Sirtuin 6 (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Sirtuin 6" in English language version.

Last modified: 19:46:24, 11 August 2026 (UTC)

Ref.Un. Ref.Website

Global rank English rank

3326nih.gov

5^th place

1914doi.org

2^nd place

74adsabs.harvard.edu

14^th place

9^th place

62ensembl.org

630^th place

326^th place

32semanticscholar.org

15^th place

8^th place

11springer.com

182^nd place

172^nd place

11patsnap.com

low place

adsabs.harvard.edu (Global: 14^th place; English: 9^th place)

ui.adsabs.harvard.edu

Frye RA (July 2000). "Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins". Biochemical and Biophysical Research Communications. 273 (2): 793–798. Bibcode:2000BBRC..273..793F. doi:10.1006/bbrc.2000.3000. PMID 10873683.
Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, et al. (February 2012). "The sirtuin SIRT6 regulates lifespan in male mice". Nature. 483 (7388): 218–221. Bibcode:2012Natur.483..218K. doi:10.1038/nature10815. PMID 22367546. S2CID 4417564.
Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A (July 2012). "Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence". Proceedings of the National Academy of Sciences of the United States of America. 109 (29): 11800–11805. Bibcode:2012PNAS..10911800M. doi:10.1073/pnas.1200583109. PMC 3406824. PMID 22753495.
You W, Rotili D, Li TM, Kambach C, Meleshin M, Schutkowski M, et al. (January 2017). "Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules". Angewandte Chemie. 56 (4): 1007–1011. Bibcode:2017ACIE...56.1007Y. doi:10.1002/anie.201610082. PMID 27990725.

doi.org (Global: 2^nd place; English: 2^nd place)

Frye RA (July 2000). "Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins". Biochemical and Biophysical Research Communications. 273 (2): 793–798. Bibcode:2000BBRC..273..793F. doi:10.1006/bbrc.2000.3000. PMID 10873683.
Van Meter M, Mao Z, Gorbunova V, Seluanov A (2011). "Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair". Aging. 3 (9). Albany NY: 829–835. doi:10.18632/aging.100389. PMC 3227448. PMID 21946623.
Nagar R, Schwartz Z, Katz A, Touitou N, Sharon E, Tzdaka K, et al. (May 2026). "SIRT6 overexpression counteracts chromatin aging in the male murine liver". Nature Communications. doi:10.1038/s41467-026-73115-y. PMID 42135312.
Bonkowski MS, Sinclair DA (2016). "Slowing ageing by design: the rise of NAD + and sirtuin-activating compounds". Nature Reviews. Molecular Cell Biology. 17 (11): 679–690. doi:10.1038/nrm.2016.93. PMC 5107309. PMID 27552971.
Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, et al. (February 2012). "The sirtuin SIRT6 regulates lifespan in male mice". Nature. 483 (7388): 218–221. Bibcode:2012Natur.483..218K. doi:10.1038/nature10815. PMID 22367546. S2CID 4417564.
Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, et al. (January 2006). "Genomic instability and aging-like phenotype in the absence of mammalian SIRT6". Cell. 124 (2): 315–329. doi:10.1016/j.cell.2005.11.044. PMID 16439206. S2CID 18517518.
Tian X, Firsanov D, Seluanov A, Vera Gorbunova V (2019). "SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species". Cell. 177 (3): 622–638. doi:10.1016/j.cell.2019.03.043. PMC 6499390. PMID 31002797.
Klein MA, Denu JM (2020). "Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators". The Journal of Biological Chemistry. 295 (32): 11021–11041. doi:10.1074/jbc.REV120.011438. PMC 7415977. PMID 32518153.
McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, et al. (January 2009). "SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair". Aging. 1 (1). Albany NY: 109–121. doi:10.18632/aging.100011. PMC 2815768. PMID 20157594.
Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A (July 2012). "Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence". Proceedings of the National Academy of Sciences of the United States of America. 109 (29): 11800–11805. Bibcode:2012PNAS..10911800M. doi:10.1073/pnas.1200583109. PMC 3406824. PMID 22753495.
Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, et al. (2015). "SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner". Cell Cycle. 14 (2). Georgetown, Tex.: 269–276. doi:10.4161/15384101.2014.980641. PMC 4614943. PMID 25607651.
Feldman JL, Baeza J, Denu JM (October 2013). "Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins". The Journal of Biological Chemistry. 288 (43): 31350–31356. doi:10.1074/jbc.C113.511261. PMC 3829447. PMID 24052263.
You W, Rotili D, Li TM, Kambach C, Meleshin M, Schutkowski M, et al. (January 2017). "Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules". Angewandte Chemie. 56 (4): 1007–1011. Bibcode:2017ACIE...56.1007Y. doi:10.1002/anie.201610082. PMID 27990725.
Liu R, Li Y, Zheng Q, Ding M, Zhou H, Li X (March 2024). "Epigenetic modification in liver fibrosis: Promising therapeutic direction with significant challenges ahead". Acta Pharmaceutica Sinica. B. 14 (3): 1009–1029. doi:10.1016/j.apsb.2023.10.023. PMC 10935124. PMID 38486982.

ensembl.org (Global: 630^th place; English: 326^th place)

may2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000077463 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034748 – Ensembl, May 2017

nih.gov (Global: 5^th place; English: 5^th place)

pubmed.ncbi.nlm.nih.gov

Frye RA (July 2000). "Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins". Biochemical and Biophysical Research Communications. 273 (2): 793–798. Bibcode:2000BBRC..273..793F. doi:10.1006/bbrc.2000.3000. PMID 10873683.
Van Meter M, Mao Z, Gorbunova V, Seluanov A (2011). "Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair". Aging. 3 (9). Albany NY: 829–835. doi:10.18632/aging.100389. PMC 3227448. PMID 21946623.
Nagar R, Schwartz Z, Katz A, Touitou N, Sharon E, Tzdaka K, et al. (May 2026). "SIRT6 overexpression counteracts chromatin aging in the male murine liver". Nature Communications. doi:10.1038/s41467-026-73115-y. PMID 42135312.
Bonkowski MS, Sinclair DA (2016). "Slowing ageing by design: the rise of NAD + and sirtuin-activating compounds". Nature Reviews. Molecular Cell Biology. 17 (11): 679–690. doi:10.1038/nrm.2016.93. PMC 5107309. PMID 27552971.
Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, et al. (February 2012). "The sirtuin SIRT6 regulates lifespan in male mice". Nature. 483 (7388): 218–221. Bibcode:2012Natur.483..218K. doi:10.1038/nature10815. PMID 22367546. S2CID 4417564.
Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, et al. (January 2006). "Genomic instability and aging-like phenotype in the absence of mammalian SIRT6". Cell. 124 (2): 315–329. doi:10.1016/j.cell.2005.11.044. PMID 16439206. S2CID 18517518.
Tian X, Firsanov D, Seluanov A, Vera Gorbunova V (2019). "SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species". Cell. 177 (3): 622–638. doi:10.1016/j.cell.2019.03.043. PMC 6499390. PMID 31002797.
Klein MA, Denu JM (2020). "Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators". The Journal of Biological Chemistry. 295 (32): 11021–11041. doi:10.1074/jbc.REV120.011438. PMC 7415977. PMID 32518153.
McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, et al. (January 2009). "SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair". Aging. 1 (1). Albany NY: 109–121. doi:10.18632/aging.100011. PMC 2815768. PMID 20157594.
Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A (July 2012). "Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence". Proceedings of the National Academy of Sciences of the United States of America. 109 (29): 11800–11805. Bibcode:2012PNAS..10911800M. doi:10.1073/pnas.1200583109. PMC 3406824. PMID 22753495.
Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, et al. (2015). "SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner". Cell Cycle. 14 (2). Georgetown, Tex.: 269–276. doi:10.4161/15384101.2014.980641. PMC 4614943. PMID 25607651.
Feldman JL, Baeza J, Denu JM (October 2013). "Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins". The Journal of Biological Chemistry. 288 (43): 31350–31356. doi:10.1074/jbc.C113.511261. PMC 3829447. PMID 24052263.
You W, Rotili D, Li TM, Kambach C, Meleshin M, Schutkowski M, et al. (January 2017). "Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules". Angewandte Chemie. 56 (4): 1007–1011. Bibcode:2017ACIE...56.1007Y. doi:10.1002/anie.201610082. PMID 27990725.
Liu R, Li Y, Zheng Q, Ding M, Zhou H, Li X (March 2024). "Epigenetic modification in liver fibrosis: Promising therapeutic direction with significant challenges ahead". Acta Pharmaceutica Sinica. B. 14 (3): 1009–1029. doi:10.1016/j.apsb.2023.10.023. PMC 10935124. PMID 38486982.

ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: SIRT6 sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)".
Van Meter M, Mao Z, Gorbunova V, Seluanov A (2011). "Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair". Aging. 3 (9). Albany NY: 829–835. doi:10.18632/aging.100389. PMC 3227448. PMID 21946623.
Bonkowski MS, Sinclair DA (2016). "Slowing ageing by design: the rise of NAD + and sirtuin-activating compounds". Nature Reviews. Molecular Cell Biology. 17 (11): 679–690. doi:10.1038/nrm.2016.93. PMC 5107309. PMID 27552971.
Tian X, Firsanov D, Seluanov A, Vera Gorbunova V (2019). "SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species". Cell. 177 (3): 622–638. doi:10.1016/j.cell.2019.03.043. PMC 6499390. PMID 31002797.
Klein MA, Denu JM (2020). "Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators". The Journal of Biological Chemistry. 295 (32): 11021–11041. doi:10.1074/jbc.REV120.011438. PMC 7415977. PMID 32518153.
McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, et al. (January 2009). "SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair". Aging. 1 (1). Albany NY: 109–121. doi:10.18632/aging.100011. PMC 2815768. PMID 20157594.
Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A (July 2012). "Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence". Proceedings of the National Academy of Sciences of the United States of America. 109 (29): 11800–11805. Bibcode:2012PNAS..10911800M. doi:10.1073/pnas.1200583109. PMC 3406824. PMID 22753495.
Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, et al. (2015). "SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner". Cell Cycle. 14 (2). Georgetown, Tex.: 269–276. doi:10.4161/15384101.2014.980641. PMC 4614943. PMID 25607651.
Feldman JL, Baeza J, Denu JM (October 2013). "Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins". The Journal of Biological Chemistry. 288 (43): 31350–31356. doi:10.1074/jbc.C113.511261. PMC 3829447. PMID 24052263.
Liu R, Li Y, Zheng Q, Ding M, Zhou H, Li X (March 2024). "Epigenetic modification in liver fibrosis: Promising therapeutic direction with significant challenges ahead". Acta Pharmaceutica Sinica. B. 14 (3): 1009–1029. doi:10.1016/j.apsb.2023.10.023. PMC 10935124. PMID 38486982.

patsnap.com (Global: low place; English: low place)

synapse.patsnap.com

"Delving into the Latest Updates on SP-624 with Synapse". Synapse. 21 September 2024. Retrieved 23 October 2024.

semanticscholar.org (Global: 15^th place; English: 8^th place)

api.semanticscholar.org

Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, et al. (February 2012). "The sirtuin SIRT6 regulates lifespan in male mice". Nature. 483 (7388): 218–221. Bibcode:2012Natur.483..218K. doi:10.1038/nature10815. PMID 22367546. S2CID 4417564.
Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, et al. (January 2006). "Genomic instability and aging-like phenotype in the absence of mammalian SIRT6". Cell. 124 (2): 315–329. doi:10.1016/j.cell.2005.11.044. PMID 16439206. S2CID 18517518.

springer.com (Global: 182^nd place; English: 172^nd place)

adisinsight.springer.com

"SP 624". AdisInsight. 29 August 2024. Retrieved 23 October 2024.