Analysis of information sources in references of the Wikipedia article "Pargyline" in English language version.
Pargyline is promoted only for the treatment of hypertension, and not for depression.
Two more novel antihypertensives appeared in the advertising pages of the BMJ before the end of 1963. The first was pargyline, brand name Eutonyl, marketed by Abbott. The company had observed that this non-hydrazine MAO inhibitor had, in common with other MAO inhibitors, a hypotensive effect. The text suggested that the drug, when combined with their other drug Enduron (methyclothiazide), allowed a lowering of the dose of Eutonyl (BMJ, 12-10-63). The selling point of Eutonyl was 'lowers blood pressure, brightens emotional outlook'.
The administration of methyldopa to mice pretreated with the MAOI pargyline resulted in central nervous system excitation [van Rossum and Hurkmans, 1963]. Warning was then issued against the concomitant use of MAOIs and methyldopa in humans [van Rossum 1963]. A case of visual hallucinations was reported following the administration of methyldopa to a patient receiving pargyline [Paykel, 1966].
Pargyline was earlier considered to be a selective inhibitor of MAO-B. In an appropriate dose and after a single administration, pargyline shows some selectivity to MAO-B, but when it is given chronically it induces a non-selective inhibition of both enzyme types [38]. [...] selegiline, in contrast to pargyline and tranylcypromine, blocks the release of NA from the storage vesicles of the rat heart [7, 66]. [...] The effects of various MAO-B inhibitors on rabbit arterial strip response to T A were studied recently [Ill]. In addition to selegiline, MDL-72145, Ro 16-6491, AGN-1135, J-508, U-1424, TZ-650 were included in these studies. All of the MAO-B selective inhibitors except selegiline potentiated the effect of T A on the pulmonary artery strip, and similar results were also obtained in anesthetized cats and rats in vivo regarding blood pressure response to T A [ 112]. Tranylcypromine, pargyline, and clorgyline were also shown to be strong potentiators of TA both in vitro and in vivo. Selegiline was the only exception, which indicates that the lack ofT A potentiation is not a general characteristic of MAO-B inhibitors.
The MAO inhibitors are subdivided, not only according to structure (hydrazine or non-hydrazine) but also according to the presence or absence of inherent amphetamine-like activity. Thus high doses of iproniazid, pheniprazine, phenelzine and tranylcypromine directly increase motor activity, whereas nialamide and pargyline do not.
Pargyline is promoted only for the treatment of hypertension, and not for depression.
Two more novel antihypertensives appeared in the advertising pages of the BMJ before the end of 1963. The first was pargyline, brand name Eutonyl, marketed by Abbott. The company had observed that this non-hydrazine MAO inhibitor had, in common with other MAO inhibitors, a hypotensive effect. The text suggested that the drug, when combined with their other drug Enduron (methyclothiazide), allowed a lowering of the dose of Eutonyl (BMJ, 12-10-63). The selling point of Eutonyl was 'lowers blood pressure, brightens emotional outlook'.
The administration of methyldopa to mice pretreated with the MAOI pargyline resulted in central nervous system excitation [van Rossum and Hurkmans, 1963]. Warning was then issued against the concomitant use of MAOIs and methyldopa in humans [van Rossum 1963]. A case of visual hallucinations was reported following the administration of methyldopa to a patient receiving pargyline [Paykel, 1966].
The MAO inhibitors are subdivided, not only according to structure (hydrazine or non-hydrazine) but also according to the presence or absence of inherent amphetamine-like activity. Thus high doses of iproniazid, pheniprazine, phenelzine and tranylcypromine directly increase motor activity, whereas nialamide and pargyline do not.
Two more novel antihypertensives appeared in the advertising pages of the BMJ before the end of 1963. The first was pargyline, brand name Eutonyl, marketed by Abbott. The company had observed that this non-hydrazine MAO inhibitor had, in common with other MAO inhibitors, a hypotensive effect. The text suggested that the drug, when combined with their other drug Enduron (methyclothiazide), allowed a lowering of the dose of Eutonyl (BMJ, 12-10-63). The selling point of Eutonyl was 'lowers blood pressure, brightens emotional outlook'.
The MAO inhibitors are subdivided, not only according to structure (hydrazine or non-hydrazine) but also according to the presence or absence of inherent amphetamine-like activity. Thus high doses of iproniazid, pheniprazine, phenelzine and tranylcypromine directly increase motor activity, whereas nialamide and pargyline do not.
Pargyline is promoted only for the treatment of hypertension, and not for depression.
Pargyline was earlier considered to be a selective inhibitor of MAO-B. In an appropriate dose and after a single administration, pargyline shows some selectivity to MAO-B, but when it is given chronically it induces a non-selective inhibition of both enzyme types [38]. [...] selegiline, in contrast to pargyline and tranylcypromine, blocks the release of NA from the storage vesicles of the rat heart [7, 66]. [...] The effects of various MAO-B inhibitors on rabbit arterial strip response to T A were studied recently [Ill]. In addition to selegiline, MDL-72145, Ro 16-6491, AGN-1135, J-508, U-1424, TZ-650 were included in these studies. All of the MAO-B selective inhibitors except selegiline potentiated the effect of T A on the pulmonary artery strip, and similar results were also obtained in anesthetized cats and rats in vivo regarding blood pressure response to T A [ 112]. Tranylcypromine, pargyline, and clorgyline were also shown to be strong potentiators of TA both in vitro and in vivo. Selegiline was the only exception, which indicates that the lack ofT A potentiation is not a general characteristic of MAO-B inhibitors.
Pargyline is promoted only for the treatment of hypertension, and not for depression.
