Analysis of information sources in references of the Wikipedia article "Scar" in English language version.
Last modified:
Early and effective acne treatment can prevent severe acne and the scarring that often follows
As part of the healing process, specialized cells called fibroblasts in adjacent areas of skin produce a fibrous connective tissue made up of collagen. The bundles formed by these whitish, rather inelastic fibres make up the bulk of the scar tissue...
{{cite book}}: CS1 maint: multiple names: authors list (link){{cite journal}}: CS1 maint: DOI inactive as of August 2026 (link){{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)Healing in 2 weeks – minimal to no scar; Healing in 3 weeks – minimal to no scar except in high risk scar formers;Healing in 4 weeks or more – hypertrophic in more than 50% of patients
myofibroblasts become differentiated from other cells in the wound within a few days after the onset of healing, and in the rat model can reach a peak where about 70% of the fibroblastic cells present are of the myofibroblast phenotype.
{{cite web}}: CS1 maint: multiple names: authors list (link)These cells, which differentiate from the unwounded tissue cell type (fibroblasts), are responsible for laying down scar tissue. Indeed, myofibroblasts remain present in hypertrophic scars up to four years after the original wounding event. An in vitro assay was accordingly developed to identify actives which prevent or reduce myofibroblast formation and thus identify actives which are effective in reducing and/or preventing scar tissue formation.
{{cite web}}: CS1 maint: multiple names: authors list (link)the number of myofibroblasts present in the forming scar tissue begins to reduce via apoptosis, until by about 30 days no myofibroblasts are obvious within the scar.
{{cite web}}: CS1 maint: multiple names: authors list (link)Deep cuts need multi-layered closure to heal optimally; otherwise, depressed or dented scars can result
This is composed of the same main protein (collagen) as normal skin, but with differences in details of composition. Most crucially, the protein fibres in normal tissue have a random (basketweave) appearance, while those in scar tissue have pronounced alignment in a single direction.
{{cite journal}}: CS1 maint: DOI inactive as of August 2026 (link)In hypertrophic scar tissue, no sweet gland and hair follicle exist usually because of the dermal and epidermal damage in extensive thermal skin injury, thus impairing regulation of body temperature
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link){{cite web}}: CS1 maint: deprecated archival service (link)Wounds that are allowed to heal secondarily tend to have larger and more noticeable scars than the scars that results from primary closure. Secondary healing also has a greater tendency for hypertrophic scar/keloid formation. (page 86)
Importantly, the endometrium is the only adult tissue to undergo rapid cyclic repair without scarring.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)Formation of a thick eschar, slow healing (>1month), Obvious scarring, hair loss.
{{cite book}}: CS1 maint: multiple names: authors list (link)Wounds that are allowed to heal secondarily tend to have larger and more noticeable scars than the scars that results from primary closure. Secondary healing also has a greater tendency for hypertrophic scar/keloid formation. (page 86)
Healing in 2 weeks – minimal to no scar; Healing in 3 weeks – minimal to no scar except in high risk scar formers;Healing in 4 weeks or more – hypertrophic in more than 50% of patients
In hypertrophic scar tissue, no sweet gland and hair follicle exist usually because of the dermal and epidermal damage in extensive thermal skin injury, thus impairing regulation of body temperature
Importantly, the endometrium is the only adult tissue to undergo rapid cyclic repair without scarring.
Early and effective acne treatment can prevent severe acne and the scarring that often follows
Deep cuts need multi-layered closure to heal optimally; otherwise, depressed or dented scars can result
In hypertrophic scar tissue, no sweet gland and hair follicle exist usually because of the dermal and epidermal damage in extensive thermal skin injury, thus impairing regulation of body temperature