Simvastatin (English Wikipedia)

"Simvastatin: updated advice on drug interactions - updated contraindications". Drug Safety Update. 6 (1). Government of the United Kingdom: S1. August 2012. Archived from the original on 27 January 2016. Retrieved 3 November 2015.

hdl.handle.net (Global: 66^th place; English: 34^th place)

WHO model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. hdl:10665/325771.

jst.go.jp (Global: 1,248^th place; English: 1,827^th place)

jstage.jst.go.jp

Endo A (2010). "A historical perspective on the discovery of statins". Proceedings of the Japan Academy, Series B. 86 (5): 484–493. Bibcode:2010PJAB...86..484E. doi:10.2183/pjab.86.484. ISSN 0386-2208. PMC 3108295. PMID 20467214.

nhs.uk (Global: 2,637^th place; English: 2,254^th place)

"Cholesterol-lowering medicines, statins - Interactions". NHS. 16 April 2012. Archived from the original on 28 September 2013. Retrieved 25 September 2013.
"About simvastatin". nhs.uk. 10 February 2022. Retrieved 19 May 2025.

nih.gov (Global: 5^th place; English: 5^th place)

pubmed.ncbi.nlm.nih.gov

Pedersen TR, Tobert JA (December 2004). "Simvastatin: a review". Expert Opinion on Pharmacotherapy. 5 (12): 2583–96. doi:10.1517/14656566.5.12.2583. PMID 15571475. S2CID 36911054.
Roizenblatt M, Naranjit N, Maia M, Gehlbach PL (November 2018). "The Question of a Role for Statins in Age-Related Macular Degeneration". International Journal of Molecular Sciences. 19 (11): 3688. doi:10.3390/ijms19113688. PMC 6274767. PMID 30469381.
Al-Holou SN, Tucker WR, Agrón E, Clemons TE, Cukras C, Ferris FL, et al. (December 2015). "The Association of Statin Use with Age-Related Macular Degeneration Progression: The Age-Related Eye Disease Study 2 Report Number 9". Ophthalmology. 122 (12): 2490–6. doi:10.1016/j.ophtha.2015.08.028. PMC 4658271. PMID 26435335.
Barbosa DT, Mendes TS, Cíntron-Colon HR, Wang SY, Bhisitkul RB, Singh K, et al. (April 2014). "Age-related macular degeneration and protective effect of HMG Co-A reductase inhibitors (statins): results from the National Health and Nutrition Examination Survey 2005-2008". Eye. 28 (4): 472–80. doi:10.1038/eye.2014.8. PMC 3983650. PMID 24503725.
Link E, Parish S, Armitage J, Bowman L, Heath S, Matsuda F, et al. (August 2008). "SLCO1B1 variants and statin-induced myopathy--a genomewide study". The New England Journal of Medicine. 359 (8): 789–99. doi:10.1056/NEJMoa0801936. PMID 18650507.
Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, et al. (October 2014). "The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update". Clinical Pharmacology and Therapeutics. 96 (4): 423–8. doi:10.1038/clpt.2014.125. PMC 4169720. PMID 24918167.
Wilke RA, Ramsey LB, Johnson SG, Maxwell WD, McLeod HL, Voora D, et al. (July 2012). "The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy". Clinical Pharmacology and Therapeutics. 92 (1): 112–7. doi:10.1038/clpt.2012.57. PMC 3384438. PMID 22617227.
Sattar N, Preiss D, Murray HM, Welsh P, Buckley BM, de Craen AJ, et al. (February 2010). "Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials". Lancet. 375 (9716): 735–42. doi:10.1016/S0140-6736(09)61965-6. PMID 20167359. S2CID 11544414.
Lilja JJ, Kivistö KT, Neuvonen PJ (November 1998). "Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors". Clinical Pharmacology and Therapeutics. 64 (5): 477–83. doi:10.1016/S0009-9236(98)90130-8. PMID 9834039. S2CID 37013910.
Lilja JJ, Neuvonen M, Neuvonen PJ (July 2004). "Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin". British Journal of Clinical Pharmacology. 58 (1): 56–60. doi:10.1111/j.1365-2125.2004.02095.x. PMC 1884539. PMID 15206993.
Lilja JJ, Kivistö KT, Neuvonen PJ (October 2000). "Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin". Clinical Pharmacology and Therapeutics. 68 (4): 384–90. doi:10.1067/mcp.2000.110216. PMID 11061578. S2CID 29029956.
Pedersen TR (2010). "Pleiotropic effects of statins: evidence against benefits beyond LDL-cholesterol lowering". American Journal of Cardiovascular Drugs. 10 (Suppl 1): 10–7. doi:10.2165/1158822-S0-000000000-00000. PMID 21391729. S2CID 23195784.
Roy A, Jana M, Kundu M, Corbett GT, Rangaswamy SB, Mishra RK, et al. (August 2015). "HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice". Cell Metabolism. 22 (2): 253–65. doi:10.1016/j.cmet.2015.05.022. PMC 4526399. PMID 26118928.
Endo A (2010). "A historical perspective on the discovery of statins". Proceedings of the Japan Academy, Series B. 86 (5): 484–493. Bibcode:2010PJAB...86..484E. doi:10.2183/pjab.86.484. ISSN 0386-2208. PMC 3108295. PMID 20467214.
Liao JK, Laufs U (2005). "Pleiotropic effects of statins". Annual Review of Pharmacology and Toxicology. 45: 89–118. doi:10.1146/annurev.pharmtox.45.120403.095748. PMC 2694580. PMID 15822172.
Tobert JA (July 2003). "Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors". Nature Reviews. Drug Discovery. 2 (7): 517–26. doi:10.1038/nrd1112. PMID 12815379. S2CID 3344720.
Scandinavian Simvastatin Survival Study Group (November 1994). "Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)". Lancet. 344 (8934): 1383–9. doi:10.1016/S0140-6736(94)90566-5. PMID 7968073. S2CID 5965882.
Mayor S (18 June 2005). "Drug regulator criticised for error in reporting consultation results". BMJ (Clinical Research Ed.). 330 (7505): 1410. doi:10.1136/bmj.330.7505.1410. ISSN 1756-1833. PMC 558369. PMID 15961813.

ncbi.nlm.nih.gov

Roizenblatt M, Naranjit N, Maia M, Gehlbach PL (November 2018). "The Question of a Role for Statins in Age-Related Macular Degeneration". International Journal of Molecular Sciences. 19 (11): 3688. doi:10.3390/ijms19113688. PMC 6274767. PMID 30469381.
Al-Holou SN, Tucker WR, Agrón E, Clemons TE, Cukras C, Ferris FL, et al. (December 2015). "The Association of Statin Use with Age-Related Macular Degeneration Progression: The Age-Related Eye Disease Study 2 Report Number 9". Ophthalmology. 122 (12): 2490–6. doi:10.1016/j.ophtha.2015.08.028. PMC 4658271. PMID 26435335.
Barbosa DT, Mendes TS, Cíntron-Colon HR, Wang SY, Bhisitkul RB, Singh K, et al. (April 2014). "Age-related macular degeneration and protective effect of HMG Co-A reductase inhibitors (statins): results from the National Health and Nutrition Examination Survey 2005-2008". Eye. 28 (4): 472–80. doi:10.1038/eye.2014.8. PMC 3983650. PMID 24503725.
Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, et al. (October 2014). "The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update". Clinical Pharmacology and Therapeutics. 96 (4): 423–8. doi:10.1038/clpt.2014.125. PMC 4169720. PMID 24918167.
Wilke RA, Ramsey LB, Johnson SG, Maxwell WD, McLeod HL, Voora D, et al. (July 2012). "The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy". Clinical Pharmacology and Therapeutics. 92 (1): 112–7. doi:10.1038/clpt.2012.57. PMC 3384438. PMID 22617227.
Lilja JJ, Neuvonen M, Neuvonen PJ (July 2004). "Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin". British Journal of Clinical Pharmacology. 58 (1): 56–60. doi:10.1111/j.1365-2125.2004.02095.x. PMC 1884539. PMID 15206993.
Roy A, Jana M, Kundu M, Corbett GT, Rangaswamy SB, Mishra RK, et al. (August 2015). "HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice". Cell Metabolism. 22 (2): 253–65. doi:10.1016/j.cmet.2015.05.022. PMC 4526399. PMID 26118928.
Endo A (2010). "A historical perspective on the discovery of statins". Proceedings of the Japan Academy, Series B. 86 (5): 484–493. Bibcode:2010PJAB...86..484E. doi:10.2183/pjab.86.484. ISSN 0386-2208. PMC 3108295. PMID 20467214.
Liao JK, Laufs U (2005). "Pleiotropic effects of statins". Annual Review of Pharmacology and Toxicology. 45: 89–118. doi:10.1146/annurev.pharmtox.45.120403.095748. PMC 2694580. PMID 15822172.
Mayor S (18 June 2005). "Drug regulator criticised for error in reporting consultation results". BMJ (Clinical Research Ed.). 330 (7505): 1410. doi:10.1136/bmj.330.7505.1410. ISSN 1756-1833. PMC 558369. PMID 15961813.
Meek C (7 June 2005). "UK decision to sell statins over the counter criticized". Canadian Medical Association Journal. 172 (12): 1543. doi:10.1503/cmaj.050532. ISSN 0820-3946. PMC 558157.

dailymed.nlm.nih.gov

"Zocor- simvastatin tablet, film coated". DailyMed. 9 August 2023. Retrieved 17 January 2024.

nlm.nih.gov

"Simvastatin". LactMed. U.S. National Library of Medicine. Retrieved 1 December 2012.

nytimes.com (Global: 7^th place; English: 7^th place)

Berenson A (23 June 2006). "Merck Loses Protection for Patent on Zocor". The New York Times. Archived from the original on 14 January 2015. Retrieved 14 January 2015.

rxlist.com (Global: low place; English: low place)

"Zocor". RxList. 14 November 2012. Archived from the original on 4 November 2012. Retrieved 1 December 2012.

semanticscholar.org (Global: 15^th place; English: 8^th place)

api.semanticscholar.org

Pedersen TR, Tobert JA (December 2004). "Simvastatin: a review". Expert Opinion on Pharmacotherapy. 5 (12): 2583–96. doi:10.1517/14656566.5.12.2583. PMID 15571475. S2CID 36911054.
Sattar N, Preiss D, Murray HM, Welsh P, Buckley BM, de Craen AJ, et al. (February 2010). "Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials". Lancet. 375 (9716): 735–42. doi:10.1016/S0140-6736(09)61965-6. PMID 20167359. S2CID 11544414.
Lilja JJ, Kivistö KT, Neuvonen PJ (November 1998). "Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors". Clinical Pharmacology and Therapeutics. 64 (5): 477–83. doi:10.1016/S0009-9236(98)90130-8. PMID 9834039. S2CID 37013910.
Lilja JJ, Kivistö KT, Neuvonen PJ (October 2000). "Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin". Clinical Pharmacology and Therapeutics. 68 (4): 384–90. doi:10.1067/mcp.2000.110216. PMID 11061578. S2CID 29029956.
Pedersen TR (2010). "Pleiotropic effects of statins: evidence against benefits beyond LDL-cholesterol lowering". American Journal of Cardiovascular Drugs. 10 (Suppl 1): 10–7. doi:10.2165/1158822-S0-000000000-00000. PMID 21391729. S2CID 23195784.
Tobert JA (July 2003). "Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors". Nature Reviews. Drug Discovery. 2 (7): 517–26. doi:10.1038/nrd1112. PMID 12815379. S2CID 3344720.
Scandinavian Simvastatin Survival Study Group (November 1994). "Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)". Lancet. 344 (8934): 1383–9. doi:10.1016/S0140-6736(94)90566-5. PMID 7968073. S2CID 5965882.

snpedia.com (Global: low place; English: low place)

"rs4149056 - SNPedia". www.snpedia.com. Archived from the original on 11 January 2009.

tga.gov.au (Global: 4,353^rd place; English: 2,806^th place)

"Prescribing medicines in pregnancy database". Australian Government. 3 March 2014. Archived from the original on 8 April 2014. Retrieved 22 April 2014.

thepharmaletter.com (Global: low place; English: low place)

"Merck gets Zocor patent extension". The Pharma Letter. 3 November 2002. Retrieved 12 October 2019.

umich.edu (Global: 429^th place; English: 307^th place)

www-personal.umich.edu

Williams O, Jacks AM, Davis J, Martinez S (1998). "Case 10: Merck(A): Mevacor". In Allan Afuah (ed.). Innovation Management - Strategies, Implementation, and Profits. Oxford University Press. ISBN 978-0-19-511346-4. Retrieved 19 July 2006.

usatoday.com (Global: 55^th place; English: 36^th place)

yourlife.usatoday.com

Sternberg S (9 June 2011). "Simvastatin can damage muscles in high doses". USA Today. Archived from the original on 11 June 2011. Retrieved 9 June 2011. The cholesterol-lowering drug simvastatin can cause severe muscle damage and should not be prescribed in high doses to patients who have taken it for less than a year or in any dose to people taking certain drugs, health officials said Tuesday. . . . Research has shown that the highest dose of simvastatin, 80 milligrams, causes muscle damage in 61 of every 1,000 patients, far higher than the eight-per-10,000 rate in patients taking a 40-milligram dose, Rosenblatt says.

uspreventiveservicestaskforce.org (Global: low place; English: low place)

"Recommendation: Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive Medication". United States Preventive Services Taskforce. 15 November 2016. Retrieved 7 May 2022.

web.archive.org (Global: 1^st place; English: 1^st place)

"Simvastatin". The American Society of Health-System Pharmacists. Archived from the original on 10 January 2015. Retrieved 8 January 2015.
"Prescribing medicines in pregnancy database". Australian Government. 3 March 2014. Archived from the original on 8 April 2014. Retrieved 22 April 2014.
Cechinel-Filho V (2012). Plant bioactives and drug discovery: principles, practice, and perspectives. Hoboken, N.J.: John Wiley & Sons. p. 104. ISBN 978-0-470-58226-8. Archived from the original on 5 March 2016.
"Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
"Zocor Full Prescribing Information" (PDF). U.S. Food and Drug Administration (FDA). Archived from the original (PDF) on 8 December 2015.
"Zocor". RxList. 14 November 2012. Archived from the original on 4 November 2012. Retrieved 1 December 2012.
"FDA Drug Safety Communication: New restrictions, contraindications, and dose limitations for Zocor (simvastatin) to reduce the risk of muscle injury". U.S. Food and Drug Administration (FDA). 8 June 2011. Archived from the original on 11 June 2011.
"Simvastatin: updated advice on drug interactions - updated contraindications". Drug Safety Update. 6 (1). Government of the United Kingdom: S1. August 2012. Archived from the original on 27 January 2016. Retrieved 3 November 2015.
"FDA Drug Safety Communication: Revised dose limitation for Zocor (simvastatin) when taken with amiodarone". U.S. Food and Drug Administration (FDA). 15 December 2011. Archived from the original on 26 November 2012. Retrieved 12 October 2019.
"rs4149056 - SNPedia". www.snpedia.com. Archived from the original on 11 January 2009.
"FDA Expands Advice on Statin Risks". U.S. Food and Drug Administration (FDA). Archived from the original on 29 June 2012. Retrieved 12 July 2012.
"FDA Drug Safety Communication: Ongoing safety review of high-dose Zocor (simvastatin) and increased risk of muscle injury". U.S. Food and Drug Administration (FDA). 19 March 2010. Archived from the original on 20 March 2010. Retrieved 21 March 2010.
Sternberg S (9 June 2011). "Simvastatin can damage muscles in high doses". USA Today. Archived from the original on 11 June 2011. Retrieved 9 June 2011. The cholesterol-lowering drug simvastatin can cause severe muscle damage and should not be prescribed in high doses to patients who have taken it for less than a year or in any dose to people taking certain drugs, health officials said Tuesday. . . . Research has shown that the highest dose of simvastatin, 80 milligrams, causes muscle damage in 61 of every 1,000 patients, far higher than the eight-per-10,000 rate in patients taking a 40-milligram dose, Rosenblatt says.
"Cholesterol-lowering medicines, statins - Interactions". NHS. 16 April 2012. Archived from the original on 28 September 2013. Retrieved 25 September 2013.
"Information on Simvastatin/Amiodarone". U.S. Food and Drug Administration (FDA). 8 August 2008. Archived from the original on 7 June 2009. Retrieved 21 September 2008.
Berenson A (23 June 2006). "Merck Loses Protection for Patent on Zocor". The New York Times. Archived from the original on 14 January 2015. Retrieved 14 January 2015.

worldcat.org (Global: 4^th place; English: 4^th place)

search.worldcat.org

Endo A (2010). "A historical perspective on the discovery of statins". Proceedings of the Japan Academy, Series B. 86 (5): 484–493. Bibcode:2010PJAB...86..484E. doi:10.2183/pjab.86.484. ISSN 0386-2208. PMC 3108295. PMID 20467214.
Mayor S (18 June 2005). "Drug regulator criticised for error in reporting consultation results". BMJ (Clinical Research Ed.). 330 (7505): 1410. doi:10.1136/bmj.330.7505.1410. ISSN 1756-1833. PMC 558369. PMID 15961813.
Meek C (7 June 2005). "UK decision to sell statins over the counter criticized". Canadian Medical Association Journal. 172 (12): 1543. doi:10.1503/cmaj.050532. ISSN 0820-3946. PMC 558157.

Simvastatin (English Wikipedia)

aafp.org (Global: 2,559th place; English: 2,163rd place)

adsabs.harvard.edu (Global: 14th place; English: 9th place)

ui.adsabs.harvard.edu

archive.org (Global: 6th place; English: 6th place)

books.google.com (Global: 3rd place; English: 3rd place)

cigna.com (Global: low place; English: low place)

clincalc.com (Global: 5,833rd place; English: 4,432nd place)

doi.org (Global: 2nd place; English: 2nd place)

drugs.com (Global: 529th place; English: 550th place)

europa.eu (Global: 62nd place; English: 100th place)

ema.europa.eu

fda.gov (Global: 470th place; English: 329th place)

fda.gov

accessdata.fda.gov

gov.uk (Global: 401st place; English: 228th place)

hdl.handle.net (Global: 66th place; English: 34th place)

jst.go.jp (Global: 1,248th place; English: 1,827th place)

jstage.jst.go.jp

nhs.uk (Global: 2,637th place; English: 2,254th place)

nih.gov (Global: 5th place; English: 5th place)

pubmed.ncbi.nlm.nih.gov

ncbi.nlm.nih.gov

dailymed.nlm.nih.gov

nlm.nih.gov

nytimes.com (Global: 7th place; English: 7th place)

rxlist.com (Global: low place; English: low place)

semanticscholar.org (Global: 15th place; English: 8th place)

api.semanticscholar.org

snpedia.com (Global: low place; English: low place)

tga.gov.au (Global: 4,353rd place; English: 2,806th place)

thepharmaletter.com (Global: low place; English: low place)

umich.edu (Global: 429th place; English: 307th place)

www-personal.umich.edu

usatoday.com (Global: 55th place; English: 36th place)

yourlife.usatoday.com

uspreventiveservicestaskforce.org (Global: low place; English: low place)

web.archive.org (Global: 1st place; English: 1st place)

worldcat.org (Global: 4th place; English: 4th place)

search.worldcat.org

aafp.org (Global: 2,559^th place; English: 2,163^rd place)

adsabs.harvard.edu (Global: 14^th place; English: 9^th place)

archive.org (Global: 6^th place; English: 6^th place)

books.google.com (Global: 3^rd place; English: 3^rd place)

clincalc.com (Global: 5,833^rd place; English: 4,432^nd place)

doi.org (Global: 2^nd place; English: 2^nd place)

drugs.com (Global: 529^th place; English: 550^th place)

europa.eu (Global: 62^nd place; English: 100^th place)

fda.gov (Global: 470^th place; English: 329^th place)

gov.uk (Global: 401^st place; English: 228^th place)

hdl.handle.net (Global: 66^th place; English: 34^th place)

jst.go.jp (Global: 1,248^th place; English: 1,827^th place)

nhs.uk (Global: 2,637^th place; English: 2,254^th place)

nih.gov (Global: 5^th place; English: 5^th place)

nytimes.com (Global: 7^th place; English: 7^th place)

semanticscholar.org (Global: 15^th place; English: 8^th place)

tga.gov.au (Global: 4,353^rd place; English: 2,806^th place)

umich.edu (Global: 429^th place; English: 307^th place)

usatoday.com (Global: 55^th place; English: 36^th place)

web.archive.org (Global: 1^st place; English: 1^st place)

worldcat.org (Global: 4^th place; English: 4^th place)