Seliciclib (English Wikipedia)

Noel S, Faveau C, Norez C, Rogier C, Mettey Y, Becq F (2006). "Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels". J Pharmacol Exp Ther. 319 (1): 349–59. doi:10.1124/jpet.106.104521. PMID 16829626. S2CID 1554921.
Rossi AG, Sawatzky DA, Walker A, Ward C, Sheldrake TA, Riley NA, Caldicott A, Martinez-Losa M, Walker TR, Duffin R, Gray M, Crescenzi E, Martin MC, Brady HJ, Savill JS, Dransfield I, Haslett C (2006). "Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis". Nature Medicine. 12 (9): 1056–1064. doi:10.1038/nm1468. PMID 16951685. S2CID 5875865.
Tomov N, Surchev L, Wiedenmann C, Döbrössy M, Nikkhah G (August 2019). "Roscovitine, an experimental CDK5 inhibitor, causes delayed suppression of microglial, but not astroglial recruitment around intracerebral dopaminergic grafts". Experimental Neurology. 318: 135–144. doi:10.1016/j.expneurol.2019.04.013. PMID 31028828. S2CID 129946710.
Doree M, Galas S (1994). "The cyclin-dependent protein kinases and the control of cell division". FASEB J. 8 (14): 1114–1121. doi:10.1096/fasebj.8.14.7958616. PMID 7958616. S2CID 3069118.

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Menn B, Bach S, Blevins TL, Campbell M, Meijer L, Timsit S (2010-08-12). Manzoni OJ (ed.). "Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models". PLOS ONE. 5 (8) e12117. Bibcode:2010PLoSO...512117M. doi:10.1371/journal.pone.0012117. ISSN 1932-6203. PMC 2920814. PMID 20711428.
Rousselet E, Létondor A, Menn B, Courbebaisse Y, Quillé ML, Timsit S (June 2018). "Sustained (S)-roscovitine delivery promotes neuroprotection associated with functional recovery and decrease in brain edema in a randomized blind focal cerebral ischemia study". Journal of Cerebral Blood Flow & Metabolism. 38 (6): 1070–1084. doi:10.1177/0271678X17712163. ISSN 0271-678X. PMC 5998998. PMID 28569655.
Pandey V, Ranjan N, Narne P, Babu PP (2019-03-21). "Roscovitine effectively enhances antitumor activity of temozolomide in vitro and in vivo mediated by increased autophagy and Caspase-3 dependent apoptosis". Scientific Reports. 9 (1): 5012. Bibcode:2019NatSR...9.5012P. doi:10.1038/s41598-019-41380-1. ISSN 2045-2322. PMC 6428853. PMID 30899038.
Yu, Alan S. L., Chertow, Glenn M., Luyckx, Valérie A., Marsden, Philip A., Skorecki, Karl, Taal, Maarten W., eds. (25 September 2019). Brenner & Rector's the kidney. Elsevier Health Sciences. ISBN 978-0-323-55085-7. OCLC 1122857051.
Le Tourneau C, Faivre S, Laurence V, Delbaldo C, Vera K, Girre V, Chiao J, Armour S, Frame S, Green SR, Gianella-Borradori A, Diéras V, Raymond E (December 2010). "Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies". European Journal of Cancer. 46 (18): 3243–3250. doi:10.1016/j.ejca.2010.08.001. ISSN 1879-0852. PMID 20822897.

Seliciclib (English Wikipedia)

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clinicaltrials.gov (Global: 5,225^th place; English: 4,062^nd place)

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