Khoury, GA; Fazelinia, H; Chin, JW; Pantazes, RJ; Cirino, PC; Maranas, CD (October 2009), "Computational design of Candida boidinii xylose reductase for altered cofactor specificity", Protein Science, 18 (10): 2125–38, doi:10.1002/pro.227, PMC2786976, PMID19693930
The iterative nature of this process allows IPRO to make additive mutations to a protein sequence that collectively improve the specificity toward desired substrates and/or cofactors. Details on how to download the software, implemented in Python, and experimental testing of predictions are outlined in this paper: Khoury, GA; Fazelinia, H; Chin, JW; Pantazes, RJ; Cirino, PC; Maranas, CD (October 2009), "Computational design of Candida boidinii xylose reductase for altered cofactor specificity", Protein Science, 18 (10): 2125–38, doi:10.1002/pro.227, PMC2786976, PMID19693930
Ardejani, MS; Li, NX; Orner, BP (April 2011), "Stabilization of a Protein Nanocage through the Plugging of a Protein–Protein Interfacial Water Pocket", Biochemistry, 50 (19): 4029–4037, doi:10.1021/bi200207w, PMID21488690
Khoury, GA; Fazelinia, H; Chin, JW; Pantazes, RJ; Cirino, PC; Maranas, CD (October 2009), "Computational design of Candida boidinii xylose reductase for altered cofactor specificity", Protein Science, 18 (10): 2125–38, doi:10.1002/pro.227, PMC2786976, PMID19693930
The iterative nature of this process allows IPRO to make additive mutations to a protein sequence that collectively improve the specificity toward desired substrates and/or cofactors. Details on how to download the software, implemented in Python, and experimental testing of predictions are outlined in this paper: Khoury, GA; Fazelinia, H; Chin, JW; Pantazes, RJ; Cirino, PC; Maranas, CD (October 2009), "Computational design of Candida boidinii xylose reductase for altered cofactor specificity", Protein Science, 18 (10): 2125–38, doi:10.1002/pro.227, PMC2786976, PMID19693930
Ardejani, MS; Li, NX; Orner, BP (April 2011), "Stabilization of a Protein Nanocage through the Plugging of a Protein–Protein Interfacial Water Pocket", Biochemistry, 50 (19): 4029–4037, doi:10.1021/bi200207w, PMID21488690
Khoury, GA; Fazelinia, H; Chin, JW; Pantazes, RJ; Cirino, PC; Maranas, CD (October 2009), "Computational design of Candida boidinii xylose reductase for altered cofactor specificity", Protein Science, 18 (10): 2125–38, doi:10.1002/pro.227, PMC2786976, PMID19693930
The iterative nature of this process allows IPRO to make additive mutations to a protein sequence that collectively improve the specificity toward desired substrates and/or cofactors. Details on how to download the software, implemented in Python, and experimental testing of predictions are outlined in this paper: Khoury, GA; Fazelinia, H; Chin, JW; Pantazes, RJ; Cirino, PC; Maranas, CD (October 2009), "Computational design of Candida boidinii xylose reductase for altered cofactor specificity", Protein Science, 18 (10): 2125–38, doi:10.1002/pro.227, PMC2786976, PMID19693930