Protein kinase B (English Wikipedia)

"Tumor Genetics; AKT Function and Oncogenic Activity" (PDF). Scientific Report. Fox Chase Cancer Center. 2005. Archived from the original (PDF) on 2010-06-04. Retrieved 2013-01-23.

figshare.com

PDB: 3D0E; Heerding DA, Rhodes N, Leber JD, Clark TJ, Keenan RM, Lafrance LV, et al. (September 2008). "Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase". Journal of Medicinal Chemistry. 51 (18): 5663–79. doi:10.1021/jm8004527. PMID 18800763.

harvard.edu

ui.adsabs.harvard.edu

Staal SP, Hartley JW, Rowe WP (July 1977). "Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma". Proceedings of the National Academy of Sciences of the United States of America. 74 (7): 3065–7. Bibcode:1977PNAS...74.3065S. doi:10.1073/pnas.74.7.3065. PMC 431413. PMID 197531.
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (February 2005). "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex". Science. 307 (5712): 1098–101. Bibcode:2005Sci...307.1098S. doi:10.1126/science.1106148. PMID 15718470. S2CID 45837814.
Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, et al. (March 2010). "Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation". PLOS ONE. 5 (3): e9646. Bibcode:2010PLoSO...5.9646M. doi:10.1371/journal.pone.0009646. PMC 2841635. PMID 20333297.
Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, et al. (February 2008). "Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance". Nature. 451 (7181): 964–9. Bibcode:2008Natur.451..964Y. doi:10.1038/nature06668. PMID 18288188. S2CID 18459576.
Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM, et al. (March 1999). "Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway". Proceedings of the National Academy of Sciences of the United States of America. 96 (5): 2110–5. Bibcode:1999PNAS...96.2110R. doi:10.1073/pnas.96.5.2110. PMC 26745. PMID 10051603.
Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, et al. (July 2009). "A gene network regulating lysosomal biogenesis and function". Science. 325 (5939): 473–7. Bibcode:2009Sci...325..473S. doi:10.1126/science.1174447. PMID 19556463. S2CID 20353685.
Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, et al. (February 2017). "mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases". Nature Communications. 8: 14338. Bibcode:2017NatCo...814338P. doi:10.1038/ncomms14338. PMC 5303831. PMID 28165011.

medicalxpress.com

AKT inhibitor AZD5363 well tolerated, yielded partial response in patients with advanced solid tumors

nih.gov

pubmed.ncbi.nlm.nih.gov

PDB: 3MV5; Freeman-Cook KD, Autry C, Borzillo G, Gordon D, Barbacci-Tobin E, Bernardo V, et al. (June 2010). "Design of selective, ATP-competitive inhibitors of Akt". Journal of Medicinal Chemistry. 53 (12): 4615–22. doi:10.1021/jm1003842. PMID 20481595.
PDB: 3D0E; Heerding DA, Rhodes N, Leber JD, Clark TJ, Keenan RM, Lafrance LV, et al. (September 2008). "Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase". Journal of Medicinal Chemistry. 51 (18): 5663–79. doi:10.1021/jm8004527. PMID 18800763.
Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T, et al. (September 2001). "Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene". Genes & Development. 15 (17): 2203–8. doi:10.1101/gad.913901. PMC 312770. PMID 11544177.
Nitulescu GM, Van De Venter M, Nitulescu G, Ungurianu A, Juzenas P, Peng Q, et al. (December 2018). "The Akt pathway in oncology therapy and beyond (Review)". International Journal of Oncology. 53 (6): 2319–2331. doi:10.3892/ijo.2018.4597. PMC 6203150. PMID 30334567.
Pal DS, Banerjee T, Lin Y, de Trogoff F, Borleis J, Iglesias PA, et al. (July 2023). "Actuation of single downstream nodes in growth factor network steers immune cell migration". Developmental Cell. 58 (13): 1170–1188.e7. doi:10.1016/j.devcel.2023.04.019. PMC 10524337. PMID 37220748.
Staal SP, Hartley JW, Rowe WP (July 1977). "Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma". Proceedings of the National Academy of Sciences of the United States of America. 74 (7): 3065–7. Bibcode:1977PNAS...74.3065S. doi:10.1073/pnas.74.7.3065. PMC 431413. PMID 197531.
Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, et al. (July 2003). "Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta". The Journal of Clinical Investigation. 112 (2): 197–208. doi:10.1172/JCI16885. PMC 164287. PMID 12843127.
Yang ZZ, Tschopp O, Baudry A, Dümmler B, Hynx D, Hemmings BA (April 2004). "Physiological functions of protein kinase B/Akt". Biochemical Society Transactions. 32 (Pt 2): 350–4. doi:10.1042/BST0320350. PMID 15046607.
Hill MM, Hemmings BA (2002). "Inhibition of protein kinase B/Akt. implications for cancer therapy". Pharmacology & Therapeutics. 93 (2–3): 243–51. doi:10.1016/S0163-7258(02)00193-6. PMID 12191616.
Mitsiades CS, Mitsiades N, Koutsilieris M (May 2004). "The Akt pathway: molecular targets for anti-cancer drug development". Current Cancer Drug Targets. 4 (3): 235–56. doi:10.2174/1568009043333032. PMID 15134532.
Xie J, Weiskirchen R (2020). "What Does the "AKT" Stand for in the Name "AKT Kinase"? Some Historical Comments". Frontiers in Oncology. 10: 1329. doi:10.3389/fonc.2020.01329. PMC 7431881. PMID 32850422.
Franke TF, Kaplan DR, Cantley LC, Toker A (January 1997). "Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate". Science. 275 (5300): 665–8. doi:10.1126/science.275.5300.665. PMID 9005852. S2CID 31186873.
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (February 2005). "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex". Science. 307 (5712): 1098–101. Bibcode:2005Sci...307.1098S. doi:10.1126/science.1106148. PMID 15718470. S2CID 45837814.
Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, et al. (October 2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity". Cell. 127 (1): 125–37. doi:10.1016/j.cell.2006.08.033. PMID 16962653. S2CID 230319.
Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, et al. (March 2010). "Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation". PLOS ONE. 5 (3): e9646. Bibcode:2010PLoSO...5.9646M. doi:10.1371/journal.pone.0009646. PMC 2841635. PMID 20333297.
Stuenaes JT, Bolling A, Ingvaldsen A, Rommundstad C, Sudar E, Lin FC, et al. (May 2010). "Beta-adrenoceptor stimulation potentiates insulin-stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA". British Journal of Pharmacology. 160 (1): 116–29. doi:10.1111/j.1476-5381.2010.00677.x. PMC 2860212. PMID 20412069.
Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, et al. (February 2008). "Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance". Nature. 451 (7181): 964–9. Bibcode:2008Natur.451..964Y. doi:10.1038/nature06668. PMID 18288188. S2CID 18459576.
Fan CD, Lum MA, Xu C, Black JD, Wang X (January 2013). "Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response". The Journal of Biological Chemistry. 288 (3): 1674–84. doi:10.1074/jbc.M112.416339. PMC 3548477. PMID 23195959.
Song G, Ouyang G, Bao S (2005). "The activation of Akt/PKB signaling pathway and cell survival". Journal of Cellular and Molecular Medicine. 9 (1): 59–71. doi:10.1111/j.1582-4934.2005.tb00337.x. PMC 6741304. PMID 15784165.
Faissner A, Heck N, Dobbertin A, Garwood J (2006). "DSD-1-Proteoglycan/Phosphacan and Receptor Protein Tyrosine Phosphatase-Beta Isoforms during Development and Regeneration of Neural Tissues". Brain Repair. Advances in Experimental Medicine and Biology. Vol. 557. pp. 25–53, Figure 2: regulation of NF–κB. doi:10.1007/0-387-30128-3_3. ISBN 978-0-306-47859-8. PMID 16955703.
Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM, et al. (March 1999). "Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway". Proceedings of the National Academy of Sciences of the United States of America. 96 (5): 2110–5. Bibcode:1999PNAS...96.2110R. doi:10.1073/pnas.96.5.2110. PMC 26745. PMID 10051603.
Kandel ES, Skeen J, Majewski N, Di Cristofano A, Pandolfi PP, Feliciano CS, et al. (November 2002). "Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage". Molecular and Cellular Biology. 22 (22): 7831–41. doi:10.1128/MCB.22.22.7831-7841.2002. PMC 134727. PMID 12391152.
Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, et al. (July 2009). "A gene network regulating lysosomal biogenesis and function". Science. 325 (5939): 473–7. Bibcode:2009Sci...325..473S. doi:10.1126/science.1174447. PMID 19556463. S2CID 20353685.
Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, et al. (February 2017). "mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases". Nature Communications. 8: 14338. Bibcode:2017NatCo...814338P. doi:10.1038/ncomms14338. PMC 5303831. PMID 28165011.
Chen J, Somanath PR, Razorenova O, Chen WS, Hay N, Bornstein P, et al. (November 2005). "Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo". Nature Medicine. 11 (11): 1188–96. doi:10.1038/nm1307. PMC 2277080. PMID 16227992.
Somanath PR, Razorenova OV, Chen J, Byzova TV (March 2006). "Akt1 in endothelial cell and angiogenesis". Cell Cycle. 5 (5): 512–8. doi:10.4161/cc.5.5.2538. PMC 1569947. PMID 16552185.
Lindhurst MJ, Sapp JC, Teer JK, Johnston JJ, Finn EM, Peters K, et al. (August 2011). "A mosaic activating mutation in AKT1 associated with the Proteus syndrome". The New England Journal of Medicine. 365 (7): 611–9. doi:10.1056/NEJMoa1104017. PMC 3170413. PMID 21793738.
Ghobrial IM, Roccaro A, Hong F, Weller E, Rubin N, Leduc R, et al. (February 2010). "Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia". Clinical Cancer Research. 16 (3): 1033–41. doi:10.1158/1078-0432.CCR-09-1837. PMC 2885252. PMID 20103671.
Cheshenko N, Trepanier JB, Stefanidou M, Buckley N, Gonzalez P, Jacobs W, et al. (July 2013). "HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression". FASEB Journal. 27 (7): 2584–99. doi:10.1096/fj.12-220285. PMC 3688744. PMID 23507869.
- "Scientists Reveal Novel Strategy for Stopping Herpes". Science News. Apr 5, 2013.
- Yap TA, Yan L, Patnaik A, Fearen I, Olmos D, Papadopoulos K, et al. (December 2011). "First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors". Journal of Clinical Oncology. 29 (35): 4688–95. doi:10.1200/JCO.2011.35.5263. PMID 22025163.
- Jabbarzadeh Kaboli P, Salimian F, Aghapour S, Xiang S, Zhao Q, Li M, et al. (June 2020). "Akt-targeted therapy as a promising strategy to overcome drug resistance in breast cancer - A comprehensive review from chemotherapy to immunotherapy". Pharmacological Research. 156: 104806. doi:10.1016/j.phrs.2020.104806. PMID 32294525. S2CID 215793444.
- Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, et al. (September 2011). "AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias". Cell. 146 (5): 697–708. doi:10.1016/j.cell.2011.07.032. PMC 3826540. PMID 21884932.
- Bessière L, Todeschini AL, Auguste A, Sarnacki S, Flatters D, Legois B, et al. (May 2015). "A Hot-spot of In-frame Duplications Activates the Oncoprotein AKT1 in Juvenile Granulosa Cell Tumors". eBioMedicine. 2 (5): 421–31. doi:10.1016/j.ebiom.2015.03.002. PMC 4485906. PMID 26137586.
- Auguste A, Bessière L, Todeschini AL, Caburet S, Sarnacki S, Prat J, et al. (December 2015). "Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads". Human Molecular Genetics. 24 (23): 6687–98. doi:10.1093/hmg/ddv373. PMID 26362254.
ncbi.nlm.nih.gov
- Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T, et al. (September 2001). "Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene". Genes & Development. 15 (17): 2203–8. doi:10.1101/gad.913901. PMC 312770. PMID 11544177.
- Nitulescu GM, Van De Venter M, Nitulescu G, Ungurianu A, Juzenas P, Peng Q, et al. (December 2018). "The Akt pathway in oncology therapy and beyond (Review)". International Journal of Oncology. 53 (6): 2319–2331. doi:10.3892/ijo.2018.4597. PMC 6203150. PMID 30334567.
- Pal DS, Banerjee T, Lin Y, de Trogoff F, Borleis J, Iglesias PA, et al. (July 2023). "Actuation of single downstream nodes in growth factor network steers immune cell migration". Developmental Cell. 58 (13): 1170–1188.e7. doi:10.1016/j.devcel.2023.04.019. PMC 10524337. PMID 37220748.
- Staal SP, Hartley JW, Rowe WP (July 1977). "Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma". Proceedings of the National Academy of Sciences of the United States of America. 74 (7): 3065–7. Bibcode:1977PNAS...74.3065S. doi:10.1073/pnas.74.7.3065. PMC 431413. PMID 197531.
- Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, et al. (July 2003). "Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta". The Journal of Clinical Investigation. 112 (2): 197–208. doi:10.1172/JCI16885. PMC 164287. PMID 12843127.
- Xie J, Weiskirchen R (2020). "What Does the "AKT" Stand for in the Name "AKT Kinase"? Some Historical Comments". Frontiers in Oncology. 10: 1329. doi:10.3389/fonc.2020.01329. PMC 7431881. PMID 32850422.
- Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, et al. (March 2010). "Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation". PLOS ONE. 5 (3): e9646. Bibcode:2010PLoSO...5.9646M. doi:10.1371/journal.pone.0009646. PMC 2841635. PMID 20333297.
- Stuenaes JT, Bolling A, Ingvaldsen A, Rommundstad C, Sudar E, Lin FC, et al. (May 2010). "Beta-adrenoceptor stimulation potentiates insulin-stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA". British Journal of Pharmacology. 160 (1): 116–29. doi:10.1111/j.1476-5381.2010.00677.x. PMC 2860212. PMID 20412069.
- Fan CD, Lum MA, Xu C, Black JD, Wang X (January 2013). "Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response". The Journal of Biological Chemistry. 288 (3): 1674–84. doi:10.1074/jbc.M112.416339. PMC 3548477. PMID 23195959.
- Cooper GM (2000). "Figure 15.37: PTEN and PI3K". The cell: a molecular approach. Washington, D.C.: ASM Press. ISBN 978-0-87893-106-4.
- Song G, Ouyang G, Bao S (2005). "The activation of Akt/PKB signaling pathway and cell survival". Journal of Cellular and Molecular Medicine. 9 (1): 59–71. doi:10.1111/j.1582-4934.2005.tb00337.x. PMC 6741304. PMID 15784165.
- Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2002). "Figure 15-60: BAD phosphorylation by Akt". Molecular biology of the cell. New York: Garland Science. ISBN 978-0-8153-3218-3.
- Lodish H, Berk A, Zipursky LS, Matsudaira P, Baltimore D, Darnell J (1999). "Figure 23-50: BAD interaction with Bcl-2". Molecular cell biology. New York: Scientific American Books. ISBN 978-0-7167-3136-8.
- Faissner A, Heck N, Dobbertin A, Garwood J (2006). "DSD-1-Proteoglycan/Phosphacan and Receptor Protein Tyrosine Phosphatase-Beta Isoforms during Development and Regeneration of Neural Tissues". Brain Repair. Advances in Experimental Medicine and Biology. Vol. 557. pp. 25–53, Figure 2: regulation of NF–κB. doi:10.1007/0-387-30128-3_3. ISBN 978-0-306-47859-8. PMID 16955703.
- Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM, et al. (March 1999). "Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway". Proceedings of the National Academy of Sciences of the United States of America. 96 (5): 2110–5. Bibcode:1999PNAS...96.2110R. doi:10.1073/pnas.96.5.2110. PMC 26745. PMID 10051603.
- Kandel ES, Skeen J, Majewski N, Di Cristofano A, Pandolfi PP, Feliciano CS, et al. (November 2002). "Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage". Molecular and Cellular Biology. 22 (22): 7831–41. doi:10.1128/MCB.22.22.7831-7841.2002. PMC 134727. PMID 12391152.
- Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, et al. (February 2017). "mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases". Nature Communications. 8: 14338. Bibcode:2017NatCo...814338P. doi:10.1038/ncomms14338. PMC 5303831. PMID 28165011.
- Chen J, Somanath PR, Razorenova O, Chen WS, Hay N, Bornstein P, et al. (November 2005). "Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo". Nature Medicine. 11 (11): 1188–96. doi:10.1038/nm1307. PMC 2277080. PMID 16227992.
- Somanath PR, Razorenova OV, Chen J, Byzova TV (March 2006). "Akt1 in endothelial cell and angiogenesis". Cell Cycle. 5 (5): 512–8. doi:10.4161/cc.5.5.2538. PMC 1569947. PMID 16552185.
- Lindhurst MJ, Sapp JC, Teer JK, Johnston JJ, Finn EM, Peters K, et al. (August 2011). "A mosaic activating mutation in AKT1 associated with the Proteus syndrome". The New England Journal of Medicine. 365 (7): 611–9. doi:10.1056/NEJMoa1104017. PMC 3170413. PMID 21793738.
- Ghobrial IM, Roccaro A, Hong F, Weller E, Rubin N, Leduc R, et al. (February 2010). "Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia". Clinical Cancer Research. 16 (3): 1033–41. doi:10.1158/1078-0432.CCR-09-1837. PMC 2885252. PMID 20103671.
- Cheshenko N, Trepanier JB, Stefanidou M, Buckley N, Gonzalez P, Jacobs W, et al. (July 2013). "HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression". FASEB Journal. 27 (7): 2584–99. doi:10.1096/fj.12-220285. PMC 3688744. PMID 23507869.
  - "Scientists Reveal Novel Strategy for Stopping Herpes". Science News. Apr 5, 2013.
  - Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, et al. (September 2011). "AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias". Cell. 146 (5): 697–708. doi:10.1016/j.cell.2011.07.032. PMC 3826540. PMID 21884932.
  - Bessière L, Todeschini AL, Auguste A, Sarnacki S, Flatters D, Legois B, et al. (May 2015). "A Hot-spot of In-frame Duplications Activates the Oncoprotein AKT1 in Juvenile Granulosa Cell Tumors". eBioMedicine. 2 (5): 421–31. doi:10.1016/j.ebiom.2015.03.002. PMC 4485906. PMID 26137586.

onclive.com

global.onclive.com

"PARP/AKT Inhibitor Combination Active in Multiple Tumor Types. April 2016". Archived from the original on 2016-05-07. Retrieved 2016-04-20.

rcsb.org

PDB: 3MV5; Freeman-Cook KD, Autry C, Borzillo G, Gordon D, Barbacci-Tobin E, Bernardo V, et al. (June 2010). "Design of selective, ATP-competitive inhibitors of Akt". Journal of Medicinal Chemistry. 53 (12): 4615–22. doi:10.1021/jm1003842. PMID 20481595.
PDB: 3D0E; Heerding DA, Rhodes N, Leber JD, Clark TJ, Keenan RM, Lafrance LV, et al. (September 2008). "Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase". Journal of Medicinal Chemistry. 51 (18): 5663–79. doi:10.1021/jm8004527. PMID 18800763.

sci-news.com

Cheshenko N, Trepanier JB, Stefanidou M, Buckley N, Gonzalez P, Jacobs W, et al. (July 2013). "HSV activates Akt to trigger calcium release and promote viral entry: novel candidate target for treatment and suppression". FASEB Journal. 27 (7): 2584–99. doi:10.1096/fj.12-220285. PMC 3688744. PMID 23507869.
- "Scientists Reveal Novel Strategy for Stopping Herpes". Science News. Apr 5, 2013.

semanticscholar.org

api.semanticscholar.org

Franke TF, Kaplan DR, Cantley LC, Toker A (January 1997). "Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate". Science. 275 (5300): 665–8. doi:10.1126/science.275.5300.665. PMID 9005852. S2CID 31186873.
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (February 2005). "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex". Science. 307 (5712): 1098–101. Bibcode:2005Sci...307.1098S. doi:10.1126/science.1106148. PMID 15718470. S2CID 45837814.
Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, et al. (October 2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity". Cell. 127 (1): 125–37. doi:10.1016/j.cell.2006.08.033. PMID 16962653. S2CID 230319.
Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, et al. (February 2008). "Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance". Nature. 451 (7181): 964–9. Bibcode:2008Natur.451..964Y. doi:10.1038/nature06668. PMID 18288188. S2CID 18459576.
Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, et al. (July 2009). "A gene network regulating lysosomal biogenesis and function". Science. 325 (5939): 473–7. Bibcode:2009Sci...325..473S. doi:10.1126/science.1174447. PMID 19556463. S2CID 20353685.
Jabbarzadeh Kaboli P, Salimian F, Aghapour S, Xiang S, Zhao Q, Li M, et al. (June 2020). "Akt-targeted therapy as a promising strategy to overcome drug resistance in breast cancer - A comprehensive review from chemotherapy to immunotherapy". Pharmacological Research. 156: 104806. doi:10.1016/j.phrs.2020.104806. PMID 32294525. S2CID 215793444.

web.archive.org

"Tumor Genetics; AKT Function and Oncogenic Activity" (PDF). Scientific Report. Fox Chase Cancer Center. 2005. Archived from the original (PDF) on 2010-06-04. Retrieved 2013-01-23.
"PARP/AKT Inhibitor Combination Active in Multiple Tumor Types. April 2016". Archived from the original on 2016-05-07. Retrieved 2016-04-20.