Ranitidine (English Wikipedia)

"Comunicazione AIFA sui farmaci contenenti ranitidina". Agenzia Italiana del Farmaco (in Italian). Rome, Italy. Archived from the original on 18 April 2020. Retrieved 30 March 2020.

GSKpro.com

"Zantac recall – UK recall of Zantac (Ranitidine API), incl. Zantac Injection, Zantac Tablets, Zantac Syrup". GlaxoSmithKline UK Limited. Brentford, Middlesex, United Kingdom. October 2019. Archived from the original on 11 December 2021. Retrieved 30 March 2020.

aafp.org

Tang AW (October 2003). "A practical guide to anaphylaxis". American Family Physician. 68 (7): 1325–1332. PMID 14567487. Archived from the original on 10 January 2017. Retrieved 3 February 2017.

aapsus.org

"Anaphylaxis: Diagnosis and Management in the Rural Emergency Department" (PDF). American Journal of Clinical Medicine. Archived (PDF) from the original on 14 August 2016. Retrieved 3 February 2017.

abda.de

"Online Nachricht: AMK: Liste der (Chargen-)Rückrufe Ranitidin-haltiger Arzneimittel". Arzneimittelkommission der Deutschen Apotheker (AMK) (in German). 17 September 2019. Archived from the original on 20 September 2019. Retrieved 20 March 2020.

bfarm.de

"Ranitidine - core safety profile" (PDF). Bundesinstitut für Arzneimittel und MedizinProdukte. Archived (PDF) from the original on 26 November 2020. Retrieved 29 September 2019.

biopharmadive.com

"CVS suspends Zantac sales, as recalls widen over carcinogen fears". BioPharma Dive. 30 September 2019. Archived from the original on 19 October 2019. Retrieved 18 October 2019.

bloomberg.com

"Zantac's Maker Kept Quiet About Cancer Risks for 40 Years". Bloomberg.com. 15 February 2023. Archived from the original on 19 February 2023. Retrieved 20 February 2023.
Edney A (30 September 2019). "Major U.S. drugstore chains pull Zantac amid carcinogen concern". Bloomberg. Archived from the original on 3 October 2019. Retrieved 3 October 2019.

books.google.com

Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 444. ISBN 9783527607495. Archived from the original on 20 December 2016.

canada.ca

"Nitrosamine impurities in medications: Medications affected". Health Canada. 19 March 2021. Retrieved 7 January 2024.

recalls-rappels.canada.ca

"Acid Reducer (Ranitidine) Tablet: N-nitrosodimethylamine (NDMA) impurity". Health Canada. 6 December 2021. Retrieved 7 January 2024.

clincalc.com

"Ranitidine - Drug Usage Statistics". ClinCalc. Archived from the original on 7 December 2021. Retrieved 25 March 2024.

cnn.com

Criss D (30 September 2019). "Walmart, CVS, Walgreens pull Zantac and similar heartburn drugs because of cancer worries". CNN. Archived from the original on 3 October 2019. Retrieved 3 October 2019.

cvshealth.com

"CVS pharmacy statement regarding Zantac and other Ranitidine products". CVS Health. 3 October 2019. Archived from the original on 3 October 2019. Retrieved 3 October 2019.

doi.org

Gardner JD, Ciociola AA, Robinson M, McIsaac RL (July 2002). "Determination of the time of onset of action of ranitidine and famotidine on intra-gastric acidity". Alimentary Pharmacology & Therapeutics. 16 (7): 1317–1326. doi:10.1046/j.1365-2036.2002.01291.x. PMID 12144582. S2CID 34396030.
Wagner JA, Dinh JC, Lightdale JR, Gold BD, Colombo JM (July 2021). "Is this the end for ranitidine? NDMA presence continues to confound". Clinical and Translational Science. 14 (4): 1197–1200. doi:10.1111/cts.12995. PMC 8301580. PMID 33934515.
Wang CH, Chen II, Chen CH, Tseng YT (September 2022). "Pharmacoepidemiological Research on N-Nitrosodimethylamine-Contaminated Ranitidine Use and Long-Term Cancer Risk: A Population-Based Longitudinal Cohort Study". International Journal of Environmental Research and Public Health. 19 (19): 12469. doi:10.3390/ijerph191912469. PMC 9566239. PMID 36231768.
Tleyjeh IM, Abdulhak AB, Riaz M, Garbati MA, Al-Tannir M, Alasmari FA, et al. (2013). "The association between histamine 2 receptor antagonist use and Clostridium difficile infection: a systematic review and meta-analysis". PLOS ONE. 8 (3): e56498. Bibcode:2013PLoSO...856498T. doi:10.1371/journal.pone.0056498. PMC 3587620. PMID 23469173.
Clark K, Lam LT, Gibson S, Currow D (June 2009). "The effect of ranitidine versus proton pump inhibitors on gastric secretions: a meta-analysis of randomised control trials". Anaesthesia. 64 (6): 652–657. doi:10.1111/j.1365-2044.2008.05861.x. PMID 19453319. S2CID 7799380.
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. (February 2013). "Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012". Intensive Care Medicine. 39 (2): 165–228. doi:10.1007/s00134-012-2769-8. PMC 2249616. PMID 23361625.
Force RW, Nahata MC (October 1992). "Effect of histamine H2-receptor antagonists on vitamin B12 absorption". The Annals of Pharmacotherapy. 26 (10): 1283–1286. doi:10.1177/106002809202601018. PMID 1358279. S2CID 35308626.
Mitchell SL, Rockwood K (May 2001). "The association between antiulcer medication and initiation of cobalamin replacement in older persons". Journal of Clinical Epidemiology. 54 (5): 531–534. doi:10.1016/S0895-4356(00)00340-1. PMID 11337218.
Neal KR, Briji SO, Slack RC, Hawkey CJ, Logan RF (January 1994). "Recent treatment with H2 antagonists and antibiotics and gastric surgery as risk factors for Salmonella infection". BMJ. 308 (6922): 176. doi:10.1136/bmj.308.6922.176. PMC 2542523. PMID 7906170.
Neal KR, Scott HM, Slack RC, Logan RF (February 1996). "Omeprazole as a risk factor for campylobacter gastroenteritis: case-control study". BMJ. 312 (7028): 414–415. doi:10.1136/bmj.312.7028.414. PMC 2350063. PMID 8601113.
Wickramasinghe LS, Basu SK (1984). "Salmonellosis during treatment with ranitidine". Unreviewed reports. BMJ. 289 (6454): 1272. doi:10.1136/bmj.289.6454.1272.
Ruddell WS, Axon AT, Findlay JM, Bartholomew BA, Hill MJ (March 1980). "Effect of cimetidine on the gastric bacterial flora". Lancet. 1 (8170): 672–674. doi:10.1016/s0140-6736(80)92826-3. PMID 6103090. S2CID 35753958.
Untersmayr E, Bakos N, Schöll I, Kundi M, Roth-Walter F, Szalai K, et al. (April 2005). "Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients". FASEB Journal. 19 (6): 656–658. doi:10.1096/fj.04-3170fje. PMID 15671152. S2CID 18832411.
Mallow S, Rebuck JA, Osler T, Ahern J, Healey MA, Rogers FB (2004). "Do proton pump inhibitors increase the incidence of nosocomial pneumonia and related infectious complications when compared with histamine-2 receptor antagonists in critically ill trauma patients?". Current Surgery. 61 (5): 452–458. doi:10.1016/j.cursur.2004.03.014. PMID 15475094.
Canani RB, Cirillo P, Roggero P, Romano C, Malamisura B, Terrin G, et al. (May 2006). "Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children". Pediatrics. 117 (5): e817–e820. doi:10.1542/peds.2005-1655. PMID 16651285. S2CID 23719299.
Bangia AV, Kamath N, Mohan V (February 2011). "Ranitidine-induced thrombocytopenia: A rare drug reaction". Indian Journal of Pharmacology. 43 (1): 76–77. doi:10.4103/0253-7613.75676. PMC 3062128. PMID 21455428.
Guillet R, Stoll BJ, Cotten CM, Gantz M, McDonald S, Poole WK, et al. (February 2006). "Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants". Pediatrics. 117 (2): e137–e142. doi:10.1542/peds.2005-1543. PMID 16390920. S2CID 41491264.
Terrin G, Passariello A, De Curtis M, Manguso F, Salvia G, Lega L, et al. (January 2012). "Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns". Pediatrics. 129 (1): e40–e45. doi:10.1542/peds.2011-0796. PMID 22157140.
Brahm NC, Yeager LL, Fox MD, Farmer KC, Palmer TA (August 2010). "Commonly prescribed medications and potential false-positive urine drug screens". American Journal of Health-System Pharmacy. 67 (16): 1344–1350. doi:10.2146/ajhp090477. PMID 20689123. S2CID 12339028.
Roberts CJ (1984). "Clinical pharmacokinetics of ranitidine". Clinical Pharmacokinetics. 9 (3): 211–221. doi:10.2165/00003088-198409030-00003. PMID 6329583. S2CID 21561498.
Yeomans ND, Tulassay Z, Juhász L, Rácz I, Howard JM, van Rensburg CJ, et al. (March 1998). "A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group". The New England Journal of Medicine. 338 (11): 719–726. doi:10.1056/NEJM199803123381104. PMID 9494148.

drugbank.com

go.drugbank.com

"Zantac (ranitidine hydrochloride)" (PDF). Food and Drug Administration (FDA); GlaxoSmithKline (GSK). April 2009. Archived (PDF) from the original on 21 June 2022. Retrieved 8 August 2023. via DrugBank database Archived 10 August 2023 at the Wayback Machine

drugs.com

"Ranitidine use during pregnancy". Drugs.com. 2 December 2019. Archived from the original on 29 October 2019. Retrieved 18 December 2019.
"Ranitidine hydrochloride monograph". The American Society of Health-System Pharmacists. Archived from the original on 9 September 2017. Retrieved 1 December 2015.

espacenet.com

worldwide.espacenet.com

US patent 4128658, "Aminoalkyl furan derivatives"

essentialmeds.org

list.essentialmeds.org

"eEML - Electronic Essential Medicines List". list.essentialmeds.org. Archived from the original on 20 February 2023. Retrieved 20 February 2023.

europa.eu

ema.europa.eu

"Ranitidine-containing medicinal products". European Medicines Agency (EMA). 30 April 2020. Archived from the original on 6 May 2020. Retrieved 6 May 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
"EMA to provide guidance on avoiding nitrosamines in human medicines". European Medicines Agency (Press release). 13 September 2019. Archived from the original on 31 December 2019. Retrieved 19 September 2019.
"Suspension of ranitidine medicines in the EU". European Medicines Agency (Press release). 30 April 2020. Archived from the original on 5 January 2021. Retrieved 2 June 2020.
"EMA to review ranitidine medicines following detection of NDMA". European Medicines Agency (EMA) (Press release). 13 September 2019. Archived from the original on 13 February 2020. Retrieved 19 September 2019.
EMA (30 April 2020). "Suspension of ranitidine medicines in the EU". European Medicines Agency. Archived from the original on 5 January 2021. Retrieved 27 March 2023.
"Nitrosamine impurities". European Medicines Agency (EMA). 6 August 2020. Archived from the original on 4 August 2020. Retrieved 6 August 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
European Medicines Regulatory Network approach for the implementation of the CHMP Opinion pursuant to Article 5(3) of Regulation (EC) No 726/2004 for nitrosamine impurities in human medicines (PDF) (Report). 18 February 2021. EMA/425645/2020. Archived (PDF) from the original on 4 July 2022. Retrieved 20 February 2021.
"Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 28-30 April 2020". European Medicines Agency (EMA). 30 April 2020. Archived from the original on 7 May 2020. Retrieved 6 May 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

fda.gov

"Statement alerting patients and health care professionals of NDMA found in samples of ranitidine". U.S. Food and Drug Administration (FDA). 13 September 2019. Archived from the original on 26 September 2019. Retrieved 26 September 2019. This article incorporates text from this source, which is in the public domain.
"FDA updates and press announcements on NDMA in Zantac (ranitidine)". U.S. Food and Drug Administration (FDA). 28 October 2019. Archived from the original on 29 October 2019. Retrieved 28 October 2019. FDA observed the testing method used by a third-party laboratory uses higher temperatures. The higher temperatures generated very high levels of NDMA from ranitidine products because of the test procedure. The FDA published the method for testing angiotensin II receptor blockers (ARBs) for nitrosamine impurities. That method is not suitable for testing ranitidine because heating the sample generates NDMA.
FDA recommends using an LC-HRMS testing protocol to test samples of ranitidine. FDA's LC-HRMS testing method does not use elevated temperatures and has shown the presence of much lower levels of NDMA in ranitidine medicines than reported by the third-party laboratory. International regulators using similar LC-MS testing methods have also shown the presence of low levels of NDMA in ranitidine samples. This article incorporates text from this source, which is in the public domain.
"Questions and Answers: NDMA impurities in ranitidine (commonly known as Zantac)". U.S. Food and Drug Administration (FDA). 11 October 2019. Archived from the original on 24 October 2019. Retrieved 23 October 2019. This article incorporates text from this source, which is in the public domain.
"FDA Requests Removal of All Ranitidine Products (Zantac) from the Market". U.S. Food and Drug Administration (FDA) (Press release). 1 April 2020. Archived from the original on 28 March 2021. Retrieved 1 April 2020. This article incorporates text from this source, which is in the public domain.
"Zantac (ranitidine): Safety Information - NDMA Found in Samples of Some Ranitidine Medicines". U.S. Food and Drug Administration (FDA). 12 September 2019. Archived from the original on 6 May 2020. Retrieved 6 May 2020.
"FDA updates and press announcements on Angiotensin II Receptor Blocker (ARB) recalls (Valsartan, Losartan, and Irbesartan)". U.S. Food and Drug Administration (FDA). 20 September 2019. Archived from the original on 3 October 2019. Retrieved 2 October 2019. This article incorporates text from this source, which is in the public domain.
"Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) method for the determination of NDMA in Ranitidine drug substance and drug product" (PDF). U.S. Food and Drug Administration (FDA). FY19-177-DP A-S. Archived from the original on 2 November 2019. This article incorporates text from this source, which is in the public domain.
"Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method for the determination of NDMA in Ranitidine drug substance and solid dosage drug product" (PDF). U.S. Food and Drug Administration (FDA). 17 October 2019. Archived from the original on 2 November 2019. This article incorporates text from this source, which is in the public domain.
"Statement on new testing results, including low levels of impurities in ranitidine drugs". U.S. Food and Drug Administration (FDA) (Press release). 1 November 2019. Archived from the original on 2 November 2019. Retrieved 1 November 2019. This article incorporates text from this source, which is in the public domain.
"Laboratory tests - Ranitidine". U.S. Food and Drug Administration (FDA). 1 November 2019. Archived from the original on 2 November 2019. Retrieved 1 November 2019. This article incorporates text from this source, which is in the public domain.
"FDA updates and press announcements on NDMA in Zantac (ranitidine)". U.S. Food and Drug Administration (FDA). 4 December 2019. Archived from the original on 6 December 2019. Retrieved 6 December 2019. Today, we are announcing that we have asked manufacturers of ranitidine and nizatidine products to expand their testing for NDMA to include all lots of the medication before making them available to consumers. If testing shows NDMA above the acceptable daily intake limit (96 nanograms per day or 0.32 parts per million for ranitidine), the manufacturer must inform the agency and should not release the lot for consumer use. This article incorporates text from this source, which is in the public domain.
"FDA Provides Guidance to Industry for Detecting and Preventing Nitrosamines in Drugs". U.S. Food and Drug Administration (FDA) (Press release). 1 September 2020. Archived from the original on 1 September 2020. Retrieved 1 September 2020.
"Control of Nitrosamine Impurities in Human Drugs" (PDF). U.S. Food and Drug Administration (FDA). 1 September 2020. Archived from the original on 2 September 2020. Retrieved 1 September 2020. This article incorporates text from this source, which is in the public domain.
Control of Nitrosamine Impurities in Human Drugs (Report). U.S. Food and Drug Administration (FDA). September 2020. FDA-2020-D-1530. Archived from the original on 1 June 2022. Retrieved 24 June 2022. This article incorporates text from this source, which is in the public domain.
"Control of Nitrosamine Impurities in Human Drugs". U.S. Food and Drug Administration. 24 February 2021. Retrieved 6 September 2024.
"Apotex Corp. issues voluntary nationwide recall of Ranitidine tablets 75mg and 150mg (all pack sizes and formats) due to the potential for detection of an amount of unexpected impurity, N-nitrosodimethylamine (NDMA) impurity in the product". U.S. Food and Drug Administration (FDA). 26 September 2019. Archived from the original on 26 September 2019. Retrieved 26 September 2019. This article incorporates text from this source, which is in the public domain.
"Sanofi provides update on precautionary voluntary recall of Zantac OTC in U.S." U.S. Food and Drug Administration (FDA). 23 October 2019. Archived from the original on 24 October 2019. Retrieved 23 October 2019. This article incorporates text from this source, which is in the public domain.
"Perrigo Company plc issues voluntary worldwide recall of Ranitidine due to possible presence of impurity, N-nitrosodimethylamine (NDMA) impurity in the product". U.S. Food and Drug Administration (FDA). 23 October 2019. Archived from the original on 24 October 2019. Retrieved 23 October 2019. This article incorporates text from this source, which is in the public domain.
"Dr. Reddy's confirms its voluntary nationwide recall of all Ranitidine products in the U.S. market". U.S. Food and Drug Administration (FDA). 23 October 2019. Archived from the original on 24 October 2019. Retrieved 23 October 2019. This article incorporates text from this source, which is in the public domain.
"Novitium Pharma issues voluntary national recall of Ranitidine Hydrochloride capsules 150mg and 300mg due to an elevated amount of unexpected impurity, N-nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA). 25 October 2019. Archived from the original on 29 October 2019. Retrieved 28 October 2019. This article incorporates text from this source, which is in the public domain.
"Aurobindo Pharma USA, Inc. initiates voluntary nationwide consumer level recall of 38 lots of Ranitidine tablets 150mg, Ranitidine capsules 150mg, Ranitidine capsules 300mg and ranitidine Syrup 15mg/mL due to the detection of NDMA (Nitrosodimethylamine) impurity". U.S. Food and Drug Administration (FDA) (Press release). 6 November 2019. Archived from the original on 11 November 2019. Retrieved 10 November 2019. This article incorporates text from this source, which is in the public domain.
"Amneal Pharmaceuticals, LLC. issues voluntary nationwide recall of Ranitidine tablets, USP, 150mg and 300mg, and Ranitidine syrup (Ranitidine Oral Solution, USP), 15 mg/mL, due to possible presence of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA) (Press release). 12 November 2019. Archived from the original on 12 November 2019. Retrieved 12 November 2019. This article incorporates text from this source, which is in the public domain.
"American Health Packaging issues voluntary nationwide recall of Ranitidine syrup (Ranitidine Oral Solution USP) 150 mg/10 mL liquid unit dose cups due to the detection of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA) (Press release). 8 November 2019. Archived from the original on 12 November 2019. Retrieved 12 November 2019. This article incorporates text from this source, which is in the public domain.
"Golden State Medical Supply, Inc. issues a voluntary nationwide recall of Ranitidine hydrochloride 150mg and 300mg capsules (manufactured by Novitium Pharma LLC) due to an elevated amount of unexpected impurity, N-nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA) (Press release). 15 November 2019. Archived from the original on 23 November 2019. Retrieved 22 November 2019. This article incorporates text from this source, which is in the public domain.
"Precision Dose Inc. issues voluntary nationwide recall of ranitidine oral solution, USP 150 mg/10 mL due to possible presence of N-nitrosodimethylamine impurity". U.S. Food and Drug Administration (FDA) (Press release). 19 November 2019. Archived from the original on 23 November 2019. Retrieved 22 November 2019. This article incorporates text from this source, which is in the public domain.
"Glenmark Pharmaceuticals Inc., USA voluntarily recalls all unexpired lots of its Ranitidine tablets and ceases distribution, due to possible presence of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA). 17 December 2019. Archived from the original on 18 December 2019. Retrieved 18 December 2019.
"Appco Pharma LLC issues voluntary nationwide recall of Ranitidine hydrochloride capsules 150 mg and 300 mg due to an elevated amount of unexpected impurity, N-nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA). 7 January 2020. Archived from the original on 9 January 2020. Retrieved 8 January 2020.
"Denton Pharma, Inc. dba Northwind Pharmaceuticals voluntarily recalls all unexpired lots of its Ranitidine tablets and ceases distribution, due to possible presence of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA). 6 January 2020. Archived from the original on 9 January 2020. Retrieved 8 January 2020.
"American Health Packaging issues voluntary nationwide recall of Ranitidine tablets, USP 150 mg, 100 count unit dose blisters due to the detection of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA). 27 February 2020. Archived from the original on 28 February 2020. Retrieved 28 February 2020. This article incorporates text from this source, which is in the public domain.
"All Ranitidine Products (Zantac): Press Release - FDA Requests Removal". U.S. Food and Drug Administration (FDA). 1 April 2020. Archived from the original on 6 May 2020. Retrieved 6 May 2020.

accessdata.fda.gov

"Zantac (ranitidine hydrochloride)" (PDF). Food and Drug Administration (FDA); GlaxoSmithKline (GSK). April 2009. Archived (PDF) from the original on 21 June 2022. Retrieved 8 August 2023. via DrugBank database Archived 10 August 2023 at the Wayback Machine
"Zantac". U.S. Food and Drug Administration (FDA). NDA 021698. Archived from the original on 30 October 2019. Retrieved 18 October 2019. This article incorporates text from this source, which is in the public domain.

fiercepharma.com

Palmer E (19 September 2019). "Novartis doesn't wait for FDA investigation and halts distribution of its generic Zantac". FiercePharma. Archived from the original on 20 September 2019. Retrieved 20 September 2019. Novartis on Wednesday said it was stopping worldwide distribution of its generic versions of the antacid while regulators investigate the fact that the impurity NDMA has been detected in these ranitidine-based drugs.

foxbusiness.com

Kazin M (2 October 2019). "Walmart suspends sale of Zantac, other products containing ranitidine over cancer risk". Fox Business. Archived from the original on 3 October 2019. Retrieved 3 October 2019.

gov.uk

"Class 2 Medicines recall: Zantac Injection 50mg/2ml, Zantac Syrup 150mg/10ml, Zantac Tablets 150mg, Zantac Tablets 300mg (EL (19)A 24)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 8 October 2019. Archived from the original on 27 December 2019. Retrieved 30 March 2020. GlaxoSmithKline, trading as Glaxo Welcome Ltd, is recalling all unexpired stock of Zantac (ranitidine hydrochloride) prescription only medicines (POM) from pharmacies.
"Press release – Zantac – MHRA drug alert issued as GlaxoSmithKline recalls all unexpired stock". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 8 October 2019. Archived from the original on 28 December 2019. Retrieved 30 March 2020. The MHRA has issued an alert to healthcare professionals, as GlaxoSmithKline is recalling all unexpired stock of four types of Zantac, the medicine used to treat conditions such as heartburn and stomach ulcers.
"Class 2 Medicines recall: Ranitidine Effervescent Tablets 150mg, Ranitidine Effervescent Tablets 300mg (EL (19)A/27)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 17 October 2019. Archived from the original on 28 January 2020. Retrieved 30 March 2020. Teva UK Limited trading as ratiopharm GmbH is recalling all unexpired stock of Ranitidine Effervescent Tablets from pharmacies.
"Press release – Ranitidine – MHRA drug alert issued for Teva UK recall". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 17 October 2019. Archived from the original on 28 February 2020. Retrieved 30 March 2020. Teva UK Ltd is recalling unexpired stock of certain batches of 2 types of Ranitidine medicines used to treat conditions such as heartburn and stomach ulcers.
"Class 2 Medicines recall: Ranitidine 150mg/10ml Oral Solution (EL (19)A/29)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency. 25 October 2019. Archived from the original on 31 December 2019. Retrieved 30 March 2020. Rosemont Pharmaceuticals Limited is recalling unexpired stock from pharmacies as a precautionary measure due to possible contamination with an impurity.
"Class 2 Medicines recall: Zantac 75 Relief Tablets, Zantac 75 Tablets, Galpharm Indigestion Relief 75mg Tablets, Boots Heartburn & Indigestion Relief 75mg Tablets, Kirkland Indigestion Relief 75mg Tablets, Morrisons Indigestion & Heartburn Relief 75mg Tablets, Boots Heartburn & Indigestion Relief 75mg Tablets (EL (19)A/30)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 25 October 2019. Archived from the original on 31 December 2019. Retrieved 30 March 2020. Omega Pharma Limited and Galpharm International Limited are recalling unexpired stock from pharmacies and retail stores as a precautionary measure due to possible contamination with an impurity.
"Press release – Ranitidine – MHRA drug alerts issued as Perrigo recalls prescription only and over-the-counter products". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 25 October 2019. Archived from the original on 31 December 2019. Retrieved 30 March 2020. The MHRA has issued alerts to healthcare professionals and retailers, as Perrigo Company plc is recalling all unexpired stock of certain batches of Ranitidine medicines used to treat conditions such as heartburn and stomach ulcers.
"Class 2 Medicines Recall: Ranitidine Oral Solution 30mg/ml, PL 31862/0023, Ranitidine 150mg Tablets, PL 11311/0138 (EL(19)A/36)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 19 November 2019. Archived from the original on 21 January 2020. Retrieved 30 March 2020. Creo Pharma Limited and Tillomed Laboratories Limited are recalling all unexpired stock of the products listed in this alert.
"Press release – Ranitidine Oral Solution and Tablets recall". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 19 November 2019. Archived from the original on 20 November 2019. Retrieved 30 March 2020. Ranitidine – MHRA drug alert issued as Creo Pharma Limited and Tillomed Laboratories recall unexpired stock.
"Class 2 Medicines recall: Ranitidine 75mg Tablets, (various liveries) (EL(19)A/37)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 21 November 2019. Archived from the original on 21 February 2020. Retrieved 30 March 2020. OTC Concepts Ltd, Relonchem Ltd, Noumed Life Sciences Ltd and Medreich Plc. are recalling stock from pharmacies and retail stores as a precautionary measure due to possible contamination with an impurity.
"Press release – MHRA drug alert: recalls for 13 over-the-counter Ranitidine medicines". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 21 November 2019. Archived from the original on 22 November 2019. Retrieved 30 March 2020. A drug alert has been issued to retailers and healthcare professionals as 4 companies are recalling batches of certain over-the-counter Ranitidine medicines used to treat conditions such as stomach ulcers and heartburn.
"Class 2 Medicines recall: Ranitidine 150mg Film-Coated Tablets, PL 20075/0063, Ranitidine 300mg Film-Coated Tablets, PL 20075/0064 (EL(19)A/40)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 5 December 2019. Archived from the original on 4 March 2020. Retrieved 30 March 2020. Accord Healthcare are recalling all unexpired stock of the below products from pharmacies and retail stores as a precautionary measure.
"Class 2 Medicines Recall: Medley Pharma Limited, Ranitidine 150mg Tablets BP, PL 43870/0026, Ranitidine 300mg Tablets BP, PL 43870/0027 (EL(19)A/41)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 16 December 2019. Archived from the original on 5 March 2020. Retrieved 30 March 2020. Medley Pharma Limited is recalling all unexpired stock of the below products from pharmacies and retail stores as a precautionary measure.
"Class 2 Medicines recall: Medreich PLC, Ranitidine 150mg Tablets, PL 21880/0091, Ranitidine 300mg Tablets, PL 21880/0092 (EL (20)A/05)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 3 February 2020. Archived from the original on 16 June 2020. Retrieved 30 March 2020. Medreich Plc is recalling all unexpired stock of the above products from pharmacies and wholesalers as a precautionary measure due to possible contamination with an impurity N-nitrosodimethylamine (NDMA) which has genotoxic and carcinogenic potential.

handle.net

hdl.handle.net

World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

harvard.edu

ui.adsabs.harvard.edu

Tleyjeh IM, Abdulhak AB, Riaz M, Garbati MA, Al-Tannir M, Alasmari FA, et al. (2013). "The association between histamine 2 receptor antagonist use and Clostridium difficile infection: a systematic review and meta-analysis". PLOS ONE. 8 (3): e56498. Bibcode:2013PLoSO...856498T. doi:10.1371/journal.pone.0056498. PMC 3587620. PMID 23469173.

healthycanadians.gc.ca

"Health Canada assessing NDMA in ranitidine". Health Canada. 13 September 2019. Archived from the original on 26 September 2019. Retrieved 26 September 2019.
"Health Canada requests that companies stop distributing ranitidine drugs in Canada while it assesses NDMA; additional products being recalled - Recalls and safety alerts". Health Canada. 26 September 2019. Archived from the original on 26 September 2019. Retrieved 26 September 2019.

hres.ca

pdf.hres.ca

https://pdf.hres.ca/dpd_pm/00003505.PDF ^{[bare URL PDF]}

in-pharmatechnologist.com

"Sandoz ceases distribution of ranitidine product". Pharmaceutical news, Pharma industry, Pharmaceutical manufacturing. 19 September 2019. Archived from the original on 10 January 2020. Retrieved 24 September 2019.
"Sandoz expands recall of antacid". Pharmaceutical news, Pharma industry, Pharmaceutical manufacturing. 24 September 2019. Archived from the original on 27 January 2020. Retrieved 24 September 2019.

latimes.com

"Carcinogen scare sets off global race to contain tainted Zantac". Los Angeles Times. 18 September 2019. Archived from the original on 22 September 2019. Retrieved 24 September 2019.

lexi.com

online.lexi.com

"Ranitidine drug information". Lexicomp. Archived from the original on 20 April 2014.

medicaldialogues.in

"Rantac OD 300". Medical Dialogues. Archived from the original on 4 July 2022. Retrieved 19 January 2021.

medicines.org.uk

"Ranitidine 50mg/2ml Solution for Injection and Infusion". medicines.org.uk. 13 October 2021. Retrieved 7 January 2024.
"Boots Heartburn & Indigestion Relief 75mg Tablets (P)". medicines.org.uk. 3 October 2016. Retrieved 7 January 2024.
"Boots Heartburn & Indigestion Relief 75mg Tablets". medicines.org.uk. 3 October 2016. Retrieved 7 January 2024.

mhprofessional.com

Brunton L, Lazo J, Parker K (August 2005). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 ed.). McGraw-Hill. p. 972. ISBN 978-0-07-142280-2. Archived from the original on 11 April 2016.

mhra.gov.uk

cas.mhra.gov.uk

"MHRA Central Alerting System – Ranitidine: all oral formulations. Supply disruption". CAS.MHRA.GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 15 October 2019. Archived from the original on 13 August 2020. Retrieved 30 March 2020. All oral formulations of ranitidine are shortly anticipated to be out of stock until further notice. This alert provides healthcare professionals with advice on the management of patients currently taking ranitidine.

nhs.uk

"Ranitidine: medicine to lower stomach acid". nhs.uk. 29 August 2018. Archived from the original on 3 December 2021. Retrieved 20 February 2023.
"Ranitidine: medicine to lower stomach acid". NHS (UK). 16 July 2021. Archived from the original on 3 December 2021. Retrieved 3 December 2021.

nih.gov

pubmed.ncbi.nlm.nih.gov

Gardner JD, Ciociola AA, Robinson M, McIsaac RL (July 2002). "Determination of the time of onset of action of ranitidine and famotidine on intra-gastric acidity". Alimentary Pharmacology & Therapeutics. 16 (7): 1317–1326. doi:10.1046/j.1365-2036.2002.01291.x. PMID 12144582. S2CID 34396030.
Wagner JA, Dinh JC, Lightdale JR, Gold BD, Colombo JM (July 2021). "Is this the end for ranitidine? NDMA presence continues to confound". Clinical and Translational Science. 14 (4): 1197–1200. doi:10.1111/cts.12995. PMC 8301580. PMID 33934515.
Wang CH, Chen II, Chen CH, Tseng YT (September 2022). "Pharmacoepidemiological Research on N-Nitrosodimethylamine-Contaminated Ranitidine Use and Long-Term Cancer Risk: A Population-Based Longitudinal Cohort Study". International Journal of Environmental Research and Public Health. 19 (19): 12469. doi:10.3390/ijerph191912469. PMC 9566239. PMID 36231768.
Tleyjeh IM, Abdulhak AB, Riaz M, Garbati MA, Al-Tannir M, Alasmari FA, et al. (2013). "The association between histamine 2 receptor antagonist use and Clostridium difficile infection: a systematic review and meta-analysis". PLOS ONE. 8 (3): e56498. Bibcode:2013PLoSO...856498T. doi:10.1371/journal.pone.0056498. PMC 3587620. PMID 23469173.
Clark K, Lam LT, Gibson S, Currow D (June 2009). "The effect of ranitidine versus proton pump inhibitors on gastric secretions: a meta-analysis of randomised control trials". Anaesthesia. 64 (6): 652–657. doi:10.1111/j.1365-2044.2008.05861.x. PMID 19453319. S2CID 7799380.
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. (February 2013). "Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012". Intensive Care Medicine. 39 (2): 165–228. doi:10.1007/s00134-012-2769-8. PMC 2249616. PMID 23361625.
Tang AW (October 2003). "A practical guide to anaphylaxis". American Family Physician. 68 (7): 1325–1332. PMID 14567487. Archived from the original on 10 January 2017. Retrieved 3 February 2017.
Force RW, Nahata MC (October 1992). "Effect of histamine H2-receptor antagonists on vitamin B12 absorption". The Annals of Pharmacotherapy. 26 (10): 1283–1286. doi:10.1177/106002809202601018. PMID 1358279. S2CID 35308626.
Mitchell SL, Rockwood K (May 2001). "The association between antiulcer medication and initiation of cobalamin replacement in older persons". Journal of Clinical Epidemiology. 54 (5): 531–534. doi:10.1016/S0895-4356(00)00340-1. PMID 11337218.
Cobelens FG, Leentvaar-Kuijpers A, Kleijnen J, Coutinho RA (November 1998). "Incidence and risk factors of diarrhoea in Dutch travellers: consequences for priorities in pre-travel health advice". Tropical Medicine & International Health. 3 (11): 896–903. PMID 9855403.
Neal KR, Briji SO, Slack RC, Hawkey CJ, Logan RF (January 1994). "Recent treatment with H2 antagonists and antibiotics and gastric surgery as risk factors for Salmonella infection". BMJ. 308 (6922): 176. doi:10.1136/bmj.308.6922.176. PMC 2542523. PMID 7906170.
Neal KR, Scott HM, Slack RC, Logan RF (February 1996). "Omeprazole as a risk factor for campylobacter gastroenteritis: case-control study". BMJ. 312 (7028): 414–415. doi:10.1136/bmj.312.7028.414. PMC 2350063. PMID 8601113.
Ruddell WS, Axon AT, Findlay JM, Bartholomew BA, Hill MJ (March 1980). "Effect of cimetidine on the gastric bacterial flora". Lancet. 1 (8170): 672–674. doi:10.1016/s0140-6736(80)92826-3. PMID 6103090. S2CID 35753958.
Untersmayr E, Bakos N, Schöll I, Kundi M, Roth-Walter F, Szalai K, et al. (April 2005). "Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients". FASEB Journal. 19 (6): 656–658. doi:10.1096/fj.04-3170fje. PMID 15671152. S2CID 18832411.
Mallow S, Rebuck JA, Osler T, Ahern J, Healey MA, Rogers FB (2004). "Do proton pump inhibitors increase the incidence of nosocomial pneumonia and related infectious complications when compared with histamine-2 receptor antagonists in critically ill trauma patients?". Current Surgery. 61 (5): 452–458. doi:10.1016/j.cursur.2004.03.014. PMID 15475094.
Canani RB, Cirillo P, Roggero P, Romano C, Malamisura B, Terrin G, et al. (May 2006). "Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children". Pediatrics. 117 (5): e817–e820. doi:10.1542/peds.2005-1655. PMID 16651285. S2CID 23719299.
Bangia AV, Kamath N, Mohan V (February 2011). "Ranitidine-induced thrombocytopenia: A rare drug reaction". Indian Journal of Pharmacology. 43 (1): 76–77. doi:10.4103/0253-7613.75676. PMC 3062128. PMID 21455428.
Guillet R, Stoll BJ, Cotten CM, Gantz M, McDonald S, Poole WK, et al. (February 2006). "Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants". Pediatrics. 117 (2): e137–e142. doi:10.1542/peds.2005-1543. PMID 16390920. S2CID 41491264.
Terrin G, Passariello A, De Curtis M, Manguso F, Salvia G, Lega L, et al. (January 2012). "Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns". Pediatrics. 129 (1): e40–e45. doi:10.1542/peds.2011-0796. PMID 22157140.
Brahm NC, Yeager LL, Fox MD, Farmer KC, Palmer TA (August 2010). "Commonly prescribed medications and potential false-positive urine drug screens". American Journal of Health-System Pharmacy. 67 (16): 1344–1350. doi:10.2146/ajhp090477. PMID 20689123. S2CID 12339028.
Morgan KA, Ahlawat R (2023). "Ranitidine". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 30422583. Archived from the original on 22 March 2023. Retrieved 8 August 2023.
Roberts CJ (1984). "Clinical pharmacokinetics of ranitidine". Clinical Pharmacokinetics. 9 (3): 211–221. doi:10.2165/00003088-198409030-00003. PMID 6329583. S2CID 21561498.
Yeomans ND, Tulassay Z, Juhász L, Rácz I, Howard JM, van Rensburg CJ, et al. (March 1998). "A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs. Acid Suppression Trial: Ranitidine versus Omeprazole for NSAID-associated Ulcer Treatment (ASTRONAUT) Study Group". The New England Journal of Medicine. 338 (11): 719–726. doi:10.1056/NEJM199803123381104. PMID 9494148.

ncbi.nlm.nih.gov

Wagner JA, Dinh JC, Lightdale JR, Gold BD, Colombo JM (July 2021). "Is this the end for ranitidine? NDMA presence continues to confound". Clinical and Translational Science. 14 (4): 1197–1200. doi:10.1111/cts.12995. PMC 8301580. PMID 33934515.
Wang CH, Chen II, Chen CH, Tseng YT (September 2022). "Pharmacoepidemiological Research on N-Nitrosodimethylamine-Contaminated Ranitidine Use and Long-Term Cancer Risk: A Population-Based Longitudinal Cohort Study". International Journal of Environmental Research and Public Health. 19 (19): 12469. doi:10.3390/ijerph191912469. PMC 9566239. PMID 36231768.
Tleyjeh IM, Abdulhak AB, Riaz M, Garbati MA, Al-Tannir M, Alasmari FA, et al. (2013). "The association between histamine 2 receptor antagonist use and Clostridium difficile infection: a systematic review and meta-analysis". PLOS ONE. 8 (3): e56498. Bibcode:2013PLoSO...856498T. doi:10.1371/journal.pone.0056498. PMC 3587620. PMID 23469173.
Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. (February 2013). "Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012". Intensive Care Medicine. 39 (2): 165–228. doi:10.1007/s00134-012-2769-8. PMC 2249616. PMID 23361625.
Neal KR, Briji SO, Slack RC, Hawkey CJ, Logan RF (January 1994). "Recent treatment with H2 antagonists and antibiotics and gastric surgery as risk factors for Salmonella infection". BMJ. 308 (6922): 176. doi:10.1136/bmj.308.6922.176. PMC 2542523. PMID 7906170.
Neal KR, Scott HM, Slack RC, Logan RF (February 1996). "Omeprazole as a risk factor for campylobacter gastroenteritis: case-control study". BMJ. 312 (7028): 414–415. doi:10.1136/bmj.312.7028.414. PMC 2350063. PMID 8601113.
Bangia AV, Kamath N, Mohan V (February 2011). "Ranitidine-induced thrombocytopenia: A rare drug reaction". Indian Journal of Pharmacology. 43 (1): 76–77. doi:10.4103/0253-7613.75676. PMC 3062128. PMID 21455428.
Morgan KA, Ahlawat R (2023). "Ranitidine". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 30422583. Archived from the original on 22 March 2023. Retrieved 8 August 2023.

dailymed.nlm.nih.gov

"Zantac 150 (ranitidine hydrochloride) Tablets, USP Zantac 300 (ranitidine hydrochloride) Tablets, USP". DailyMed. 28 June 2018. Archived from the original on 4 July 2022. Retrieved 18 February 2021.
"Zantac 150". DailyMed. 3 April 2018. Archived from the original on 4 July 2022. Retrieved 18 February 2021.
"Ranitidine hydrochloride capsule". DailyMed. 21 November 2018. Retrieved 7 January 2024.
"Ranitidine Hydrochloride". DailyMed. August 2020. Archived from the original on 10 August 2023. Retrieved 8 August 2023.

livertox.nlm.nih.gov

"Ranitidine: Hepatotoxicity". U.S. National Institutes of Health (NIH). 28 June 2016. Archived from the original on 28 August 2016. Retrieved 25 August 2016.

nytimes.com

Thomas K (19 September 2019). "Should you keep taking Zantac for your heartburn?". The New York Times. Archived from the original on 23 September 2019. Retrieved 24 September 2019.
Garcia SE (30 September 2019). "Zantac pulled from shelves by Walgreens, Rite Aid and CVS over carcinogen fears". The New York Times. Archived from the original on 3 October 2019. Retrieved 3 October 2019.
Thomas K (18 October 2019). "Zantac recall widens as Sanofi pulls its drug over carcinogen fears". The New York Times. Archived from the original on 18 October 2019. Retrieved 18 October 2019.

pharmaceutical-journal.com

Connelly D (4 October 2021). "Return of ranitidine being considered by UK manufacturer". The Pharmaceutical Journal. Archived from the original on 3 December 2021. Retrieved 3 December 2021.

pharmasight.org

"Reflux Remedies: ranitidine". PharmaSight OTC Health. Archived from the original on 12 January 2013. Retrieved 16 November 2011.
"Reflux Remedies: ranitidine". PharmaSight OTC Health. PharmaSight.org. Archived from the original on 21 August 2017. Retrieved 16 November 2011.

prnewswire.com

"Sandoz Inc. issues voluntary recall of Ranitidine Hydrochloride capsules 150mg and 300mg due to an elevated amount of unexpected impurity, N-nitrosodimethylamine (NDMA), in the product" (Press release). Sandoz Inc. 23 September 2019. Archived from the original on 24 September 2019. Retrieved 24 September 2019 – via PR Newswire.

regulations.gov

Valisure, (and FDA CDER). "Requests FDA to issue a regulation, revise industry guidance, and request a recall and suspend sales of ranitidine from the US market and take such other actions listed in the petition --Valisure FDA Petition, Attachments (and responses)". www.regulations.gov. Retrieved 16 May 2024. ranitidine formed millions of nanograms of NDMA [per tablet]

semanticscholar.org

api.semanticscholar.org

Gardner JD, Ciociola AA, Robinson M, McIsaac RL (July 2002). "Determination of the time of onset of action of ranitidine and famotidine on intra-gastric acidity". Alimentary Pharmacology & Therapeutics. 16 (7): 1317–1326. doi:10.1046/j.1365-2036.2002.01291.x. PMID 12144582. S2CID 34396030.
Clark K, Lam LT, Gibson S, Currow D (June 2009). "The effect of ranitidine versus proton pump inhibitors on gastric secretions: a meta-analysis of randomised control trials". Anaesthesia. 64 (6): 652–657. doi:10.1111/j.1365-2044.2008.05861.x. PMID 19453319. S2CID 7799380.
Force RW, Nahata MC (October 1992). "Effect of histamine H2-receptor antagonists on vitamin B12 absorption". The Annals of Pharmacotherapy. 26 (10): 1283–1286. doi:10.1177/106002809202601018. PMID 1358279. S2CID 35308626.
Ruddell WS, Axon AT, Findlay JM, Bartholomew BA, Hill MJ (March 1980). "Effect of cimetidine on the gastric bacterial flora". Lancet. 1 (8170): 672–674. doi:10.1016/s0140-6736(80)92826-3. PMID 6103090. S2CID 35753958.
Untersmayr E, Bakos N, Schöll I, Kundi M, Roth-Walter F, Szalai K, et al. (April 2005). "Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients". FASEB Journal. 19 (6): 656–658. doi:10.1096/fj.04-3170fje. PMID 15671152. S2CID 18832411.
Canani RB, Cirillo P, Roggero P, Romano C, Malamisura B, Terrin G, et al. (May 2006). "Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children". Pediatrics. 117 (5): e817–e820. doi:10.1542/peds.2005-1655. PMID 16651285. S2CID 23719299.
Guillet R, Stoll BJ, Cotten CM, Gantz M, McDonald S, Poole WK, et al. (February 2006). "Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants". Pediatrics. 117 (2): e137–e142. doi:10.1542/peds.2005-1543. PMID 16390920. S2CID 41491264.
Brahm NC, Yeager LL, Fox MD, Farmer KC, Palmer TA (August 2010). "Commonly prescribed medications and potential false-positive urine drug screens". American Journal of Health-System Pharmacy. 67 (16): 1344–1350. doi:10.2146/ajhp090477. PMID 20689123. S2CID 12339028.
Roberts CJ (1984). "Clinical pharmacokinetics of ranitidine". Clinical Pharmacokinetics. 9 (3): 211–221. doi:10.2165/00003088-198409030-00003. PMID 6329583. S2CID 21561498.

tga.gov.au

"Ranitidine". Therapeutic Goods Administration (TGA). 2 April 2020. Archived from the original on 29 August 2021. Retrieved 19 July 2020.
"Ranitidine". Therapeutic Goods Administration. 17 October 2019. Archived from the original on 19 October 2019. Retrieved 19 October 2019.

upi.com

"Heartburn drug recalled, removed from shelves over cancer concerns". United Press International. 30 September 2019. Archived from the original on 1 October 2019. Retrieved 1 October 2019.

usatoday.com

Bomey N (19 September 2019). "Ranitidine warnings: Generic Zantac distribution halted on cancer fear". USA Today. Archived from the original on 20 September 2019. Retrieved 20 September 2019.

valisure.com

"Earliest NDMA alert". www.valisure.com. Valisure discovered the link of Zantac and its generics to the carcinogen NDMA during its routine testing of every batch of every medication, and first notified the FDA of its initial findings in June of 2019

web.archive.org

"Zantac 150 (ranitidine hydrochloride) Tablets, USP Zantac 300 (ranitidine hydrochloride) Tablets, USP". DailyMed. 28 June 2018. Archived from the original on 4 July 2022. Retrieved 18 February 2021.
"Ranitidine use during pregnancy". Drugs.com. 2 December 2019. Archived from the original on 29 October 2019. Retrieved 18 December 2019.
"Zantac 150". DailyMed. 3 April 2018. Archived from the original on 4 July 2022. Retrieved 18 February 2021.
"Ranitidine-containing medicinal products". European Medicines Agency (EMA). 30 April 2020. Archived from the original on 6 May 2020. Retrieved 6 May 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
"Ranitidine hydrochloride monograph". The American Society of Health-System Pharmacists. Archived from the original on 9 September 2017. Retrieved 1 December 2015.
"Health Canada assessing NDMA in ranitidine". Health Canada. 13 September 2019. Archived from the original on 26 September 2019. Retrieved 26 September 2019.
"Statement alerting patients and health care professionals of NDMA found in samples of ranitidine". U.S. Food and Drug Administration (FDA). 13 September 2019. Archived from the original on 26 September 2019. Retrieved 26 September 2019. This article incorporates text from this source, which is in the public domain.
"EMA to provide guidance on avoiding nitrosamines in human medicines". European Medicines Agency (Press release). 13 September 2019. Archived from the original on 31 December 2019. Retrieved 19 September 2019.
"FDA updates and press announcements on NDMA in Zantac (ranitidine)". U.S. Food and Drug Administration (FDA). 28 October 2019. Archived from the original on 29 October 2019. Retrieved 28 October 2019. FDA observed the testing method used by a third-party laboratory uses higher temperatures. The higher temperatures generated very high levels of NDMA from ranitidine products because of the test procedure. The FDA published the method for testing angiotensin II receptor blockers (ARBs) for nitrosamine impurities. That method is not suitable for testing ranitidine because heating the sample generates NDMA.
FDA recommends using an LC-HRMS testing protocol to test samples of ranitidine. FDA's LC-HRMS testing method does not use elevated temperatures and has shown the presence of much lower levels of NDMA in ranitidine medicines than reported by the third-party laboratory. International regulators using similar LC-MS testing methods have also shown the presence of low levels of NDMA in ranitidine samples. This article incorporates text from this source, which is in the public domain.
"Questions and Answers: NDMA impurities in ranitidine (commonly known as Zantac)". U.S. Food and Drug Administration (FDA). 11 October 2019. Archived from the original on 24 October 2019. Retrieved 23 October 2019. This article incorporates text from this source, which is in the public domain.
"FDA Requests Removal of All Ranitidine Products (Zantac) from the Market". U.S. Food and Drug Administration (FDA) (Press release). 1 April 2020. Archived from the original on 28 March 2021. Retrieved 1 April 2020. This article incorporates text from this source, which is in the public domain.
"Suspension of ranitidine medicines in the EU". European Medicines Agency (Press release). 30 April 2020. Archived from the original on 5 January 2021. Retrieved 2 June 2020.
"Ranitidine". Therapeutic Goods Administration (TGA). 2 April 2020. Archived from the original on 29 August 2021. Retrieved 19 July 2020.
"Zantac's Maker Kept Quiet About Cancer Risks for 40 Years". Bloomberg.com. 15 February 2023. Archived from the original on 19 February 2023. Retrieved 20 February 2023.
Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 444. ISBN 9783527607495. Archived from the original on 20 December 2016.
"eEML - Electronic Essential Medicines List". list.essentialmeds.org. Archived from the original on 20 February 2023. Retrieved 20 February 2023.
"Ranitidine: medicine to lower stomach acid". nhs.uk. 29 August 2018. Archived from the original on 3 December 2021. Retrieved 20 February 2023.
"Reflux Remedies: ranitidine". PharmaSight OTC Health. Archived from the original on 12 January 2013. Retrieved 16 November 2011.
Tang AW (October 2003). "A practical guide to anaphylaxis". American Family Physician. 68 (7): 1325–1332. PMID 14567487. Archived from the original on 10 January 2017. Retrieved 3 February 2017.
"Anaphylaxis: Diagnosis and Management in the Rural Emergency Department" (PDF). American Journal of Clinical Medicine. Archived (PDF) from the original on 14 August 2016. Retrieved 3 February 2017.
"Reflux Remedies: ranitidine". PharmaSight OTC Health. PharmaSight.org. Archived from the original on 21 August 2017. Retrieved 16 November 2011.
"Ranitidine: Hepatotoxicity". U.S. National Institutes of Health (NIH). 28 June 2016. Archived from the original on 28 August 2016. Retrieved 25 August 2016.
"Rantac OD 300". Medical Dialogues. Archived from the original on 4 July 2022. Retrieved 19 January 2021.
"Ranitidine drug information". Lexicomp. Archived from the original on 20 April 2014.
"Ranitidine - core safety profile" (PDF). Bundesinstitut für Arzneimittel und MedizinProdukte. Archived (PDF) from the original on 26 November 2020. Retrieved 29 September 2019.
"Zantac (ranitidine): Safety Information - NDMA Found in Samples of Some Ranitidine Medicines". U.S. Food and Drug Administration (FDA). 12 September 2019. Archived from the original on 6 May 2020. Retrieved 6 May 2020.
"Health Canada requests that companies stop distributing ranitidine drugs in Canada while it assesses NDMA; additional products being recalled - Recalls and safety alerts". Health Canada. 26 September 2019. Archived from the original on 26 September 2019. Retrieved 26 September 2019.
"EMA to review ranitidine medicines following detection of NDMA". European Medicines Agency (EMA) (Press release). 13 September 2019. Archived from the original on 13 February 2020. Retrieved 19 September 2019.
"FDA updates and press announcements on Angiotensin II Receptor Blocker (ARB) recalls (Valsartan, Losartan, and Irbesartan)". U.S. Food and Drug Administration (FDA). 20 September 2019. Archived from the original on 3 October 2019. Retrieved 2 October 2019. This article incorporates text from this source, which is in the public domain.
"Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) method for the determination of NDMA in Ranitidine drug substance and drug product" (PDF). U.S. Food and Drug Administration (FDA). FY19-177-DP A-S. Archived from the original on 2 November 2019. This article incorporates text from this source, which is in the public domain.
"Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method for the determination of NDMA in Ranitidine drug substance and solid dosage drug product" (PDF). U.S. Food and Drug Administration (FDA). 17 October 2019. Archived from the original on 2 November 2019. This article incorporates text from this source, which is in the public domain.
Bomey N (19 September 2019). "Ranitidine warnings: Generic Zantac distribution halted on cancer fear". USA Today. Archived from the original on 20 September 2019. Retrieved 20 September 2019.
Palmer E (19 September 2019). "Novartis doesn't wait for FDA investigation and halts distribution of its generic Zantac". FiercePharma. Archived from the original on 20 September 2019. Retrieved 20 September 2019. Novartis on Wednesday said it was stopping worldwide distribution of its generic versions of the antacid while regulators investigate the fact that the impurity NDMA has been detected in these ranitidine-based drugs.
"Sandoz ceases distribution of ranitidine product". Pharmaceutical news, Pharma industry, Pharmaceutical manufacturing. 19 September 2019. Archived from the original on 10 January 2020. Retrieved 24 September 2019.
"Sandoz expands recall of antacid". Pharmaceutical news, Pharma industry, Pharmaceutical manufacturing. 24 September 2019. Archived from the original on 27 January 2020. Retrieved 24 September 2019.
"Sandoz Inc. issues voluntary recall of Ranitidine Hydrochloride capsules 150mg and 300mg due to an elevated amount of unexpected impurity, N-nitrosodimethylamine (NDMA), in the product" (Press release). Sandoz Inc. 23 September 2019. Archived from the original on 24 September 2019. Retrieved 24 September 2019 – via PR Newswire.
Thomas K (19 September 2019). "Should you keep taking Zantac for your heartburn?". The New York Times. Archived from the original on 23 September 2019. Retrieved 24 September 2019.
"Carcinogen scare sets off global race to contain tainted Zantac". Los Angeles Times. 18 September 2019. Archived from the original on 22 September 2019. Retrieved 24 September 2019.
"Comunicazione AIFA sui farmaci contenenti ranitidina". Agenzia Italiana del Farmaco (in Italian). Rome, Italy. Archived from the original on 18 April 2020. Retrieved 30 March 2020.
"Online Nachricht: AMK: Liste der (Chargen-)Rückrufe Ranitidin-haltiger Arzneimittel". Arzneimittelkommission der Deutschen Apotheker (AMK) (in German). 17 September 2019. Archived from the original on 20 September 2019. Retrieved 20 March 2020.
"Ranitidine". Therapeutic Goods Administration. 17 October 2019. Archived from the original on 19 October 2019. Retrieved 19 October 2019.
"Statement on new testing results, including low levels of impurities in ranitidine drugs". U.S. Food and Drug Administration (FDA) (Press release). 1 November 2019. Archived from the original on 2 November 2019. Retrieved 1 November 2019. This article incorporates text from this source, which is in the public domain.
"Laboratory tests - Ranitidine". U.S. Food and Drug Administration (FDA). 1 November 2019. Archived from the original on 2 November 2019. Retrieved 1 November 2019. This article incorporates text from this source, which is in the public domain.
"FDA updates and press announcements on NDMA in Zantac (ranitidine)". U.S. Food and Drug Administration (FDA). 4 December 2019. Archived from the original on 6 December 2019. Retrieved 6 December 2019. Today, we are announcing that we have asked manufacturers of ranitidine and nizatidine products to expand their testing for NDMA to include all lots of the medication before making them available to consumers. If testing shows NDMA above the acceptable daily intake limit (96 nanograms per day or 0.32 parts per million for ranitidine), the manufacturer must inform the agency and should not release the lot for consumer use. This article incorporates text from this source, which is in the public domain.
"Ranitidine - Drug Usage Statistics". ClinCalc. Archived from the original on 7 December 2021. Retrieved 25 March 2024.
EMA (30 April 2020). "Suspension of ranitidine medicines in the EU". European Medicines Agency. Archived from the original on 5 January 2021. Retrieved 27 March 2023.
"Nitrosamine impurities". European Medicines Agency (EMA). 6 August 2020. Archived from the original on 4 August 2020. Retrieved 6 August 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
"FDA Provides Guidance to Industry for Detecting and Preventing Nitrosamines in Drugs". U.S. Food and Drug Administration (FDA) (Press release). 1 September 2020. Archived from the original on 1 September 2020. Retrieved 1 September 2020.
"Control of Nitrosamine Impurities in Human Drugs" (PDF). U.S. Food and Drug Administration (FDA). 1 September 2020. Archived from the original on 2 September 2020. Retrieved 1 September 2020. This article incorporates text from this source, which is in the public domain.
Control of Nitrosamine Impurities in Human Drugs (Report). U.S. Food and Drug Administration (FDA). September 2020. FDA-2020-D-1530. Archived from the original on 1 June 2022. Retrieved 24 June 2022. This article incorporates text from this source, which is in the public domain.
European Medicines Regulatory Network approach for the implementation of the CHMP Opinion pursuant to Article 5(3) of Regulation (EC) No 726/2004 for nitrosamine impurities in human medicines (PDF) (Report). 18 February 2021. EMA/425645/2020. Archived (PDF) from the original on 4 July 2022. Retrieved 20 February 2021.
"Apotex Corp. issues voluntary nationwide recall of Ranitidine tablets 75mg and 150mg (all pack sizes and formats) due to the potential for detection of an amount of unexpected impurity, N-nitrosodimethylamine (NDMA) impurity in the product". U.S. Food and Drug Administration (FDA). 26 September 2019. Archived from the original on 26 September 2019. Retrieved 26 September 2019. This article incorporates text from this source, which is in the public domain.
"Heartburn drug recalled, removed from shelves over cancer concerns". United Press International. 30 September 2019. Archived from the original on 1 October 2019. Retrieved 1 October 2019.
Garcia SE (30 September 2019). "Zantac pulled from shelves by Walgreens, Rite Aid and CVS over carcinogen fears". The New York Times. Archived from the original on 3 October 2019. Retrieved 3 October 2019.
"CVS pharmacy statement regarding Zantac and other Ranitidine products". CVS Health. 3 October 2019. Archived from the original on 3 October 2019. Retrieved 3 October 2019.
Kazin M (2 October 2019). "Walmart suspends sale of Zantac, other products containing ranitidine over cancer risk". Fox Business. Archived from the original on 3 October 2019. Retrieved 3 October 2019.
Criss D (30 September 2019). "Walmart, CVS, Walgreens pull Zantac and similar heartburn drugs because of cancer worries". CNN. Archived from the original on 3 October 2019. Retrieved 3 October 2019.
Edney A (30 September 2019). "Major U.S. drugstore chains pull Zantac amid carcinogen concern". Bloomberg. Archived from the original on 3 October 2019. Retrieved 3 October 2019.
"Zantac recall – UK recall of Zantac (Ranitidine API), incl. Zantac Injection, Zantac Tablets, Zantac Syrup". GlaxoSmithKline UK Limited. Brentford, Middlesex, United Kingdom. October 2019. Archived from the original on 11 December 2021. Retrieved 30 March 2020.
"Class 2 Medicines recall: Zantac Injection 50mg/2ml, Zantac Syrup 150mg/10ml, Zantac Tablets 150mg, Zantac Tablets 300mg (EL (19)A 24)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 8 October 2019. Archived from the original on 27 December 2019. Retrieved 30 March 2020. GlaxoSmithKline, trading as Glaxo Welcome Ltd, is recalling all unexpired stock of Zantac (ranitidine hydrochloride) prescription only medicines (POM) from pharmacies.
"Press release – Zantac – MHRA drug alert issued as GlaxoSmithKline recalls all unexpired stock". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 8 October 2019. Archived from the original on 28 December 2019. Retrieved 30 March 2020. The MHRA has issued an alert to healthcare professionals, as GlaxoSmithKline is recalling all unexpired stock of four types of Zantac, the medicine used to treat conditions such as heartburn and stomach ulcers.
"Class 2 Medicines recall: Ranitidine Effervescent Tablets 150mg, Ranitidine Effervescent Tablets 300mg (EL (19)A/27)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 17 October 2019. Archived from the original on 28 January 2020. Retrieved 30 March 2020. Teva UK Limited trading as ratiopharm GmbH is recalling all unexpired stock of Ranitidine Effervescent Tablets from pharmacies.
"Press release – Ranitidine – MHRA drug alert issued for Teva UK recall". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 17 October 2019. Archived from the original on 28 February 2020. Retrieved 30 March 2020. Teva UK Ltd is recalling unexpired stock of certain batches of 2 types of Ranitidine medicines used to treat conditions such as heartburn and stomach ulcers.
"Class 2 Medicines recall: Ranitidine 150mg/10ml Oral Solution (EL (19)A/29)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency. 25 October 2019. Archived from the original on 31 December 2019. Retrieved 30 March 2020. Rosemont Pharmaceuticals Limited is recalling unexpired stock from pharmacies as a precautionary measure due to possible contamination with an impurity.
"Class 2 Medicines recall: Zantac 75 Relief Tablets, Zantac 75 Tablets, Galpharm Indigestion Relief 75mg Tablets, Boots Heartburn & Indigestion Relief 75mg Tablets, Kirkland Indigestion Relief 75mg Tablets, Morrisons Indigestion & Heartburn Relief 75mg Tablets, Boots Heartburn & Indigestion Relief 75mg Tablets (EL (19)A/30)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 25 October 2019. Archived from the original on 31 December 2019. Retrieved 30 March 2020. Omega Pharma Limited and Galpharm International Limited are recalling unexpired stock from pharmacies and retail stores as a precautionary measure due to possible contamination with an impurity.
"Press release – Ranitidine – MHRA drug alerts issued as Perrigo recalls prescription only and over-the-counter products". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 25 October 2019. Archived from the original on 31 December 2019. Retrieved 30 March 2020. The MHRA has issued alerts to healthcare professionals and retailers, as Perrigo Company plc is recalling all unexpired stock of certain batches of Ranitidine medicines used to treat conditions such as heartburn and stomach ulcers.
"Class 2 Medicines Recall: Ranitidine Oral Solution 30mg/ml, PL 31862/0023, Ranitidine 150mg Tablets, PL 11311/0138 (EL(19)A/36)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 19 November 2019. Archived from the original on 21 January 2020. Retrieved 30 March 2020. Creo Pharma Limited and Tillomed Laboratories Limited are recalling all unexpired stock of the products listed in this alert.
"Press release – Ranitidine Oral Solution and Tablets recall". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 19 November 2019. Archived from the original on 20 November 2019. Retrieved 30 March 2020. Ranitidine – MHRA drug alert issued as Creo Pharma Limited and Tillomed Laboratories recall unexpired stock.
"Class 2 Medicines recall: Ranitidine 75mg Tablets, (various liveries) (EL(19)A/37)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 21 November 2019. Archived from the original on 21 February 2020. Retrieved 30 March 2020. OTC Concepts Ltd, Relonchem Ltd, Noumed Life Sciences Ltd and Medreich Plc. are recalling stock from pharmacies and retail stores as a precautionary measure due to possible contamination with an impurity.
"Press release – MHRA drug alert: recalls for 13 over-the-counter Ranitidine medicines". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 21 November 2019. Archived from the original on 22 November 2019. Retrieved 30 March 2020. A drug alert has been issued to retailers and healthcare professionals as 4 companies are recalling batches of certain over-the-counter Ranitidine medicines used to treat conditions such as stomach ulcers and heartburn.
"Class 2 Medicines recall: Ranitidine 150mg Film-Coated Tablets, PL 20075/0063, Ranitidine 300mg Film-Coated Tablets, PL 20075/0064 (EL(19)A/40)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 5 December 2019. Archived from the original on 4 March 2020. Retrieved 30 March 2020. Accord Healthcare are recalling all unexpired stock of the below products from pharmacies and retail stores as a precautionary measure.
"Class 2 Medicines Recall: Medley Pharma Limited, Ranitidine 150mg Tablets BP, PL 43870/0026, Ranitidine 300mg Tablets BP, PL 43870/0027 (EL(19)A/41)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 16 December 2019. Archived from the original on 5 March 2020. Retrieved 30 March 2020. Medley Pharma Limited is recalling all unexpired stock of the below products from pharmacies and retail stores as a precautionary measure.
"Class 2 Medicines recall: Medreich PLC, Ranitidine 150mg Tablets, PL 21880/0091, Ranitidine 300mg Tablets, PL 21880/0092 (EL (20)A/05)". GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 3 February 2020. Archived from the original on 16 June 2020. Retrieved 30 March 2020. Medreich Plc is recalling all unexpired stock of the above products from pharmacies and wholesalers as a precautionary measure due to possible contamination with an impurity N-nitrosodimethylamine (NDMA) which has genotoxic and carcinogenic potential.
"MHRA Central Alerting System – Ranitidine: all oral formulations. Supply disruption". CAS.MHRA.GOV.uk. United Kingdom: Medicines and Healthcare products Regulatory Agency (MHRA). 15 October 2019. Archived from the original on 13 August 2020. Retrieved 30 March 2020. All oral formulations of ranitidine are shortly anticipated to be out of stock until further notice. This alert provides healthcare professionals with advice on the management of patients currently taking ranitidine.
Thomas K (18 October 2019). "Zantac recall widens as Sanofi pulls its drug over carcinogen fears". The New York Times. Archived from the original on 18 October 2019. Retrieved 18 October 2019.
"Sanofi provides update on precautionary voluntary recall of Zantac OTC in U.S." U.S. Food and Drug Administration (FDA). 23 October 2019. Archived from the original on 24 October 2019. Retrieved 23 October 2019. This article incorporates text from this source, which is in the public domain.
"Perrigo Company plc issues voluntary worldwide recall of Ranitidine due to possible presence of impurity, N-nitrosodimethylamine (NDMA) impurity in the product". U.S. Food and Drug Administration (FDA). 23 October 2019. Archived from the original on 24 October 2019. Retrieved 23 October 2019. This article incorporates text from this source, which is in the public domain.
"Dr. Reddy's confirms its voluntary nationwide recall of all Ranitidine products in the U.S. market". U.S. Food and Drug Administration (FDA). 23 October 2019. Archived from the original on 24 October 2019. Retrieved 23 October 2019. This article incorporates text from this source, which is in the public domain.
"Novitium Pharma issues voluntary national recall of Ranitidine Hydrochloride capsules 150mg and 300mg due to an elevated amount of unexpected impurity, N-nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA). 25 October 2019. Archived from the original on 29 October 2019. Retrieved 28 October 2019. This article incorporates text from this source, which is in the public domain.
"Aurobindo Pharma USA, Inc. initiates voluntary nationwide consumer level recall of 38 lots of Ranitidine tablets 150mg, Ranitidine capsules 150mg, Ranitidine capsules 300mg and ranitidine Syrup 15mg/mL due to the detection of NDMA (Nitrosodimethylamine) impurity". U.S. Food and Drug Administration (FDA) (Press release). 6 November 2019. Archived from the original on 11 November 2019. Retrieved 10 November 2019. This article incorporates text from this source, which is in the public domain.
"Amneal Pharmaceuticals, LLC. issues voluntary nationwide recall of Ranitidine tablets, USP, 150mg and 300mg, and Ranitidine syrup (Ranitidine Oral Solution, USP), 15 mg/mL, due to possible presence of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA) (Press release). 12 November 2019. Archived from the original on 12 November 2019. Retrieved 12 November 2019. This article incorporates text from this source, which is in the public domain.
"American Health Packaging issues voluntary nationwide recall of Ranitidine syrup (Ranitidine Oral Solution USP) 150 mg/10 mL liquid unit dose cups due to the detection of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA) (Press release). 8 November 2019. Archived from the original on 12 November 2019. Retrieved 12 November 2019. This article incorporates text from this source, which is in the public domain.
"Golden State Medical Supply, Inc. issues a voluntary nationwide recall of Ranitidine hydrochloride 150mg and 300mg capsules (manufactured by Novitium Pharma LLC) due to an elevated amount of unexpected impurity, N-nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA) (Press release). 15 November 2019. Archived from the original on 23 November 2019. Retrieved 22 November 2019. This article incorporates text from this source, which is in the public domain.
"Precision Dose Inc. issues voluntary nationwide recall of ranitidine oral solution, USP 150 mg/10 mL due to possible presence of N-nitrosodimethylamine impurity". U.S. Food and Drug Administration (FDA) (Press release). 19 November 2019. Archived from the original on 23 November 2019. Retrieved 22 November 2019. This article incorporates text from this source, which is in the public domain.
"Glenmark Pharmaceuticals Inc., USA voluntarily recalls all unexpired lots of its Ranitidine tablets and ceases distribution, due to possible presence of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA). 17 December 2019. Archived from the original on 18 December 2019. Retrieved 18 December 2019.
"Appco Pharma LLC issues voluntary nationwide recall of Ranitidine hydrochloride capsules 150 mg and 300 mg due to an elevated amount of unexpected impurity, N-nitrosodimethylamine (NDMA)". U.S. Food and Drug Administration (FDA). 7 January 2020. Archived from the original on 9 January 2020. Retrieved 8 January 2020.
"Denton Pharma, Inc. dba Northwind Pharmaceuticals voluntarily recalls all unexpired lots of its Ranitidine tablets and ceases distribution, due to possible presence of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA). 6 January 2020. Archived from the original on 9 January 2020. Retrieved 8 January 2020.
"American Health Packaging issues voluntary nationwide recall of Ranitidine tablets, USP 150 mg, 100 count unit dose blisters due to the detection of N-nitrosodimethylamine (NDMA) impurity". U.S. Food and Drug Administration (FDA). 27 February 2020. Archived from the original on 28 February 2020. Retrieved 28 February 2020. This article incorporates text from this source, which is in the public domain.
"All Ranitidine Products (Zantac): Press Release - FDA Requests Removal". U.S. Food and Drug Administration (FDA). 1 April 2020. Archived from the original on 6 May 2020. Retrieved 6 May 2020.
"Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 28-30 April 2020". European Medicines Agency (EMA). 30 April 2020. Archived from the original on 7 May 2020. Retrieved 6 May 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
"Ranitidine: medicine to lower stomach acid". NHS (UK). 16 July 2021. Archived from the original on 3 December 2021. Retrieved 3 December 2021.
Connelly D (4 October 2021). "Return of ranitidine being considered by UK manufacturer". The Pharmaceutical Journal. Archived from the original on 3 December 2021. Retrieved 3 December 2021.
Morgan KA, Ahlawat R (2023). "Ranitidine". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 30422583. Archived from the original on 22 March 2023. Retrieved 8 August 2023.
"Zantac (ranitidine hydrochloride)" (PDF). Food and Drug Administration (FDA); GlaxoSmithKline (GSK). April 2009. Archived (PDF) from the original on 21 June 2022. Retrieved 8 August 2023. via DrugBank database Archived 10 August 2023 at the Wayback Machine
"Ranitidine Hydrochloride". DailyMed. August 2020. Archived from the original on 10 August 2023. Retrieved 8 August 2023.
Brunton L, Lazo J, Parker K (August 2005). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 ed.). McGraw-Hill. p. 972. ISBN 978-0-07-142280-2. Archived from the original on 11 April 2016.
"Zantac". U.S. Food and Drug Administration (FDA). NDA 021698. Archived from the original on 30 October 2019. Retrieved 18 October 2019. This article incorporates text from this source, which is in the public domain.
"CVS suspends Zantac sales, as recalls widen over carcinogen fears". BioPharma Dive. 30 September 2019. Archived from the original on 19 October 2019. Retrieved 18 October 2019.