Smoothened (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Smoothened" in English language version.

refsWebsite

Global rank English rank

52nih.gov

4^th place

30doi.org

2^nd place

9harvard.edu

18^th place

17^th place

5semanticscholar.org

11^th place

8^th place

2ensembl.org

1,626^th place

1,007^th place

1handle.net

102^nd place

76^th place

1onclive.com

low place

1cancer.gov

1,684^th place

1,350^th place

cancer.gov

Patidegib

doi.org

Ruiz-Gómez A, Molnar C, Holguín H, Mayor F, de Celis JF (April 2007). "The cell biology of Smo signalling and its relationships with GPCRs". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1768 (4): 901–12. doi:10.1016/j.bbamem.2006.09.020. hdl:10261/4737. PMID 17094938.
Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC (July 2014). "Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs". Nature Communications. 5: 4355. Bibcode:2014NatCo...5.4355W. doi:10.1038/ncomms5355. PMC 4198951. PMID 25008467.
Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA (August 2000). "Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine". Nature. 406 (6799): 1005–9. Bibcode:2000Natur.406.1005T. doi:10.1038/35023008. PMID 10984056. S2CID 4313790.
Kong JH, Siebold C, Rohatgi R (May 2019). "Biochemical mechanisms of vertebrate hedgehog signaling". Development. 146 (10): dev166892. doi:10.1242/dev.166892. PMC 6550017. PMID 31092502.
Jeng KS, Chang CF, Lin SS (January 2020). "Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments". Int J Mol Sci. 21 (3): 758. doi:10.3390/ijms21030758. PMC 7037908. PMID 31979397.
Liu X, Ding C, Tan W, Zhang A (February 2020). "Medulloblastoma: Molecular understanding, treatment evolution, and new developments". Pharmacol. Ther. 210: 107516. doi:10.1016/j.pharmthera.2020.107516. PMID 32105673. S2CID 211557426.
Laliscia C, Baldaccini D, Antonuzzo A, Paiar F (2019). "Vismodegibfor the treatment of radiation-induced basal cell carcinoma - a case report and brief literature study". Contemp Oncol (Pozn). 23 (4): 251–253. doi:10.5114/wo.2019.91540. PMC 6978755. PMID 31992959.
Liao S, Floyd C, Verratti N, Leung L, Wu C (March 2020). "Analysis of vismodegib resistance in D473G and W535L mutants of SMO receptor and design of novel drug derivatives using molecular dynamics simulations". Life Sci. 244: 117302. doi:10.1016/j.lfs.2020.117302. PMID 31953165.
Rohatgi R, Milenkovic L, Scott MP (July 2007). "Patched1 regulates hedgehog signaling at the primary cilium". Science. 317 (5836): 372–6. Bibcode:2007Sci...317..372R. doi:10.1126/science.1139740. PMID 17641202.
Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF (October 2005). "Vertebrate Smoothened functions at the primary cilium". Nature. 437 (7061): 1018–21. Bibcode:2005Natur.437.1018C. doi:10.1038/nature04117. PMID 16136078. S2CID 4431804.
Wang Y, Zhou Z, Walsh CT, McMahon AP (February 2009). "Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2623–8. Bibcode:2009PNAS..106.2623W. doi:10.1073/pnas.0812110106. PMC 2650314. PMID 19196978.
Milenkovic L, Scott MP, Rohatgi R (November 2009). "Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium". The Journal of Cell Biology. 187 (3): 365–74. doi:10.1083/jcb.200907126. PMC 2779247. PMID 19948480.
Arensdorf AM, Marada S, Ogden SK (January 2016). "Smoothened Regulation: A Tale of Two Signals". Trends in Pharmacological Sciences. 37 (1): 62–72. doi:10.1016/j.tips.2015.09.001. PMC 4593303. PMID 26432668.
Rohatgi R, Milenkovic L, Corcoran RB, Scott MP (March 2009). "Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process". Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3196–201. Bibcode:2009PNAS..106.3196R. doi:10.1073/pnas.0813373106. PMC 2642660. PMID 19218434.
Cohen MM (November 2003). "The hedgehog signaling network". American Journal of Medical Genetics. Part A. 123A (1): 5–28. doi:10.1002/ajmg.a.20495. PMID 14556242. S2CID 31906029.
Aikin RA, Ayers KL, Thérond PP (April 2008). "The role of kinases in the Hedgehog signalling pathway". EMBO Reports. 9 (4): 330–6. doi:10.1038/embor.2008.38. PMC 2288774. PMID 18379584.
Lum L, Zhang C, Oh S, Mann RK, von Kessler DP, Taipale J, Weis-Garcia F, Gong R, Wang B, Beachy PA (November 2003). "Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2". Molecular Cell. 12 (5): 1261–74. doi:10.1016/S1097-2765(03)00426-X. PMID 14636583.
Jia J, Tong C, Jiang J (November 2003). "Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail". Genes & Development. 17 (21): 2709–20. doi:10.1101/gad.1136603. PMC 280620. PMID 14597665.
Hu A, Song BL (December 2019). "The interplay of Patched, Smoothened and cholesterol in Hedgehog signaling". Curr. Opin. Cell Biol. 61: 31–38. doi:10.1016/j.ceb.2019.06.008. PMID 31369952.
Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A (July 2019). "Smoothened stimulation by membrane sterols drives Hedgehog pathway activity". Nature. 571 (7764): 284–288. doi:10.1038/s41586-019-1355-4. PMC 6709672. PMID 31263273.
Kowatsch C, Woolley RE, Kinnebrew M, Rohatgi R, Siebold C (August 2019). "Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling". Curr. Opin. Struct. Biol. 57: 204–214. doi:10.1016/j.sbi.2019.05.015. PMC 6744280. PMID 31247512.
Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R (October 2019). "Cholesterol accessibility at the ciliary membrane controls hedgehog signaling". eLife. 8. doi:10.7554/eLife.50051. PMC 6850779. PMID 31657721.
Luchetti G, Sircar R, Kong JH, Nachtergaele S, Sagner A, Byrne EF, Covey DF, Siebold C, Rohatgi R (October 2016). "Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling". eLife. 5. doi:10.7554/eLife.20304. PMC 5123864. PMID 27705744.
*Hedger G, Koldsø H, Chavent M, Siebold C, Rohatgi R, Sansom MSP (March 2019). "Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened". Structure. 27 (3): 549–559.e2. doi:10.1016/j.str.2018.11.003. PMC 6408332. PMID 30595453.
Byrne EF, Luchetti G, Rohatgi R, Siebold C (April 2018). "Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates". Curr. Opin. Cell Biol. 51: 81–88. doi:10.1016/j.ceb.2017.10.004. PMC 5949240. PMID 29268141.
Gigante ED, Caspary T (February 2020). "Signaling in the primary cilium through the lens of the Hedgehog pathway". Wiley Interdiscip Rev Dev Biol. 9 (6): e377. doi:10.1002/wdev.377. PMC 7444278. PMID 32084300.
*Weiss LE, Milenkovic L, Yoon J, Stearns T, Moerner WE (March 2019). "Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol". Proc. Natl. Acad. Sci. U.S.A. 116 (12): 5550–5557. Bibcode:2019PNAS..116.5550W. doi:10.1073/pnas.1816747116. PMC 6431229. PMID 30819883.
An X, Bai Q, Bai F, Shi D, Liu H, Yao X (2019). "Deciphering the Allosteric Effect of Antagonist Vismodegib on Smoothened Receptor Deactivation Using Metadynamics Simulation". Front Chem. 7: 406. Bibcode:2019FrCh....7..406Y. doi:10.3389/fchem.2019.00406. PMC 6558189. PMID 31214579.
Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein EH, de Sauvage FJ (January 1998). "Activating Smoothened mutations in sporadic basal-cell carcinoma". Nature. 391 (6662): 90–2. Bibcode:1998Natur.391...90X. doi:10.1038/34201. PMID 9422511. S2CID 205003240.
Blassberg R, Macrae JI, Briscoe J, Jacob J (February 2016). "Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome". Human Molecular Genetics. 25 (4): 693–705. doi:10.1093/hmg/ddv507. PMC 4743690. PMID 26685159.

ensembl.org

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000128602 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000001761 – Ensembl, May 2017

handle.net

hdl.handle.net

Ruiz-Gómez A, Molnar C, Holguín H, Mayor F, de Celis JF (April 2007). "The cell biology of Smo signalling and its relationships with GPCRs". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1768 (4): 901–12. doi:10.1016/j.bbamem.2006.09.020. hdl:10261/4737. PMID 17094938.

harvard.edu

ui.adsabs.harvard.edu

Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC (July 2014). "Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs". Nature Communications. 5: 4355. Bibcode:2014NatCo...5.4355W. doi:10.1038/ncomms5355. PMC 4198951. PMID 25008467.
Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA (August 2000). "Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine". Nature. 406 (6799): 1005–9. Bibcode:2000Natur.406.1005T. doi:10.1038/35023008. PMID 10984056. S2CID 4313790.
Rohatgi R, Milenkovic L, Scott MP (July 2007). "Patched1 regulates hedgehog signaling at the primary cilium". Science. 317 (5836): 372–6. Bibcode:2007Sci...317..372R. doi:10.1126/science.1139740. PMID 17641202.
Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF (October 2005). "Vertebrate Smoothened functions at the primary cilium". Nature. 437 (7061): 1018–21. Bibcode:2005Natur.437.1018C. doi:10.1038/nature04117. PMID 16136078. S2CID 4431804.
Wang Y, Zhou Z, Walsh CT, McMahon AP (February 2009). "Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2623–8. Bibcode:2009PNAS..106.2623W. doi:10.1073/pnas.0812110106. PMC 2650314. PMID 19196978.
Rohatgi R, Milenkovic L, Corcoran RB, Scott MP (March 2009). "Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process". Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3196–201. Bibcode:2009PNAS..106.3196R. doi:10.1073/pnas.0813373106. PMC 2642660. PMID 19218434.
*Weiss LE, Milenkovic L, Yoon J, Stearns T, Moerner WE (March 2019). "Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol". Proc. Natl. Acad. Sci. U.S.A. 116 (12): 5550–5557. Bibcode:2019PNAS..116.5550W. doi:10.1073/pnas.1816747116. PMC 6431229. PMID 30819883.
An X, Bai Q, Bai F, Shi D, Liu H, Yao X (2019). "Deciphering the Allosteric Effect of Antagonist Vismodegib on Smoothened Receptor Deactivation Using Metadynamics Simulation". Front Chem. 7: 406. Bibcode:2019FrCh....7..406Y. doi:10.3389/fchem.2019.00406. PMC 6558189. PMID 31214579.
Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein EH, de Sauvage FJ (January 1998). "Activating Smoothened mutations in sporadic basal-cell carcinoma". Nature. 391 (6662): 90–2. Bibcode:1998Natur.391...90X. doi:10.1038/34201. PMID 9422511. S2CID 205003240.

nih.gov

pubmed.ncbi.nlm.nih.gov

Ruiz-Gómez A, Molnar C, Holguín H, Mayor F, de Celis JF (April 2007). "The cell biology of Smo signalling and its relationships with GPCRs". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1768 (4): 901–12. doi:10.1016/j.bbamem.2006.09.020. hdl:10261/4737. PMID 17094938.
Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC (July 2014). "Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs". Nature Communications. 5: 4355. Bibcode:2014NatCo...5.4355W. doi:10.1038/ncomms5355. PMC 4198951. PMID 25008467.
Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA (August 2000). "Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine". Nature. 406 (6799): 1005–9. Bibcode:2000Natur.406.1005T. doi:10.1038/35023008. PMID 10984056. S2CID 4313790.
Kong JH, Siebold C, Rohatgi R (May 2019). "Biochemical mechanisms of vertebrate hedgehog signaling". Development. 146 (10): dev166892. doi:10.1242/dev.166892. PMC 6550017. PMID 31092502.
Jeng KS, Chang CF, Lin SS (January 2020). "Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments". Int J Mol Sci. 21 (3): 758. doi:10.3390/ijms21030758. PMC 7037908. PMID 31979397.
Liu X, Ding C, Tan W, Zhang A (February 2020). "Medulloblastoma: Molecular understanding, treatment evolution, and new developments". Pharmacol. Ther. 210: 107516. doi:10.1016/j.pharmthera.2020.107516. PMID 32105673. S2CID 211557426.
Laliscia C, Baldaccini D, Antonuzzo A, Paiar F (2019). "Vismodegibfor the treatment of radiation-induced basal cell carcinoma - a case report and brief literature study". Contemp Oncol (Pozn). 23 (4): 251–253. doi:10.5114/wo.2019.91540. PMC 6978755. PMID 31992959.
Liao S, Floyd C, Verratti N, Leung L, Wu C (March 2020). "Analysis of vismodegib resistance in D473G and W535L mutants of SMO receptor and design of novel drug derivatives using molecular dynamics simulations". Life Sci. 244: 117302. doi:10.1016/j.lfs.2020.117302. PMID 31953165.
Rohatgi R, Milenkovic L, Scott MP (July 2007). "Patched1 regulates hedgehog signaling at the primary cilium". Science. 317 (5836): 372–6. Bibcode:2007Sci...317..372R. doi:10.1126/science.1139740. PMID 17641202.
Corbit KC, Aanstad P, Singla V, Norman AR, Stainier DY, Reiter JF (October 2005). "Vertebrate Smoothened functions at the primary cilium". Nature. 437 (7061): 1018–21. Bibcode:2005Natur.437.1018C. doi:10.1038/nature04117. PMID 16136078. S2CID 4431804.
Wang Y, Zhou Z, Walsh CT, McMahon AP (February 2009). "Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2623–8. Bibcode:2009PNAS..106.2623W. doi:10.1073/pnas.0812110106. PMC 2650314. PMID 19196978.
Milenkovic L, Scott MP, Rohatgi R (November 2009). "Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium". The Journal of Cell Biology. 187 (3): 365–74. doi:10.1083/jcb.200907126. PMC 2779247. PMID 19948480.
Arensdorf AM, Marada S, Ogden SK (January 2016). "Smoothened Regulation: A Tale of Two Signals". Trends in Pharmacological Sciences. 37 (1): 62–72. doi:10.1016/j.tips.2015.09.001. PMC 4593303. PMID 26432668.
Rohatgi R, Milenkovic L, Corcoran RB, Scott MP (March 2009). "Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process". Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3196–201. Bibcode:2009PNAS..106.3196R. doi:10.1073/pnas.0813373106. PMC 2642660. PMID 19218434.
Cohen MM (November 2003). "The hedgehog signaling network". American Journal of Medical Genetics. Part A. 123A (1): 5–28. doi:10.1002/ajmg.a.20495. PMID 14556242. S2CID 31906029.
Aikin RA, Ayers KL, Thérond PP (April 2008). "The role of kinases in the Hedgehog signalling pathway". EMBO Reports. 9 (4): 330–6. doi:10.1038/embor.2008.38. PMC 2288774. PMID 18379584.
Lum L, Zhang C, Oh S, Mann RK, von Kessler DP, Taipale J, Weis-Garcia F, Gong R, Wang B, Beachy PA (November 2003). "Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2". Molecular Cell. 12 (5): 1261–74. doi:10.1016/S1097-2765(03)00426-X. PMID 14636583.
Jia J, Tong C, Jiang J (November 2003). "Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail". Genes & Development. 17 (21): 2709–20. doi:10.1101/gad.1136603. PMC 280620. PMID 14597665.
Hu A, Song BL (December 2019). "The interplay of Patched, Smoothened and cholesterol in Hedgehog signaling". Curr. Opin. Cell Biol. 61: 31–38. doi:10.1016/j.ceb.2019.06.008. PMID 31369952.
Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A (July 2019). "Smoothened stimulation by membrane sterols drives Hedgehog pathway activity". Nature. 571 (7764): 284–288. doi:10.1038/s41586-019-1355-4. PMC 6709672. PMID 31263273.
Kowatsch C, Woolley RE, Kinnebrew M, Rohatgi R, Siebold C (August 2019). "Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling". Curr. Opin. Struct. Biol. 57: 204–214. doi:10.1016/j.sbi.2019.05.015. PMC 6744280. PMID 31247512.
Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R (October 2019). "Cholesterol accessibility at the ciliary membrane controls hedgehog signaling". eLife. 8. doi:10.7554/eLife.50051. PMC 6850779. PMID 31657721.
Luchetti G, Sircar R, Kong JH, Nachtergaele S, Sagner A, Byrne EF, Covey DF, Siebold C, Rohatgi R (October 2016). "Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling". eLife. 5. doi:10.7554/eLife.20304. PMC 5123864. PMID 27705744.
*Hedger G, Koldsø H, Chavent M, Siebold C, Rohatgi R, Sansom MSP (March 2019). "Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened". Structure. 27 (3): 549–559.e2. doi:10.1016/j.str.2018.11.003. PMC 6408332. PMID 30595453.
Byrne EF, Luchetti G, Rohatgi R, Siebold C (April 2018). "Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates". Curr. Opin. Cell Biol. 51: 81–88. doi:10.1016/j.ceb.2017.10.004. PMC 5949240. PMID 29268141.
Gigante ED, Caspary T (February 2020). "Signaling in the primary cilium through the lens of the Hedgehog pathway". Wiley Interdiscip Rev Dev Biol. 9 (6): e377. doi:10.1002/wdev.377. PMC 7444278. PMID 32084300.
*Weiss LE, Milenkovic L, Yoon J, Stearns T, Moerner WE (March 2019). "Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol". Proc. Natl. Acad. Sci. U.S.A. 116 (12): 5550–5557. Bibcode:2019PNAS..116.5550W. doi:10.1073/pnas.1816747116. PMC 6431229. PMID 30819883.
An X, Bai Q, Bai F, Shi D, Liu H, Yao X (2019). "Deciphering the Allosteric Effect of Antagonist Vismodegib on Smoothened Receptor Deactivation Using Metadynamics Simulation". Front Chem. 7: 406. Bibcode:2019FrCh....7..406Y. doi:10.3389/fchem.2019.00406. PMC 6558189. PMID 31214579.
Xie J, Murone M, Luoh SM, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam CW, Hynes M, Goddard A, Rosenthal A, Epstein EH, de Sauvage FJ (January 1998). "Activating Smoothened mutations in sporadic basal-cell carcinoma". Nature. 391 (6662): 90–2. Bibcode:1998Natur.391...90X. doi:10.1038/34201. PMID 9422511. S2CID 205003240.
Blassberg R, Macrae JI, Briscoe J, Jacob J (February 2016). "Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome". Human Molecular Genetics. 25 (4): 693–705. doi:10.1093/hmg/ddv507. PMC 4743690. PMID 26685159.

ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wang C, Wu H, Evron T, Vardy E, Han GW, Huang XP, Hufeisen SJ, Mangano TJ, Urban DJ, Katritch V, Cherezov V, Caron MG, Roth BL, Stevens RC (July 2014). "Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs". Nature Communications. 5: 4355. Bibcode:2014NatCo...5.4355W. doi:10.1038/ncomms5355. PMC 4198951. PMID 25008467.
Kong JH, Siebold C, Rohatgi R (May 2019). "Biochemical mechanisms of vertebrate hedgehog signaling". Development. 146 (10): dev166892. doi:10.1242/dev.166892. PMC 6550017. PMID 31092502.
Jeng KS, Chang CF, Lin SS (January 2020). "Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments". Int J Mol Sci. 21 (3): 758. doi:10.3390/ijms21030758. PMC 7037908. PMID 31979397.
Laliscia C, Baldaccini D, Antonuzzo A, Paiar F (2019). "Vismodegibfor the treatment of radiation-induced basal cell carcinoma - a case report and brief literature study". Contemp Oncol (Pozn). 23 (4): 251–253. doi:10.5114/wo.2019.91540. PMC 6978755. PMID 31992959.
Wang Y, Zhou Z, Walsh CT, McMahon AP (February 2009). "Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2623–8. Bibcode:2009PNAS..106.2623W. doi:10.1073/pnas.0812110106. PMC 2650314. PMID 19196978.
Milenkovic L, Scott MP, Rohatgi R (November 2009). "Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium". The Journal of Cell Biology. 187 (3): 365–74. doi:10.1083/jcb.200907126. PMC 2779247. PMID 19948480.
Arensdorf AM, Marada S, Ogden SK (January 2016). "Smoothened Regulation: A Tale of Two Signals". Trends in Pharmacological Sciences. 37 (1): 62–72. doi:10.1016/j.tips.2015.09.001. PMC 4593303. PMID 26432668.
Rohatgi R, Milenkovic L, Corcoran RB, Scott MP (March 2009). "Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process". Proceedings of the National Academy of Sciences of the United States of America. 106 (9): 3196–201. Bibcode:2009PNAS..106.3196R. doi:10.1073/pnas.0813373106. PMC 2642660. PMID 19218434.
Aikin RA, Ayers KL, Thérond PP (April 2008). "The role of kinases in the Hedgehog signalling pathway". EMBO Reports. 9 (4): 330–6. doi:10.1038/embor.2008.38. PMC 2288774. PMID 18379584.
Jia J, Tong C, Jiang J (November 2003). "Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail". Genes & Development. 17 (21): 2709–20. doi:10.1101/gad.1136603. PMC 280620. PMID 14597665.
Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A (July 2019). "Smoothened stimulation by membrane sterols drives Hedgehog pathway activity". Nature. 571 (7764): 284–288. doi:10.1038/s41586-019-1355-4. PMC 6709672. PMID 31263273.
Kowatsch C, Woolley RE, Kinnebrew M, Rohatgi R, Siebold C (August 2019). "Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling". Curr. Opin. Struct. Biol. 57: 204–214. doi:10.1016/j.sbi.2019.05.015. PMC 6744280. PMID 31247512.
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