PCSK9 (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "PCSK9" in English language version.

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"VERVE-101: CRISPR-Based Gene Editing Therapy Shows Promise in Reducing LDL-C and PCSK9 Levels in Patients With HeFH". American College of Cardiology.

archive.today

"Alnylam Reports Positive Preliminary Clinical Results for ALN-PCS, an RNAi Therapeutic Targeting PCSK9 for the Treatment of Severe Hypercholesterolemia". Press Release. BusinessWire. 2011-01-04. Archived from the original on 2013-02-21. Retrieved 2011-01-04.

arstechnica.com

"CRISPR gene editing shown to permanently lower high cholesterol". Ars Technica. 15 November 2023. Retrieved 15 November 2023.

biogps.org

"BioGPS - your Gene Portal System". biogps.org. Retrieved 19 August 2016.

corporate-ir.net

phx.corporate-ir.net

"Alnylam Reports Positive Preliminary Clinical Results for ALN-PCS, an RNAi Therapeutic Targeting PCSK9 for the Treatment of Severe Hypercholesterolemia". Press Release. BusinessWire. 2011-01-04. Archived from the original on 2013-02-21. Retrieved 2011-01-04.

doi.org

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Zhang L, Song K, Zhu M, Shi J, Zhang H, Xu L, et al. (August 2016). "Proprotein convertase subtilisin/kexin type 9 (PCSK9) in lipid metabolism, atherosclerosis and ischemic stroke". International Journal of Neuroscience. 126 (8): 675–680. doi:10.3109/00207454.2015.1057636. PMID 26040332. S2CID 40377207.
Lagace TA (October 2014). "PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells". Current Opinion in Lipidology. 25 (5): 387–393. doi:10.1097/MOL.0000000000000114. PMC 4166010. PMID 25110901.
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Lambert G, Sjouke B, Choque B, Kastelein JJ, Hovingh GK (December 2012). "The PCSK9 decade". Journal of Lipid Research. 53 (12): 2515–2524. doi:10.1194/jlr.R026658. PMC 3494258. PMID 22811413.
Joseph L, Robinson JG (2015). "Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition and the Future of Lipid Lowering Therapy". Progress in Cardiovascular Diseases. 58 (1): 19–31. doi:10.1016/j.pcad.2015.04.004. PMID 25936907.
Hlatky MA, Kazi DS (November 2017). "PCSK9 Inhibitors: Economics and Policy". Journal of the American College of Cardiology. 70 (21): 2677–2687. doi:10.1016/j.jacc.2017.10.001. PMID 29169476.
Baum SJ, Toth PP, Underberg JA, Jellinger P, Ross J, Wilemon K (April 2017). "PCSK9 inhibitor access barriers-issues and recommendations: Improving the access process for patients, clinicians and payers". Clinical Cardiology. 40 (4): 243–254. doi:10.1002/clc.22713. PMC 5412679. PMID 28328015.
Navar AM, Taylor B, Mulder H, Fievitz E, Monda KL, Fievitz A, et al. (November 2017). "Association of Prior Authorization and Out-of-pocket Costs With Patient Access to PCSK9 Inhibitor Therapy". JAMA Cardiology (Original Investigation). 2 (11): 1217–1225. doi:10.1001/jamacardio.2017.3451. PMC 5963012. PMID 28973087.
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- Du F, Hui Y, Zhang M, Linton MF, Fazio S, Fan D (December 2011). "Novel domain interaction regulates secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9) protein". Journal of Biological Chemistry. 286 (50): 43054–43061. doi:10.1074/jbc.M111.273474. PMC 3234880. PMID 22027821.
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- Zhang DW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, et al. (June 2007). "Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation". The Journal of Biological Chemistry. 282 (25): 18602–18612. doi:10.1074/jbc.M702027200. PMID 17452316.
- Bergeron N, Phan BA, Ding Y, Fong A, Krauss RM (October 2015). "Proprotein convertase subtilisin/kexin type 9 inhibition: a new therapeutic mechanism for reducing cardiovascular disease risk". Circulation. 132 (17): 1648–1666. doi:10.1161/CIRCULATIONAHA.115.016080. PMID 26503748.
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- Rashid S, Tavori H, Brown PE, Linton MF, He J, Giunzioni I, et al. (July 2014). "Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms". Circulation. 130 (5): 431–441. doi:10.1161/CIRCULATIONAHA.113.006720. PMC 4115295. PMID 25070550.
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- Zhang DW, Garuti R, Tang WJ, Cohen JC, Hobbs HH (September 2008). "Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor". Proceedings of the National Academy of Sciences of the United States of America. 105 (35): 13045–13050. Bibcode:2008PNAS..10513045Z. doi:10.1073/pnas.0806312105. PMC 2526098. PMID 18753623.
- Dubuc G, Chamberland A, Wassef H, Davignon J, Seidah NG, Bernier L, et al. (August 2004). "Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia". Arteriosclerosis, Thrombosis, and Vascular Biology. 24 (8): 1454–1459. doi:10.1161/01.ATV.0000134621.14315.43. PMID 15178557.
- O'Connell EM, Lohoff FW (2020). "Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in the Brain and Relevance for Neuropsychiatric Disorders". Frontiers in Neuroscience. 14: 609. doi:10.3389/fnins.2020.00609. PMC 7303295. PMID 32595449.
- Norata GD, Tavori H, Pirillo A, Fazio S, Catapano AL (October 2016). "Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering". Cardiovascular Research. 112 (1): 429–442. doi:10.1093/cvr/cvw194. PMC 5031950. PMID 27496869.
- Ferri N, Tibolla G, Pirillo A, Cipollone F, Mezzetti A, Pacia S, et al. (February 2012). "Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels". Atherosclerosis. 220 (2): 381–386. doi:10.1016/j.atherosclerosis.2011.11.026. PMID 22176652.
- Wu CY, Tang ZH, Jiang L, Li XF, Jiang ZS, Liu LS (January 2012). "PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway". Molecular and Cellular Biochemistry. 359 (1–2): 347–358. doi:10.1007/s11010-011-1028-6. PMID 21847580. S2CID 8017156.
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- Robinson JG (August 2016). "Nonstatins and Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Role in Non-Familial Hypercholesterolemia". Progress in Cardiovascular Diseases. 59 (2): 165–171. doi:10.1016/j.pcad.2016.07.011. PMID 27498088.
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Hosseini K, Soleimani H, Maleki S, Nasrollahizadeh A, Tayebi S, Nelson J, et al. (2024-07-30). "Early administration of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in patients with acute coronary syndrome: a systematic review and meta-analysis". BMC Cardiovascular Disorders. 24 (1): 395. doi:10.1186/s12872-024-04057-w. ISSN 1471-2261. PMC 11287928. PMID 39080549.
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