PKM2 (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "PKM2" in English language version.

refsWebsite

Global rank English rank

79nih.gov

4^th place

54doi.org

2^nd place

12semanticscholar.org

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8^th place

7harvard.edu

18^th place

17^th place

4worldcat.org

5^th place

2ensembl.org

1,626^th place

1,007^th place

1wikipathways.org

low place

1zenodo.org

621^st place

380^th place

1frontiersin.org

4,679^th place

low place

doi.org

Kitagawa S, Obata T, Hasumura S, Pastan I, Cheng SY (March 1987). "A cellular 3,3',5-triiodo-L-thyronine binding protein from a human carcinoma cell line. Purification and characterization". The Journal of Biological Chemistry. 262 (8): 3903–8. doi:10.1016/S0021-9258(18)61442-5. PMID 3818670.
Tsutsumi H, Tani K, Fujii H, Miwa S (January 1988). "Expression of L- and M-type pyruvate kinase in human tissues". Genomics. 2 (1): 86–9. doi:10.1016/0888-7543(88)90112-7. PMID 2838416.
Tani K, Yoshida MC, Satoh H, Mitamura K, Noguchi T, Tanaka T, Fujii H, Miwa S (December 1988). "Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma". Gene. 73 (2): 509–16. doi:10.1016/0378-1119(88)90515-X. PMID 2854097.
Popescu NC, Cheng SY (November 1990). "Chromosomal localization of the gene for a human cytosolic thyroid hormone binding protein homologous to the subunit of pyruvate kinase, subtype M2". Somatic Cell and Molecular Genetics. 16 (6): 593–8. doi:10.1007/BF01233100. PMID 2267632. S2CID 8182554.
Corcoran E, Phelan JJ, Fottrell PF (September 1976). "Purification and properties of pyruvate kinase from human lung". Biochimica et Biophysica Acta (BBA) - Protein Structure. 446 (1): 96–104. doi:10.1016/0005-2795(76)90101-x. PMID 974119.
Tolle SW, Dyson RD, Newburgh RW, Cardenas JM (December 1976). "Pyruvate kinase isozymes in neurons, glia, neuroblastoma, and glioblastoma". Journal of Neurochemistry. 27 (6): 1355–1360. doi:10.1111/j.1471-4159.1976.tb02615.x. PMID 1003209. S2CID 35715586.
Reinacher M, Eigenbrodt E (1981). "Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-Pk) in tumors of chicken and rat". Virchows Archiv B. 37 (1): 79–88. doi:10.1007/BF02892557. PMID 6116351. S2CID 34155302.
Schering B, Eigenbrodt E, Linder D, Schoner W (August 1982). "Purification and properties of pyruvate kinase type M2 from rat lung". Biochimica et Biophysica Acta (BBA) - General Subjects. 717 (2): 337–47. doi:10.1016/0304-4165(82)90188-X. PMID 7115773.
MacDonald MJ, Chang CM (October 1985). "Pancreatic islets contain the M2 isoenzyme of pyruvate kinase. Its phosphorylation has no effect on enzyme activity". Molecular and Cellular Biochemistry. 68 (2): 115–20. doi:10.1007/bf00219375. PMID 3908905. S2CID 6187554.
Brinck U, Eigenbrodt E, Oehmke M, Mazurek S, Fischer G (1994). "L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases". Virchows Archiv. 424 (2): 177–85. doi:10.1007/BF00193498. PMID 8180780. S2CID 5550950.
Steinberg P, Klingelhöffer A, Schäfer A, Wüst G, Weisse G, Oesch F, Eigenbrodt E (March 1999). "Expression of pyruvate kinase M2 in preneoplastic hepatic foci of N-nitrosomorpholine-treated rats". Virchows Archiv. 434 (3): 213–20. doi:10.1007/s004280050330. PMID 10190300. S2CID 28167108.
Warburg, Otto; Wind, Franz; Negelein, Erwin (1927-03-07). "The Metabolism of Tumors in the Body". The Journal of General Physiology. 8 (6): 519–530. doi:10.1085/jgp.8.6.519. ISSN 0022-1295. PMC 2140820. PMID 19872213.
Liberti, Maria V.; Locasale, Jason W. (March 2016). "The Warburg Effect: How Does it Benefit Cancer Cells?". Trends in Biochemical Sciences. 41 (3): 211–218. doi:10.1016/j.tibs.2015.12.001. ISSN 0968-0004. PMC 4783224. PMID 26778478.
Noguchi T, Inoue H, Tanaka T (October 1986). "The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing". The Journal of Biological Chemistry. 261 (29): 13807–12. doi:10.1016/S0021-9258(18)67091-7. PMID 3020052.
Dombrauckas JD, Santarsiero BD, Mesecar AD (July 2005). "Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis". Biochemistry. 44 (27): 9417–29. doi:10.1021/bi0474923. PMID 15996096. S2CID 24625677.
Vaupel P, Harrison L (2004). "Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response". The Oncologist. 9 (Suppl 5): 4–9. doi:10.1634/theoncologist.9-90005-4. PMID 15591417.
Gupta V, Bamezai RN (November 2010). "Human pyruvate kinase M2: a multifunctional protein". Protein Science. 19 (11): 2031–44. doi:10.1002/pro.505. PMC 3005776. PMID 20857498.
Boeckel JN, Derlet A, Glaser SF, Luczak A, Lucas T, Heumüller AW, Krüger M, Zehendner CM, Kaluza D, Doddaballapur A, Ohtani K, Treguer K, Dimmeler S (July 2016). "JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 36 (7): 1425–33. doi:10.1161/ATVBAHA.116.307695. PMID 27199445.
Eigenbrodt E, Glossmann H (1980). "Glycolysis – one of the keys to cancer". Trends Pharmacol. Sci. 1 (2): 240–245. doi:10.1016/0165-6147(80)90009-7.
Mazurek S, Boschek CB, Hugo F, Eigenbrodt E (August 2005). "Pyruvate kinase type M2 and its role in tumor growth and spreading". Seminars in Cancer Biology. 15 (4): 300–8. doi:10.1016/j.semcancer.2005.04.009. PMID 15908230.
Palsson-McDermott EM, Dyck L, Zasłona Z, Menon D, McGettrick AF, Mills KH, O'Neill LA (2017-10-13). "Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors". Frontiers in Immunology. 8: 1300. doi:10.3389/fimmu.2017.01300. PMC 5646285. PMID 29081778.
Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang JK, Jiang JK, Israelsen WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Vanden Heiden M, Xavier RJ, O'Neill LA (January 2015). "Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages". Cell Metabolism. 21 (1): 65–80. doi:10.1016/j.cmet.2014.12.005. PMC 5198835. PMID 25565206.
Zhang Z, Deng W, Kang R, Xie M, Billiar T, Wang H, Cao L, Tang D (September 2016). "Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2". Molecular Medicine. 22: 162–172. doi:10.2119/molmed.2015.00250. PMC 5004715. PMID 26982513.
Yang L, Xie M, Yang M, Yu Y, Zhu S, Hou W, Kang R, Lotze MT, Billiar TR, Wang H, Cao L, Tang D (July 2014). "PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis". Nature Communications. 5 (1): 4436. Bibcode:2014NatCo...5.4436Y. doi:10.1038/ncomms5436. PMC 4104986. PMID 25019241.
Deng W, Zhu S, Zeng L, Liu J, Kang R, Yang M, Cao L, Wang H, Billiar TR, Jiang J, Xie M, Tang D (July 2018). "The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis". Cell Reports. 24 (2): 366–378. doi:10.1016/j.celrep.2018.06.026. PMC 6094382. PMID 29996098.
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Dürr P (February 1999). "Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1291–6. Bibcode:1999PNAS...96.1291Z. doi:10.1073/pnas.96.4.1291. PMC 15456. PMID 9990017.
Mazurek S, Zwerschke W, Jansen-Dürr P, Eigenbrodt E (October 2001). "Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7". Oncogene. 20 (47): 6891–8. doi:10.1038/sj.onc.1204792. PMID 11687968. S2CID 24269991.
Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC (March 2008). "Pyruvate kinase M2 is a phosphotyrosine-binding protein". Nature. 452 (7184): 181–6. Bibcode:2008Natur.452..181C. doi:10.1038/nature06667. PMID 18337815. S2CID 4346405.
Ignacak J, Stachurska MB (March 2003). "The dual activity of pyruvate kinase type M2 from chromatin extracts of neoplastic cells". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 134 (3): 425–33. doi:10.1016/S1096-4959(02)00283-X. PMID 12628374.
Hoshino A, Hirst JA, Fujii H (June 2007). "Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase". The Journal of Biological Chemistry. 282 (24): 17706–11. doi:10.1074/jbc.M700094200. PMID 17446165.
Steták A, Veress R, Ovádi J, Csermely P, Kéri G, Ullrich A (February 2007). "Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death". Cancer Research. 67 (4): 1602–8. doi:10.1158/0008-5472.CAN-06-2870. PMID 17308100.
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC (March 2008). "The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth". Nature. 452 (7184): 230–3. Bibcode:2008Natur.452..230C. doi:10.1038/nature06734. PMID 18337823. S2CID 16111842.
Bluemlein K, Grüning NM, Feichtinger RG, Lehrach H, Kofler B, Ralser M (May 2011). "No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis". Oncotarget. 2 (5): 393–400. doi:10.18632/oncotarget.278. PMC 3248187. PMID 21789790.
Zahra K, Dey T, Mishra SP, Pandey U (2020-03-02). "Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis". Frontiers in Oncology. 10: 159. doi:10.3389/fonc.2020.00159. PMC 7061896. PMID 32195169.
Oude Weernink PA, Rijksen G, Staal GE (1991). "Phosphorylation of pyruvate kinase and glycolytic metabolism in three human glioma cell lines". Tumour Biology. 12 (6): 339–52. doi:10.1159/000217735. PMID 1798909.
Eigenbrodt E, Mazurek S, Friis RR (1998). "Double role of pyruvate kinase type M2 in the regulation of phosphometabolite pools". Cell Growth and Oncogenesis. Molecular and Cell Biology Updates. Basel/Switzerland: Birkhäuser Verlag. pp. 15–30. doi:10.1007/978-3-0348-8950-6_2. ISBN 3-7643-5727-4.
Garcia-Gonzalo FR, Cruz C, Muñoz P, Mazurek S, Eigenbrodt E, Ventura F, Bartrons R, Rosa JL (March 2003). "Interaction between HERC1 and M2-type pyruvate kinase". FEBS Letters. 539 (1–3): 78–84. doi:10.1016/S0014-5793(03)00205-9. PMID 12650930. S2CID 32809019.
Siwko S, Mochly-Rosen D (2007). "Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase". The International Journal of Biochemistry & Cell Biology. 39 (5): 978–87. doi:10.1016/j.biocel.2007.01.018. PMC 1931518. PMID 17337233.
Zhang Z, Deng W, Kang R, Xie M, Billiar T, Wang H, et al. (September 2016). "Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2". Molecular Medicine. 22: 162–172. doi:10.2119/molmed.2015.00250. PMC 5004715. PMID 26982513.
Yang L, Xie M, Yang M, Yu Y, Zhu S, Hou W, et al. (July 2014). "PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis". Nature Communications. 5: 4436. Bibcode:2014NatCo...5.4436Y. doi:10.1038/ncomms5436. PMC 4104986. PMID 25019241.
Huang J, Liu K, Zhu S, Xie M, Kang R, Cao L, Tang D (August 2018). "AMPK regulates immunometabolism in sepsis". Brain, Behavior, and Immunity. 72: 89–100. doi:10.1016/j.bbi.2017.11.003. PMID 29109024. S2CID 38415440.
Zahra, Kulsoom; Dey, Tulika; Ashish; Mishra, Surendra Pratap; Pandey, Uma (2020). "Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis". Frontiers in Oncology. 10: 159. doi:10.3389/fonc.2020.00159. ISSN 2234-943X. PMC 7061896. PMID 32195169.
Puckett, Dexter L.; Alquraishi, Mohammed; Chowanadisai, Winyoo; Bettaieb, Ahmed (January 2021). "The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs". International Journal of Molecular Sciences. 22 (3): 1171. doi:10.3390/ijms22031171. ISSN 1422-0067. PMC 7865720. PMID 33503959.
Ashizawa K, Willingham MC, Liang CM, Cheng SY (September 1991). "In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate". The Journal of Biological Chemistry. 266 (25): 16842–6. doi:10.1016/S0021-9258(18)55378-3. PMID 1885610.
Kato H, Fukuda T, Parkison C, McPhie P, Cheng SY (October 1989). "Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase". Proceedings of the National Academy of Sciences of the United States of America. 86 (20): 7861–5. Bibcode:1989PNAS...86.7861K. doi:10.1073/pnas.86.20.7861. PMC 298171. PMID 2813362.
Le Mellay V, Houben R, Troppmair J, Hagemann C, Mazurek S, Frey U, Beigel J, Weber C, Benz R, Eigenbrodt E, Rapp UR (2002). "Regulation of glycolysis by Raf protein serine/threonine kinases". Advances in Enzyme Regulation. 42: 317–32. doi:10.1016/S0065-2571(01)00036-X. PMID 12123723.
Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Alfred Yung WK, Lu Z (August 2012). "PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis". Cell. 150 (4): 685–96. doi:10.1016/j.cell.2012.07.018. PMC 3431020. PMID 22901803.
Keller KE, Tan IS, Lee YS (November 2012). "SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions". Science. 338 (6110): 1069–72. Bibcode:2012Sci...338.1069K. doi:10.1126/science.1224409. PMC 3527123. PMID 23086999.
Keller KE, Doctor ZM, Dwyer ZW, Lee YS (March 2014). "SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells". Molecular Cell. 53 (5): 700–9. doi:10.1016/j.molcel.2014.02.015. PMC 4000728. PMID 24606918.
Akhtar K, Gupta V, Koul A, Alam N, Bhat R, Bamezai RN (May 2009). "Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme". The Journal of Biological Chemistry. 284 (18): 11971–81. doi:10.1074/jbc.M808761200. PMC 2673266. PMID 19265196.
Gupta V, Kalaiarasan P, Faheem M, Singh N, Iqbal MA, Bamezai RN (May 2010). "Dominant negative mutations affect oligomerization of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy". The Journal of Biological Chemistry. 285 (22): 16864–73. doi:10.1074/jbc.M109.065029. PMC 2878009. PMID 20304929.
Iqbal MA, Siddiqui FA, Chaman N, Gupta V, Kumar B, Gopinath P, Bamezai RN (March 2014). "Missense mutations in pyruvate kinase M2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative manner". The Journal of Biological Chemistry. 289 (12): 8098–105. doi:10.1074/jbc.M113.515742. PMC 3961641. PMID 24492614.
Gupta V, Wellen KE, Mazurek S, Bamezai RN (2013). "Pyruvate kinase M2: regulatory circuits and potential for therapeutic intervention". Current Pharmaceutical Design. 20 (15): 2595–606. doi:10.2174/13816128113199990484. PMID 23859618.
Williams JM, Chen GC, Zhu L, Rest RF (January 1998). "Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth". Molecular Microbiology. 27 (1): 171–86. doi:10.1046/j.1365-2958.1998.00670.x. PMID 9466265.

ensembl.org

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000067225 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032294 – Ensembl, May 2017

frontiersin.org

Christos Chinopoulos (2020), From Glucose to Lactate and Transiting Intermediates Through Mitochondria, Bypassing Pyruvate Kinase: Considerations for Cells Exhibiting Dimeric PKM2 or Otherwise Inhibited Kinase Activity, https://www.frontiersin.org/articles/10.3389/fphys.2020.543564/full

harvard.edu

ui.adsabs.harvard.edu

Yang L, Xie M, Yang M, Yu Y, Zhu S, Hou W, Kang R, Lotze MT, Billiar TR, Wang H, Cao L, Tang D (July 2014). "PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis". Nature Communications. 5 (1): 4436. Bibcode:2014NatCo...5.4436Y. doi:10.1038/ncomms5436. PMC 4104986. PMID 25019241.
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Dürr P (February 1999). "Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1291–6. Bibcode:1999PNAS...96.1291Z. doi:10.1073/pnas.96.4.1291. PMC 15456. PMID 9990017.
Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC (March 2008). "Pyruvate kinase M2 is a phosphotyrosine-binding protein". Nature. 452 (7184): 181–6. Bibcode:2008Natur.452..181C. doi:10.1038/nature06667. PMID 18337815. S2CID 4346405.
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC (March 2008). "The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth". Nature. 452 (7184): 230–3. Bibcode:2008Natur.452..230C. doi:10.1038/nature06734. PMID 18337823. S2CID 16111842.
Yang L, Xie M, Yang M, Yu Y, Zhu S, Hou W, et al. (July 2014). "PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis". Nature Communications. 5: 4436. Bibcode:2014NatCo...5.4436Y. doi:10.1038/ncomms5436. PMC 4104986. PMID 25019241.
Kato H, Fukuda T, Parkison C, McPhie P, Cheng SY (October 1989). "Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase". Proceedings of the National Academy of Sciences of the United States of America. 86 (20): 7861–5. Bibcode:1989PNAS...86.7861K. doi:10.1073/pnas.86.20.7861. PMC 298171. PMID 2813362.
Keller KE, Tan IS, Lee YS (November 2012). "SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions". Science. 338 (6110): 1069–72. Bibcode:2012Sci...338.1069K. doi:10.1126/science.1224409. PMC 3527123. PMID 23086999.

nih.gov

pubmed.ncbi.nlm.nih.gov

Kitagawa S, Obata T, Hasumura S, Pastan I, Cheng SY (March 1987). "A cellular 3,3',5-triiodo-L-thyronine binding protein from a human carcinoma cell line. Purification and characterization". The Journal of Biological Chemistry. 262 (8): 3903–8. doi:10.1016/S0021-9258(18)61442-5. PMID 3818670.
Tsutsumi H, Tani K, Fujii H, Miwa S (January 1988). "Expression of L- and M-type pyruvate kinase in human tissues". Genomics. 2 (1): 86–9. doi:10.1016/0888-7543(88)90112-7. PMID 2838416.
Tani K, Yoshida MC, Satoh H, Mitamura K, Noguchi T, Tanaka T, Fujii H, Miwa S (December 1988). "Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma". Gene. 73 (2): 509–16. doi:10.1016/0378-1119(88)90515-X. PMID 2854097.
Popescu NC, Cheng SY (November 1990). "Chromosomal localization of the gene for a human cytosolic thyroid hormone binding protein homologous to the subunit of pyruvate kinase, subtype M2". Somatic Cell and Molecular Genetics. 16 (6): 593–8. doi:10.1007/BF01233100. PMID 2267632. S2CID 8182554.
Corcoran E, Phelan JJ, Fottrell PF (September 1976). "Purification and properties of pyruvate kinase from human lung". Biochimica et Biophysica Acta (BBA) - Protein Structure. 446 (1): 96–104. doi:10.1016/0005-2795(76)90101-x. PMID 974119.
Tolle SW, Dyson RD, Newburgh RW, Cardenas JM (December 1976). "Pyruvate kinase isozymes in neurons, glia, neuroblastoma, and glioblastoma". Journal of Neurochemistry. 27 (6): 1355–1360. doi:10.1111/j.1471-4159.1976.tb02615.x. PMID 1003209. S2CID 35715586.
Reinacher M, Eigenbrodt E (1981). "Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-Pk) in tumors of chicken and rat". Virchows Archiv B. 37 (1): 79–88. doi:10.1007/BF02892557. PMID 6116351. S2CID 34155302.
Schering B, Eigenbrodt E, Linder D, Schoner W (August 1982). "Purification and properties of pyruvate kinase type M2 from rat lung". Biochimica et Biophysica Acta (BBA) - General Subjects. 717 (2): 337–47. doi:10.1016/0304-4165(82)90188-X. PMID 7115773.
MacDonald MJ, Chang CM (October 1985). "Pancreatic islets contain the M2 isoenzyme of pyruvate kinase. Its phosphorylation has no effect on enzyme activity". Molecular and Cellular Biochemistry. 68 (2): 115–20. doi:10.1007/bf00219375. PMID 3908905. S2CID 6187554.
Brinck U, Eigenbrodt E, Oehmke M, Mazurek S, Fischer G (1994). "L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases". Virchows Archiv. 424 (2): 177–85. doi:10.1007/BF00193498. PMID 8180780. S2CID 5550950.
Steinberg P, Klingelhöffer A, Schäfer A, Wüst G, Weisse G, Oesch F, Eigenbrodt E (March 1999). "Expression of pyruvate kinase M2 in preneoplastic hepatic foci of N-nitrosomorpholine-treated rats". Virchows Archiv. 434 (3): 213–20. doi:10.1007/s004280050330. PMID 10190300. S2CID 28167108.
Warburg, Otto; Wind, Franz; Negelein, Erwin (1927-03-07). "The Metabolism of Tumors in the Body". The Journal of General Physiology. 8 (6): 519–530. doi:10.1085/jgp.8.6.519. ISSN 0022-1295. PMC 2140820. PMID 19872213.
Liberti, Maria V.; Locasale, Jason W. (March 2016). "The Warburg Effect: How Does it Benefit Cancer Cells?". Trends in Biochemical Sciences. 41 (3): 211–218. doi:10.1016/j.tibs.2015.12.001. ISSN 0968-0004. PMC 4783224. PMID 26778478.
Noguchi T, Inoue H, Tanaka T (October 1986). "The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing". The Journal of Biological Chemistry. 261 (29): 13807–12. doi:10.1016/S0021-9258(18)67091-7. PMID 3020052.
Dombrauckas JD, Santarsiero BD, Mesecar AD (July 2005). "Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis". Biochemistry. 44 (27): 9417–29. doi:10.1021/bi0474923. PMID 15996096. S2CID 24625677.
Vaupel P, Harrison L (2004). "Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response". The Oncologist. 9 (Suppl 5): 4–9. doi:10.1634/theoncologist.9-90005-4. PMID 15591417.
Gupta V, Bamezai RN (November 2010). "Human pyruvate kinase M2: a multifunctional protein". Protein Science. 19 (11): 2031–44. doi:10.1002/pro.505. PMC 3005776. PMID 20857498.
Boeckel JN, Derlet A, Glaser SF, Luczak A, Lucas T, Heumüller AW, Krüger M, Zehendner CM, Kaluza D, Doddaballapur A, Ohtani K, Treguer K, Dimmeler S (July 2016). "JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 36 (7): 1425–33. doi:10.1161/ATVBAHA.116.307695. PMID 27199445.
Eigenbrodt E, Reinacher M, Scheefers-Borchel U, Scheefers H, Friis R (1992). "Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells". Critical Reviews in Oncogenesis. 3 (1–2): 91–115. PMID 1532331.
Mazurek S, Boschek CB, Hugo F, Eigenbrodt E (August 2005). "Pyruvate kinase type M2 and its role in tumor growth and spreading". Seminars in Cancer Biology. 15 (4): 300–8. doi:10.1016/j.semcancer.2005.04.009. PMID 15908230.
Palsson-McDermott EM, Dyck L, Zasłona Z, Menon D, McGettrick AF, Mills KH, O'Neill LA (2017-10-13). "Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors". Frontiers in Immunology. 8: 1300. doi:10.3389/fimmu.2017.01300. PMC 5646285. PMID 29081778.
Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang JK, Jiang JK, Israelsen WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Vanden Heiden M, Xavier RJ, O'Neill LA (January 2015). "Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages". Cell Metabolism. 21 (1): 65–80. doi:10.1016/j.cmet.2014.12.005. PMC 5198835. PMID 25565206.
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Keller KE, Doctor ZM, Dwyer ZW, Lee YS (March 2014). "SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells". Molecular Cell. 53 (5): 700–9. doi:10.1016/j.molcel.2014.02.015. PMC 4000728. PMID 24606918.
Akhtar K, Gupta V, Koul A, Alam N, Bhat R, Bamezai RN (May 2009). "Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme". The Journal of Biological Chemistry. 284 (18): 11971–81. doi:10.1074/jbc.M808761200. PMC 2673266. PMID 19265196.
Gupta V, Kalaiarasan P, Faheem M, Singh N, Iqbal MA, Bamezai RN (May 2010). "Dominant negative mutations affect oligomerization of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy". The Journal of Biological Chemistry. 285 (22): 16864–73. doi:10.1074/jbc.M109.065029. PMC 2878009. PMID 20304929.
Iqbal MA, Siddiqui FA, Chaman N, Gupta V, Kumar B, Gopinath P, Bamezai RN (March 2014). "Missense mutations in pyruvate kinase M2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative manner". The Journal of Biological Chemistry. 289 (12): 8098–105. doi:10.1074/jbc.M113.515742. PMC 3961641. PMID 24492614.
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ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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Yang L, Xie M, Yang M, Yu Y, Zhu S, Hou W, Kang R, Lotze MT, Billiar TR, Wang H, Cao L, Tang D (July 2014). "PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis". Nature Communications. 5 (1): 4436. Bibcode:2014NatCo...5.4436Y. doi:10.1038/ncomms5436. PMC 4104986. PMID 25019241.
Deng W, Zhu S, Zeng L, Liu J, Kang R, Yang M, Cao L, Wang H, Billiar TR, Jiang J, Xie M, Tang D (July 2018). "The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis". Cell Reports. 24 (2): 366–378. doi:10.1016/j.celrep.2018.06.026. PMC 6094382. PMID 29996098.
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Dürr P (February 1999). "Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1291–6. Bibcode:1999PNAS...96.1291Z. doi:10.1073/pnas.96.4.1291. PMC 15456. PMID 9990017.
Bluemlein K, Grüning NM, Feichtinger RG, Lehrach H, Kofler B, Ralser M (May 2011). "No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis". Oncotarget. 2 (5): 393–400. doi:10.18632/oncotarget.278. PMC 3248187. PMID 21789790.
Zahra K, Dey T, Mishra SP, Pandey U (2020-03-02). "Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis". Frontiers in Oncology. 10: 159. doi:10.3389/fonc.2020.00159. PMC 7061896. PMID 32195169.
Siwko S, Mochly-Rosen D (2007). "Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase". The International Journal of Biochemistry & Cell Biology. 39 (5): 978–87. doi:10.1016/j.biocel.2007.01.018. PMC 1931518. PMID 17337233.
Zhang Z, Deng W, Kang R, Xie M, Billiar T, Wang H, et al. (September 2016). "Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2". Molecular Medicine. 22: 162–172. doi:10.2119/molmed.2015.00250. PMC 5004715. PMID 26982513.
Yang L, Xie M, Yang M, Yu Y, Zhu S, Hou W, et al. (July 2014). "PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis". Nature Communications. 5: 4436. Bibcode:2014NatCo...5.4436Y. doi:10.1038/ncomms5436. PMC 4104986. PMID 25019241.
Zahra, Kulsoom; Dey, Tulika; Ashish; Mishra, Surendra Pratap; Pandey, Uma (2020). "Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis". Frontiers in Oncology. 10: 159. doi:10.3389/fonc.2020.00159. ISSN 2234-943X. PMC 7061896. PMID 32195169.
Puckett, Dexter L.; Alquraishi, Mohammed; Chowanadisai, Winyoo; Bettaieb, Ahmed (January 2021). "The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs". International Journal of Molecular Sciences. 22 (3): 1171. doi:10.3390/ijms22031171. ISSN 1422-0067. PMC 7865720. PMID 33503959.
Kato H, Fukuda T, Parkison C, McPhie P, Cheng SY (October 1989). "Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase". Proceedings of the National Academy of Sciences of the United States of America. 86 (20): 7861–5. Bibcode:1989PNAS...86.7861K. doi:10.1073/pnas.86.20.7861. PMC 298171. PMID 2813362.
Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Alfred Yung WK, Lu Z (August 2012). "PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis". Cell. 150 (4): 685–96. doi:10.1016/j.cell.2012.07.018. PMC 3431020. PMID 22901803.
Keller KE, Tan IS, Lee YS (November 2012). "SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions". Science. 338 (6110): 1069–72. Bibcode:2012Sci...338.1069K. doi:10.1126/science.1224409. PMC 3527123. PMID 23086999.
Keller KE, Doctor ZM, Dwyer ZW, Lee YS (March 2014). "SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells". Molecular Cell. 53 (5): 700–9. doi:10.1016/j.molcel.2014.02.015. PMC 4000728. PMID 24606918.
Akhtar K, Gupta V, Koul A, Alam N, Bhat R, Bamezai RN (May 2009). "Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme". The Journal of Biological Chemistry. 284 (18): 11971–81. doi:10.1074/jbc.M808761200. PMC 2673266. PMID 19265196.
Gupta V, Kalaiarasan P, Faheem M, Singh N, Iqbal MA, Bamezai RN (May 2010). "Dominant negative mutations affect oligomerization of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy". The Journal of Biological Chemistry. 285 (22): 16864–73. doi:10.1074/jbc.M109.065029. PMC 2878009. PMID 20304929.
Iqbal MA, Siddiqui FA, Chaman N, Gupta V, Kumar B, Gopinath P, Bamezai RN (March 2014). "Missense mutations in pyruvate kinase M2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative manner". The Journal of Biological Chemistry. 289 (12): 8098–105. doi:10.1074/jbc.M113.515742. PMC 3961641. PMID 24492614.

semanticscholar.org

api.semanticscholar.org

Popescu NC, Cheng SY (November 1990). "Chromosomal localization of the gene for a human cytosolic thyroid hormone binding protein homologous to the subunit of pyruvate kinase, subtype M2". Somatic Cell and Molecular Genetics. 16 (6): 593–8. doi:10.1007/BF01233100. PMID 2267632. S2CID 8182554.
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Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC (March 2008). "Pyruvate kinase M2 is a phosphotyrosine-binding protein". Nature. 452 (7184): 181–6. Bibcode:2008Natur.452..181C. doi:10.1038/nature06667. PMID 18337815. S2CID 4346405.
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC (March 2008). "The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth". Nature. 452 (7184): 230–3. Bibcode:2008Natur.452..230C. doi:10.1038/nature06734. PMID 18337823. S2CID 16111842.
Garcia-Gonzalo FR, Cruz C, Muñoz P, Mazurek S, Eigenbrodt E, Ventura F, Bartrons R, Rosa JL (March 2003). "Interaction between HERC1 and M2-type pyruvate kinase". FEBS Letters. 539 (1–3): 78–84. doi:10.1016/S0014-5793(03)00205-9. PMID 12650930. S2CID 32809019.
Huang J, Liu K, Zhu S, Xie M, Kang R, Cao L, Tang D (August 2018). "AMPK regulates immunometabolism in sepsis". Brain, Behavior, and Immunity. 72: 89–100. doi:10.1016/j.bbi.2017.11.003. PMID 29109024. S2CID 38415440.

wikipathways.org

The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

worldcat.org

search.worldcat.org

Warburg, Otto; Wind, Franz; Negelein, Erwin (1927-03-07). "The Metabolism of Tumors in the Body". The Journal of General Physiology. 8 (6): 519–530. doi:10.1085/jgp.8.6.519. ISSN 0022-1295. PMC 2140820. PMID 19872213.
Liberti, Maria V.; Locasale, Jason W. (March 2016). "The Warburg Effect: How Does it Benefit Cancer Cells?". Trends in Biochemical Sciences. 41 (3): 211–218. doi:10.1016/j.tibs.2015.12.001. ISSN 0968-0004. PMC 4783224. PMID 26778478.
Zahra, Kulsoom; Dey, Tulika; Ashish; Mishra, Surendra Pratap; Pandey, Uma (2020). "Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis". Frontiers in Oncology. 10: 159. doi:10.3389/fonc.2020.00159. ISSN 2234-943X. PMC 7061896. PMID 32195169.
Puckett, Dexter L.; Alquraishi, Mohammed; Chowanadisai, Winyoo; Bettaieb, Ahmed (January 2021). "The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs". International Journal of Molecular Sciences. 22 (3): 1171. doi:10.3390/ijms22031171. ISSN 1422-0067. PMC 7865720. PMID 33503959.

zenodo.org

Popescu NC, Cheng SY (November 1990). "Chromosomal localization of the gene for a human cytosolic thyroid hormone binding protein homologous to the subunit of pyruvate kinase, subtype M2". Somatic Cell and Molecular Genetics. 16 (6): 593–8. doi:10.1007/BF01233100. PMID 2267632. S2CID 8182554.