Remacemide (English Wikipedia)

Santangeli S, Sills GJ, Thompson GG, Brodie MJ (March 2002). "Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes". European Journal of Pharmacology. 438 (1–2): 63–8. doi:10.1016/S0014-2999(02)01297-9. PMID 11906711.
Muir KW, Lees KR (September 1995). "Initial experience with remacemide hydrochloride in patients with acute ischemic stroke". Annals of the New York Academy of Sciences. 765 (1 Neuroprotecti): 322–3. Bibcode:1995NYASA.765..322M. doi:10.1111/j.1749-6632.1995.tb16602.x. PMID 7486631. S2CID 7573258.
Dyker AG, Lees KR (September 1999). "Remacemide hydrochloride: a double-blind, placebo-controlled, safety and tolerability study in patients with acute ischemic stroke". Stroke. 30 (9): 1796–801. doi:10.1161/01.STR.30.9.1796. PMID 10471426.
Wesnes KA, Edgar C, Dean AD, Wroe SJ (March 2009). "The cognitive and psychomotor effects of remacemide and carbamazepine in newly diagnosed epilepsy". Epilepsy & Behavior. 14 (3): 522–8. doi:10.1016/j.yebeh.2008.11.012. PMID 19111629. S2CID 6582499.
Leach JP, Marson AG, Hutton JL (2002). "Remacemide for drug-resistant localization related epilepsy". The Cochrane Database of Systematic Reviews (4): CD001900. doi:10.1002/14651858.CD001900. PMC 12145949. PMID 12519561.
Palmer GC, Murray RJ, Wilson TC, Eisman MS, Ray RK, Griffith RC, et al. (June 1992). "Biological profile of the metabolites and potential metabolites of the anticonvulsant remacemide". Epilepsy Research. 12 (1): 9–20. doi:10.1016/0920-1211(92)90086-9. PMID 1388119. S2CID 23097783.
"A multicenter randomized controlled trial of remacemide hydrochloride as monotherapy for PD. Parkinson Study Group". Neurology. 54 (8): 1583–8. April 2000. doi:10.1212/wnl.54.8.1583. PMID 10762497. S2CID 216064344.
Ramaekers G, Lamers J, Verhey F, Muntjewerff D, Mobbs E, Sanders N, et al. (January 2002). "A comparative study of the effects of carbamazepine and the NMDA receptor antagonist remacemide on road tracking and car-following performance in actual traffic". Psychopharmacology. 159 (2): 203–10. doi:10.1007/s002130100898. PMID 11862350. S2CID 2774324.
Wright LK, Pearson EC, Hammond TG, Paule MG (May–Jun 2007). "Behavioral effects associated with chronic ketamine or remacemide exposure in rats". Neurotoxicology and Teratology. 29 (3): 348–59. Bibcode:2007NTxT...29..348W. doi:10.1016/j.ntt.2006.12.004. PMID 17291718.
Popke EJ, Allen RR, Pearson EC, Hammond TG, Paule MG (1 July 2001). "Differential effects of two NMDA receptor antagonists on cognitive-behavioral development in nonhuman primates I". Neurotoxicology and Teratology. 23 (4): 319–32. Bibcode:2001NTxT...23..319P. doi:10.1016/S0892-0362(01)00156-8. PMID 11485835.
Popke EJ, Allen RR, Pearson EC, Hammond TG, Paule MG (1 July 2001). "Differential effects of two NMDA receptor antagonists on cognitive--behavioral performance in young nonhuman primates II". Neurotoxicology and Teratology. 23 (4): 333–47. Bibcode:2001NTxT...23..333P. doi:10.1016/S0892-0362(01)00138-6. PMID 11485836.
Popke EJ, Patton R, Newport GD, Rushing LG, Fogle CM, Allen RR, et al. (1 March 2002). "Assessing the potential toxicity of MK-801 and remacemide: chronic exposure in juvenile rhesus monkeys". Neurotoxicology and Teratology. 24 (2): 193–207. Bibcode:2002NTxT...24..193P. doi:10.1016/S0892-0362(02)00206-4. PMID 11943507.
Paule MG, Fogle CM, Allen RR, Pearson EC, Hammond TG, Popke EJ (May 2003). "Chronic exposure to NMDA receptor and sodium channel blockers during development in monkeys and rats: long-term effects on cognitive function". Annals of the New York Academy of Sciences. 993 (1): 116–22, discussion 123–4. doi:10.1111/j.1749-6632.2003.tb07519.x. PMID 12853303. S2CID 19776727.
Stagnitto ML, Palmer GC, Ordy JM, Griffith RC, Napier JJ, Becker CN, et al. (Sep–Oct 1990). "Preclinical profile of remacemide: a novel anticonvulsant effective against maximal electroshock seizures in mice". Epilepsy Research. 7 (1): 11–28. doi:10.1016/0920-1211(90)90050-6. PMID 1963406. S2CID 13657516.
Leach JP, Girvan J, Jamieson V, Jones T, Richens A, Brodie MJ (June 1997). "Lack of pharmacokinetic interaction between remacemide hydrochloride and sodium valproate in epileptic patients". Seizure. 6 (3): 179–84. doi:10.1016/S1059-1311(97)80003-9. PMID 9203245. S2CID 18469302.
Leach JP, Blacklaw J, Jamieson V, Jones T, Richens A, Brodie MJ (November 1996). "Mutual interaction between remacemide hydrochloride and carbamazepine: two drugs with active metabolites". Epilepsia. 37 (11): 1100–6. doi:10.1111/j.1528-1157.1996.tb01031.x. PMID 8917061. S2CID 23489355.
Lewis GR, Steele G, McBride L, Florence AJ, Kennedy AR, Shankland N, et al. (1 March 2005). "Hydrophobic vs. Hydrophilic: Ionic Competition in Remacemide Salt Structures". Crystal Growth & Design. 5 (2): 427–438. doi:10.1021/cg049836u.
van Luijtelaar EL, Coenen AM (April 1995). "Effects of remacemide and its metabolite FPL 12495 on spike-wave discharges, electroencephalogram and behaviour in rats with absence epilepsy". Neuropharmacology. 34 (4): 419–25. doi:10.1016/0028-3908(95)00008-T. hdl:2066/28626. PMID 7566473. S2CID 12067526.
Hardebo JE, Nilsson B (October 1979). "Estimation of cerebral extraction of circulating compounds by the brain uptake index method: influence of circulation time, volume injection, and cerebral blood flow". Acta Physiologica Scandinavica. 107 (2): 153–9. doi:10.1111/j.1748-1716.1979.tb06455.x. PMID 525379.
Oldendorf WH, Pardridge WM, Braun LD, Crane PD (May 1982). "Measurement of cerebral glucose utilization using washout after carotid injection in the rat". Journal of Neurochemistry. 38 (5): 1413–8. doi:10.1111/j.1471-4159.1982.tb07920.x. PMID 7062059. S2CID 44670571.
Garske GE, Palmer GC, Napier JJ, Griffith RC, Freedman LR, Harris EW, et al. (September 1991). "Preclinical profile of the anticonvulsant remacemide and its enantiomers in the rat". Epilepsy Research. 9 (3): 161–74. doi:10.1016/0920-1211(91)90050-p. PMID 1660399. S2CID 40219442.
Hu RQ, Davies JA (December 1995). "The effect of the desglycinyl metabolite of remacemide on cortical wedges prepared from DBA/2 mice". European Journal of Pharmacology. 287 (3): 251–6. doi:10.1016/0014-2999(95)00500-5. PMID 8991798.
Norris SK, King AE (July 1997). "Electrophysiological effects of the anticonvulsant remacemide hydrochloride and its metabolite ARL 12495AA on rat CA1 hippocampal neurons in vitro". Neuropharmacology. 36 (7): 951–9. doi:10.1016/S0028-3908(97)00069-5. PMID 9257939. S2CID 20522408.
Leach JP, Sills GJ, Butler E, Forrest G, Thompson GG, Brodie MJ (July 1997). "Neurochemical actions of the desglycinyl metabolite of remacemide hydrochloride (ARL 12495AA) in mouse brain". British Journal of Pharmacology. 121 (5): 923–6. doi:10.1038/sj.bjp.0701219. PMC 1564774. PMID 9222548.
Kieburtz K, Feigin A, McDermott M, Como P, Abwender D, Zimmerman C, et al. (May 1996). "A controlled trial of remacemide hydrochloride in Huntington's disease". Movement Disorders. 11 (3): 273–7. doi:10.1002/mds.870110310. PMID 8723144. S2CID 33908305.
Greenamyre JT, Eller RV, Zhang Z, Ovadia A, Kurlan R, Gash DM (June 1994). "Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease". Annals of Neurology. 35 (6): 655–61. doi:10.1002/ana.410350605. PMID 8210221. S2CID 21875296.

fda.gov

FDA (2009-05-05). "Cumulative List of all Products that have received Orphan Designation". FDA. Archived from the original (excel document) on April 8, 2013. Retrieved 28 April 2012.

handle.net

hdl.handle.net

van Luijtelaar EL, Coenen AM (April 1995). "Effects of remacemide and its metabolite FPL 12495 on spike-wave discharges, electroencephalogram and behaviour in rats with absence epilepsy". Neuropharmacology. 34 (4): 419–25. doi:10.1016/0028-3908(95)00008-T. hdl:2066/28626. PMID 7566473. S2CID 12067526.

harvard.edu

ui.adsabs.harvard.edu

Muir KW, Lees KR (September 1995). "Initial experience with remacemide hydrochloride in patients with acute ischemic stroke". Annals of the New York Academy of Sciences. 765 (1 Neuroprotecti): 322–3. Bibcode:1995NYASA.765..322M. doi:10.1111/j.1749-6632.1995.tb16602.x. PMID 7486631. S2CID 7573258.
Wright LK, Pearson EC, Hammond TG, Paule MG (May–Jun 2007). "Behavioral effects associated with chronic ketamine or remacemide exposure in rats". Neurotoxicology and Teratology. 29 (3): 348–59. Bibcode:2007NTxT...29..348W. doi:10.1016/j.ntt.2006.12.004. PMID 17291718.
Popke EJ, Allen RR, Pearson EC, Hammond TG, Paule MG (1 July 2001). "Differential effects of two NMDA receptor antagonists on cognitive-behavioral development in nonhuman primates I". Neurotoxicology and Teratology. 23 (4): 319–32. Bibcode:2001NTxT...23..319P. doi:10.1016/S0892-0362(01)00156-8. PMID 11485835.
Popke EJ, Allen RR, Pearson EC, Hammond TG, Paule MG (1 July 2001). "Differential effects of two NMDA receptor antagonists on cognitive--behavioral performance in young nonhuman primates II". Neurotoxicology and Teratology. 23 (4): 333–47. Bibcode:2001NTxT...23..333P. doi:10.1016/S0892-0362(01)00138-6. PMID 11485836.
Popke EJ, Patton R, Newport GD, Rushing LG, Fogle CM, Allen RR, et al. (1 March 2002). "Assessing the potential toxicity of MK-801 and remacemide: chronic exposure in juvenile rhesus monkeys". Neurotoxicology and Teratology. 24 (2): 193–207. Bibcode:2002NTxT...24..193P. doi:10.1016/S0892-0362(02)00206-4. PMID 11943507.

highbeam.com

business.highbeam.com

"remacemide AstraZeneca discontinued, Europe, USA, Canada (epilepsy)". R & D Focus Drug News. March 15, 2004. Archived from the original on May 18, 2013. Retrieved 2 May 2012.

huginonline.com

reports.huginonline.com

"Astra 98 Annual Report" (PDF). Stellan Ståls Grafiska AB. Retrieved 28 April 2012.

huntington-study-group.org

"Completed Clinical Trials". Huntington Study Group. 2010. Archived from the original on 28 June 2012. Retrieved 29 April 2012.
"Clinical Trials and Observational Studies in Progress". Huntington Study Group. 2010. Archived from the original on 18 May 2009. Retrieved 29 April 2012.

nih.gov

pubmed.ncbi.nlm.nih.gov

Santangeli S, Sills GJ, Thompson GG, Brodie MJ (March 2002). "Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes". European Journal of Pharmacology. 438 (1–2): 63–8. doi:10.1016/S0014-2999(02)01297-9. PMID 11906711.
Muir KW, Lees KR (September 1995). "Initial experience with remacemide hydrochloride in patients with acute ischemic stroke". Annals of the New York Academy of Sciences. 765 (1 Neuroprotecti): 322–3. Bibcode:1995NYASA.765..322M. doi:10.1111/j.1749-6632.1995.tb16602.x. PMID 7486631. S2CID 7573258.
Dyker AG, Lees KR (September 1999). "Remacemide hydrochloride: a double-blind, placebo-controlled, safety and tolerability study in patients with acute ischemic stroke". Stroke. 30 (9): 1796–801. doi:10.1161/01.STR.30.9.1796. PMID 10471426.
Wesnes KA, Edgar C, Dean AD, Wroe SJ (March 2009). "The cognitive and psychomotor effects of remacemide and carbamazepine in newly diagnosed epilepsy". Epilepsy & Behavior. 14 (3): 522–8. doi:10.1016/j.yebeh.2008.11.012. PMID 19111629. S2CID 6582499.
Leach JP, Marson AG, Hutton JL (2002). "Remacemide for drug-resistant localization related epilepsy". The Cochrane Database of Systematic Reviews (4): CD001900. doi:10.1002/14651858.CD001900. PMC 12145949. PMID 12519561.
Palmer GC, Murray RJ, Wilson TC, Eisman MS, Ray RK, Griffith RC, et al. (June 1992). "Biological profile of the metabolites and potential metabolites of the anticonvulsant remacemide". Epilepsy Research. 12 (1): 9–20. doi:10.1016/0920-1211(92)90086-9. PMID 1388119. S2CID 23097783.
"A multicenter randomized controlled trial of remacemide hydrochloride as monotherapy for PD. Parkinson Study Group". Neurology. 54 (8): 1583–8. April 2000. doi:10.1212/wnl.54.8.1583. PMID 10762497. S2CID 216064344.
Ramaekers G, Lamers J, Verhey F, Muntjewerff D, Mobbs E, Sanders N, et al. (January 2002). "A comparative study of the effects of carbamazepine and the NMDA receptor antagonist remacemide on road tracking and car-following performance in actual traffic". Psychopharmacology. 159 (2): 203–10. doi:10.1007/s002130100898. PMID 11862350. S2CID 2774324.
Wright LK, Pearson EC, Hammond TG, Paule MG (May–Jun 2007). "Behavioral effects associated with chronic ketamine or remacemide exposure in rats". Neurotoxicology and Teratology. 29 (3): 348–59. Bibcode:2007NTxT...29..348W. doi:10.1016/j.ntt.2006.12.004. PMID 17291718.
Popke EJ, Allen RR, Pearson EC, Hammond TG, Paule MG (1 July 2001). "Differential effects of two NMDA receptor antagonists on cognitive-behavioral development in nonhuman primates I". Neurotoxicology and Teratology. 23 (4): 319–32. Bibcode:2001NTxT...23..319P. doi:10.1016/S0892-0362(01)00156-8. PMID 11485835.
Popke EJ, Allen RR, Pearson EC, Hammond TG, Paule MG (1 July 2001). "Differential effects of two NMDA receptor antagonists on cognitive--behavioral performance in young nonhuman primates II". Neurotoxicology and Teratology. 23 (4): 333–47. Bibcode:2001NTxT...23..333P. doi:10.1016/S0892-0362(01)00138-6. PMID 11485836.
Popke EJ, Patton R, Newport GD, Rushing LG, Fogle CM, Allen RR, et al. (1 March 2002). "Assessing the potential toxicity of MK-801 and remacemide: chronic exposure in juvenile rhesus monkeys". Neurotoxicology and Teratology. 24 (2): 193–207. Bibcode:2002NTxT...24..193P. doi:10.1016/S0892-0362(02)00206-4. PMID 11943507.
Paule MG, Fogle CM, Allen RR, Pearson EC, Hammond TG, Popke EJ (May 2003). "Chronic exposure to NMDA receptor and sodium channel blockers during development in monkeys and rats: long-term effects on cognitive function". Annals of the New York Academy of Sciences. 993 (1): 116–22, discussion 123–4. doi:10.1111/j.1749-6632.2003.tb07519.x. PMID 12853303. S2CID 19776727.
Stagnitto ML, Palmer GC, Ordy JM, Griffith RC, Napier JJ, Becker CN, et al. (Sep–Oct 1990). "Preclinical profile of remacemide: a novel anticonvulsant effective against maximal electroshock seizures in mice". Epilepsy Research. 7 (1): 11–28. doi:10.1016/0920-1211(90)90050-6. PMID 1963406. S2CID 13657516.
"The impact of remacemide hydrochloride on levodopa concentrations in Parkinson's disease. Parkinson Study Group". Clinical Neuropharmacology. 22 (4): 220–5. Jul–Aug 1999. PMID 10442252.
Leach JP, Girvan J, Jamieson V, Jones T, Richens A, Brodie MJ (June 1997). "Lack of pharmacokinetic interaction between remacemide hydrochloride and sodium valproate in epileptic patients". Seizure. 6 (3): 179–84. doi:10.1016/S1059-1311(97)80003-9. PMID 9203245. S2CID 18469302.
Leach JP, Blacklaw J, Jamieson V, Jones T, Richens A, Brodie MJ (November 1996). "Mutual interaction between remacemide hydrochloride and carbamazepine: two drugs with active metabolites". Epilepsia. 37 (11): 1100–6. doi:10.1111/j.1528-1157.1996.tb01031.x. PMID 8917061. S2CID 23489355.
Subramaniam S, Donevan SD, Rogawski MA (January 1996). "Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite". The Journal of Pharmacology and Experimental Therapeutics. 276 (1): 161–8. PMID 8558426.
Heyn H, McCarthy DJ, Curry SH, Eisman MS, Anders MW (May–Jun 1994). "Brain uptake and biotransformation of remacemide hydrochloride, a novel anticonvulsant". Drug Metabolism and Disposition. 22 (3): 443–6. PMID 8070322.
van Luijtelaar EL, Coenen AM (April 1995). "Effects of remacemide and its metabolite FPL 12495 on spike-wave discharges, electroencephalogram and behaviour in rats with absence epilepsy". Neuropharmacology. 34 (4): 419–25. doi:10.1016/0028-3908(95)00008-T. hdl:2066/28626. PMID 7566473. S2CID 12067526.
Hardebo JE, Nilsson B (October 1979). "Estimation of cerebral extraction of circulating compounds by the brain uptake index method: influence of circulation time, volume injection, and cerebral blood flow". Acta Physiologica Scandinavica. 107 (2): 153–9. doi:10.1111/j.1748-1716.1979.tb06455.x. PMID 525379.
Oldendorf WH, Pardridge WM, Braun LD, Crane PD (May 1982). "Measurement of cerebral glucose utilization using washout after carotid injection in the rat". Journal of Neurochemistry. 38 (5): 1413–8. doi:10.1111/j.1471-4159.1982.tb07920.x. PMID 7062059. S2CID 44670571.
Garske GE, Palmer GC, Napier JJ, Griffith RC, Freedman LR, Harris EW, et al. (September 1991). "Preclinical profile of the anticonvulsant remacemide and its enantiomers in the rat". Epilepsy Research. 9 (3): 161–74. doi:10.1016/0920-1211(91)90050-p. PMID 1660399. S2CID 40219442.
Hu RQ, Davies JA (December 1995). "The effect of the desglycinyl metabolite of remacemide on cortical wedges prepared from DBA/2 mice". European Journal of Pharmacology. 287 (3): 251–6. doi:10.1016/0014-2999(95)00500-5. PMID 8991798.
Norris SK, King AE (July 1997). "Electrophysiological effects of the anticonvulsant remacemide hydrochloride and its metabolite ARL 12495AA on rat CA1 hippocampal neurons in vitro". Neuropharmacology. 36 (7): 951–9. doi:10.1016/S0028-3908(97)00069-5. PMID 9257939. S2CID 20522408.
Leach JP, Sills GJ, Butler E, Forrest G, Thompson GG, Brodie MJ (July 1997). "Neurochemical actions of the desglycinyl metabolite of remacemide hydrochloride (ARL 12495AA) in mouse brain". British Journal of Pharmacology. 121 (5): 923–6. doi:10.1038/sj.bjp.0701219. PMC 1564774. PMID 9222548.
Norris SK, King AE (June 1997). "The stereo-isomers of the anticonvulsant ARL 12495AA limit sustained repetitive firing and modify action potential properties of rat hippocampal neurons in vitro". The Journal of Pharmacology and Experimental Therapeutics. 281 (3): 1191–8. PMID 9190853.
Palmer GC, Harris EW, Napier JJ, Stagnitto ML, Garske GE, Griffith RC, Swinyard EA (1990). "Status of PR 934-423, a novel anticonvulsant targeted for generalized tonic/clonic seizures (new designation is FPL 12924AA)". Progress in Clinical and Biological Research. 361: 435–41. PMID 2290849.
Kieburtz K, Feigin A, McDermott M, Como P, Abwender D, Zimmerman C, et al. (May 1996). "A controlled trial of remacemide hydrochloride in Huntington's disease". Movement Disorders. 11 (3): 273–7. doi:10.1002/mds.870110310. PMID 8723144. S2CID 33908305.
Greenamyre JT, Eller RV, Zhang Z, Ovadia A, Kurlan R, Gash DM (June 1994). "Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease". Annals of Neurology. 35 (6): 655–61. doi:10.1002/ana.410350605. PMID 8210221. S2CID 21875296.

ncbi.nlm.nih.gov

Leach JP, Marson AG, Hutton JL (2002). "Remacemide for drug-resistant localization related epilepsy". The Cochrane Database of Systematic Reviews (4): CD001900. doi:10.1002/14651858.CD001900. PMC 12145949. PMID 12519561.
Leach JP, Sills GJ, Butler E, Forrest G, Thompson GG, Brodie MJ (July 1997). "Neurochemical actions of the desglycinyl metabolite of remacemide hydrochloride (ARL 12495AA) in mouse brain". British Journal of Pharmacology. 121 (5): 923–6. doi:10.1038/sj.bjp.0701219. PMC 1564774. PMID 9222548.

parkinson-study-group.org

"Clinical Trials in Progress - Parkinson Study Group". Archived from the original on 11 September 2011. Retrieved 2 May 2012.

semanticscholar.org

api.semanticscholar.org

Muir KW, Lees KR (September 1995). "Initial experience with remacemide hydrochloride in patients with acute ischemic stroke". Annals of the New York Academy of Sciences. 765 (1 Neuroprotecti): 322–3. Bibcode:1995NYASA.765..322M. doi:10.1111/j.1749-6632.1995.tb16602.x. PMID 7486631. S2CID 7573258.
Wesnes KA, Edgar C, Dean AD, Wroe SJ (March 2009). "The cognitive and psychomotor effects of remacemide and carbamazepine in newly diagnosed epilepsy". Epilepsy & Behavior. 14 (3): 522–8. doi:10.1016/j.yebeh.2008.11.012. PMID 19111629. S2CID 6582499.
Palmer GC, Murray RJ, Wilson TC, Eisman MS, Ray RK, Griffith RC, et al. (June 1992). "Biological profile of the metabolites and potential metabolites of the anticonvulsant remacemide". Epilepsy Research. 12 (1): 9–20. doi:10.1016/0920-1211(92)90086-9. PMID 1388119. S2CID 23097783.
"A multicenter randomized controlled trial of remacemide hydrochloride as monotherapy for PD. Parkinson Study Group". Neurology. 54 (8): 1583–8. April 2000. doi:10.1212/wnl.54.8.1583. PMID 10762497. S2CID 216064344.
Ramaekers G, Lamers J, Verhey F, Muntjewerff D, Mobbs E, Sanders N, et al. (January 2002). "A comparative study of the effects of carbamazepine and the NMDA receptor antagonist remacemide on road tracking and car-following performance in actual traffic". Psychopharmacology. 159 (2): 203–10. doi:10.1007/s002130100898. PMID 11862350. S2CID 2774324.
Paule MG, Fogle CM, Allen RR, Pearson EC, Hammond TG, Popke EJ (May 2003). "Chronic exposure to NMDA receptor and sodium channel blockers during development in monkeys and rats: long-term effects on cognitive function". Annals of the New York Academy of Sciences. 993 (1): 116–22, discussion 123–4. doi:10.1111/j.1749-6632.2003.tb07519.x. PMID 12853303. S2CID 19776727.
Stagnitto ML, Palmer GC, Ordy JM, Griffith RC, Napier JJ, Becker CN, et al. (Sep–Oct 1990). "Preclinical profile of remacemide: a novel anticonvulsant effective against maximal electroshock seizures in mice". Epilepsy Research. 7 (1): 11–28. doi:10.1016/0920-1211(90)90050-6. PMID 1963406. S2CID 13657516.
Leach JP, Girvan J, Jamieson V, Jones T, Richens A, Brodie MJ (June 1997). "Lack of pharmacokinetic interaction between remacemide hydrochloride and sodium valproate in epileptic patients". Seizure. 6 (3): 179–84. doi:10.1016/S1059-1311(97)80003-9. PMID 9203245. S2CID 18469302.
Leach JP, Blacklaw J, Jamieson V, Jones T, Richens A, Brodie MJ (November 1996). "Mutual interaction between remacemide hydrochloride and carbamazepine: two drugs with active metabolites". Epilepsia. 37 (11): 1100–6. doi:10.1111/j.1528-1157.1996.tb01031.x. PMID 8917061. S2CID 23489355.
van Luijtelaar EL, Coenen AM (April 1995). "Effects of remacemide and its metabolite FPL 12495 on spike-wave discharges, electroencephalogram and behaviour in rats with absence epilepsy". Neuropharmacology. 34 (4): 419–25. doi:10.1016/0028-3908(95)00008-T. hdl:2066/28626. PMID 7566473. S2CID 12067526.
Oldendorf WH, Pardridge WM, Braun LD, Crane PD (May 1982). "Measurement of cerebral glucose utilization using washout after carotid injection in the rat". Journal of Neurochemistry. 38 (5): 1413–8. doi:10.1111/j.1471-4159.1982.tb07920.x. PMID 7062059. S2CID 44670571.
Garske GE, Palmer GC, Napier JJ, Griffith RC, Freedman LR, Harris EW, et al. (September 1991). "Preclinical profile of the anticonvulsant remacemide and its enantiomers in the rat". Epilepsy Research. 9 (3): 161–74. doi:10.1016/0920-1211(91)90050-p. PMID 1660399. S2CID 40219442.
Norris SK, King AE (July 1997). "Electrophysiological effects of the anticonvulsant remacemide hydrochloride and its metabolite ARL 12495AA on rat CA1 hippocampal neurons in vitro". Neuropharmacology. 36 (7): 951–9. doi:10.1016/S0028-3908(97)00069-5. PMID 9257939. S2CID 20522408.
Kieburtz K, Feigin A, McDermott M, Como P, Abwender D, Zimmerman C, et al. (May 1996). "A controlled trial of remacemide hydrochloride in Huntington's disease". Movement Disorders. 11 (3): 273–7. doi:10.1002/mds.870110310. PMID 8723144. S2CID 33908305.
Greenamyre JT, Eller RV, Zhang Z, Ovadia A, Kurlan R, Gash DM (June 1994). "Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease". Annals of Neurology. 35 (6): 655–61. doi:10.1002/ana.410350605. PMID 8210221. S2CID 21875296.

thepharmaletter.com

"FISONS DISCONTINUES TIPREDANE DEV'T". the pharma letter. 12 April 1993. Retrieved 28 April 2012.
"Sweden's Astra Buys Most Of Fisons R&D Ops". the pharma letter. 27 March 1995. Retrieved 28 April 2012.

ukmi.nhs.uk

"remacemide () UKMi New Drugs Online Database". Archived from the original on 21 May 2013. Retrieved 2 May 2012.

web.archive.org

FDA (2009-05-05). "Cumulative List of all Products that have received Orphan Designation". FDA. Archived from the original (excel document) on April 8, 2013. Retrieved 28 April 2012.
"remacemide () UKMi New Drugs Online Database". Archived from the original on 21 May 2013. Retrieved 2 May 2012.
"remacemide AstraZeneca discontinued, Europe, USA, Canada (epilepsy)". R & D Focus Drug News. March 15, 2004. Archived from the original on May 18, 2013. Retrieved 2 May 2012.
"Completed Clinical Trials". Huntington Study Group. 2010. Archived from the original on 28 June 2012. Retrieved 29 April 2012.
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