Analysis of information sources in references of the Wikipedia article "Psilocybin" in English language version.
An interesting fact may be the much shorter half-life (mean 74.1 ± 19.6 minutes i.v. compared to 163 ± 64 minutes p.o.) and duration of action (subjective effects lasting only 15–30 minutes) when psilocybin is given intravenously, as performed in a recent double-blind placebo controlled trial.29
With a logS value of −3.009 and a plasma protein binding of 0.66, respectively, psilocybin has poor water solubility and is moderately bound to plasma proteins.
When selecting adverse event profile rates, the shortest time period available was selected and analyzed (eg, day 1 instead of day 30) since the half-life of psilocin is 3 ± 1.1 hours when taken orally and the duration of action can range between 3 to 12 hours.12,13
As you are aware, mushrooms containing the above substances are collected and used for their hallucinogenic effects. As a matter of international law, no plants (natural material) containing psilocin and psilocybin are at present controlled under the Convention on Psychotropic Substances of 1971. Consequently, preparations made of these plants are not under international control and, therefore, not subject of the articles of the 1971 Convention [emphasis added]. Criminal cases are decided with reference to domestic law, which may otherwise provide for controls over mushrooms containing psilocine and psilocybin. As the Board can only speak as to the contours of the international drug conventions, I am unable to provide an opinion on the litigation in question.(Letter from Secretary of the UN International Narcotics Control Board to the Dutch Ministry of Health)
An interesting fact may be the much shorter half-life (mean 74.1 ± 19.6 minutes i.v. compared to 163 ± 64 minutes p.o.) and duration of action (subjective effects lasting only 15–30 minutes) when psilocybin is given intravenously, as performed in a recent double-blind placebo controlled trial.29
When selecting adverse event profile rates, the shortest time period available was selected and analyzed (eg, day 1 instead of day 30) since the half-life of psilocin is 3 ± 1.1 hours when taken orally and the duration of action can range between 3 to 12 hours.12,13
When selecting adverse event profile rates, the shortest time period available was selected and analyzed (eg, day 1 instead of day 30) since the half-life of psilocin is 3 ± 1.1 hours when taken orally and the duration of action can range between 3 to 12 hours.12,13
An interesting fact may be the much shorter half-life (mean 74.1 ± 19.6 minutes i.v. compared to 163 ± 64 minutes p.o.) and duration of action (subjective effects lasting only 15–30 minutes) when psilocybin is given intravenously, as performed in a recent double-blind placebo controlled trial.29
{{cite web}}: CS1 maint: bot: original URL status unknown (link)As you are aware, mushrooms containing the above substances are collected and used for their hallucinogenic effects. As a matter of international law, no plants (natural material) containing psilocin and psilocybin are at present controlled under the Convention on Psychotropic Substances of 1971. Consequently, preparations made of these plants are not under international control and, therefore, not subject of the articles of the 1971 Convention [emphasis added]. Criminal cases are decided with reference to domestic law, which may otherwise provide for controls over mushrooms containing psilocine and psilocybin. As the Board can only speak as to the contours of the international drug conventions, I am unable to provide an opinion on the litigation in question.(Letter from Secretary of the UN International Narcotics Control Board to the Dutch Ministry of Health)