 3466B". Advances in Research on Neurodegeneration. Journal of Neural Transmission. Supplementum. Vol. 60. pp. 197–214. doi:10.1007/978-3-7091-6301-6_13. ISBN 978-3-211-83537-1. PMID 11205140.
Sagot Y, Toni N, Perrelet D, Lurot S, King B, Rixner H, et al. (October 2000). "An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease". British Journal of Pharmacology. 131 (4): 721–728. doi:10.1038/sj.bjp.0703633. PMC 1572390. PMID 11030721.
Andringa G, Eshuis S, Perentes E, Maguire RP, Roth D, Ibrahim M, et al. (November 2003). "TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally MPTP-treated primates". Neurobiology of Disease. 14 (2): 205–217. doi:10.1016/S0969-9961(03)00125-6. PMID 14572443. S2CID 25987945.
Andringa G, Cools AR (2000). "The neuroprotective effects of CGP 3466B in the best in vivo model of Parkinson's disease, the bilaterally MPTP-treated rhesus monkey". Advances in Research on Neurodegeneration. Journal of Neural Transmission. Supplementum. Vol. 60. pp. 215–225. doi:10.1007/978-3-7091-6301-6_14. ISBN 978-3-211-83537-1. PMID 11205142.
Erb M, Meinen S, Barzaghi P, Sumanovski LT, Courdier-Früh I, Rüegg MA, et al. (December 2009). "Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-alpha2 deficiency". The Journal of Pharmacology and Experimental Therapeutics. 331 (3): 787–795. doi:10.1124/jpet.109.160754. PMID 19759319. S2CID 26038408.
Colognato H, Yurchenco PD (June 2000). "Form and function: the laminin family of heterotrimers". Developmental Dynamics. 218 (2): 213–234. doi:10.1002/(SICI)1097-0177(200006)218:2<213::AID-DVDY1>3.0.CO;2-R. PMID 10842354. S2CID 33567462.
Miyagoe-Suzuki Y, Nakagawa M, Takeda S (2000). "Merosin and congenital muscular dystrophy". Microscopy Research and Technique. 48 (3–4): 181–191. doi:10.1002/(SICI)1097-0029(20000201/15)48:3/4<181::AID-JEMT6>3.0.CO;2-Q. PMID 10679965. S2CID 23239499.
Erb M, Meinen S, Barzaghi P, Sumanovski LT, Courdier-Früh I, Rüegg MA, et al. (December 2009). "Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-alpha2 deficiency". The Journal of Pharmacology and Experimental Therapeutics. 331 (3): 787–795. doi:10.1124/jpet.109.160754. PMID 19759319. S2CID 26038408.
Meinen S, Lin S, Thurnherr R, Erb M, Meier T, Rüegg MA (August 2011). "Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice". EMBO Molecular Medicine. 3 (8): 465–479. doi:10.1002/emmm.201100151. PMC 3377088. PMID 21674808.
Miller R, Bradley W, Cudkowicz M, Hubble J, Meininger V, Mitsumoto H, et al. (August 2007). "Phase II/III randomized trial of TCH346 in patients with ALS". Neurology. 69 (8): 776–784. doi:10.1212/01.wnl.0000269676.07319.09. PMID 17709710. S2CID 29883238.
Harraz MM, Tyagi R, Cortés P, Snyder SH (March 2016). "Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation". Molecular Psychiatry. 21 (3): 313–319. doi:10.1038/mp.2015.211. PMC 4830355. PMID 26782056.

europa.eu

ema.europa.eu

Committee for Orphan Medicinal Products. "Public summary of opinion on orphan designation: Omigapil maleate for the congenital muscular dystrophy with merosin (laminin alpha 2) deficiency" (PDF). EMA/COMP/204694/2008 Rev.1.

harvard.edu

ui.adsabs.harvard.edu

Hara MR, Thomas B, Cascio MB, Bae BI, Hester LD, Dawson VL, et al. (March 2006). "Neuroprotection by pharmacologic blockade of the GAPDH death cascade". Proceedings of the National Academy of Sciences of the United States of America. 103 (10): 3887–3889. Bibcode:2006PNAS..103.3887H. doi:10.1073/pnas.0511321103. PMC 1450161. PMID 16505364.

mdausa.org

"Santhera to Test Compound in CMD". Archived from the original on 2011-10-25. Retrieved 2011-09-18.

muscular-dystrophy.org

Muscular Dystrophy Campaign. "New collaboration to support omigapil clinical trial for congenital muscular dystrophy". Archived from the original on 5 May 2012. Retrieved 13 May 2012.

nih.gov

pubmed.ncbi.nlm.nih.gov

Olanow CW, Schapira AH, LeWitt PA, Kieburtz K, Sauer D, Olivieri G, et al. (December 2006). "TCH346 as a neuroprotective drug in Parkinson's disease: a double-blind, randomised, controlled trial". The Lancet. Neurology. 5 (12): 1013–1020. doi:10.1016/S1474-4422(06)70602-0. PMID 17110281. S2CID 1562331.
Meinen S, Lin S, Thurnherr R, Erb M, Meier T, Rüegg MA (August 2011). "Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice". EMBO Molecular Medicine. 3 (8): 465–479. doi:10.1002/emmm.201100151. PMC 3377088. PMID 21674808.
Olanow CW, Schapira AH, LeWitt PA, Kieburtz K, Sauer D, Olivieri G, et al. (December 2006). "TCH346 as a neuroprotective drug in Parkinson's disease: a double-blind, randomised, controlled trial". The Lancet. Neurology. 5 (12): 1013–1020. doi:10.1016/S1474-4422(06)70602-0. PMID 17110281. S2CID 1562331.
Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M, Ozeki Y, et al. (July 2005). "S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding". Nature Cell Biology. 7 (7): 665–674. doi:10.1038/ncb1268. PMID 15951807. S2CID 1922911.
Sen N, Hara MR, Kornberg MD, Cascio MB, Bae BI, Shahani N, et al. (July 2008). "Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis". Nature Cell Biology. 10 (7): 866–873. doi:10.1038/ncb1747. PMC 2689382. PMID 18552833.
Hara MR, Thomas B, Cascio MB, Bae BI, Hester LD, Dawson VL, et al. (March 2006). "Neuroprotection by pharmacologic blockade of the GAPDH death cascade". Proceedings of the National Academy of Sciences of the United States of America. 103 (10): 3887–3889. Bibcode:2006PNAS..103.3887H. doi:10.1073/pnas.0511321103. PMC 1450161. PMID 16505364.
Jenkins JL, Tanner JJ (March 2006). "High-resolution structure of human D-glyceraldehyde-3-phosphate dehydrogenase". Acta Crystallographica. Section D, Biological Crystallography. 62 (Pt 3): 290–301. doi:10.1107/S0907444905042289. PMID 16510976.
Kragten E, Lalande I, Zimmermann K, Roggo S, Schindler P, Muller D, et al. (March 1998). "Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl". The Journal of Biological Chemistry. 273 (10): 5821–5828. doi:10.1074/jbc.273.10.5821. PMID 9488718.
Waldmeier P, Bozyczko-Coyne D, Williams M, Vaught JL (November 2006). "Recent clinical failures in Parkinson's disease with apoptosis inhibitors underline the need for a paradigm shift in drug discovery for neurodegenerative diseases". Biochemical Pharmacology. 72 (10): 1197–1206. doi:10.1016/j.bcp.2006.06.031. PMID 16901468.
Waldmeier PC, Boulton AA, Cools AR, Kato AC, Tatton WG (2000). "Neurorescuing effects of the GAPDH ligand CGP 3466B". Advances in Research on Neurodegeneration. Journal of Neural Transmission. Supplementum. Vol. 60. pp. 197–214. doi:10.1007/978-3-7091-6301-6_13. ISBN 978-3-211-83537-1. PMID 11205140.
Sagot Y, Toni N, Perrelet D, Lurot S, King B, Rixner H, et al. (October 2000). "An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease". British Journal of Pharmacology. 131 (4): 721–728. doi:10.1038/sj.bjp.0703633. PMC 1572390. PMID 11030721.
Andringa G, Eshuis S, Perentes E, Maguire RP, Roth D, Ibrahim M, et al. (November 2003). "TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally MPTP-treated primates". Neurobiology of Disease. 14 (2): 205–217. doi:10.1016/S0969-9961(03)00125-6. PMID 14572443. S2CID 25987945.
Andringa G, Cools AR (2000). "The neuroprotective effects of CGP 3466B in the best in vivo model of Parkinson's disease, the bilaterally MPTP-treated rhesus monkey". Advances in Research on Neurodegeneration. Journal of Neural Transmission. Supplementum. Vol. 60. pp. 215–225. doi:10.1007/978-3-7091-6301-6_14. ISBN 978-3-211-83537-1. PMID 11205142.
Erb M, Meinen S, Barzaghi P, Sumanovski LT, Courdier-Früh I, Rüegg MA, et al. (December 2009). "Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-alpha2 deficiency". The Journal of Pharmacology and Experimental Therapeutics. 331 (3): 787–795. doi:10.1124/jpet.109.160754. PMID 19759319. S2CID 26038408.
Colognato H, Yurchenco PD (June 2000). "Form and function: the laminin family of heterotrimers". Developmental Dynamics. 218 (2): 213–234. doi:10.1002/(SICI)1097-0177(200006)218:2<213::AID-DVDY1>3.0.CO;2-R. PMID 10842354. S2CID 33567462.
Miyagoe-Suzuki Y, Nakagawa M, Takeda S (2000). "Merosin and congenital muscular dystrophy". Microscopy Research and Technique. 48 (3–4): 181–191. doi:10.1002/(SICI)1097-0029(20000201/15)48:3/4<181::AID-JEMT6>3.0.CO;2-Q. PMID 10679965. S2CID 23239499.
Erb M, Meinen S, Barzaghi P, Sumanovski LT, Courdier-Früh I, Rüegg MA, et al. (December 2009). "Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-alpha2 deficiency". The Journal of Pharmacology and Experimental Therapeutics. 331 (3): 787–795. doi:10.1124/jpet.109.160754. PMID 19759319. S2CID 26038408.
Meinen S, Lin S, Thurnherr R, Erb M, Meier T, Rüegg MA (August 2011). "Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice". EMBO Molecular Medicine. 3 (8): 465–479. doi:10.1002/emmm.201100151. PMC 3377088. PMID 21674808.
Miller R, Bradley W, Cudkowicz M, Hubble J, Meininger V, Mitsumoto H, et al. (August 2007). "Phase II/III randomized trial of TCH346 in patients with ALS". Neurology. 69 (8): 776–784. doi:10.1212/01.wnl.0000269676.07319.09. PMID 17709710. S2CID 29883238.
Harraz MM, Tyagi R, Cortés P, Snyder SH (March 2016). "Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation". Molecular Psychiatry. 21 (3): 313–319. doi:10.1038/mp.2015.211. PMC 4830355. PMID 26782056.

ncbi.nlm.nih.gov

Meinen S, Lin S, Thurnherr R, Erb M, Meier T, Rüegg MA (August 2011). "Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice". EMBO Molecular Medicine. 3 (8): 465–479. doi:10.1002/emmm.201100151. PMC 3377088. PMID 21674808.
Sen N, Hara MR, Kornberg MD, Cascio MB, Bae BI, Shahani N, et al. (July 2008). "Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis". Nature Cell Biology. 10 (7): 866–873. doi:10.1038/ncb1747. PMC 2689382. PMID 18552833.
Hara MR, Thomas B, Cascio MB, Bae BI, Hester LD, Dawson VL, et al. (March 2006). "Neuroprotection by pharmacologic blockade of the GAPDH death cascade". Proceedings of the National Academy of Sciences of the United States of America. 103 (10): 3887–3889. Bibcode:2006PNAS..103.3887H. doi:10.1073/pnas.0511321103. PMC 1450161. PMID 16505364.
Sagot Y, Toni N, Perrelet D, Lurot S, King B, Rixner H, et al. (October 2000). "An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease". British Journal of Pharmacology. 131 (4): 721–728. doi:10.1038/sj.bjp.0703633. PMC 1572390. PMID 11030721.
Meinen S, Lin S, Thurnherr R, Erb M, Meier T, Rüegg MA (August 2011). "Apoptosis inhibitors and mini-agrin have additive benefits in congenital muscular dystrophy mice". EMBO Molecular Medicine. 3 (8): 465–479. doi:10.1002/emmm.201100151. PMC 3377088. PMID 21674808.
Harraz MM, Tyagi R, Cortés P, Snyder SH (March 2016). "Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation". Molecular Psychiatry. 21 (3): 313–319. doi:10.1038/mp.2015.211. PMC 4830355. PMID 26782056.

santhera.com

"Santhera Pharmaceuticals: Development of SNT-317 (INN: omigapil) in CMD and other neuromuscular diseases" (PDF). Archived from the original (PDF) on 2016-03-04. Retrieved 2012-05-07.

semanticscholar.org

api.semanticscholar.org

Olanow CW, Schapira AH, LeWitt PA, Kieburtz K, Sauer D, Olivieri G, et al. (December 2006). "TCH346 as a neuroprotective drug in Parkinson's disease: a double-blind, randomised, controlled trial". The Lancet. Neurology. 5 (12): 1013–1020. doi:10.1016/S1474-4422(06)70602-0. PMID 17110281. S2CID 1562331.
Olanow CW, Schapira AH, LeWitt PA, Kieburtz K, Sauer D, Olivieri G, et al. (December 2006). "TCH346 as a neuroprotective drug in Parkinson's disease: a double-blind, randomised, controlled trial". The Lancet. Neurology. 5 (12): 1013–1020. doi:10.1016/S1474-4422(06)70602-0. PMID 17110281. S2CID 1562331.
Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M, Ozeki Y, et al. (July 2005). "S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding". Nature Cell Biology. 7 (7): 665–674. doi:10.1038/ncb1268. PMID 15951807. S2CID 1922911.
Andringa G, Eshuis S, Perentes E, Maguire RP, Roth D, Ibrahim M, et al. (November 2003). "TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally MPTP-treated primates". Neurobiology of Disease. 14 (2): 205–217. doi:10.1016/S0969-9961(03)00125-6. PMID 14572443. S2CID 25987945.
Erb M, Meinen S, Barzaghi P, Sumanovski LT, Courdier-Früh I, Rüegg MA, et al. (December 2009). "Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-alpha2 deficiency". The Journal of Pharmacology and Experimental Therapeutics. 331 (3): 787–795. doi:10.1124/jpet.109.160754. PMID 19759319. S2CID 26038408.
Colognato H, Yurchenco PD (June 2000). "Form and function: the laminin family of heterotrimers". Developmental Dynamics. 218 (2): 213–234. doi:10.1002/(SICI)1097-0177(200006)218:2<213::AID-DVDY1>3.0.CO;2-R. PMID 10842354. S2CID 33567462.
Miyagoe-Suzuki Y, Nakagawa M, Takeda S (2000). "Merosin and congenital muscular dystrophy". Microscopy Research and Technique. 48 (3–4): 181–191. doi:10.1002/(SICI)1097-0029(20000201/15)48:3/4<181::AID-JEMT6>3.0.CO;2-Q. PMID 10679965. S2CID 23239499.
Erb M, Meinen S, Barzaghi P, Sumanovski LT, Courdier-Früh I, Rüegg MA, et al. (December 2009). "Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-alpha2 deficiency". The Journal of Pharmacology and Experimental Therapeutics. 331 (3): 787–795. doi:10.1124/jpet.109.160754. PMID 19759319. S2CID 26038408.
Miller R, Bradley W, Cudkowicz M, Hubble J, Meininger V, Mitsumoto H, et al. (August 2007). "Phase II/III randomized trial of TCH346 in patients with ALS". Neurology. 69 (8): 776–784. doi:10.1212/01.wnl.0000269676.07319.09. PMID 17709710. S2CID 29883238.

web.archive.org

"Santhera to Test Compound in CMD". Archived from the original on 2011-10-25. Retrieved 2011-09-18.
"Santhera Pharmaceuticals: Development of SNT-317 (INN: omigapil) in CMD and other neuromuscular diseases" (PDF). Archived from the original (PDF) on 2016-03-04. Retrieved 2012-05-07.
Muscular Dystrophy Campaign. "New collaboration to support omigapil clinical trial for congenital muscular dystrophy". Archived from the original on 5 May 2012. Retrieved 13 May 2012.