Analysis of information sources in references of the Wikipedia article "Orbitofrontal cortex" in English language version.
The posterior orbitofrontal cortex targets dual systems in the amygdala which have opposite effects on central autonomic structures. Both pathways originate in posterior orbitofrontal cortex, but one targets heavily the inhibitory intercalated masses, whose activation can ultimately disinhibit central autonomic structures during emotional arousal.
The specific innervation of inhibitory systems in the amygdala found here, along with the differential impact that dopamine has on them, makes it possible to hypothesize how distinct autonomic states may be achieved. A strong pOFC influence on IM that activates DARPP-32+ and CB+ neurons may help modulate autonomic function by downregulating CeM and thereby facilitate social interactions in primates....On the other hand, in a panic condition, when survival is perceived to be threatened, dopamine levels markedly increase. DARPP-32+ neurons in IM may thus be primarily inhibited, rendering the pOFC pathway ineffective.
Individuals with SUDs show several processing abnormalities during risk-taking decision-making, which include altered valuation of options (VMPFC) and outcomes (OFC and striatum), poor estimation of uncertainty (ACC and insular cortex), diminished executive control (DLPFC), and an attenuated influence of emotional salience (amygdala), and reduced responsiveness to somatic markers (somatosensory cortex). These neural processing differences during risk-taking among individuals with SUDs have been linked to poorer behavioral performance on risk-taking tasks and a more extensive history of substance use
A medial region of the OFC showed greater activation by drug cues compared with control cues and was consistently activated in the nontreatment-seeking subgroup. There is substantial evidence that this region plays a role in appetitive behavior and decision making (86,87), in particular with regard to expectations of reward (88) predicted by conditioned stimuli (89–94), which can control instrumental action selectio
The posterior orbitofrontal cortex targets dual systems in the amygdala which have opposite effects on central autonomic structures. Both pathways originate in posterior orbitofrontal cortex, but one targets heavily the inhibitory intercalated masses, whose activation can ultimately disinhibit central autonomic structures during emotional arousal.
The specific innervation of inhibitory systems in the amygdala found here, along with the differential impact that dopamine has on them, makes it possible to hypothesize how distinct autonomic states may be achieved. A strong pOFC influence on IM that activates DARPP-32+ and CB+ neurons may help modulate autonomic function by downregulating CeM and thereby facilitate social interactions in primates....On the other hand, in a panic condition, when survival is perceived to be threatened, dopamine levels markedly increase. DARPP-32+ neurons in IM may thus be primarily inhibited, rendering the pOFC pathway ineffective.
Individuals with SUDs show several processing abnormalities during risk-taking decision-making, which include altered valuation of options (VMPFC) and outcomes (OFC and striatum), poor estimation of uncertainty (ACC and insular cortex), diminished executive control (DLPFC), and an attenuated influence of emotional salience (amygdala), and reduced responsiveness to somatic markers (somatosensory cortex). These neural processing differences during risk-taking among individuals with SUDs have been linked to poorer behavioral performance on risk-taking tasks and a more extensive history of substance use
A medial region of the OFC showed greater activation by drug cues compared with control cues and was consistently activated in the nontreatment-seeking subgroup. There is substantial evidence that this region plays a role in appetitive behavior and decision making (86,87), in particular with regard to expectations of reward (88) predicted by conditioned stimuli (89–94), which can control instrumental action selectio
The posterior orbitofrontal cortex targets dual systems in the amygdala which have opposite effects on central autonomic structures. Both pathways originate in posterior orbitofrontal cortex, but one targets heavily the inhibitory intercalated masses, whose activation can ultimately disinhibit central autonomic structures during emotional arousal.
The specific innervation of inhibitory systems in the amygdala found here, along with the differential impact that dopamine has on them, makes it possible to hypothesize how distinct autonomic states may be achieved. A strong pOFC influence on IM that activates DARPP-32+ and CB+ neurons may help modulate autonomic function by downregulating CeM and thereby facilitate social interactions in primates....On the other hand, in a panic condition, when survival is perceived to be threatened, dopamine levels markedly increase. DARPP-32+ neurons in IM may thus be primarily inhibited, rendering the pOFC pathway ineffective.
Individuals with SUDs show several processing abnormalities during risk-taking decision-making, which include altered valuation of options (VMPFC) and outcomes (OFC and striatum), poor estimation of uncertainty (ACC and insular cortex), diminished executive control (DLPFC), and an attenuated influence of emotional salience (amygdala), and reduced responsiveness to somatic markers (somatosensory cortex). These neural processing differences during risk-taking among individuals with SUDs have been linked to poorer behavioral performance on risk-taking tasks and a more extensive history of substance use
A medial region of the OFC showed greater activation by drug cues compared with control cues and was consistently activated in the nontreatment-seeking subgroup. There is substantial evidence that this region plays a role in appetitive behavior and decision making (86,87), in particular with regard to expectations of reward (88) predicted by conditioned stimuli (89–94), which can control instrumental action selectio
