PPARGC1A (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "PPARGC1A" in English language version.

refsWebsite

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65nih.gov

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42doi.org

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9harvard.edu

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9semanticscholar.org

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2handle.net

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1ensembl.org

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1nature.com

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1buckinstitute.org

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1elsevier.com

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buckinstitute.org

"Videos | The Buck Institute for Research on Aging". Buckinstitute.org. Retrieved 2013-10-11.

doi.org

Esterbauer H, Oberkofler H, Krempler F, Patsch W (Feb 2000). "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression". Genomics. 62 (1): 98–102. doi:10.1006/geno.1999.5977. PMID 10585775.
Pollard KS, Salama SR, Lambert N, Lambot MA, Coppens S, Pedersen JS, Katzman S, King B, Onodera C, Siepel A, Kern AD, Dehay C, Igel H, Ares M, Vanderhaeghen P, Haussler D (September 2006). "An RNA gene expressed during cortical development evolved rapidly in humans" (PDF). Nature. 443 (7108): 167–72. Bibcode:2006Natur.443..167P. doi:10.1038/nature05113. PMID 16915236. S2CID 18107797.
Valero T (2014). "Mitochondrial biogenesis: pharmacological approaches". Curr. Pharm. Des. 20 (35): 5507–9. doi:10.2174/138161282035140911142118. hdl:10454/13341. PMID 24606795. Mitochondrial biogenesis is therefore defined as the process via which cells increase their individual mitochondrial mass [3]. ... This work reviews different strategies to enhance mitochondrial bioenergetics in order to ameliorate the neurodegenerative process, with an emphasis on clinical trials reports that indicate their potential. Among them creatine, Coenzyme Q10 and mitochondrial targeted antioxidants/peptides are reported to have the most remarkable effects in clinical trials.
Sanchis-Gomar F, García-Giménez JL, Gómez-Cabrera MC, Pallardó FV (2014). "Mitochondrial biogenesis in health and disease. Molecular and therapeutic approaches". Curr. Pharm. Des. 20 (35): 5619–5633. doi:10.2174/1381612820666140306095106. PMID 24606801. Mitochondrial biogenesis (MB) is the essential mechanism by which cells control the number of mitochondria.
Dorn GW, Vega RB, Kelly DP (2015). "Mitochondrial biogenesis and dynamics in the developing and diseased heart". Genes Dev. 29 (19): 1981–91. doi:10.1101/gad.269894.115. PMC 4604339. PMID 26443844.
Klein MA, Denu JM (2020). "Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators". Journal of Biological Chemistry. 295 (32): 11021–11041. doi:10.1074/jbc.REV120.011438. PMC 7415977. PMID 32518153.
Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM (2002). "Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres". Nature. 418 (6899): 797–801. Bibcode:2002Natur.418..797L. doi:10.1038/nature00904. PMID 12181572. S2CID 4415526.
Pilegaard H, Saltin B, Neufer PD (February 2003). "Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle". J. Physiol. 546 (Pt 3): 851–8. doi:10.1113/jphysiol.2002.034850. PMC 2342594. PMID 12563009.
Vainshtein A, Tryon LD, Pauly M, Hood DA (2015). "Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle". American Journal of Physiology. 308 (9): C710-719. doi:10.1152/ajpcell.00380.2014. PMC 4420796. PMID 25673772.
Halling JF, Ringholm S, Nielsen MM, Overby P, Pilegaard H (2016). "PGC-1α promotes exercise-induced autophagy in mouse skeletal muscle". Physiological Reports. 4 (3): e12698. doi:10.14814/phy2.12698. PMC 4758928. PMID 26869683.
Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM (2011). "The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex". Cell Metabolism. 13 (2): 160–169. doi:10.1016/j.cmet.2011.01.003. PMC 3057411. PMID 21284983.
Canettieri, G., Koo, S.-H., Berdeaux, R., Heredia, J., Hedrick, S., Zhang, X., & Montminy (2005). "Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling". Cell Metabolism. 2 (5): 331–338. doi:10.1016/j.cmet.2005.09.008. PMID 16271533.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Yoon, J. Cliff; Puigserver, Pere; Chen, Guoxun; Donovan, Jerry; Wu, Zhidan; Rhee, James; Adelmant, Guillaume; Stafford, John; Kahn, C. Ronald; Granner, Daryl K.; Newgard, Christopher B. (September 2001). "Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1". Nature. 413 (6852): 131–138. Bibcode:2001Natur.413..131Y. doi:10.1038/35093050. ISSN 1476-4687. PMID 11557972. S2CID 11184579.
Liang H, Ward WF (December 2006). "PGC-1alpha: a key regulator of energy metabolism". Adv Physiol Educ. 30 (4): 145–51. doi:10.1152/advan.00052.2006. PMID 17108241. S2CID 835984.
Summermatter S, Santos G, Pérez-Schindler J, Handschin C (May 2013). "Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A" (PDF). Proc. Natl. Acad. Sci. U.S.A. 110 (21): 8738–43. Bibcode:2013PNAS..110.8738S. doi:10.1073/pnas.1212976110. PMC 3666691. PMID 23650363.
Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P (March 2005). "Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1". Nature. 434 (7029): 113–8. Bibcode:2005Natur.434..113R. doi:10.1038/nature03354. PMID 15744310. S2CID 4380393.
Romanino K, Mazelin L, Albert V, Conjard-Duplany A, Lin S, Bentzinger CF, Handschin C, Puigserver P, Zorzato F, Schaeffer L, Gangloff YG, Rüegg MA (December 2011). "Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function". Proc. Natl. Acad. Sci. U.S.A. 108 (51): 20808–13. Bibcode:2011PNAS..10820808R. doi:10.1073/pnas.1111448109. PMC 3251091. PMID 22143799.
Summermatter S, Thurnheer R, Santos G, Mosca B, Baum O, Treves S, Hoppeler H, Zorzato F, Handschin C (January 2012). "Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type" (PDF). Am. J. Physiol., Cell Physiol. 302 (1): C88–99. doi:10.1152/ajpcell.00190.2011. PMID 21918181.
Viatour P, Merville MP, Bours V, Chariot A (January 2005). "Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation" (PDF). Trends Biochem. Sci. 30 (1): 43–52. doi:10.1016/j.tibs.2004.11.009. hdl:2268/1280. PMID 15653325.
Harris CD, Ermak G, Davies KJ (November 2005). "Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease". Cell. Mol. Life Sci. 62 (21): 2477–86. doi:10.1007/s00018-005-5085-4. PMC 11139107. PMID 16231093. S2CID 7184948.
Olesen J, Larsson S, Iversen N, Yousafzai S, Hellsten Y, Pilegaard H (2012). Calbet JA (ed.). "Skeletal muscle PGC-1α is required for maintaining an acute LPS-induced TNFα response". PLOS ONE. 7 (2): e32222. Bibcode:2012PLoSO...732222O. doi:10.1371/journal.pone.0032222. PMC 3288087. PMID 22384185.
Brault JJ, Jespersen JG, Goldberg AL (June 2010). "Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy". J. Biol. Chem. 285 (25): 19460–71. doi:10.1074/jbc.M110.113092. PMC 2885225. PMID 20404331.
Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM (2016). "PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection". Nature. 531 (7595): 528–32. Bibcode:2016Natur.531..528T. doi:10.1038/nature17184. PMC 4909121. PMID 26982719.
Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR (October 2010). "PGC-1{alpha}, A Potential Therapeutic Target for Early Intervention in Parkinson's Disease". Sci Transl Med. 2 (52): 52ra73. doi:10.1126/scitranslmed.3001059. PMC 3129986. PMID 20926834.
Soyal SM, Felder TK, Auer S, Hahne P, Oberkofler H, Witting A, Paulmichl M, Landwehrmeyer GB, Weydt P, Patsch W (2012). "A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset". Human Molecular Genetics. 21 (15): 3461–73. doi:10.1093/hmg/dds177. PMID 22589246.
Eschbach J, Schwalenstöcker B, Soyal SM, Bayer H, Wiesner D, Akimoto C, Nilsson AC, Birve A, Meyer T, Dupuis L, Danzer KM, Andersen PM, Witting A, Ludolph AC, Patsch W, Weydt P (2013). "PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis". Human Molecular Genetics. 22 (17): 3477–84. doi:10.1093/hmg/ddt202. PMID 23669350.
Crane JD, Ogborn DI, Cupido C, Melov S, Hubbard A, Bourgeois JM, Tarnopolsky MA (February 2012). "Massage therapy attenuates inflammatory signaling after exercise-induced muscle damage". Sci Transl Med. 4 (119): 119ra13. doi:10.1126/scitranslmed.3002882. PMID 22301554. S2CID 2610669.
Yakeu G, Butcher L, Isa S, Webb R, Roberts AW, Thomas AW, Backx K, James PE, Morris K (October 2010). "Low-intensity exercise enhances expression of markers of alternative activation in circulating leukocytes: roles of PPARγ and Th2 cytokines". Atherosclerosis. 212 (2): 668–73. doi:10.1016/j.atherosclerosis.2010.07.002. PMID 20723894.
Chan MM, Adapala N, Chen C (2012). "Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection". PPAR Res. 2012: 796235. doi:10.1155/2012/796235. PMC 3289877. PMID 22448168.
Vats D, Mukundan L, Odegaard JI, Zhang L, Smith KL, Morel CR, Wagner RA, Greaves DR, Murray PJ, Chawla A (July 2006). "Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation". Cell Metab. 4 (1): 13–24. doi:10.1016/j.cmet.2006.05.011. PMC 1904486. PMID 16814729.
Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE (2014). "β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors". Cell Metabolism. 19 (1): 96–108. doi:10.1016/j.cmet.2013.12.003. PMC 4017355. PMID 24411942.
Ballmann C, Tang Y, Bush Z, Rowe GC (October 2016). "Adult expression of PGC-1α and -1β in skeletal muscle is not required for endurance exercise-induced enhancement of exercise capacity". Am J Physiol Endocrinol Metab. 311 (6): E928 – E938. doi:10.1152/ajpendo.00209.2016. PMC 5183883. PMID 27780821.
Halling JF, Jessen H, Nøhr-Meldgaard J, Buch BT, Christensen NM, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H (July 2019). "PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training". Am J Physiol Endocrinol Metab. 317 (3): E513 – E525. doi:10.1152/ajpendo.00059.2019. PMID 31265325. S2CID 195786475.
Wehbe, Zeinab; Behringer, Sidney; Alatibi, Khaled; Watkins, David; Rosenblatt, David; Spiekerkoetter, Ute; Tucci, Sara (November 2019). "The emerging role of the mitochondrial fatty-acid synthase (mtFASII) in the regulation of energy metabolism". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1864 (11): 1629–1643. doi:10.1016/j.bbalip.2019.07.012. PMID 31376476.
Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM (November 1999). "Activation of PPARgamma coactivator-1 through transcription factor docking". Science. 286 (5443): 1368–71. doi:10.1126/science.286.5443.1368. PMID 10558993.
Schreiber SN, Emter R, Hock MB, Knutti D, Cardenas J, Podvinec M, et al. (April 2004). "The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis". Proceedings of the National Academy of Sciences of the United States of America. 101 (17): 6472–7. Bibcode:2004PNAS..101.6472S. doi:10.1073/pnas.0308686101. PMC 404069. PMID 15087503.
Zhang Y, Castellani LW, Sinal CJ, Gonzalez FJ, Edwards PA (January 2004). "Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR". Genes Dev. 18 (2): 157–69. doi:10.1101/gad.1138104. PMC 324422. PMID 14729567.
Olson BL, Hock MB, Ekholm-Reed S, Wohlschlegel JA, Dev KK, Kralli A, Reed SI (January 2008). "SCFCdc4 acts antagonistically to the PGC-1α transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis". Genes Dev. 22 (2): 252–64. doi:10.1101/gad.1624208. PMC 2192758. PMID 18198341.
Wallberg AE, Yamamura S, Malik S, Spiegelman BM, Roeder RG (November 2003). "Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha". Mol. Cell. 12 (5): 1137–49. doi:10.1016/S1097-2765(03)00391-5. PMID 14636573.
Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM (1999). "Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1". Cell. 98 (1): 115–24. doi:10.1016/S0092-8674(00)80611-X. PMID 10412986. S2CID 16143809.
Delerive P, Wu Y, Burris TP, Chin WW, Suen CS (February 2002). "PGC-1 functions as a transcriptional coactivator for the retinoid X receptors". J. Biol. Chem. 277 (6): 3913–7. doi:10.1074/jbc.M109409200. PMID 11714715.
Wu Y, Delerive P, Chin WW, Burris TP (March 2002). "Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1". J. Biol. Chem. 277 (11): 8898–905. doi:10.1074/jbc.M110761200. PMID 11751919.

elsevier.com

linkinghub.elsevier.com

Wehbe, Zeinab; Behringer, Sidney; Alatibi, Khaled; Watkins, David; Rosenblatt, David; Spiekerkoetter, Ute; Tucci, Sara (November 2019). "The emerging role of the mitochondrial fatty-acid synthase (mtFASII) in the regulation of energy metabolism". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1864 (11): 1629–1643. doi:10.1016/j.bbalip.2019.07.012. PMID 31376476.

ensembl.org

May2017.archive.ensembl.org

GRCm38: Ensembl release 89: ENSMUSG00000029167 – Ensembl, May 2017

handle.net

hdl.handle.net

Valero T (2014). "Mitochondrial biogenesis: pharmacological approaches". Curr. Pharm. Des. 20 (35): 5507–9. doi:10.2174/138161282035140911142118. hdl:10454/13341. PMID 24606795. Mitochondrial biogenesis is therefore defined as the process via which cells increase their individual mitochondrial mass [3]. ... This work reviews different strategies to enhance mitochondrial bioenergetics in order to ameliorate the neurodegenerative process, with an emphasis on clinical trials reports that indicate their potential. Among them creatine, Coenzyme Q10 and mitochondrial targeted antioxidants/peptides are reported to have the most remarkable effects in clinical trials.
Viatour P, Merville MP, Bours V, Chariot A (January 2005). "Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation" (PDF). Trends Biochem. Sci. 30 (1): 43–52. doi:10.1016/j.tibs.2004.11.009. hdl:2268/1280. PMID 15653325.

harvard.edu

ui.adsabs.harvard.edu

Pollard KS, Salama SR, Lambert N, Lambot MA, Coppens S, Pedersen JS, Katzman S, King B, Onodera C, Siepel A, Kern AD, Dehay C, Igel H, Ares M, Vanderhaeghen P, Haussler D (September 2006). "An RNA gene expressed during cortical development evolved rapidly in humans" (PDF). Nature. 443 (7108): 167–72. Bibcode:2006Natur.443..167P. doi:10.1038/nature05113. PMID 16915236. S2CID 18107797.
Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM (2002). "Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres". Nature. 418 (6899): 797–801. Bibcode:2002Natur.418..797L. doi:10.1038/nature00904. PMID 12181572. S2CID 4415526.
Yoon, J. Cliff; Puigserver, Pere; Chen, Guoxun; Donovan, Jerry; Wu, Zhidan; Rhee, James; Adelmant, Guillaume; Stafford, John; Kahn, C. Ronald; Granner, Daryl K.; Newgard, Christopher B. (September 2001). "Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1". Nature. 413 (6852): 131–138. Bibcode:2001Natur.413..131Y. doi:10.1038/35093050. ISSN 1476-4687. PMID 11557972. S2CID 11184579.
Summermatter S, Santos G, Pérez-Schindler J, Handschin C (May 2013). "Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A" (PDF). Proc. Natl. Acad. Sci. U.S.A. 110 (21): 8738–43. Bibcode:2013PNAS..110.8738S. doi:10.1073/pnas.1212976110. PMC 3666691. PMID 23650363.
Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P (March 2005). "Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1". Nature. 434 (7029): 113–8. Bibcode:2005Natur.434..113R. doi:10.1038/nature03354. PMID 15744310. S2CID 4380393.
Romanino K, Mazelin L, Albert V, Conjard-Duplany A, Lin S, Bentzinger CF, Handschin C, Puigserver P, Zorzato F, Schaeffer L, Gangloff YG, Rüegg MA (December 2011). "Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function". Proc. Natl. Acad. Sci. U.S.A. 108 (51): 20808–13. Bibcode:2011PNAS..10820808R. doi:10.1073/pnas.1111448109. PMC 3251091. PMID 22143799.
Olesen J, Larsson S, Iversen N, Yousafzai S, Hellsten Y, Pilegaard H (2012). Calbet JA (ed.). "Skeletal muscle PGC-1α is required for maintaining an acute LPS-induced TNFα response". PLOS ONE. 7 (2): e32222. Bibcode:2012PLoSO...732222O. doi:10.1371/journal.pone.0032222. PMC 3288087. PMID 22384185.
Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM (2016). "PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection". Nature. 531 (7595): 528–32. Bibcode:2016Natur.531..528T. doi:10.1038/nature17184. PMC 4909121. PMID 26982719.
Schreiber SN, Emter R, Hock MB, Knutti D, Cardenas J, Podvinec M, et al. (April 2004). "The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis". Proceedings of the National Academy of Sciences of the United States of America. 101 (17): 6472–7. Bibcode:2004PNAS..101.6472S. doi:10.1073/pnas.0308686101. PMC 404069. PMID 15087503.

latimes.com

Brown E (2012-02-01). "Study works out kinks in understanding of massage". Los Angeles Times.

nature.com

Yoon, J. Cliff; Puigserver, Pere; Chen, Guoxun; Donovan, Jerry; Wu, Zhidan; Rhee, James; Adelmant, Guillaume; Stafford, John; Kahn, C. Ronald; Granner, Daryl K.; Newgard, Christopher B. (September 2001). "Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1". Nature. 413 (6852): 131–138. Bibcode:2001Natur.413..131Y. doi:10.1038/35093050. ISSN 1476-4687. PMID 11557972. S2CID 11184579.

nih.gov

pubmed.ncbi.nlm.nih.gov

Esterbauer H, Oberkofler H, Krempler F, Patsch W (Feb 2000). "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression". Genomics. 62 (1): 98–102. doi:10.1006/geno.1999.5977. PMID 10585775.
Pollard KS, Salama SR, Lambert N, Lambot MA, Coppens S, Pedersen JS, Katzman S, King B, Onodera C, Siepel A, Kern AD, Dehay C, Igel H, Ares M, Vanderhaeghen P, Haussler D (September 2006). "An RNA gene expressed during cortical development evolved rapidly in humans" (PDF). Nature. 443 (7108): 167–72. Bibcode:2006Natur.443..167P. doi:10.1038/nature05113. PMID 16915236. S2CID 18107797.
Valero T (2014). "Mitochondrial biogenesis: pharmacological approaches". Curr. Pharm. Des. 20 (35): 5507–9. doi:10.2174/138161282035140911142118. hdl:10454/13341. PMID 24606795. Mitochondrial biogenesis is therefore defined as the process via which cells increase their individual mitochondrial mass [3]. ... This work reviews different strategies to enhance mitochondrial bioenergetics in order to ameliorate the neurodegenerative process, with an emphasis on clinical trials reports that indicate their potential. Among them creatine, Coenzyme Q10 and mitochondrial targeted antioxidants/peptides are reported to have the most remarkable effects in clinical trials.
Sanchis-Gomar F, García-Giménez JL, Gómez-Cabrera MC, Pallardó FV (2014). "Mitochondrial biogenesis in health and disease. Molecular and therapeutic approaches". Curr. Pharm. Des. 20 (35): 5619–5633. doi:10.2174/1381612820666140306095106. PMID 24606801. Mitochondrial biogenesis (MB) is the essential mechanism by which cells control the number of mitochondria.
Dorn GW, Vega RB, Kelly DP (2015). "Mitochondrial biogenesis and dynamics in the developing and diseased heart". Genes Dev. 29 (19): 1981–91. doi:10.1101/gad.269894.115. PMC 4604339. PMID 26443844.
Klein MA, Denu JM (2020). "Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators". Journal of Biological Chemistry. 295 (32): 11021–11041. doi:10.1074/jbc.REV120.011438. PMC 7415977. PMID 32518153.
Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM (2002). "Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres". Nature. 418 (6899): 797–801. Bibcode:2002Natur.418..797L. doi:10.1038/nature00904. PMID 12181572. S2CID 4415526.
Pilegaard H, Saltin B, Neufer PD (February 2003). "Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle". J. Physiol. 546 (Pt 3): 851–8. doi:10.1113/jphysiol.2002.034850. PMC 2342594. PMID 12563009.
Vainshtein A, Tryon LD, Pauly M, Hood DA (2015). "Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle". American Journal of Physiology. 308 (9): C710-719. doi:10.1152/ajpcell.00380.2014. PMC 4420796. PMID 25673772.
Halling JF, Ringholm S, Nielsen MM, Overby P, Pilegaard H (2016). "PGC-1α promotes exercise-induced autophagy in mouse skeletal muscle". Physiological Reports. 4 (3): e12698. doi:10.14814/phy2.12698. PMC 4758928. PMID 26869683.
Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM (2011). "The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex". Cell Metabolism. 13 (2): 160–169. doi:10.1016/j.cmet.2011.01.003. PMC 3057411. PMID 21284983.
Canettieri, G., Koo, S.-H., Berdeaux, R., Heredia, J., Hedrick, S., Zhang, X., & Montminy (2005). "Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling". Cell Metabolism. 2 (5): 331–338. doi:10.1016/j.cmet.2005.09.008. PMID 16271533.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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ncbi.nlm.nih.gov

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Olesen J, Larsson S, Iversen N, Yousafzai S, Hellsten Y, Pilegaard H (2012). Calbet JA (ed.). "Skeletal muscle PGC-1α is required for maintaining an acute LPS-induced TNFα response". PLOS ONE. 7 (2): e32222. Bibcode:2012PLoSO...732222O. doi:10.1371/journal.pone.0032222. PMC 3288087. PMID 22384185.
Brault JJ, Jespersen JG, Goldberg AL (June 2010). "Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy". J. Biol. Chem. 285 (25): 19460–71. doi:10.1074/jbc.M110.113092. PMC 2885225. PMID 20404331.
Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM (2016). "PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection". Nature. 531 (7595): 528–32. Bibcode:2016Natur.531..528T. doi:10.1038/nature17184. PMC 4909121. PMID 26982719.
Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, Federoff HJ, Wüllner U, Papapetropoulos S, Youdim MB, Cantuti-Castelvetri I, Young AB, Vance JM, Davis RL, Hedreen JC, Adler CH, Beach TG, Graeber MB, Middleton FA, Rochet JC, Scherzer CR (October 2010). "PGC-1{alpha}, A Potential Therapeutic Target for Early Intervention in Parkinson's Disease". Sci Transl Med. 2 (52): 52ra73. doi:10.1126/scitranslmed.3001059. PMC 3129986. PMID 20926834.
Chan MM, Adapala N, Chen C (2012). "Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection". PPAR Res. 2012: 796235. doi:10.1155/2012/796235. PMC 3289877. PMID 22448168.
Vats D, Mukundan L, Odegaard JI, Zhang L, Smith KL, Morel CR, Wagner RA, Greaves DR, Murray PJ, Chawla A (July 2006). "Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation". Cell Metab. 4 (1): 13–24. doi:10.1016/j.cmet.2006.05.011. PMC 1904486. PMID 16814729.
Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE (2014). "β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors". Cell Metabolism. 19 (1): 96–108. doi:10.1016/j.cmet.2013.12.003. PMC 4017355. PMID 24411942.
Ballmann C, Tang Y, Bush Z, Rowe GC (October 2016). "Adult expression of PGC-1α and -1β in skeletal muscle is not required for endurance exercise-induced enhancement of exercise capacity". Am J Physiol Endocrinol Metab. 311 (6): E928 – E938. doi:10.1152/ajpendo.00209.2016. PMC 5183883. PMID 27780821.
Schreiber SN, Emter R, Hock MB, Knutti D, Cardenas J, Podvinec M, et al. (April 2004). "The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis". Proceedings of the National Academy of Sciences of the United States of America. 101 (17): 6472–7. Bibcode:2004PNAS..101.6472S. doi:10.1073/pnas.0308686101. PMC 404069. PMID 15087503.
Zhang Y, Castellani LW, Sinal CJ, Gonzalez FJ, Edwards PA (January 2004). "Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR". Genes Dev. 18 (2): 157–69. doi:10.1101/gad.1138104. PMC 324422. PMID 14729567.
Olson BL, Hock MB, Ekholm-Reed S, Wohlschlegel JA, Dev KK, Kralli A, Reed SI (January 2008). "SCFCdc4 acts antagonistically to the PGC-1α transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis". Genes Dev. 22 (2): 252–64. doi:10.1101/gad.1624208. PMC 2192758. PMID 18198341.

semanticscholar.org

api.semanticscholar.org

Pollard KS, Salama SR, Lambert N, Lambot MA, Coppens S, Pedersen JS, Katzman S, King B, Onodera C, Siepel A, Kern AD, Dehay C, Igel H, Ares M, Vanderhaeghen P, Haussler D (September 2006). "An RNA gene expressed during cortical development evolved rapidly in humans" (PDF). Nature. 443 (7108): 167–72. Bibcode:2006Natur.443..167P. doi:10.1038/nature05113. PMID 16915236. S2CID 18107797.
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Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P (March 2005). "Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1". Nature. 434 (7029): 113–8. Bibcode:2005Natur.434..113R. doi:10.1038/nature03354. PMID 15744310. S2CID 4380393.
Harris CD, Ermak G, Davies KJ (November 2005). "Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease". Cell. Mol. Life Sci. 62 (21): 2477–86. doi:10.1007/s00018-005-5085-4. PMC 11139107. PMID 16231093. S2CID 7184948.
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Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM (1999). "Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1". Cell. 98 (1): 115–24. doi:10.1016/S0092-8674(00)80611-X. PMID 10412986. S2CID 16143809.

ulb.ac.be

dipot.ulb.ac.be

Pollard KS, Salama SR, Lambert N, Lambot MA, Coppens S, Pedersen JS, Katzman S, King B, Onodera C, Siepel A, Kern AD, Dehay C, Igel H, Ares M, Vanderhaeghen P, Haussler D (September 2006). "An RNA gene expressed during cortical development evolved rapidly in humans" (PDF). Nature. 443 (7108): 167–72. Bibcode:2006Natur.443..167P. doi:10.1038/nature05113. PMID 16915236. S2CID 18107797.

uliege.be

orbi.uliege.be

Viatour P, Merville MP, Bours V, Chariot A (January 2005). "Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation" (PDF). Trends Biochem. Sci. 30 (1): 43–52. doi:10.1016/j.tibs.2004.11.009. hdl:2268/1280. PMID 15653325.

unibas.ch

edoc.unibas.ch

Summermatter S, Santos G, Pérez-Schindler J, Handschin C (May 2013). "Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A" (PDF). Proc. Natl. Acad. Sci. U.S.A. 110 (21): 8738–43. Bibcode:2013PNAS..110.8738S. doi:10.1073/pnas.1212976110. PMC 3666691. PMID 23650363.
Summermatter S, Thurnheer R, Santos G, Mosca B, Baum O, Treves S, Hoppeler H, Zorzato F, Handschin C (January 2012). "Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type" (PDF). Am. J. Physiol., Cell Physiol. 302 (1): C88–99. doi:10.1152/ajpcell.00190.2011. PMID 21918181.

worldcat.org

search.worldcat.org

Yoon, J. Cliff; Puigserver, Pere; Chen, Guoxun; Donovan, Jerry; Wu, Zhidan; Rhee, James; Adelmant, Guillaume; Stafford, John; Kahn, C. Ronald; Granner, Daryl K.; Newgard, Christopher B. (September 2001). "Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1". Nature. 413 (6852): 131–138. Bibcode:2001Natur.413..131Y. doi:10.1038/35093050. ISSN 1476-4687. PMID 11557972. S2CID 11184579.