Proteolysis targeting chimera (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Proteolysis targeting chimera" in English language version.

refsWebsite

Global rank English rank

40nih.gov

4^th place

23doi.org

2^nd place

4harvard.edu

18^th place

17^th place

2semanticscholar.org

11^th place

8^th place

1nhregister.com

6,740^th place

3,817^th place

1bostonglobe.com

553^rd place

334^th place

1clinicaltrials.gov

5,225^th place

4,062^nd place

bostonglobe.com

"Scientist wants to hijack cells' tiny garbage trucks to fight cancer". Boston Globe. Retrieved 2016-05-21.

clinicaltrials.gov

"A Study of ARV-766 Given by Mouth in Men With Metastatic Prostate Cancer". ClinicalTrialsGov. NCT05067140.

doi.org

Ishoey M, Chorn S, Singh N, Jaeger MG, Brand M, Paulk J, et al. (March 2018). "Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders". ACS Chemical Biology. 13 (3): 553–560. doi:10.1021/acschembio.7b00969. PMID 29356495.
Luh LM, Scheib U, Juenemann K, Wortmann L, Brands M, Cromm PM (September 2020). "Prey for the Proteasome: Targeted Protein Degradation-A Medicinal Chemist's Perspective". Angewandte Chemie. 59 (36): 15448–15466. doi:10.1002/anie.202004310. PMC 7496094. PMID 32428344.
Cermakova K, Hodges HC (August 2018). "Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation". Molecules. 23 (8): 1958. doi:10.3390/molecules23081958. PMC 6102721. PMID 30082609.
Noblejas-López MD, Tébar-García D, López-Rosa R, Alcaraz-Sanabria A, Cristóbal-Cueto P, Pinedo-Serrano A, et al. (October 2023). "TACkling Cancer by Targeting Selective Protein Degradation". Pharmaceutics. 15 (10): 2442. doi:10.3390/pharmaceutics15102442. PMC 10610449. PMID 37896202.
Sakamoto KM, Kim KB, Kumagai A, Mercurio F, Crews CM, Deshaies RJ (July 2001). "Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8554–8559. Bibcode:2001PNAS...98.8554S. doi:10.1073/pnas.141230798. PMC 37474. PMID 11438690.
Chi KR (May 2016). "Drug developers delve into the cell's trash-disposal machinery". Nature Reviews. Drug Discovery. 15 (5): 295–297. doi:10.1038/nrd.2016.86. PMID 27139985. S2CID 34652880.
Zengerle M, Chan KH, Ciulli A (August 2015). "Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4". ACS Chemical Biology. 10 (8): 1770–1777. doi:10.1021/acschembio.5b00216. PMC 4548256. PMID 26035625.
Bondeson DP, Mares A, Smith IE, Ko E, Campos S, Miah AH, et al. (August 2015). "Catalytic in vivo protein knockdown by small-molecule PROTACs". Nature Chemical Biology. 11 (8): 611–617. doi:10.1038/nchembio.1858. PMC 4629852. PMID 26075522.
Buckley DL, Raina K, Darricarrere N, Hines J, Gustafson JL, Smith IE, et al. (August 2015). "HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins". ACS Chemical Biology. 10 (8): 1831–1837. doi:10.1021/acschembio.5b00442. PMC 4629848. PMID 26070106.
Lu J, Qian Y, Altieri M, Dong H, Wang J, Raina K, et al. (June 2015). "Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4". Chemistry & Biology. 22 (6): 755–763. doi:10.1016/j.chembiol.2015.05.009. PMC 4475452. PMID 26051217.
Winter GE, Buckley DL, Paulk J, Roberts JM, Souza A, Dhe-Paganon S, et al. (June 2015). "DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation". Science. 348 (6241): 1376–1381. doi:10.1126/science.aab1433. PMC 4937790. PMID 25999370.
Schneekloth AR, Pucheault M, Tae HS, Crews CM (November 2008). "Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics". Bioorganic & Medicinal Chemistry Letters. 18 (22): 5904–5908. doi:10.1016/j.bmcl.2008.07.114. PMC 3175619. PMID 18752944.
Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, et al. (April 2021). "DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras". Journal of the American Chemical Society. 143 (13): 5141–5149. doi:10.1021/jacs.1c00990. PMC 8309050. PMID 33783207.
Xue G, Xie J, Hinterndorfer M, Cigler M, Dötsch L, Imrichova H, et al. (November 2023). "Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype". Nature Communications. 14 (1): 7908. Bibcode:2023NatCo..14.7908X. doi:10.1038/s41467-023-43657-6. PMC 10689823. PMID 38036533.
Ocaña A, Pandiella A (September 2020). "Proteolysis targeting chimeras (PROTACs) in cancer therapy". Journal of Experimental & Clinical Cancer Research. 39 (1): 189. doi:10.1186/s13046-020-01672-1. PMC 7493969. PMID 32933565.
Itoh Y, Kitaguchi R, Ishikawa M, Naito M, Hashimoto Y (November 2011). "Design, synthesis and biological evaluation of nuclear receptor-degradation inducers". Bioorganic & Medicinal Chemistry. 19 (22): 6768–6778. doi:10.1016/j.bmc.2011.09.041. PMID 22014751.
Schneider M, Radoux CJ, Hercules A, Ochoa D, Dunham I, Zalmas LP, et al. (October 2021). "The PROTACtable genome". Nature Reviews. Drug Discovery. 20 (10): 789–797. doi:10.1038/s41573-021-00245-x. PMID 34285415. S2CID 236157200.
Cecchini C, Pannilunghi S, Tardy S, Scapozza L (2021). "From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation". Frontiers in Chemistry. 9: 672267. Bibcode:2021FrCh....9..215C. doi:10.3389/fchem.2021.672267. PMC 8093871. PMID 33959589.
Bondeson DP, Crews CM (January 2017). "Targeted Protein Degradation by Small Molecules". Annual Review of Pharmacology and Toxicology. 57: 107–123. doi:10.1146/annurev-pharmtox-010715-103507. PMC 5586045. PMID 27732798.
Morreale F, Kleaine S, et al. (June 2022). "BacPROTACs mediate targeted protein degradation in bacteria". Cell. 185 (13): 2338–2353. doi:10.1016/j.cell.2022.05.009. PMC 9240326.
Schade M, Scott JS, Hayhow TG, Pike A, Terstiege I, Ahlqvist M, et al. (August 2024). "Structural and Physicochemical Features of Oral PROTACs". Journal of Medicinal Chemistry. 67 (15): 13106–13116. doi:10.1021/acs.jmedchem.4c01017. PMID 39078401.
Oughtred R, Rust J, Chang C, Breitkreutz BJ, Stark C, Willems A, et al. (January 2021). "The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions". Protein Science. 30 (1): 187–200. doi:10.1002/pro.3978. PMC 7737760. PMID 33070389.
Liu Y, Yang J, Wang T, Luo M, Chen Y, Chen C, et al. (October 2023). "Expanding PROTACtable genome universe of E3 ligases". Nature Communications. 14 (1): 6509. Bibcode:2023NatCo..14.6509L. doi:10.1038/s41467-023-42233-2. PMC 10579327. PMID 37845222.

harvard.edu

ui.adsabs.harvard.edu

Sakamoto KM, Kim KB, Kumagai A, Mercurio F, Crews CM, Deshaies RJ (July 2001). "Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8554–8559. Bibcode:2001PNAS...98.8554S. doi:10.1073/pnas.141230798. PMC 37474. PMID 11438690.
Xue G, Xie J, Hinterndorfer M, Cigler M, Dötsch L, Imrichova H, et al. (November 2023). "Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype". Nature Communications. 14 (1): 7908. Bibcode:2023NatCo..14.7908X. doi:10.1038/s41467-023-43657-6. PMC 10689823. PMID 38036533.
Cecchini C, Pannilunghi S, Tardy S, Scapozza L (2021). "From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation". Frontiers in Chemistry. 9: 672267. Bibcode:2021FrCh....9..215C. doi:10.3389/fchem.2021.672267. PMC 8093871. PMID 33959589.
Liu Y, Yang J, Wang T, Luo M, Chen Y, Chen C, et al. (October 2023). "Expanding PROTACtable genome universe of E3 ligases". Nature Communications. 14 (1): 6509. Bibcode:2023NatCo..14.6509L. doi:10.1038/s41467-023-42233-2. PMC 10579327. PMID 37845222.

nhregister.com

"Connecticut to support New Haven biotech to the tune of $4.25 million". New Haven Register. 2013-09-26. Retrieved 2016-05-13.

nih.gov

pubmed.ncbi.nlm.nih.gov

Ishoey M, Chorn S, Singh N, Jaeger MG, Brand M, Paulk J, et al. (March 2018). "Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders". ACS Chemical Biology. 13 (3): 553–560. doi:10.1021/acschembio.7b00969. PMID 29356495.
Luh LM, Scheib U, Juenemann K, Wortmann L, Brands M, Cromm PM (September 2020). "Prey for the Proteasome: Targeted Protein Degradation-A Medicinal Chemist's Perspective". Angewandte Chemie. 59 (36): 15448–15466. doi:10.1002/anie.202004310. PMC 7496094. PMID 32428344.
Cermakova K, Hodges HC (August 2018). "Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation". Molecules. 23 (8): 1958. doi:10.3390/molecules23081958. PMC 6102721. PMID 30082609.
Noblejas-López MD, Tébar-García D, López-Rosa R, Alcaraz-Sanabria A, Cristóbal-Cueto P, Pinedo-Serrano A, et al. (October 2023). "TACkling Cancer by Targeting Selective Protein Degradation". Pharmaceutics. 15 (10): 2442. doi:10.3390/pharmaceutics15102442. PMC 10610449. PMID 37896202.
Sakamoto KM, Kim KB, Kumagai A, Mercurio F, Crews CM, Deshaies RJ (July 2001). "Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8554–8559. Bibcode:2001PNAS...98.8554S. doi:10.1073/pnas.141230798. PMC 37474. PMID 11438690.
Chi KR (May 2016). "Drug developers delve into the cell's trash-disposal machinery". Nature Reviews. Drug Discovery. 15 (5): 295–297. doi:10.1038/nrd.2016.86. PMID 27139985. S2CID 34652880.
Zengerle M, Chan KH, Ciulli A (August 2015). "Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4". ACS Chemical Biology. 10 (8): 1770–1777. doi:10.1021/acschembio.5b00216. PMC 4548256. PMID 26035625.
Bondeson DP, Mares A, Smith IE, Ko E, Campos S, Miah AH, et al. (August 2015). "Catalytic in vivo protein knockdown by small-molecule PROTACs". Nature Chemical Biology. 11 (8): 611–617. doi:10.1038/nchembio.1858. PMC 4629852. PMID 26075522.
Buckley DL, Raina K, Darricarrere N, Hines J, Gustafson JL, Smith IE, et al. (August 2015). "HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins". ACS Chemical Biology. 10 (8): 1831–1837. doi:10.1021/acschembio.5b00442. PMC 4629848. PMID 26070106.
Lu J, Qian Y, Altieri M, Dong H, Wang J, Raina K, et al. (June 2015). "Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4". Chemistry & Biology. 22 (6): 755–763. doi:10.1016/j.chembiol.2015.05.009. PMC 4475452. PMID 26051217.
Winter GE, Buckley DL, Paulk J, Roberts JM, Souza A, Dhe-Paganon S, et al. (June 2015). "DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation". Science. 348 (6241): 1376–1381. doi:10.1126/science.aab1433. PMC 4937790. PMID 25999370.
Schneekloth AR, Pucheault M, Tae HS, Crews CM (November 2008). "Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics". Bioorganic & Medicinal Chemistry Letters. 18 (22): 5904–5908. doi:10.1016/j.bmcl.2008.07.114. PMC 3175619. PMID 18752944.
Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, et al. (April 2021). "DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras". Journal of the American Chemical Society. 143 (13): 5141–5149. doi:10.1021/jacs.1c00990. PMC 8309050. PMID 33783207.
Xue G, Xie J, Hinterndorfer M, Cigler M, Dötsch L, Imrichova H, et al. (November 2023). "Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype". Nature Communications. 14 (1): 7908. Bibcode:2023NatCo..14.7908X. doi:10.1038/s41467-023-43657-6. PMC 10689823. PMID 38036533.
Ocaña A, Pandiella A (September 2020). "Proteolysis targeting chimeras (PROTACs) in cancer therapy". Journal of Experimental & Clinical Cancer Research. 39 (1): 189. doi:10.1186/s13046-020-01672-1. PMC 7493969. PMID 32933565.
Itoh Y, Kitaguchi R, Ishikawa M, Naito M, Hashimoto Y (November 2011). "Design, synthesis and biological evaluation of nuclear receptor-degradation inducers". Bioorganic & Medicinal Chemistry. 19 (22): 6768–6778. doi:10.1016/j.bmc.2011.09.041. PMID 22014751.
Schneider M, Radoux CJ, Hercules A, Ochoa D, Dunham I, Zalmas LP, et al. (October 2021). "The PROTACtable genome". Nature Reviews. Drug Discovery. 20 (10): 789–797. doi:10.1038/s41573-021-00245-x. PMID 34285415. S2CID 236157200.
Cecchini C, Pannilunghi S, Tardy S, Scapozza L (2021). "From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation". Frontiers in Chemistry. 9: 672267. Bibcode:2021FrCh....9..215C. doi:10.3389/fchem.2021.672267. PMC 8093871. PMID 33959589.
Bondeson DP, Crews CM (January 2017). "Targeted Protein Degradation by Small Molecules". Annual Review of Pharmacology and Toxicology. 57: 107–123. doi:10.1146/annurev-pharmtox-010715-103507. PMC 5586045. PMID 27732798.
Schade M, Scott JS, Hayhow TG, Pike A, Terstiege I, Ahlqvist M, et al. (August 2024). "Structural and Physicochemical Features of Oral PROTACs". Journal of Medicinal Chemistry. 67 (15): 13106–13116. doi:10.1021/acs.jmedchem.4c01017. PMID 39078401.
Oughtred R, Rust J, Chang C, Breitkreutz BJ, Stark C, Willems A, et al. (January 2021). "The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions". Protein Science. 30 (1): 187–200. doi:10.1002/pro.3978. PMC 7737760. PMID 33070389.
Liu Y, Yang J, Wang T, Luo M, Chen Y, Chen C, et al. (October 2023). "Expanding PROTACtable genome universe of E3 ligases". Nature Communications. 14 (1): 6509. Bibcode:2023NatCo..14.6509L. doi:10.1038/s41467-023-42233-2. PMC 10579327. PMID 37845222.

ncbi.nlm.nih.gov

Luh LM, Scheib U, Juenemann K, Wortmann L, Brands M, Cromm PM (September 2020). "Prey for the Proteasome: Targeted Protein Degradation-A Medicinal Chemist's Perspective". Angewandte Chemie. 59 (36): 15448–15466. doi:10.1002/anie.202004310. PMC 7496094. PMID 32428344.
Cermakova K, Hodges HC (August 2018). "Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation". Molecules. 23 (8): 1958. doi:10.3390/molecules23081958. PMC 6102721. PMID 30082609.
Noblejas-López MD, Tébar-García D, López-Rosa R, Alcaraz-Sanabria A, Cristóbal-Cueto P, Pinedo-Serrano A, et al. (October 2023). "TACkling Cancer by Targeting Selective Protein Degradation". Pharmaceutics. 15 (10): 2442. doi:10.3390/pharmaceutics15102442. PMC 10610449. PMID 37896202.
Sakamoto KM, Kim KB, Kumagai A, Mercurio F, Crews CM, Deshaies RJ (July 2001). "Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8554–8559. Bibcode:2001PNAS...98.8554S. doi:10.1073/pnas.141230798. PMC 37474. PMID 11438690.
Zengerle M, Chan KH, Ciulli A (August 2015). "Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4". ACS Chemical Biology. 10 (8): 1770–1777. doi:10.1021/acschembio.5b00216. PMC 4548256. PMID 26035625.
Bondeson DP, Mares A, Smith IE, Ko E, Campos S, Miah AH, et al. (August 2015). "Catalytic in vivo protein knockdown by small-molecule PROTACs". Nature Chemical Biology. 11 (8): 611–617. doi:10.1038/nchembio.1858. PMC 4629852. PMID 26075522.
Buckley DL, Raina K, Darricarrere N, Hines J, Gustafson JL, Smith IE, et al. (August 2015). "HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins". ACS Chemical Biology. 10 (8): 1831–1837. doi:10.1021/acschembio.5b00442. PMC 4629848. PMID 26070106.
Lu J, Qian Y, Altieri M, Dong H, Wang J, Raina K, et al. (June 2015). "Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4". Chemistry & Biology. 22 (6): 755–763. doi:10.1016/j.chembiol.2015.05.009. PMC 4475452. PMID 26051217.
Winter GE, Buckley DL, Paulk J, Roberts JM, Souza A, Dhe-Paganon S, et al. (June 2015). "DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation". Science. 348 (6241): 1376–1381. doi:10.1126/science.aab1433. PMC 4937790. PMID 25999370.
Schneekloth AR, Pucheault M, Tae HS, Crews CM (November 2008). "Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics". Bioorganic & Medicinal Chemistry Letters. 18 (22): 5904–5908. doi:10.1016/j.bmcl.2008.07.114. PMC 3175619. PMID 18752944.
Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, et al. (April 2021). "DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras". Journal of the American Chemical Society. 143 (13): 5141–5149. doi:10.1021/jacs.1c00990. PMC 8309050. PMID 33783207.
Xue G, Xie J, Hinterndorfer M, Cigler M, Dötsch L, Imrichova H, et al. (November 2023). "Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype". Nature Communications. 14 (1): 7908. Bibcode:2023NatCo..14.7908X. doi:10.1038/s41467-023-43657-6. PMC 10689823. PMID 38036533.
Ocaña A, Pandiella A (September 2020). "Proteolysis targeting chimeras (PROTACs) in cancer therapy". Journal of Experimental & Clinical Cancer Research. 39 (1): 189. doi:10.1186/s13046-020-01672-1. PMC 7493969. PMID 32933565.
Cecchini C, Pannilunghi S, Tardy S, Scapozza L (2021). "From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation". Frontiers in Chemistry. 9: 672267. Bibcode:2021FrCh....9..215C. doi:10.3389/fchem.2021.672267. PMC 8093871. PMID 33959589.
Bondeson DP, Crews CM (January 2017). "Targeted Protein Degradation by Small Molecules". Annual Review of Pharmacology and Toxicology. 57: 107–123. doi:10.1146/annurev-pharmtox-010715-103507. PMC 5586045. PMID 27732798.
Morreale F, Kleaine S, et al. (June 2022). "BacPROTACs mediate targeted protein degradation in bacteria". Cell. 185 (13): 2338–2353. doi:10.1016/j.cell.2022.05.009. PMC 9240326.
Oughtred R, Rust J, Chang C, Breitkreutz BJ, Stark C, Willems A, et al. (January 2021). "The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions". Protein Science. 30 (1): 187–200. doi:10.1002/pro.3978. PMC 7737760. PMID 33070389.
Liu Y, Yang J, Wang T, Luo M, Chen Y, Chen C, et al. (October 2023). "Expanding PROTACtable genome universe of E3 ligases". Nature Communications. 14 (1): 6509. Bibcode:2023NatCo..14.6509L. doi:10.1038/s41467-023-42233-2. PMC 10579327. PMID 37845222.

semanticscholar.org

api.semanticscholar.org

Chi KR (May 2016). "Drug developers delve into the cell's trash-disposal machinery". Nature Reviews. Drug Discovery. 15 (5): 295–297. doi:10.1038/nrd.2016.86. PMID 27139985. S2CID 34652880.
Schneider M, Radoux CJ, Hercules A, Ochoa D, Dunham I, Zalmas LP, et al. (October 2021). "The PROTACtable genome". Nature Reviews. Drug Discovery. 20 (10): 789–797. doi:10.1038/s41573-021-00245-x. PMID 34285415. S2CID 236157200.