Protein C (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Protein C" in English language version.

refsWebsite

Global rank English rank

58nih.gov

4^th place

40doi.org

2^nd place

7semanticscholar.org

11^th place

8^th place

6harvard.edu

18^th place

17^th place

2ensembl.org

1,626^th place

1,007^th place

1handle.net

102^nd place

76^th place

1europa.eu

68^th place

117^th place

doi.org (Global: 2^nd place; English: 2^nd place)

Nicolaes GA, Dahlbäck B (February 2003). "Congenital and acquired activated protein C resistance". Seminars in Vascular Medicine. 3 (1): 33–46. doi:10.1055/s-2003-38331. PMID 15199491. S2CID 260369702.
Foster DC, Yoshitake S, Davie EW (July 1985). "The nucleotide sequence of the gene for human protein C". Proceedings of the National Academy of Sciences of the United States of America. 82 (14): 4673–4677. Bibcode:1985PNAS...82.4673F. doi:10.1073/pnas.82.14.4673. PMC 390448. PMID 2991887.
Mosnier LO, Zlokovic BV, Griffin JH (April 2007). "The cytoprotective protein C pathway". Blood. 109 (8): 3161–3172. doi:10.1182/blood-2006-09-003004. PMID 17110453.
Eichacker PQ, Natanson C, Danner RL (October 2006). "Surviving sepsis--practice guidelines, marketing campaigns, and Eli Lilly". The New England Journal of Medicine. 355 (16): 1640–1642. doi:10.1056/NEJMp068197. PMID 17050887.
Martí-Carvajal AJ, Solà I, Gluud C, Lathyris D, Cardona AF (December 2012). "Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients". The Cochrane Database of Systematic Reviews. 2018 (12) CD004388. doi:10.1002/14651858.CD004388.pub6. PMC 6464614. PMID 23235609.
Kylat RI, Ohlsson A (April 2012). "Recombinant human activated protein C for severe sepsis in neonates". The Cochrane Database of Systematic Reviews. 2012 (4) CD005385. doi:10.1002/14651858.CD005385.pub3. PMC 6984667. PMID 22513930.
Stenflo J (January 1976). "A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization". The Journal of Biological Chemistry. 251 (2): 355–363. doi:10.1016/S0021-9258(17)33886-3. PMID 1245477.
Kisiel W, Ericsson LH, Davie EW (November 1976). "Proteolytic activation of protein C from bovine plasma". Biochemistry. 15 (22): 4893–4900. doi:10.1021/bi00667a022. PMID 990250.
Mosnier LO, Griffin JH (September 2006). "Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities". Frontiers in Bioscience. 11: 2381–2399. doi:10.2741/1977. PMID 16720321.
Kisiel W, Canfield WM, Ericsson LH, Davie EW (December 1977). "Anticoagulant properties of bovine plasma protein C following activation by thrombin". Biochemistry. 16 (26): 5824–5831. doi:10.1021/bi00645a029. PMID 588557.
Vehar GA, Davie EW (February 1980). "Preparation and properties of bovine factor VIII (antihemophilic factor)". Biochemistry. 19 (3): 401–410. doi:10.1021/bi00544a001. PMID 7356933.
Walker FJ (June 1980). "Regulation of activated protein C by a new protein. A possible function for bovine protein S". The Journal of Biological Chemistry. 255 (12): 5521–5524. doi:10.1016/S0021-9258(19)70660-7. PMID 6892911.
Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C (November 1981). "Deficiency of protein C in congenital thrombotic disease". The Journal of Clinical Investigation. 68 (5): 1370–1373. doi:10.1172/JCI110385. PMC 370934. PMID 6895379.
Goldenberg NA, Manco-Johnson MJ (November 2008). "Protein C deficiency". Haemophilia. 14 (6): 1214–1221. doi:10.1111/j.1365-2516.2008.01838.x. PMID 19141162. S2CID 2979452.
Beckmann RJ, Schmidt RJ, Santerre RF, Plutzky J, Crabtree GR, Long GL (July 1985). "The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs". Nucleic Acids Research. 13 (14): 5233–5247. doi:10.1093/nar/13.14.5233. PMC 321861. PMID 2991859.
Taylor FB, Chang A, Esmon CT, D'Angelo A, Vigano-D'Angelo S, Blick KE (March 1987). "Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon". The Journal of Clinical Investigation. 79 (3): 918–925. doi:10.1172/JCI112902. PMC 424237. PMID 3102560.
Dahlbäck B, Carlsson M, Svensson PJ (February 1993). "Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C". Proceedings of the National Academy of Sciences of the United States of America. 90 (3): 1004–1008. Bibcode:1993PNAS...90.1004D. doi:10.1073/pnas.90.3.1004. PMC 45799. PMID 8430067.
Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, et al. (May 1994). "Mutation in blood coagulation factor V associated with resistance to activated protein C". Nature. 369 (6475): 64–67. Bibcode:1994Natur.369...64B. doi:10.1038/369064a0. PMID 8164741. S2CID 4314040.
PROWESS: recombinant Human Activated PROtein C Worldwide Evaluation in Severe Sepsis; Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, et al. (March 2001). "Efficacy and safety of recombinant human activated protein C for severe sepsis". The New England Journal of Medicine. 344 (10): 699–709. doi:10.1056/NEJM200103083441001. hdl:2078.1/42889. PMID 11236773.
Hosac AM (April 2002). "Drotrecogin alfa (activated): the first FDA-approved treatment for severe sepsis". Proceedings. 15 (2): 224–227. doi:10.1080/08998280.2002.11927844. PMC 1276518. PMID 16333441.
Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W (June 2002). "Activation of endothelial cell protease activated receptor 1 by the protein C pathway". Science. 296 (5574): 1880–1882. Bibcode:2002Sci...296.1880R. doi:10.1126/science.1071699. PMID 12052963. S2CID 43006410.
Wildhagen KC, Lutgens E, Loubele ST, ten Cate H, Nicolaes GA (December 2011). "The structure-function relationship of activated protein C. Lessons from natural and engineered mutations". Thrombosis and Haemostasis. 106 (6): 1034–1045. doi:10.1160/TH11-08-0522. PMID 22072231. S2CID 3060393.
D'Ursi P, Marino F, Caprera A, Milanesi L, Faioni EM, Rovida E (March 2007). "ProCMD: a database and 3D web resource for protein C mutants". BMC Bioinformatics. 8 (Suppl 1) S11. doi:10.1186/1471-2105-8-S1-S11. PMC 1885840. PMID 17430555.
Yan SC, Grinnell BW, Wold F (July 1989). "Post-translational modifications of proteins: some problems left to solve". Trends in Biochemical Sciences. 14 (7): 264–268. doi:10.1016/0968-0004(89)90060-1. PMID 2672445.
Weiler-Guettler H, Christie PD, Beeler DL, Healy AM, Hancock WW, Rayburn H, et al. (May 1998). "A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state". The Journal of Clinical Investigation. 101 (9): 1983–1991. doi:10.1172/JCI2006. PMC 508785. PMID 9576763.
Gu JM, Crawley JT, Ferrell G, Zhang F, Li W, Esmon NL, et al. (November 2002). "Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality". The Journal of Biological Chemistry. 277 (45): 43335–43343. doi:10.1074/jbc.M207538200. PMID 12218060.
Esmon CT (September 2003). "The protein C pathway". Chest. 124 (3 Suppl): 26S–32S. doi:10.1378/chest.124.3_suppl.26S. PMID 12970121.
España F, Berrettini M, Griffin JH (August 1989). "Purification and characterization of plasma protein C inhibitor". Thrombosis Research. 55 (3): 369–384. doi:10.1016/0049-3848(89)90069-8. PMID 2551064.
Nicolaes GA, Tans G, Thomassen MC, Hemker HC, Pabinger I, Varadi K, et al. (September 1995). "Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C". The Journal of Biological Chemistry. 270 (36): 21158–21166. doi:10.1074/jbc.270.36.21158. PMID 7673148.
Nicolaes GA, Bock PE, Segers K, Wildhagen KC, Dahlbäck B, Rosing J (July 2010). "Inhibition of thrombin formation by active site mutated (S360A) activated protein C". The Journal of Biological Chemistry. 285 (30): 22890–22900. doi:10.1074/jbc.M110.131029. PMC 2906281. PMID 20484050.
Wildhagen KC, Schrijver R, Beckers L, ten Cate H, Reutelingsperger CP, Lutgens E, et al. (July 2014). "Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis". PLOS ONE. 9 (7) e101446. Bibcode:2014PLoSO...9j1446W. doi:10.1371/journal.pone.0101446. PMC 4102480. PMID 25032959.
Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G (June 2008). "Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)". Chest. 133 (6 Suppl): 160S–198S. doi:10.1378/chest.08-0670. PMID 18574265.
Šimčíková D, Heneberg P (December 2019). "Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases". Scientific Reports. 9 (1) 18577. Bibcode:2019NatSR...918577S. doi:10.1038/s41598-019-54976-4. PMC 6901466. PMID 31819097.
Dahlbäck B (January 2003). "The discovery of activated protein C resistance". Journal of Thrombosis and Haemostasis. 1 (1): 3–9. doi:10.1046/j.1538-7836.2003.00016.x. PMID 12871530. S2CID 2147784.
Gillrie MR, Lee K, Gowda DC, Davis SP, Monestier M, Cui L, et al. (March 2012). "Plasmodium falciparum histones induce endothelial proinflammatory response and barrier dysfunction". The American Journal of Pathology. 180 (3): 1028–1039. doi:10.1016/j.ajpath.2011.11.037. PMC 3448071. PMID 22260922.
Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, et al. (September 2005). "Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death". The New England Journal of Medicine. 353 (13): 1332–1341. doi:10.1056/NEJMoa050935. PMID 16192478. S2CID 6918625.
Martí-Carvajal AJ, Solà I, Lathyris D, Cardona AF (March 2012). Martí-Carvajal AJ (ed.). "Human recombinant activated protein C for severe sepsis". The Cochrane Database of Systematic Reviews (3) CD004388. doi:10.1002/14651858.CD004388.pub5. PMID 22419295.
Griffin JH, Fernández JA, Mosnier LO, Liu D, Cheng T, Guo H, et al. (2006). "The promise of protein C". Blood Cells, Molecules & Diseases. 36 (2): 211–216. doi:10.1016/j.bcmd.2005.12.023. PMID 16464623.
Esmon NL, DeBault LE, Esmon CT (May 1983). "Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C". The Journal of Biological Chemistry. 258 (9): 5548–5553. doi:10.1016/S0021-9258(20)81925-5. PMID 6304092.
Slungaard A, Vercellotti GM, Tran T, Gleich GJ, Key NS (April 1993). "Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease". The Journal of Clinical Investigation. 91 (4): 1721–1730. doi:10.1172/JCI116382. PMC 288152. PMID 8386194.

ensembl.org (Global: 1,626^th place; English: 1,007^th place)

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000115718 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024386 – Ensembl, May 2017

europa.eu (Global: 68^th place; English: 117^th place)

ema.europa.eu

"Ceprotin EPAR". European Medicines Agency (EMA). 17 September 2018. Retrieved 29 November 2020.

handle.net (Global: 102^nd place; English: 76^th place)

hdl.handle.net

PROWESS: recombinant Human Activated PROtein C Worldwide Evaluation in Severe Sepsis; Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, et al. (March 2001). "Efficacy and safety of recombinant human activated protein C for severe sepsis". The New England Journal of Medicine. 344 (10): 699–709. doi:10.1056/NEJM200103083441001. hdl:2078.1/42889. PMID 11236773.

harvard.edu (Global: 18^th place; English: 17^th place)

ui.adsabs.harvard.edu

Foster DC, Yoshitake S, Davie EW (July 1985). "The nucleotide sequence of the gene for human protein C". Proceedings of the National Academy of Sciences of the United States of America. 82 (14): 4673–4677. Bibcode:1985PNAS...82.4673F. doi:10.1073/pnas.82.14.4673. PMC 390448. PMID 2991887.
Dahlbäck B, Carlsson M, Svensson PJ (February 1993). "Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C". Proceedings of the National Academy of Sciences of the United States of America. 90 (3): 1004–1008. Bibcode:1993PNAS...90.1004D. doi:10.1073/pnas.90.3.1004. PMC 45799. PMID 8430067.
Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, et al. (May 1994). "Mutation in blood coagulation factor V associated with resistance to activated protein C". Nature. 369 (6475): 64–67. Bibcode:1994Natur.369...64B. doi:10.1038/369064a0. PMID 8164741. S2CID 4314040.
Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W (June 2002). "Activation of endothelial cell protease activated receptor 1 by the protein C pathway". Science. 296 (5574): 1880–1882. Bibcode:2002Sci...296.1880R. doi:10.1126/science.1071699. PMID 12052963. S2CID 43006410.
Wildhagen KC, Schrijver R, Beckers L, ten Cate H, Reutelingsperger CP, Lutgens E, et al. (July 2014). "Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis". PLOS ONE. 9 (7) e101446. Bibcode:2014PLoSO...9j1446W. doi:10.1371/journal.pone.0101446. PMC 4102480. PMID 25032959.
Šimčíková D, Heneberg P (December 2019). "Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases". Scientific Reports. 9 (1) 18577. Bibcode:2019NatSR...918577S. doi:10.1038/s41598-019-54976-4. PMC 6901466. PMID 31819097.

nih.gov (Global: 4^th place; English: 4^th place)

pubmed.ncbi.nlm.nih.gov

Nicolaes GA, Dahlbäck B (February 2003). "Congenital and acquired activated protein C resistance". Seminars in Vascular Medicine. 3 (1): 33–46. doi:10.1055/s-2003-38331. PMID 15199491. S2CID 260369702.
Foster DC, Yoshitake S, Davie EW (July 1985). "The nucleotide sequence of the gene for human protein C". Proceedings of the National Academy of Sciences of the United States of America. 82 (14): 4673–4677. Bibcode:1985PNAS...82.4673F. doi:10.1073/pnas.82.14.4673. PMC 390448. PMID 2991887.
Mosnier LO, Zlokovic BV, Griffin JH (April 2007). "The cytoprotective protein C pathway". Blood. 109 (8): 3161–3172. doi:10.1182/blood-2006-09-003004. PMID 17110453.
Eichacker PQ, Natanson C, Danner RL (October 2006). "Surviving sepsis--practice guidelines, marketing campaigns, and Eli Lilly". The New England Journal of Medicine. 355 (16): 1640–1642. doi:10.1056/NEJMp068197. PMID 17050887.
Martí-Carvajal AJ, Solà I, Gluud C, Lathyris D, Cardona AF (December 2012). "Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients". The Cochrane Database of Systematic Reviews. 2018 (12) CD004388. doi:10.1002/14651858.CD004388.pub6. PMC 6464614. PMID 23235609.
Kylat RI, Ohlsson A (April 2012). "Recombinant human activated protein C for severe sepsis in neonates". The Cochrane Database of Systematic Reviews. 2012 (4) CD005385. doi:10.1002/14651858.CD005385.pub3. PMC 6984667. PMID 22513930.
Mammen EF, Thomas WR, Seegers WH (December 1960). "Activation of purified prothrombin to autoprothrombin I or autoprothrombin II (platelet cofactor II or autoprothrombin II-A)". Thrombosis et Diathesis Haemorrhagica. 5: 218–249. PMID 13765990.
Stenflo J (January 1976). "A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization". The Journal of Biological Chemistry. 251 (2): 355–363. doi:10.1016/S0021-9258(17)33886-3. PMID 1245477.
Kisiel W, Ericsson LH, Davie EW (November 1976). "Proteolytic activation of protein C from bovine plasma". Biochemistry. 15 (22): 4893–4900. doi:10.1021/bi00667a022. PMID 990250.
Mosnier LO, Griffin JH (September 2006). "Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotic activities". Frontiers in Bioscience. 11: 2381–2399. doi:10.2741/1977. PMID 16720321.
Kisiel W, Canfield WM, Ericsson LH, Davie EW (December 1977). "Anticoagulant properties of bovine plasma protein C following activation by thrombin". Biochemistry. 16 (26): 5824–5831. doi:10.1021/bi00645a029. PMID 588557.
Vehar GA, Davie EW (February 1980). "Preparation and properties of bovine factor VIII (antihemophilic factor)". Biochemistry. 19 (3): 401–410. doi:10.1021/bi00544a001. PMID 7356933.
Walker FJ (June 1980). "Regulation of activated protein C by a new protein. A possible function for bovine protein S". The Journal of Biological Chemistry. 255 (12): 5521–5524. doi:10.1016/S0021-9258(19)70660-7. PMID 6892911.
Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C (November 1981). "Deficiency of protein C in congenital thrombotic disease". The Journal of Clinical Investigation. 68 (5): 1370–1373. doi:10.1172/JCI110385. PMC 370934. PMID 6895379.
Goldenberg NA, Manco-Johnson MJ (November 2008). "Protein C deficiency". Haemophilia. 14 (6): 1214–1221. doi:10.1111/j.1365-2516.2008.01838.x. PMID 19141162. S2CID 2979452.
Beckmann RJ, Schmidt RJ, Santerre RF, Plutzky J, Crabtree GR, Long GL (July 1985). "The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs". Nucleic Acids Research. 13 (14): 5233–5247. doi:10.1093/nar/13.14.5233. PMC 321861. PMID 2991859.
Taylor FB, Chang A, Esmon CT, D'Angelo A, Vigano-D'Angelo S, Blick KE (March 1987). "Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon". The Journal of Clinical Investigation. 79 (3): 918–925. doi:10.1172/JCI112902. PMC 424237. PMID 3102560.
Dahlbäck B, Carlsson M, Svensson PJ (February 1993). "Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C". Proceedings of the National Academy of Sciences of the United States of America. 90 (3): 1004–1008. Bibcode:1993PNAS...90.1004D. doi:10.1073/pnas.90.3.1004. PMC 45799. PMID 8430067.
Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, et al. (May 1994). "Mutation in blood coagulation factor V associated with resistance to activated protein C". Nature. 369 (6475): 64–67. Bibcode:1994Natur.369...64B. doi:10.1038/369064a0. PMID 8164741. S2CID 4314040.
PROWESS: recombinant Human Activated PROtein C Worldwide Evaluation in Severe Sepsis; Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, et al. (March 2001). "Efficacy and safety of recombinant human activated protein C for severe sepsis". The New England Journal of Medicine. 344 (10): 699–709. doi:10.1056/NEJM200103083441001. hdl:2078.1/42889. PMID 11236773.
Hosac AM (April 2002). "Drotrecogin alfa (activated): the first FDA-approved treatment for severe sepsis". Proceedings. 15 (2): 224–227. doi:10.1080/08998280.2002.11927844. PMC 1276518. PMID 16333441.
Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W (June 2002). "Activation of endothelial cell protease activated receptor 1 by the protein C pathway". Science. 296 (5574): 1880–1882. Bibcode:2002Sci...296.1880R. doi:10.1126/science.1071699. PMID 12052963. S2CID 43006410.
Wildhagen KC, Lutgens E, Loubele ST, ten Cate H, Nicolaes GA (December 2011). "The structure-function relationship of activated protein C. Lessons from natural and engineered mutations". Thrombosis and Haemostasis. 106 (6): 1034–1045. doi:10.1160/TH11-08-0522. PMID 22072231. S2CID 3060393.
D'Ursi P, Marino F, Caprera A, Milanesi L, Faioni EM, Rovida E (March 2007). "ProCMD: a database and 3D web resource for protein C mutants". BMC Bioinformatics. 8 (Suppl 1) S11. doi:10.1186/1471-2105-8-S1-S11. PMC 1885840. PMID 17430555.
Yan SC, Grinnell BW, Wold F (July 1989). "Post-translational modifications of proteins: some problems left to solve". Trends in Biochemical Sciences. 14 (7): 264–268. doi:10.1016/0968-0004(89)90060-1. PMID 2672445.
Weiler-Guettler H, Christie PD, Beeler DL, Healy AM, Hancock WW, Rayburn H, et al. (May 1998). "A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state". The Journal of Clinical Investigation. 101 (9): 1983–1991. doi:10.1172/JCI2006. PMC 508785. PMID 9576763.
Gu JM, Crawley JT, Ferrell G, Zhang F, Li W, Esmon NL, et al. (November 2002). "Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality". The Journal of Biological Chemistry. 277 (45): 43335–43343. doi:10.1074/jbc.M207538200. PMID 12218060.
Esmon CT (September 2003). "The protein C pathway". Chest. 124 (3 Suppl): 26S–32S. doi:10.1378/chest.124.3_suppl.26S. PMID 12970121.
España F, Berrettini M, Griffin JH (August 1989). "Purification and characterization of plasma protein C inhibitor". Thrombosis Research. 55 (3): 369–384. doi:10.1016/0049-3848(89)90069-8. PMID 2551064.
Nicolaes GA, Tans G, Thomassen MC, Hemker HC, Pabinger I, Varadi K, et al. (September 1995). "Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C". The Journal of Biological Chemistry. 270 (36): 21158–21166. doi:10.1074/jbc.270.36.21158. PMID 7673148.
Nicolaes GA, Bock PE, Segers K, Wildhagen KC, Dahlbäck B, Rosing J (July 2010). "Inhibition of thrombin formation by active site mutated (S360A) activated protein C". The Journal of Biological Chemistry. 285 (30): 22890–22900. doi:10.1074/jbc.M110.131029. PMC 2906281. PMID 20484050.
Wildhagen KC, Schrijver R, Beckers L, ten Cate H, Reutelingsperger CP, Lutgens E, et al. (July 2014). "Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis". PLOS ONE. 9 (7) e101446. Bibcode:2014PLoSO...9j1446W. doi:10.1371/journal.pone.0101446. PMC 4102480. PMID 25032959.
Ansell J, Hirsh J, Hylek E, Jacobson A, Crowther M, Palareti G (June 2008). "Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)". Chest. 133 (6 Suppl): 160S–198S. doi:10.1378/chest.08-0670. PMID 18574265.
Šimčíková D, Heneberg P (December 2019). "Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases". Scientific Reports. 9 (1) 18577. Bibcode:2019NatSR...918577S. doi:10.1038/s41598-019-54976-4. PMC 6901466. PMID 31819097.
Dahlbäck B (January 2003). "The discovery of activated protein C resistance". Journal of Thrombosis and Haemostasis. 1 (1): 3–9. doi:10.1046/j.1538-7836.2003.00016.x. PMID 12871530. S2CID 2147784.
Gillrie MR, Lee K, Gowda DC, Davis SP, Monestier M, Cui L, et al. (March 2012). "Plasmodium falciparum histones induce endothelial proinflammatory response and barrier dysfunction". The American Journal of Pathology. 180 (3): 1028–1039. doi:10.1016/j.ajpath.2011.11.037. PMC 3448071. PMID 22260922.
Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, et al. (September 2005). "Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death". The New England Journal of Medicine. 353 (13): 1332–1341. doi:10.1056/NEJMoa050935. PMID 16192478. S2CID 6918625.
Martí-Carvajal AJ, Solà I, Lathyris D, Cardona AF (March 2012). Martí-Carvajal AJ (ed.). "Human recombinant activated protein C for severe sepsis". The Cochrane Database of Systematic Reviews (3) CD004388. doi:10.1002/14651858.CD004388.pub5. PMID 22419295.
Griffin JH, Fernández JA, Mosnier LO, Liu D, Cheng T, Guo H, et al. (2006). "The promise of protein C". Blood Cells, Molecules & Diseases. 36 (2): 211–216. doi:10.1016/j.bcmd.2005.12.023. PMID 16464623.
Esmon NL, DeBault LE, Esmon CT (May 1983). "Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C". The Journal of Biological Chemistry. 258 (9): 5548–5553. doi:10.1016/S0021-9258(20)81925-5. PMID 6304092.
Slungaard A, Vercellotti GM, Tran T, Gleich GJ, Key NS (April 1993). "Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease". The Journal of Clinical Investigation. 91 (4): 1721–1730. doi:10.1172/JCI116382. PMC 288152. PMID 8386194.

ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Foster DC, Yoshitake S, Davie EW (July 1985). "The nucleotide sequence of the gene for human protein C". Proceedings of the National Academy of Sciences of the United States of America. 82 (14): 4673–4677. Bibcode:1985PNAS...82.4673F. doi:10.1073/pnas.82.14.4673. PMC 390448. PMID 2991887.
Martí-Carvajal AJ, Solà I, Gluud C, Lathyris D, Cardona AF (December 2012). "Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients". The Cochrane Database of Systematic Reviews. 2018 (12) CD004388. doi:10.1002/14651858.CD004388.pub6. PMC 6464614. PMID 23235609.
Kylat RI, Ohlsson A (April 2012). "Recombinant human activated protein C for severe sepsis in neonates". The Cochrane Database of Systematic Reviews. 2012 (4) CD005385. doi:10.1002/14651858.CD005385.pub3. PMC 6984667. PMID 22513930.
Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C (November 1981). "Deficiency of protein C in congenital thrombotic disease". The Journal of Clinical Investigation. 68 (5): 1370–1373. doi:10.1172/JCI110385. PMC 370934. PMID 6895379.
Beckmann RJ, Schmidt RJ, Santerre RF, Plutzky J, Crabtree GR, Long GL (July 1985). "The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs". Nucleic Acids Research. 13 (14): 5233–5247. doi:10.1093/nar/13.14.5233. PMC 321861. PMID 2991859.
Taylor FB, Chang A, Esmon CT, D'Angelo A, Vigano-D'Angelo S, Blick KE (March 1987). "Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon". The Journal of Clinical Investigation. 79 (3): 918–925. doi:10.1172/JCI112902. PMC 424237. PMID 3102560.
Dahlbäck B, Carlsson M, Svensson PJ (February 1993). "Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C". Proceedings of the National Academy of Sciences of the United States of America. 90 (3): 1004–1008. Bibcode:1993PNAS...90.1004D. doi:10.1073/pnas.90.3.1004. PMC 45799. PMID 8430067.
Hosac AM (April 2002). "Drotrecogin alfa (activated): the first FDA-approved treatment for severe sepsis". Proceedings. 15 (2): 224–227. doi:10.1080/08998280.2002.11927844. PMC 1276518. PMID 16333441.
D'Ursi P, Marino F, Caprera A, Milanesi L, Faioni EM, Rovida E (March 2007). "ProCMD: a database and 3D web resource for protein C mutants". BMC Bioinformatics. 8 (Suppl 1) S11. doi:10.1186/1471-2105-8-S1-S11. PMC 1885840. PMID 17430555.
Weiler-Guettler H, Christie PD, Beeler DL, Healy AM, Hancock WW, Rayburn H, et al. (May 1998). "A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state". The Journal of Clinical Investigation. 101 (9): 1983–1991. doi:10.1172/JCI2006. PMC 508785. PMID 9576763.
Nicolaes GA, Bock PE, Segers K, Wildhagen KC, Dahlbäck B, Rosing J (July 2010). "Inhibition of thrombin formation by active site mutated (S360A) activated protein C". The Journal of Biological Chemistry. 285 (30): 22890–22900. doi:10.1074/jbc.M110.131029. PMC 2906281. PMID 20484050.
Wildhagen KC, Schrijver R, Beckers L, ten Cate H, Reutelingsperger CP, Lutgens E, et al. (July 2014). "Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis". PLOS ONE. 9 (7) e101446. Bibcode:2014PLoSO...9j1446W. doi:10.1371/journal.pone.0101446. PMC 4102480. PMID 25032959.
Šimčíková D, Heneberg P (December 2019). "Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases". Scientific Reports. 9 (1) 18577. Bibcode:2019NatSR...918577S. doi:10.1038/s41598-019-54976-4. PMC 6901466. PMID 31819097.
Gillrie MR, Lee K, Gowda DC, Davis SP, Monestier M, Cui L, et al. (March 2012). "Plasmodium falciparum histones induce endothelial proinflammatory response and barrier dysfunction". The American Journal of Pathology. 180 (3): 1028–1039. doi:10.1016/j.ajpath.2011.11.037. PMC 3448071. PMID 22260922.
Slungaard A, Vercellotti GM, Tran T, Gleich GJ, Key NS (April 1993). "Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease". The Journal of Clinical Investigation. 91 (4): 1721–1730. doi:10.1172/JCI116382. PMC 288152. PMID 8386194.

semanticscholar.org (Global: 11^th place; English: 8^th place)

api.semanticscholar.org

Nicolaes GA, Dahlbäck B (February 2003). "Congenital and acquired activated protein C resistance". Seminars in Vascular Medicine. 3 (1): 33–46. doi:10.1055/s-2003-38331. PMID 15199491. S2CID 260369702.
Goldenberg NA, Manco-Johnson MJ (November 2008). "Protein C deficiency". Haemophilia. 14 (6): 1214–1221. doi:10.1111/j.1365-2516.2008.01838.x. PMID 19141162. S2CID 2979452.
Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, et al. (May 1994). "Mutation in blood coagulation factor V associated with resistance to activated protein C". Nature. 369 (6475): 64–67. Bibcode:1994Natur.369...64B. doi:10.1038/369064a0. PMID 8164741. S2CID 4314040.
Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W (June 2002). "Activation of endothelial cell protease activated receptor 1 by the protein C pathway". Science. 296 (5574): 1880–1882. Bibcode:2002Sci...296.1880R. doi:10.1126/science.1071699. PMID 12052963. S2CID 43006410.
Wildhagen KC, Lutgens E, Loubele ST, ten Cate H, Nicolaes GA (December 2011). "The structure-function relationship of activated protein C. Lessons from natural and engineered mutations". Thrombosis and Haemostasis. 106 (6): 1034–1045. doi:10.1160/TH11-08-0522. PMID 22072231. S2CID 3060393.
Dahlbäck B (January 2003). "The discovery of activated protein C resistance". Journal of Thrombosis and Haemostasis. 1 (1): 3–9. doi:10.1046/j.1538-7836.2003.00016.x. PMID 12871530. S2CID 2147784.
Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, et al. (September 2005). "Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death". The New England Journal of Medicine. 353 (13): 1332–1341. doi:10.1056/NEJMoa050935. PMID 16192478. S2CID 6918625.

Protein C (English Wikipedia)

doi.org (Global: 2nd place; English: 2nd place)

ensembl.org (Global: 1,626th place; English: 1,007th place)