Quercetin (English Wikipedia)

Day AJ, Rothwell JA, Morgan RA (2004). "Characterization of polyphenol metabolites". In Bao Y, Fenwick R (eds.). Phytochemicals in health and disease. New York, NY: Dekker. pp. 50–67. ISBN 0-8247-4023-8.

brenda-enzymes.org

"Information on EC 3.2.1.66 - quercitrinase". BRENDA (BRaunschweig ENzyme DAtabase). Helmholtz Centre for Infection Research.

britannica.com

"Quercetin (biochemistry)". Encyclopædia Britannica.

doi.org

Fischer C, Speth V, Fleig-Eberenz S, Neuhaus G (Oct 1997). "Induction of Zygotic Polyembryos in Wheat: Influence of Auxin Polar Transport". The Plant Cell. 9 (10): 1767–1780. doi:10.1105/tpc.9.10.1767. PMC 157020. PMID 12237347.
Formica JV, Regelson W (1995). "Review of the biology of quercetin and related bioflavonoids". Food and Chemical Toxicology. 33 (12): 1061–80. doi:10.1016/0278-6915(95)00077-1. PMID 8847003.
Slimestad R, Fossen T, Vågen IM (December 2007). "Onions: a source of unique dietary flavonoids". Journal of Agricultural and Food Chemistry. 55 (25): 10067–80. doi:10.1021/jf0712503. PMID 17997520.
Mitchell AE, Hong YJ, Koh E, Barrett DM, Bryant DE, Denison RF, Kaffka S (Jul 2007). "Ten-year comparison of the influence of organic and conventional crop management practices on the content of flavonoids in tomatoes". Journal of Agricultural and Food Chemistry. 55 (15): 6154–9. doi:10.1021/jf070344+. PMID 17590007.
Petrus K, Schwartz H, Sontag G (Jun 2011). "Analysis of flavonoids in honey by HPLC coupled with coulometric electrode array detection and electrospray ionization mass spectrometry". Analytical and Bioanalytical Chemistry. 400 (8): 2555–63. doi:10.1007/s00216-010-4614-7. PMID 21229237. S2CID 24796542.
Winkel-Shirley B (Jun 2001). "Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology". Plant Physiology. 126 (2): 485–93. doi:10.1104/pp.126.2.485. PMC 1540115. PMID 11402179.
Juergenliemk G, Boje K, Huewel S, Lohmann C, Galla HJ, Nahrstedt A (Nov 2003). "In vitro studies indicate that miquelianin (quercetin 3-O-beta-D-glucuronopyranoside) is able to reach the CNS from the small intestine". Planta Medica. 69 (11): 1013–7. doi:10.1055/s-2003-45148. PMID 14735439. S2CID 260253046.
Tranchimand S, Brouant P, Iacazio G (Nov 2010). "The rutin catabolic pathway with special emphasis on quercetinase". Biodegradation. 21 (6): 833–59. doi:10.1007/s10532-010-9359-7. PMID 20419500. S2CID 30101803.
Gugler, R.; Leschik, M.; Dengler, H. J. (1 March 1975). "Disposition of quercetin in man after single oral and intravenous doses". European Journal of Clinical Pharmacology. 9 (2): 229–234. doi:10.1007/BF00614022. PMID 1233267. S2CID 23812714.
Williams RJ, Spencer JP, Rice-Evans C (Apr 2004). "Flavonoids: antioxidants or signalling molecules?". (review). Free Radical Biology & Medicine. 36 (7): 838–49. doi:10.1016/j.freeradbiomed.2004.01.001. PMID 15019969.
Barnes S, Prasain J, D'Alessandro T, Arabshahi A, Botting N, Lila MA, Jackson G, Janle EM, Weaver CM (May 2011). "The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems". (review). Food & Function. 2 (5): 235–44. doi:10.1039/c1fo10025d. PMC 4122511. PMID 21779561.
Luca SV, Macovei I, Bujor A, Trifan A (2020). "Bioactivity of dietary polyphenols: The role of metabolites". Critical Reviews in Food Science and Nutrition. 60 (4): 626–659. doi:10.1080/10408398.2018.1546669. PMID 30614249. S2CID 58651581.
Dabeek WM, Marra MV (2019). "Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans". Nutrients. 11 (10): 2288. doi:10.3390/nu11102288. PMC 6835347. PMID 31557798.
Shen P, Lin W, Deng X, Ba X, Han L, Chen Z, Qin K, Huang Y, Tu S (2021). "Potential Implications of Quercetin in Autoimmune Diseases". Front Immunol. 12: 689044. doi:10.3389/fimmu.2021.689044. PMC 8260830. PMID 34248976.
Alizadeh SR, Ebrahimzadeh MA (February 2022). "Quercetin derivatives: Drug design, development, and biological activities, a review". Eur J Med Chem. 229: 114068. doi:10.1016/j.ejmech.2021.114068. PMID 34971873. S2CID 245485982.
Wittig, Jörg; Herderich, Markus; Graefe, Eva Ulrike; Veit, Markus (April 2001). "Identification of quercetin glucuronides in human plasma by high-performance liquid chromatography–tandem mass spectrometry". Journal of Chromatography B: Biomedical Sciences and Applications. 753 (2): 237–243. doi:10.1016/s0378-4347(00)00549-1. PMID 11334336.
Procházková D, Boušová I, Wilhelmová N (2011). "Antioxidant and prooxidant properties of flavonoids". Fitoterapia. 82 (4): 513–523. doi:10.1016/j.fitote.2011.01.018. PMID 21277359.
Elbarbry F, Ung A, Abdelkawy K (January 2018). "Studying the Inhibitory Effect of Quercetin and Thymoquinone on Human Cytochrome P450 Enzyme Activities". Pharmacognosy Magazine. 13 (Suppl 4): S895 – S899. doi:10.4103/0973-1296.224342 (inactive 1 November 2024). PMC 5822518. PMID 29491651.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
Rastogi, Himanshu; Jana, Snehasis (December 2014). "Evaluation of Inhibitory Effects of Caffeic acid and Quercetin on Human Liver Cytochrome P450 Activities". Phytotherapy Research. 28 (12): 1873–1878. doi:10.1002/ptr.5220. PMID 25196644. S2CID 41563915.
Xiao, Jian; Huang, Wei-Hua; Peng, Jing-Bo; Tan, Zhi-Rong; Ou-Yang, Dong-Sheng; Hu, Dong-Li; Zhang, Wei; Chen, Yao (2014). "Quercetin Significantly Inhibits the Metabolism of Caffeine, a Substrate of Cytochrome P450 1A2 Unrelated to CYP1A2*1C (−2964G>A) and 1F* (734C>A) Gene Polymorphisms". BioMed Research International. 2014: 1–6. doi:10.1155/2014/405071. PMC 4082882. PMID 25025048.
Yang F, Song L, Wang H, Wang J, Xu Z, Xing N (June 2015). "Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential (Review)". Oncol. Rep. 33 (6): 2659–68. doi:10.3892/or.2015.3886. PMID 25845380.
Miles SL, McFarland M, Niles RM (2014). "Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease". Nutrition Reviews. 72 (11): 720–34. doi:10.1111/nure.12152. PMID 25323953.
D'Andrea G (2015). "Quercetin: A flavonol with multifaceted therapeutic applications?". Fitoterapia. 106: 256–71. doi:10.1016/j.fitote.2015.09.018. PMID 26393898.
European Food Safety Agency (EFSA) NDA Panel (Dietetic Products, Nutrition and Allergies) (8 April 2011). "Scientific Opinion on the substantiation of health claims related to quercetin and protection of DNA, proteins and lipids from oxidative damage (ID 1647), "cardiovascular system" (ID 1844), "mental state and performance" (ID 1845), and "liver, kidneys" (ID 1846) pursuant to Article 13(1) of Regulation (EC) No 1924/2006". EFSA Journal. 9 (4): 2067–82. doi:10.2903/j.efsa.2011.2067. Retrieved 24 September 2014.
Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schäfer B, Hirsch-Ernst KI, Lampen A (January 2018). "Safety Aspects of the Use of Quercetin as a Dietary Supplement". Mol Nutr Food Res (Review). 62 (1). doi:10.1002/mnfr.201700447. PMID 29127724. S2CID 24772872.

europa.eu

efsa.europa.eu

European Food Safety Agency (EFSA) NDA Panel (Dietetic Products, Nutrition and Allergies) (8 April 2011). "Scientific Opinion on the substantiation of health claims related to quercetin and protection of DNA, proteins and lipids from oxidative damage (ID 1647), "cardiovascular system" (ID 1844), "mental state and performance" (ID 1845), and "liver, kidneys" (ID 1846) pursuant to Article 13(1) of Regulation (EC) No 1924/2006". EFSA Journal. 9 (4): 2067–82. doi:10.2903/j.efsa.2011.2067. Retrieved 24 September 2014.

fda.gov

King JL (2 March 2017). "Warning Letter to Cape Fear Naturals". Inspections, Compliance, Enforcement, and Criminal Investigations, US Food and Drug Administration. Retrieved 29 November 2018.
Pace R (17 April 2017). "Warning Letter to DoctorVicks.com". Inspections, Compliance, Enforcement, and Criminal Investigations, US Food and Drug Administration. Retrieved 29 November 2018.

accessdata.fda.gov

"GRN No. 341 (Quercetin)". US Food and Drug Administration. 22 November 2010. Retrieved 27 October 2021.

merriam-webster.com

"Quercetin". Merriam-Webster. 29 November 2023.

nih.gov

pubmed.ncbi.nlm.nih.gov

Fischer C, Speth V, Fleig-Eberenz S, Neuhaus G (Oct 1997). "Induction of Zygotic Polyembryos in Wheat: Influence of Auxin Polar Transport". The Plant Cell. 9 (10): 1767–1780. doi:10.1105/tpc.9.10.1767. PMC 157020. PMID 12237347.
Formica JV, Regelson W (1995). "Review of the biology of quercetin and related bioflavonoids". Food and Chemical Toxicology. 33 (12): 1061–80. doi:10.1016/0278-6915(95)00077-1. PMID 8847003.
Slimestad R, Fossen T, Vågen IM (December 2007). "Onions: a source of unique dietary flavonoids". Journal of Agricultural and Food Chemistry. 55 (25): 10067–80. doi:10.1021/jf0712503. PMID 17997520.
Mitchell AE, Hong YJ, Koh E, Barrett DM, Bryant DE, Denison RF, Kaffka S (Jul 2007). "Ten-year comparison of the influence of organic and conventional crop management practices on the content of flavonoids in tomatoes". Journal of Agricultural and Food Chemistry. 55 (15): 6154–9. doi:10.1021/jf070344+. PMID 17590007.
Petrus K, Schwartz H, Sontag G (Jun 2011). "Analysis of flavonoids in honey by HPLC coupled with coulometric electrode array detection and electrospray ionization mass spectrometry". Analytical and Bioanalytical Chemistry. 400 (8): 2555–63. doi:10.1007/s00216-010-4614-7. PMID 21229237. S2CID 24796542.
Winkel-Shirley B (Jun 2001). "Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology". Plant Physiology. 126 (2): 485–93. doi:10.1104/pp.126.2.485. PMC 1540115. PMID 11402179.
Juergenliemk G, Boje K, Huewel S, Lohmann C, Galla HJ, Nahrstedt A (Nov 2003). "In vitro studies indicate that miquelianin (quercetin 3-O-beta-D-glucuronopyranoside) is able to reach the CNS from the small intestine". Planta Medica. 69 (11): 1013–7. doi:10.1055/s-2003-45148. PMID 14735439. S2CID 260253046.
Tranchimand S, Brouant P, Iacazio G (Nov 2010). "The rutin catabolic pathway with special emphasis on quercetinase". Biodegradation. 21 (6): 833–59. doi:10.1007/s10532-010-9359-7. PMID 20419500. S2CID 30101803.
Gugler, R.; Leschik, M.; Dengler, H. J. (1 March 1975). "Disposition of quercetin in man after single oral and intravenous doses". European Journal of Clinical Pharmacology. 9 (2): 229–234. doi:10.1007/BF00614022. PMID 1233267. S2CID 23812714.
Williams RJ, Spencer JP, Rice-Evans C (Apr 2004). "Flavonoids: antioxidants or signalling molecules?". (review). Free Radical Biology & Medicine. 36 (7): 838–49. doi:10.1016/j.freeradbiomed.2004.01.001. PMID 15019969.
Barnes S, Prasain J, D'Alessandro T, Arabshahi A, Botting N, Lila MA, Jackson G, Janle EM, Weaver CM (May 2011). "The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems". (review). Food & Function. 2 (5): 235–44. doi:10.1039/c1fo10025d. PMC 4122511. PMID 21779561.
Luca SV, Macovei I, Bujor A, Trifan A (2020). "Bioactivity of dietary polyphenols: The role of metabolites". Critical Reviews in Food Science and Nutrition. 60 (4): 626–659. doi:10.1080/10408398.2018.1546669. PMID 30614249. S2CID 58651581.
Dabeek WM, Marra MV (2019). "Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans". Nutrients. 11 (10): 2288. doi:10.3390/nu11102288. PMC 6835347. PMID 31557798.
Shen P, Lin W, Deng X, Ba X, Han L, Chen Z, Qin K, Huang Y, Tu S (2021). "Potential Implications of Quercetin in Autoimmune Diseases". Front Immunol. 12: 689044. doi:10.3389/fimmu.2021.689044. PMC 8260830. PMID 34248976.
Alizadeh SR, Ebrahimzadeh MA (February 2022). "Quercetin derivatives: Drug design, development, and biological activities, a review". Eur J Med Chem. 229: 114068. doi:10.1016/j.ejmech.2021.114068. PMID 34971873. S2CID 245485982.
Graefe EU, Derendorf H, Veit M (1999). "Pharmacokinetics and bioavailability of the flavonol quercetin in humans" (PDF). (review). International Journal of Clinical Pharmacology and Therapeutics. 37 (5): 219–33. PMID 10363620. Archived from the original (PDF) on 2017-05-17. Retrieved 2016-01-01.
Wittig, Jörg; Herderich, Markus; Graefe, Eva Ulrike; Veit, Markus (April 2001). "Identification of quercetin glucuronides in human plasma by high-performance liquid chromatography–tandem mass spectrometry". Journal of Chromatography B: Biomedical Sciences and Applications. 753 (2): 237–243. doi:10.1016/s0378-4347(00)00549-1. PMID 11334336.
Procházková D, Boušová I, Wilhelmová N (2011). "Antioxidant and prooxidant properties of flavonoids". Fitoterapia. 82 (4): 513–523. doi:10.1016/j.fitote.2011.01.018. PMID 21277359.
Elbarbry F, Ung A, Abdelkawy K (January 2018). "Studying the Inhibitory Effect of Quercetin and Thymoquinone on Human Cytochrome P450 Enzyme Activities". Pharmacognosy Magazine. 13 (Suppl 4): S895 – S899. doi:10.4103/0973-1296.224342 (inactive 1 November 2024). PMC 5822518. PMID 29491651.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
Rastogi, Himanshu; Jana, Snehasis (December 2014). "Evaluation of Inhibitory Effects of Caffeic acid and Quercetin on Human Liver Cytochrome P450 Activities". Phytotherapy Research. 28 (12): 1873–1878. doi:10.1002/ptr.5220. PMID 25196644. S2CID 41563915.
Xiao, Jian; Huang, Wei-Hua; Peng, Jing-Bo; Tan, Zhi-Rong; Ou-Yang, Dong-Sheng; Hu, Dong-Li; Zhang, Wei; Chen, Yao (2014). "Quercetin Significantly Inhibits the Metabolism of Caffeine, a Substrate of Cytochrome P450 1A2 Unrelated to CYP1A2*1C (−2964G>A) and 1F* (734C>A) Gene Polymorphisms". BioMed Research International. 2014: 1–6. doi:10.1155/2014/405071. PMC 4082882. PMID 25025048.
Yang F, Song L, Wang H, Wang J, Xu Z, Xing N (June 2015). "Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential (Review)". Oncol. Rep. 33 (6): 2659–68. doi:10.3892/or.2015.3886. PMID 25845380.
Miles SL, McFarland M, Niles RM (2014). "Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease". Nutrition Reviews. 72 (11): 720–34. doi:10.1111/nure.12152. PMID 25323953.
D'Andrea G (2015). "Quercetin: A flavonol with multifaceted therapeutic applications?". Fitoterapia. 106: 256–71. doi:10.1016/j.fitote.2015.09.018. PMID 26393898.
Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schäfer B, Hirsch-Ernst KI, Lampen A (January 2018). "Safety Aspects of the Use of Quercetin as a Dietary Supplement". Mol Nutr Food Res (Review). 62 (1). doi:10.1002/mnfr.201700447. PMID 29127724. S2CID 24772872.

ncbi.nlm.nih.gov

Fischer C, Speth V, Fleig-Eberenz S, Neuhaus G (Oct 1997). "Induction of Zygotic Polyembryos in Wheat: Influence of Auxin Polar Transport". The Plant Cell. 9 (10): 1767–1780. doi:10.1105/tpc.9.10.1767. PMC 157020. PMID 12237347.
Winkel-Shirley B (Jun 2001). "Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology". Plant Physiology. 126 (2): 485–93. doi:10.1104/pp.126.2.485. PMC 1540115. PMID 11402179.
Barnes S, Prasain J, D'Alessandro T, Arabshahi A, Botting N, Lila MA, Jackson G, Janle EM, Weaver CM (May 2011). "The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems". (review). Food & Function. 2 (5): 235–44. doi:10.1039/c1fo10025d. PMC 4122511. PMID 21779561.
Dabeek WM, Marra MV (2019). "Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans". Nutrients. 11 (10): 2288. doi:10.3390/nu11102288. PMC 6835347. PMID 31557798.
Shen P, Lin W, Deng X, Ba X, Han L, Chen Z, Qin K, Huang Y, Tu S (2021). "Potential Implications of Quercetin in Autoimmune Diseases". Front Immunol. 12: 689044. doi:10.3389/fimmu.2021.689044. PMC 8260830. PMID 34248976.
Elbarbry F, Ung A, Abdelkawy K (January 2018). "Studying the Inhibitory Effect of Quercetin and Thymoquinone on Human Cytochrome P450 Enzyme Activities". Pharmacognosy Magazine. 13 (Suppl 4): S895 – S899. doi:10.4103/0973-1296.224342 (inactive 1 November 2024). PMC 5822518. PMID 29491651.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
Xiao, Jian; Huang, Wei-Hua; Peng, Jing-Bo; Tan, Zhi-Rong; Ou-Yang, Dong-Sheng; Hu, Dong-Li; Zhang, Wei; Chen, Yao (2014). "Quercetin Significantly Inhibits the Metabolism of Caffeine, a Substrate of Cytochrome P450 1A2 Unrelated to CYP1A2*1C (−2964G>A) and 1F* (734C>A) Gene Polymorphisms". BioMed Research International. 2014: 1–6. doi:10.1155/2014/405071. PMC 4082882. PMID 25025048.

nutraceuticalsworld.com

Gross P (March 1, 2009), New Roles for Polyphenols. A 3-Part Report on Current Regulations & the State of Science, Nutraceuticals World

oregonstate.edu

lpi.oregonstate.edu

"Flavonoids". Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR. November 2015. Retrieved 1 April 2018.

pvp.com.br

"Quercetin dihydrate safety sheet". Archived from the original on September 16, 2011.

semanticscholar.org

api.semanticscholar.org

Petrus K, Schwartz H, Sontag G (Jun 2011). "Analysis of flavonoids in honey by HPLC coupled with coulometric electrode array detection and electrospray ionization mass spectrometry". Analytical and Bioanalytical Chemistry. 400 (8): 2555–63. doi:10.1007/s00216-010-4614-7. PMID 21229237. S2CID 24796542.
Juergenliemk G, Boje K, Huewel S, Lohmann C, Galla HJ, Nahrstedt A (Nov 2003). "In vitro studies indicate that miquelianin (quercetin 3-O-beta-D-glucuronopyranoside) is able to reach the CNS from the small intestine". Planta Medica. 69 (11): 1013–7. doi:10.1055/s-2003-45148. PMID 14735439. S2CID 260253046.
Tranchimand S, Brouant P, Iacazio G (Nov 2010). "The rutin catabolic pathway with special emphasis on quercetinase". Biodegradation. 21 (6): 833–59. doi:10.1007/s10532-010-9359-7. PMID 20419500. S2CID 30101803.
Gugler, R.; Leschik, M.; Dengler, H. J. (1 March 1975). "Disposition of quercetin in man after single oral and intravenous doses". European Journal of Clinical Pharmacology. 9 (2): 229–234. doi:10.1007/BF00614022. PMID 1233267. S2CID 23812714.
Luca SV, Macovei I, Bujor A, Trifan A (2020). "Bioactivity of dietary polyphenols: The role of metabolites". Critical Reviews in Food Science and Nutrition. 60 (4): 626–659. doi:10.1080/10408398.2018.1546669. PMID 30614249. S2CID 58651581.
Alizadeh SR, Ebrahimzadeh MA (February 2022). "Quercetin derivatives: Drug design, development, and biological activities, a review". Eur J Med Chem. 229: 114068. doi:10.1016/j.ejmech.2021.114068. PMID 34971873. S2CID 245485982.
Rastogi, Himanshu; Jana, Snehasis (December 2014). "Evaluation of Inhibitory Effects of Caffeic acid and Quercetin on Human Liver Cytochrome P450 Activities". Phytotherapy Research. 28 (12): 1873–1878. doi:10.1002/ptr.5220. PMID 25196644. S2CID 41563915.
Andres S, Pevny S, Ziegenhagen R, Bakhiya N, Schäfer B, Hirsch-Ernst KI, Lampen A (January 2018). "Safety Aspects of the Use of Quercetin as a Dietary Supplement". Mol Nutr Food Res (Review). 62 (1). doi:10.1002/mnfr.201700447. PMID 29127724. S2CID 24772872.

ucdavis.edu

ucce.ucdavis.edu

Graefe EU, Derendorf H, Veit M (1999). "Pharmacokinetics and bioavailability of the flavonol quercetin in humans" (PDF). (review). International Journal of Clinical Pharmacology and Therapeutics. 37 (5): 219–33. PMID 10363620. Archived from the original (PDF) on 2017-05-17. Retrieved 2016-01-01.

usda.gov

ars.usda.gov

"USDA Database for the Flavonoid Content of Selected Foods, Release 3" (PDF). U.S. Department of Agriculture. 2011.

web.archive.org

"Quercetin dihydrate safety sheet". Archived from the original on September 16, 2011.
Graefe EU, Derendorf H, Veit M (1999). "Pharmacokinetics and bioavailability of the flavonol quercetin in humans" (PDF). (review). International Journal of Clinical Pharmacology and Therapeutics. 37 (5): 219–33. PMID 10363620. Archived from the original (PDF) on 2017-05-17. Retrieved 2016-01-01.