Clinical trial number NCT00784732 for "A Study to Compare the Efficacy of QAV680 Against Placebo in Treating Seasonal Allergic Rhinitis in an Environmental Exposure Chamber" at ClinicalTrials.gov
Clinical trial number NCT02660489 for "Effect of OC459 on the Response to Rhinovirus Challenge in Asthma" at ClinicalTrials.gov
Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y (2014). "Prostanoid receptors and acute inflammation in skin". Biochimie. 107 Pt A: 78–81. doi:10.1016/j.biochi.2014.08.010. PMID25179301.
Roy SJ, Parent A, Gallant MA, de Brum-Fernandes AJ, Stanková J, Parent JL (2010). "Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif". European Journal of Pharmacology. 630 (1–3): 10–8. doi:10.1016/j.ejphar.2009.12.022. PMID20035740.
Maeda Y, Hizawa N, Takahashi D, Fukui Y, Konno S, Nishimura M (2007). "Genetic impact of functional single nucleotide polymorphisms in the 3'-UTR region of the chemoattractant receptor expressed on Th2 cells (CRTH2) gene on asthma and atopy in a Japanese population". International Archives of Allergy and Immunology. 142 (1): 51–8. doi:10.1159/000095998. PMID17016057. S2CID24547755.
Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C, Brenner D, Mayers I, Vliagoftis H, El-Sohemy A, Cameron L (2012). "The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2". Allergy. 67 (11): 1357–64. doi:10.1111/all.12003. PMID22947041. S2CID10104511.
Sidharta PN, Diamant Z, Dingemanse J (2014). "Single- and multiple-dose tolerability and pharmacokinetics of the CRTH2 antagonist setipiprant in healthy male subjects". Fundamental & Clinical Pharmacology. 28 (6): 690–9. doi:10.1111/fcp.12079. PMID24734908. S2CID8226504.
Norman P (2014). "Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs". Expert Opinion on Investigational Drugs. 23 (1): 55–66. doi:10.1517/13543784.2013.839658. PMID24073896. S2CID19977989.
Mathiesen JM, Christopoulos A, Ulven T, Royer JF, Campillo M, Heinemann A, Pardo L, Kostenis E (April 2006). "On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2". Molecular Pharmacology. 69 (4): 1441–53. doi:10.1124/mol.105.017681. PMID16418339. S2CID6326585.
Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y (2014). "Prostanoid receptors and acute inflammation in skin". Biochimie. 107 Pt A: 78–81. doi:10.1016/j.biochi.2014.08.010. PMID25179301.
Roy SJ, Parent A, Gallant MA, de Brum-Fernandes AJ, Stanková J, Parent JL (2010). "Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif". European Journal of Pharmacology. 630 (1–3): 10–8. doi:10.1016/j.ejphar.2009.12.022. PMID20035740.
Maeda Y, Hizawa N, Takahashi D, Fukui Y, Konno S, Nishimura M (2007). "Genetic impact of functional single nucleotide polymorphisms in the 3'-UTR region of the chemoattractant receptor expressed on Th2 cells (CRTH2) gene on asthma and atopy in a Japanese population". International Archives of Allergy and Immunology. 142 (1): 51–8. doi:10.1159/000095998. PMID17016057. S2CID24547755.
Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C, Brenner D, Mayers I, Vliagoftis H, El-Sohemy A, Cameron L (2012). "The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2". Allergy. 67 (11): 1357–64. doi:10.1111/all.12003. PMID22947041. S2CID10104511.
Sidharta PN, Diamant Z, Dingemanse J (2014). "Single- and multiple-dose tolerability and pharmacokinetics of the CRTH2 antagonist setipiprant in healthy male subjects". Fundamental & Clinical Pharmacology. 28 (6): 690–9. doi:10.1111/fcp.12079. PMID24734908. S2CID8226504.
Norman P (2014). "Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs". Expert Opinion on Investigational Drugs. 23 (1): 55–66. doi:10.1517/13543784.2013.839658. PMID24073896. S2CID19977989.
Mathiesen JM, Christopoulos A, Ulven T, Royer JF, Campillo M, Heinemann A, Pardo L, Kostenis E (April 2006). "On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2". Molecular Pharmacology. 69 (4): 1441–53. doi:10.1124/mol.105.017681. PMID16418339. S2CID6326585.
ncbi.nlm.nih.gov
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Maeda Y, Hizawa N, Takahashi D, Fukui Y, Konno S, Nishimura M (2007). "Genetic impact of functional single nucleotide polymorphisms in the 3'-UTR region of the chemoattractant receptor expressed on Th2 cells (CRTH2) gene on asthma and atopy in a Japanese population". International Archives of Allergy and Immunology. 142 (1): 51–8. doi:10.1159/000095998. PMID17016057. S2CID24547755.
Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C, Brenner D, Mayers I, Vliagoftis H, El-Sohemy A, Cameron L (2012). "The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2". Allergy. 67 (11): 1357–64. doi:10.1111/all.12003. PMID22947041. S2CID10104511.
Sidharta PN, Diamant Z, Dingemanse J (2014). "Single- and multiple-dose tolerability and pharmacokinetics of the CRTH2 antagonist setipiprant in healthy male subjects". Fundamental & Clinical Pharmacology. 28 (6): 690–9. doi:10.1111/fcp.12079. PMID24734908. S2CID8226504.
Norman P (2014). "Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs". Expert Opinion on Investigational Drugs. 23 (1): 55–66. doi:10.1517/13543784.2013.839658. PMID24073896. S2CID19977989.
Mathiesen JM, Christopoulos A, Ulven T, Royer JF, Campillo M, Heinemann A, Pardo L, Kostenis E (April 2006). "On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2". Molecular Pharmacology. 69 (4): 1441–53. doi:10.1124/mol.105.017681. PMID16418339. S2CID6326585.