PDK4 (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "PDK4" in English language version.

refsWebsite

Global rank English rank

29nih.gov

4^th place

20doi.org

2^nd place

6semanticscholar.org

11^th place

8^th place

2ensembl.org

1,626^th place

1,007^th place

2harvard.edu

18^th place

17^th place

1wikipathways.org

low place

1zenodo.org

621^st place

380^th place

doi.org

Gudi R, Bowker-Kinley MM, Kedishvili NY, Zhao Y, Popov KM (Dec 1995). "Diversity of the pyruvate dehydrogenase kinase gene family in humans". The Journal of Biological Chemistry. 270 (48): 28989–94. doi:10.1074/jbc.270.48.28989. PMID 7499431.
Andrews MT, Squire TL, Bowen CM, Rollins MB (Jul 1998). "Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8392–7. Bibcode:1998PNAS...95.8392A. doi:10.1073/pnas.95.14.8392. PMC 20986. PMID 9653197.
Kukimoto-Niino M, Tokmakov A, Terada T, Ohbayashi N, Fujimoto T, Gomi S, Shiromizu I, Kawamoto M, Matsusue T, Shirouzu M, Yokoyama S (Sep 2011). "Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4". Acta Crystallographica Section D. 67 (Pt 9): 763–73. doi:10.1107/S090744491102405X. PMID 21904029.
Kolobova E, Tuganova A, Boulatnikov I, Popov KM (Aug 2001). "Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites". The Biochemical Journal. 358 (Pt 1): 69–77. doi:10.1042/0264-6021:3580069. PMC 1222033. PMID 11485553.
Kwon HS, Huang B, Ho Jeoung N, Wu P, Steussy CN, Harris RA (2006). "Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1759 (3–4): 141–51. doi:10.1016/j.bbaexp.2006.04.005. PMID 16757381.
Cadoudal T, Distel E, Durant S, Fouque F, Blouin JM, Collinet M, Bortoli S, Forest C, Benelli C (Sep 2008). "Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue". Diabetes. 57 (9): 2272–9. doi:10.2337/db08-0477. PMC 2518477. PMID 18519799.
Savkur RS, Bramlett KS, Michael LF, Burris TP (Apr 2005). "Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor". Biochemical and Biophysical Research Communications. 329 (1): 391–6. doi:10.1016/j.bbrc.2005.01.141. PMID 15721319.
Kwon HS, Huang B, Unterman TG, Harris RA (Apr 2004). "Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors". Diabetes. 53 (4): 899–910. doi:10.2337/diabetes.53.4.899. PMID 15047604.
Abbot EL, McCormack JG, Reynet C, Hassall DG, Buchan KW, Yeaman SJ (Jun 2005). "Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells". The FEBS Journal. 272 (12): 3004–14. doi:10.1111/j.1742-4658.2005.04713.x. PMID 15955060. S2CID 21366281.
Spriet LL, Tunstall RJ, Watt MJ, Mehan KA, Hargreaves M, Cameron-Smith D (Jun 2004). "Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting". Journal of Applied Physiology. 96 (6): 2082–7. doi:10.1152/japplphysiol.01318.2003. PMID 14966024. S2CID 13601849.
Pilegaard H, Saltin B, Neufer PD (Mar 2003). "Effect of short-term fasting and refeeding on transcriptional regulation of metabolic genes in human skeletal muscle". Diabetes. 52 (3): 657–62. doi:10.2337/diabetes.52.3.657. PMID 12606505.
Wynn RM, Kato M, Chuang JL, Tso SC, Li J, Chuang DT (Sep 2008). "Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity". The Journal of Biological Chemistry. 283 (37): 25305–15. doi:10.1074/jbc.M802249200. PMC 2533096. PMID 18658136.
Rosa G, Di Rocco P, Manco M, Greco AV, Castagneto M, Vidal H, Mingrone G (Feb 2003). "Reduced PDK4 expression associates with increased insulin sensitivity in postobese patients". Obesity Research. 11 (2): 176–82. doi:10.1038/oby.2003.28. PMID 12582211.
Majer M, Popov KM, Harris RA, Bogardus C, Prochazka M (Oct 1998). "Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects". Molecular Genetics and Metabolism. 65 (2): 181–6. doi:10.1006/mgme.1998.2748. PMID 9787110.
Pilegaard H, Ordway GA, Saltin B, Neufer PD (Oct 2000). "Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise". American Journal of Physiology. Endocrinology and Metabolism. 279 (4): E806-14. doi:10.1152/ajpendo.2000.279.4.e806. PMID 11001762. S2CID 1008940.
Wang L, Sahlin K (Apr 2012). "The effect of continuous and interval exercise on PGC-1α and PDK4 mRNA in type I and type II fibres of human skeletal muscle". Acta Physiologica. 204 (4): 525–32. doi:10.1111/j.1748-1716.2011.02354.x. PMID 21883960. S2CID 13208033.
Lee JH, Kim EJ, Kim DK, Lee JM, Park SB, Lee IK, Harris RA, Lee MO, Choi HS (2012). "Hypoxia induces PDK4 gene expression through induction of the orphan nuclear receptor ERRγ". PLOS ONE. 7 (9): e46324. Bibcode:2012PLoSO...746324L. doi:10.1371/journal.pone.0046324. PMC 3457976. PMID 23050013.
Razeghi P, Young ME, Ying J, Depre C, Uray IP, Kolesar J, Shipley GL, Moravec CS, Davies PJ, Frazier OH, Taegtmeyer H (2002). "Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading". Cardiology. 97 (4): 203–9. doi:10.1159/000063122. PMID 12145475. S2CID 46861699.
Blouin JM, Penot G, Collinet M, Nacfer M, Forest C, Laurent-Puig P, Coumoul X, Barouki R, Benelli C, Bortoli S (Jun 2011). "Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex". International Journal of Cancer. 128 (11): 2591–601. doi:10.1002/ijc.25599. PMID 20715114. S2CID 27407499.
Liu Z, Chen X, Wang Y, Peng H, Wang Y, Jing Y, Zhang H (Oct 2014). "PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade". The Journal of Biological Chemistry. 289 (43): 29739–49. doi:10.1074/jbc.M114.584821. PMC 4207987. PMID 25164809.

ensembl.org

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000004799 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000019577 – Ensembl, May 2017

harvard.edu

ui.adsabs.harvard.edu

Andrews MT, Squire TL, Bowen CM, Rollins MB (Jul 1998). "Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8392–7. Bibcode:1998PNAS...95.8392A. doi:10.1073/pnas.95.14.8392. PMC 20986. PMID 9653197.
Lee JH, Kim EJ, Kim DK, Lee JM, Park SB, Lee IK, Harris RA, Lee MO, Choi HS (2012). "Hypoxia induces PDK4 gene expression through induction of the orphan nuclear receptor ERRγ". PLOS ONE. 7 (9): e46324. Bibcode:2012PLoSO...746324L. doi:10.1371/journal.pone.0046324. PMC 3457976. PMID 23050013.

nih.gov

pubmed.ncbi.nlm.nih.gov

Gudi R, Bowker-Kinley MM, Kedishvili NY, Zhao Y, Popov KM (Dec 1995). "Diversity of the pyruvate dehydrogenase kinase gene family in humans". The Journal of Biological Chemistry. 270 (48): 28989–94. doi:10.1074/jbc.270.48.28989. PMID 7499431.
Andrews MT, Squire TL, Bowen CM, Rollins MB (Jul 1998). "Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8392–7. Bibcode:1998PNAS...95.8392A. doi:10.1073/pnas.95.14.8392. PMC 20986. PMID 9653197.
Kukimoto-Niino M, Tokmakov A, Terada T, Ohbayashi N, Fujimoto T, Gomi S, Shiromizu I, Kawamoto M, Matsusue T, Shirouzu M, Yokoyama S (Sep 2011). "Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4". Acta Crystallographica Section D. 67 (Pt 9): 763–73. doi:10.1107/S090744491102405X. PMID 21904029.
Kolobova E, Tuganova A, Boulatnikov I, Popov KM (Aug 2001). "Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites". The Biochemical Journal. 358 (Pt 1): 69–77. doi:10.1042/0264-6021:3580069. PMC 1222033. PMID 11485553.
Kwon HS, Huang B, Ho Jeoung N, Wu P, Steussy CN, Harris RA (2006). "Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1759 (3–4): 141–51. doi:10.1016/j.bbaexp.2006.04.005. PMID 16757381.
Cadoudal T, Distel E, Durant S, Fouque F, Blouin JM, Collinet M, Bortoli S, Forest C, Benelli C (Sep 2008). "Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue". Diabetes. 57 (9): 2272–9. doi:10.2337/db08-0477. PMC 2518477. PMID 18519799.
Savkur RS, Bramlett KS, Michael LF, Burris TP (Apr 2005). "Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor". Biochemical and Biophysical Research Communications. 329 (1): 391–6. doi:10.1016/j.bbrc.2005.01.141. PMID 15721319.
Kwon HS, Huang B, Unterman TG, Harris RA (Apr 2004). "Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors". Diabetes. 53 (4): 899–910. doi:10.2337/diabetes.53.4.899. PMID 15047604.
Abbot EL, McCormack JG, Reynet C, Hassall DG, Buchan KW, Yeaman SJ (Jun 2005). "Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells". The FEBS Journal. 272 (12): 3004–14. doi:10.1111/j.1742-4658.2005.04713.x. PMID 15955060. S2CID 21366281.
Spriet LL, Tunstall RJ, Watt MJ, Mehan KA, Hargreaves M, Cameron-Smith D (Jun 2004). "Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting". Journal of Applied Physiology. 96 (6): 2082–7. doi:10.1152/japplphysiol.01318.2003. PMID 14966024. S2CID 13601849.
Pilegaard H, Saltin B, Neufer PD (Mar 2003). "Effect of short-term fasting and refeeding on transcriptional regulation of metabolic genes in human skeletal muscle". Diabetes. 52 (3): 657–62. doi:10.2337/diabetes.52.3.657. PMID 12606505.
Wynn RM, Kato M, Chuang JL, Tso SC, Li J, Chuang DT (Sep 2008). "Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity". The Journal of Biological Chemistry. 283 (37): 25305–15. doi:10.1074/jbc.M802249200. PMC 2533096. PMID 18658136.
Rosa G, Di Rocco P, Manco M, Greco AV, Castagneto M, Vidal H, Mingrone G (Feb 2003). "Reduced PDK4 expression associates with increased insulin sensitivity in postobese patients". Obesity Research. 11 (2): 176–82. doi:10.1038/oby.2003.28. PMID 12582211.
Majer M, Popov KM, Harris RA, Bogardus C, Prochazka M (Oct 1998). "Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects". Molecular Genetics and Metabolism. 65 (2): 181–6. doi:10.1006/mgme.1998.2748. PMID 9787110.
Pilegaard H, Ordway GA, Saltin B, Neufer PD (Oct 2000). "Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise". American Journal of Physiology. Endocrinology and Metabolism. 279 (4): E806-14. doi:10.1152/ajpendo.2000.279.4.e806. PMID 11001762. S2CID 1008940.
Wang L, Sahlin K (Apr 2012). "The effect of continuous and interval exercise on PGC-1α and PDK4 mRNA in type I and type II fibres of human skeletal muscle". Acta Physiologica. 204 (4): 525–32. doi:10.1111/j.1748-1716.2011.02354.x. PMID 21883960. S2CID 13208033.
Lee JH, Kim EJ, Kim DK, Lee JM, Park SB, Lee IK, Harris RA, Lee MO, Choi HS (2012). "Hypoxia induces PDK4 gene expression through induction of the orphan nuclear receptor ERRγ". PLOS ONE. 7 (9): e46324. Bibcode:2012PLoSO...746324L. doi:10.1371/journal.pone.0046324. PMC 3457976. PMID 23050013.
Razeghi P, Young ME, Ying J, Depre C, Uray IP, Kolesar J, Shipley GL, Moravec CS, Davies PJ, Frazier OH, Taegtmeyer H (2002). "Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading". Cardiology. 97 (4): 203–9. doi:10.1159/000063122. PMID 12145475. S2CID 46861699.
Blouin JM, Penot G, Collinet M, Nacfer M, Forest C, Laurent-Puig P, Coumoul X, Barouki R, Benelli C, Bortoli S (Jun 2011). "Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex". International Journal of Cancer. 128 (11): 2591–601. doi:10.1002/ijc.25599. PMID 20715114. S2CID 27407499.
Liu Z, Chen X, Wang Y, Peng H, Wang Y, Jing Y, Zhang H (Oct 2014). "PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade". The Journal of Biological Chemistry. 289 (43): 29739–49. doi:10.1074/jbc.M114.584821. PMC 4207987. PMID 25164809.

ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: PDK4 pyruvate dehydrogenase kinase, isozyme 4".
Andrews MT, Squire TL, Bowen CM, Rollins MB (Jul 1998). "Low-temperature carbon utilization is regulated by novel gene activity in the heart of a hibernating mammal". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8392–7. Bibcode:1998PNAS...95.8392A. doi:10.1073/pnas.95.14.8392. PMC 20986. PMID 9653197.
Kolobova E, Tuganova A, Boulatnikov I, Popov KM (Aug 2001). "Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites". The Biochemical Journal. 358 (Pt 1): 69–77. doi:10.1042/0264-6021:3580069. PMC 1222033. PMID 11485553.
Cadoudal T, Distel E, Durant S, Fouque F, Blouin JM, Collinet M, Bortoli S, Forest C, Benelli C (Sep 2008). "Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue". Diabetes. 57 (9): 2272–9. doi:10.2337/db08-0477. PMC 2518477. PMID 18519799.
Wynn RM, Kato M, Chuang JL, Tso SC, Li J, Chuang DT (Sep 2008). "Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity". The Journal of Biological Chemistry. 283 (37): 25305–15. doi:10.1074/jbc.M802249200. PMC 2533096. PMID 18658136.
Lee JH, Kim EJ, Kim DK, Lee JM, Park SB, Lee IK, Harris RA, Lee MO, Choi HS (2012). "Hypoxia induces PDK4 gene expression through induction of the orphan nuclear receptor ERRγ". PLOS ONE. 7 (9): e46324. Bibcode:2012PLoSO...746324L. doi:10.1371/journal.pone.0046324. PMC 3457976. PMID 23050013.
Liu Z, Chen X, Wang Y, Peng H, Wang Y, Jing Y, Zhang H (Oct 2014). "PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade". The Journal of Biological Chemistry. 289 (43): 29739–49. doi:10.1074/jbc.M114.584821. PMC 4207987. PMID 25164809.

semanticscholar.org

api.semanticscholar.org

Abbot EL, McCormack JG, Reynet C, Hassall DG, Buchan KW, Yeaman SJ (Jun 2005). "Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells". The FEBS Journal. 272 (12): 3004–14. doi:10.1111/j.1742-4658.2005.04713.x. PMID 15955060. S2CID 21366281.
Spriet LL, Tunstall RJ, Watt MJ, Mehan KA, Hargreaves M, Cameron-Smith D (Jun 2004). "Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting". Journal of Applied Physiology. 96 (6): 2082–7. doi:10.1152/japplphysiol.01318.2003. PMID 14966024. S2CID 13601849.
Pilegaard H, Ordway GA, Saltin B, Neufer PD (Oct 2000). "Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise". American Journal of Physiology. Endocrinology and Metabolism. 279 (4): E806-14. doi:10.1152/ajpendo.2000.279.4.e806. PMID 11001762. S2CID 1008940.
Wang L, Sahlin K (Apr 2012). "The effect of continuous and interval exercise on PGC-1α and PDK4 mRNA in type I and type II fibres of human skeletal muscle". Acta Physiologica. 204 (4): 525–32. doi:10.1111/j.1748-1716.2011.02354.x. PMID 21883960. S2CID 13208033.
Razeghi P, Young ME, Ying J, Depre C, Uray IP, Kolesar J, Shipley GL, Moravec CS, Davies PJ, Frazier OH, Taegtmeyer H (2002). "Downregulation of metabolic gene expression in failing human heart before and after mechanical unloading". Cardiology. 97 (4): 203–9. doi:10.1159/000063122. PMID 12145475. S2CID 46861699.
Blouin JM, Penot G, Collinet M, Nacfer M, Forest C, Laurent-Puig P, Coumoul X, Barouki R, Benelli C, Bortoli S (Jun 2011). "Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex". International Journal of Cancer. 128 (11): 2591–601. doi:10.1002/ijc.25599. PMID 20715114. S2CID 27407499.

wikipathways.org

The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78".

zenodo.org

Majer M, Popov KM, Harris RA, Bogardus C, Prochazka M (Oct 1998). "Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects". Molecular Genetics and Metabolism. 65 (2): 181–6. doi:10.1006/mgme.1998.2748. PMID 9787110.