TAR DNA-binding protein 43 (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "TAR DNA-binding protein 43" in English language version.

refsWebsite

Global rank English rank

77nih.gov

4^th place

42doi.org

2^nd place

9semanticscholar.org

11^th place

8^th place

8harvard.edu

18^th place

17^th place

2ensembl.org

1,626^th place

1,007^th place

2science.org

1,160^th place

737^th place

1nytimes.com

7^th place

1handle.net

102^nd place

76^th place

doi.org

Ou SH, Wu F, Harrich D, García-Martínez LF, Gaynor RB (June 1995). "Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs". Journal of Virology. 69 (6): 3584–3596. doi:10.1128/JVI.69.6.3584-3596.1995. PMC 189073. PMID 7745706.
Afroz T, Hock EM, Ernst P, Foglieni C, Jambeau M, Gilhespy LA, et al. (June 2017). "Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation". Nature Communications. 8 (1): 45. Bibcode:2017NatCo...8...45A. doi:10.1038/s41467-017-00062-0. PMC 5491494. PMID 28663553.
Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, et al. (March 2018). "A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing". The EMBO Journal. 37 (5): e97452. doi:10.15252/embj.201797452. PMC 5830921. PMID 29438978.
Alcalde AI, Barcina Y, Larralde J, Ilundain A (March 1986). "Role of calcium in the phloretin effects on sugar transport in rat small intestine". Revista Espanola de Fisiologia. 42 (1): 23–28. doi:10.1038/nsmb.2698. PMID 2424061. S2CID 13783277.
Conicella AE, Zerze GH, Mittal J, Fawzi NL (September 2016). "ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain". Structure. 24 (9): 1537–1549. doi:10.1016/j.str.2016.07.007. PMC 5014597. PMID 27545621.
Vivoli Vega M, Nigro A, Luti S, Capitini C, Fani G, Gonnelli L, et al. (October 2019). "Isolation and characterization of soluble human full-length TDP-43 associated with neurodegeneration". FASEB Journal. 33 (10): 10780–10793. doi:10.1096/fj.201900474R. PMID 31287959.
Arseni D, Hasegawa M, Murzin AG, Kametani F, Arai M, Yoshida M, Ryskeldi-Falcon B (January 2022). "Structure of pathological TDP-43 filaments from ALS with FTLD". Nature. 601 (7891): 139–143. Bibcode:2022Natur.601..139A. doi:10.1038/s41586-021-04199-3. PMC 7612255. PMID 34880495.
Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, et al. (March 2022). "Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43". Nature. 605 (7909): 304–309. doi:10.1038/s41586-022-04670-9. PMC 9844993. PMID 35344984. S2CID 247777613.
Qin H, Lim LZ, Wei Y, Song J (December 2014). "TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA". Proceedings of the National Academy of Sciences of the United States of America. 111 (52): 18619–18624. Bibcode:2014PNAS..11118619Q. doi:10.1073/pnas.1413994112. PMC 4284588. PMID 25503365.
Prasad A, Bharathi V, Sivalingam V, Girdhar A, Patel BK (2019-02-14). "Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis". Frontiers in Molecular Neuroscience. 12: 25. doi:10.3389/fnmol.2019.00025. PMC 6382748. PMID 30837838.
Qin H, Lim LZ, Wei Y, Song J (December 2014). "TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA". Proceedings of the National Academy of Sciences of the United States of America. 111 (52): 18619–18624. Bibcode:2014PNAS..11118619Q. doi:10.1073/pnas.1413994112. PMC 4284588. PMID 25503365.
Ratti A, Buratti E (August 2016). "Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins". Journal of Neurochemistry. 138 (Suppl 1): 95–111. doi:10.1111/jnc.13625. PMID 27015757. S2CID 12679353.
Huang C, Yan S, Zhang Z (October 2020). "Maintaining the balance of TDP-43, mitochondria, and autophagy: a promising therapeutic strategy for neurodegenerative diseases". Translational Neurodegeneration. 9 (1): 40. doi:10.1186/s40035-020-00219-w. PMC 7597011. PMID 33126923.
Pozzi S, Thammisetty SS, Codron P, Rahimian R, Plourde KV, Soucy G, et al. (February 2019). "Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology". The Journal of Clinical Investigation. 129 (4): 1581–1595. doi:10.1172/JCI123931. PMC 6436898. PMID 30667370.
Strong MJ, Volkening K, Hammond R, Yang W, Strong W, Leystra-Lantz C, Shoesmith C (June 2007). "TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein". Molecular and Cellular Neurosciences. 35 (2): 320–327. doi:10.1016/j.mcn.2007.03.007. PMID 17481916. S2CID 42553015.
Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, et al. (July 2013). "Prion-like properties of pathological TDP-43 aggregates from diseased brains". Cell Reports. 4 (1): 124–134. doi:10.1016/j.celrep.2013.06.007. PMID 23831027.
Fan AC, Leung AK (2016). "RNA Granules and Diseases: A Case Study of Stress Granules in ALS and FTLD". In Yeo GW (ed.). RNA Processing. Advances in Experimental Medicine and Biology. Vol. 907. Cham: Springer International Publishing. pp. 263–296. doi:10.1007/978-3-319-29073-7_11. ISBN 978-3-319-29071-3. PMC 5247449. PMID 27256390.
Suk TR, Rousseaux MW (August 2020). "The role of TDP-43 mislocalization in amyotrophic lateral sclerosis". Molecular Neurodegeneration. 15 (1): 45. doi:10.1186/s13024-020-00397-1. PMC 7429473. PMID 32799899. S2CID 221129473.
Hennig S, Kong G, Mannen T, Sadowska A, Kobelke S, Blythe A, et al. (August 2015). "Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles". The Journal of Cell Biology. 210 (4): 529–539. doi:10.1083/jcb.201504117. PMC 4539981. PMID 26283796.
Buratti E, Dörk T, Zuccato E, Pagani F, Romano M, Baralle FE (April 2001). "Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping". The EMBO Journal. 20 (7): 1774–1784. doi:10.1093/emboj/20.7.1774. PMC 145463. PMID 11285240.
Kuo PH, Doudeva LG, Wang YT, Shen CK, Yuan HS (April 2009). "Structural insights into TDP-43 in nucleic-acid binding and domain interactions". Nucleic Acids Research. 37 (6): 1799–1808. doi:10.1093/nar/gkp013. PMC 2665213. PMID 19174564.
Sephton CF, Cenik C, Kucukural A, Dammer EB, Cenik B, Han Y, et al. (January 2011). "Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes". The Journal of Biological Chemistry. 286 (2): 1204–1215. doi:10.1074/jbc.M110.190884. PMC 3020728. PMID 21051541.
Buratti E, Baralle FE (September 2001). "Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9". The Journal of Biological Chemistry. 276 (39): 36337–36343. doi:10.1074/jbc.M104236200. PMID 11470789.
Mercado PA, Ayala YM, Romano M, Buratti E, Baralle FE (2005-10-12). "Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene". Nucleic Acids Research. 33 (18): 6000–6010. doi:10.1093/nar/gki897. PMC 1270946. PMID 16254078.
Wang IF, Wu LS, Chang HY, Shen CK (May 2008). "TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor". Journal of Neurochemistry. 105 (3): 797–806. doi:10.1111/j.1471-4159.2007.05190.x. PMID 18088371. S2CID 41139555.
Caragounis A, Price KA, Soon CP, Filiz G, Masters CL, Li QX, et al. (May 2010). "Zinc induces depletion and aggregation of endogenous TDP-43". Free Radical Biology & Medicine. 48 (9): 1152–1161. doi:10.1016/j.freeradbiomed.2010.01.035. PMID 20138212.
Garnier C, Devred F, Byrne D, Puppo R, Roman AY, Malesinski S, et al. (July 2017). "Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates". Scientific Reports. 7 (1): 6812. Bibcode:2017NatSR...7.6812G. doi:10.1038/s41598-017-07215-7. PMC 5533730. PMID 28754988.
Mitra J, Guerrero EN, Hegde PM, Liachko NF, Wang H, Vasquez V, et al. (March 2019). "Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects". Proceedings of the National Academy of Sciences of the United States of America. 116 (10): 4696–4705. Bibcode:2019PNAS..116.4696M. doi:10.1073/pnas.1818415116. PMC 6410842. PMID 30770445.
Mackenzie IR, Neumann M, Baborie A, Sampathu DM, Du Plessis D, Jaros E, et al. (July 2011). "A harmonized classification system for FTLD-TDP pathology". Acta Neuropathologica. 122 (1): 111–113. doi:10.1007/s00401-011-0845-8. PMC 3285143. PMID 21644037.
Bräuer S, Zimyanin V, Hermann A (April 2018). "Prion-like properties of disease-relevant proteins in amyotrophic lateral sclerosis". Journal of Neural Transmission. 125 (4): 591–613. doi:10.1007/s00702-018-1851-y. PMID 29417336. S2CID 3895544.
Lau DH, Hartopp N, Welsh NJ, Mueller S, Glennon EB, Mórotz GM, et al. (February 2018). "Disruption of ER-mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis". Cell Death & Disease. 9 (3): 327. doi:10.1038/s41419-017-0022-7. PMC 5832427. PMID 29491392.
Tremblay C, St-Amour I, Schneider J, Bennett DA, Calon F (September 2011). "Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease". Journal of Neuropathology and Experimental Neurology. 70 (9): 788–798. doi:10.1097/nen.0b013e31822c62cf. PMC 3197017. PMID 21865887.
Trejo-Lopez JA, Sorrentino ZA, Riffe CJ, Lloyd GM, Labuzan SA, Dickson DW, et al. (November 2020). "Novel monoclonal antibodies targeting the RRM2 domain of human TDP-43 protein". Neuroscience Letters. 738: 135353. doi:10.1016/j.neulet.2020.135353. PMC 7924408. PMID 32905837.
Kwong LK, Neumann M, Sampathu DM, Lee VM, Trojanowski JQ (July 2007). "TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease". Acta Neuropathologica. 114 (1): 63–70. doi:10.1007/s00401-007-0226-5. PMID 17492294. S2CID 20773388.
Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, et al. (March 2008). "TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis". Science. 319 (5870): 1668–1672. Bibcode:2008Sci...319.1668S. doi:10.1126/science.1154584. PMC 7116650. PMID 18309045. S2CID 28744172.
Gendron TF, Rademakers R, Petrucelli L (2013). "TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43". Journal of Alzheimer's Disease. 33 (Suppl 1): S35–S45. doi:10.3233/JAD-2012-129036. PMC 3532959. PMID 22751173.
Babić Leko M, Župunski V, Kirincich J, Smilović D, Hortobágyi T, Hof PR, Šimić G (2019). "Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion". Behavioural Neurology. 2019: 2909168. doi:10.1155/2019/2909168. PMC 6350563. PMID 30774737.
Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, et al. (May 2022). "Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43". Nature. 605 (7909): 304–309. doi:10.1038/s41586-022-04670-9. PMC 9844993. PMID 35344984.
Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, et al. (March 2013). "Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS". Nature. 495 (7442): 467–473. Bibcode:2013Natur.495..467K. doi:10.1038/nature11922. PMC 3756911. PMID 23455423.
.Mompeán M, Romano V, Pantoja-Uceda D, Stuani C, Baralle FE, Buratti E, Laurents DV (April 2016). "The TDP-43 N-terminal domain structure at high resolution". The FEBS Journal. 283 (7): 1242–1260. doi:10.1111/febs.13651. hdl:10261/162654. PMID 26756435.
Svahn AJ, Don EK, Badrock AP, Cole NJ, Graeber MB, Yerbury JJ, et al. (September 2018). "Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons". Acta Neuropathologica. 136 (3): 445–459. doi:10.1007/s00401-018-1875-2. PMC 6096729. PMID 29943193.
de Boer EM, Orie VK, Williams T, Baker MR, De Oliveira HM, Polvikoski T, Silsby M, Menon P, van den Bos M, Halliday GM, van den Berg LH, Van Den Bosch L, van Damme P, Kiernan MC, van Es MA, Vucic S (November 2020). "TDP-43 proteinopathies: a new wave of neurodegenerative diseases". Journal of Neurology, Neurosurgery, and Psychiatry. 92 (1): 86–95. doi:10.1136/jnnp-2020-322983. PMC 7803890. PMID 33177049.

ensembl.org

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000120948 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000041459 – Ensembl, May 2017

handle.net

hdl.handle.net

.Mompeán M, Romano V, Pantoja-Uceda D, Stuani C, Baralle FE, Buratti E, Laurents DV (April 2016). "The TDP-43 N-terminal domain structure at high resolution". The FEBS Journal. 283 (7): 1242–1260. doi:10.1111/febs.13651. hdl:10261/162654. PMID 26756435.

harvard.edu

ui.adsabs.harvard.edu

Afroz T, Hock EM, Ernst P, Foglieni C, Jambeau M, Gilhespy LA, et al. (June 2017). "Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation". Nature Communications. 8 (1): 45. Bibcode:2017NatCo...8...45A. doi:10.1038/s41467-017-00062-0. PMC 5491494. PMID 28663553.
Arseni D, Hasegawa M, Murzin AG, Kametani F, Arai M, Yoshida M, Ryskeldi-Falcon B (January 2022). "Structure of pathological TDP-43 filaments from ALS with FTLD". Nature. 601 (7891): 139–143. Bibcode:2022Natur.601..139A. doi:10.1038/s41586-021-04199-3. PMC 7612255. PMID 34880495.
Qin H, Lim LZ, Wei Y, Song J (December 2014). "TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA". Proceedings of the National Academy of Sciences of the United States of America. 111 (52): 18619–18624. Bibcode:2014PNAS..11118619Q. doi:10.1073/pnas.1413994112. PMC 4284588. PMID 25503365.
Qin H, Lim LZ, Wei Y, Song J (December 2014). "TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA". Proceedings of the National Academy of Sciences of the United States of America. 111 (52): 18619–18624. Bibcode:2014PNAS..11118619Q. doi:10.1073/pnas.1413994112. PMC 4284588. PMID 25503365.
Garnier C, Devred F, Byrne D, Puppo R, Roman AY, Malesinski S, et al. (July 2017). "Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates". Scientific Reports. 7 (1): 6812. Bibcode:2017NatSR...7.6812G. doi:10.1038/s41598-017-07215-7. PMC 5533730. PMID 28754988.
Mitra J, Guerrero EN, Hegde PM, Liachko NF, Wang H, Vasquez V, et al. (March 2019). "Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects". Proceedings of the National Academy of Sciences of the United States of America. 116 (10): 4696–4705. Bibcode:2019PNAS..116.4696M. doi:10.1073/pnas.1818415116. PMC 6410842. PMID 30770445.
Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, et al. (March 2008). "TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis". Science. 319 (5870): 1668–1672. Bibcode:2008Sci...319.1668S. doi:10.1126/science.1154584. PMC 7116650. PMID 18309045. S2CID 28744172.
Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, et al. (March 2013). "Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS". Nature. 495 (7442): 467–473. Bibcode:2013Natur.495..467K. doi:10.1038/nature11922. PMC 3756911. PMID 23455423.

nih.gov

pubmed.ncbi.nlm.nih.gov

Ou SH, Wu F, Harrich D, García-Martínez LF, Gaynor RB (June 1995). "Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs". Journal of Virology. 69 (6): 3584–3596. doi:10.1128/JVI.69.6.3584-3596.1995. PMC 189073. PMID 7745706.
Afroz T, Hock EM, Ernst P, Foglieni C, Jambeau M, Gilhespy LA, et al. (June 2017). "Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation". Nature Communications. 8 (1): 45. Bibcode:2017NatCo...8...45A. doi:10.1038/s41467-017-00062-0. PMC 5491494. PMID 28663553.
Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, et al. (March 2018). "A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing". The EMBO Journal. 37 (5): e97452. doi:10.15252/embj.201797452. PMC 5830921. PMID 29438978.
Alcalde AI, Barcina Y, Larralde J, Ilundain A (March 1986). "Role of calcium in the phloretin effects on sugar transport in rat small intestine". Revista Espanola de Fisiologia. 42 (1): 23–28. doi:10.1038/nsmb.2698. PMID 2424061. S2CID 13783277.
Conicella AE, Zerze GH, Mittal J, Fawzi NL (September 2016). "ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain". Structure. 24 (9): 1537–1549. doi:10.1016/j.str.2016.07.007. PMC 5014597. PMID 27545621.
Vivoli Vega M, Nigro A, Luti S, Capitini C, Fani G, Gonnelli L, et al. (October 2019). "Isolation and characterization of soluble human full-length TDP-43 associated with neurodegeneration". FASEB Journal. 33 (10): 10780–10793. doi:10.1096/fj.201900474R. PMID 31287959.
Arseni D, Hasegawa M, Murzin AG, Kametani F, Arai M, Yoshida M, Ryskeldi-Falcon B (January 2022). "Structure of pathological TDP-43 filaments from ALS with FTLD". Nature. 601 (7891): 139–143. Bibcode:2022Natur.601..139A. doi:10.1038/s41586-021-04199-3. PMC 7612255. PMID 34880495.
Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, et al. (March 2022). "Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43". Nature. 605 (7909): 304–309. doi:10.1038/s41586-022-04670-9. PMC 9844993. PMID 35344984. S2CID 247777613.
Qin H, Lim LZ, Wei Y, Song J (December 2014). "TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA". Proceedings of the National Academy of Sciences of the United States of America. 111 (52): 18619–18624. Bibcode:2014PNAS..11118619Q. doi:10.1073/pnas.1413994112. PMC 4284588. PMID 25503365.
Prasad A, Bharathi V, Sivalingam V, Girdhar A, Patel BK (2019-02-14). "Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis". Frontiers in Molecular Neuroscience. 12: 25. doi:10.3389/fnmol.2019.00025. PMC 6382748. PMID 30837838.
Qin H, Lim LZ, Wei Y, Song J (December 2014). "TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA". Proceedings of the National Academy of Sciences of the United States of America. 111 (52): 18619–18624. Bibcode:2014PNAS..11118619Q. doi:10.1073/pnas.1413994112. PMC 4284588. PMID 25503365.
Ratti A, Buratti E (August 2016). "Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins". Journal of Neurochemistry. 138 (Suppl 1): 95–111. doi:10.1111/jnc.13625. PMID 27015757. S2CID 12679353.
Huang C, Yan S, Zhang Z (October 2020). "Maintaining the balance of TDP-43, mitochondria, and autophagy: a promising therapeutic strategy for neurodegenerative diseases". Translational Neurodegeneration. 9 (1): 40. doi:10.1186/s40035-020-00219-w. PMC 7597011. PMID 33126923.
Pozzi S, Thammisetty SS, Codron P, Rahimian R, Plourde KV, Soucy G, et al. (February 2019). "Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology". The Journal of Clinical Investigation. 129 (4): 1581–1595. doi:10.1172/JCI123931. PMC 6436898. PMID 30667370.
Strong MJ, Volkening K, Hammond R, Yang W, Strong W, Leystra-Lantz C, Shoesmith C (June 2007). "TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein". Molecular and Cellular Neurosciences. 35 (2): 320–327. doi:10.1016/j.mcn.2007.03.007. PMID 17481916. S2CID 42553015.
Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, et al. (July 2013). "Prion-like properties of pathological TDP-43 aggregates from diseased brains". Cell Reports. 4 (1): 124–134. doi:10.1016/j.celrep.2013.06.007. PMID 23831027.
Fan AC, Leung AK (2016). "RNA Granules and Diseases: A Case Study of Stress Granules in ALS and FTLD". In Yeo GW (ed.). RNA Processing. Advances in Experimental Medicine and Biology. Vol. 907. Cham: Springer International Publishing. pp. 263–296. doi:10.1007/978-3-319-29073-7_11. ISBN 978-3-319-29071-3. PMC 5247449. PMID 27256390.
Suk TR, Rousseaux MW (August 2020). "The role of TDP-43 mislocalization in amyotrophic lateral sclerosis". Molecular Neurodegeneration. 15 (1): 45. doi:10.1186/s13024-020-00397-1. PMC 7429473. PMID 32799899. S2CID 221129473.
Hennig S, Kong G, Mannen T, Sadowska A, Kobelke S, Blythe A, et al. (August 2015). "Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles". The Journal of Cell Biology. 210 (4): 529–539. doi:10.1083/jcb.201504117. PMC 4539981. PMID 26283796.
Buratti E, Dörk T, Zuccato E, Pagani F, Romano M, Baralle FE (April 2001). "Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping". The EMBO Journal. 20 (7): 1774–1784. doi:10.1093/emboj/20.7.1774. PMC 145463. PMID 11285240.
Kuo PH, Doudeva LG, Wang YT, Shen CK, Yuan HS (April 2009). "Structural insights into TDP-43 in nucleic-acid binding and domain interactions". Nucleic Acids Research. 37 (6): 1799–1808. doi:10.1093/nar/gkp013. PMC 2665213. PMID 19174564.
Sephton CF, Cenik C, Kucukural A, Dammer EB, Cenik B, Han Y, et al. (January 2011). "Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes". The Journal of Biological Chemistry. 286 (2): 1204–1215. doi:10.1074/jbc.M110.190884. PMC 3020728. PMID 21051541.
Buratti E, Baralle FE (September 2001). "Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9". The Journal of Biological Chemistry. 276 (39): 36337–36343. doi:10.1074/jbc.M104236200. PMID 11470789.
Mercado PA, Ayala YM, Romano M, Buratti E, Baralle FE (2005-10-12). "Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene". Nucleic Acids Research. 33 (18): 6000–6010. doi:10.1093/nar/gki897. PMC 1270946. PMID 16254078.
Wang IF, Wu LS, Chang HY, Shen CK (May 2008). "TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor". Journal of Neurochemistry. 105 (3): 797–806. doi:10.1111/j.1471-4159.2007.05190.x. PMID 18088371. S2CID 41139555.
Caragounis A, Price KA, Soon CP, Filiz G, Masters CL, Li QX, et al. (May 2010). "Zinc induces depletion and aggregation of endogenous TDP-43". Free Radical Biology & Medicine. 48 (9): 1152–1161. doi:10.1016/j.freeradbiomed.2010.01.035. PMID 20138212.
Garnier C, Devred F, Byrne D, Puppo R, Roman AY, Malesinski S, et al. (July 2017). "Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates". Scientific Reports. 7 (1): 6812. Bibcode:2017NatSR...7.6812G. doi:10.1038/s41598-017-07215-7. PMC 5533730. PMID 28754988.
Mitra J, Guerrero EN, Hegde PM, Liachko NF, Wang H, Vasquez V, et al. (March 2019). "Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects". Proceedings of the National Academy of Sciences of the United States of America. 116 (10): 4696–4705. Bibcode:2019PNAS..116.4696M. doi:10.1073/pnas.1818415116. PMC 6410842. PMID 30770445.
Mackenzie IR, Neumann M, Baborie A, Sampathu DM, Du Plessis D, Jaros E, et al. (July 2011). "A harmonized classification system for FTLD-TDP pathology". Acta Neuropathologica. 122 (1): 111–113. doi:10.1007/s00401-011-0845-8. PMC 3285143. PMID 21644037.
Bräuer S, Zimyanin V, Hermann A (April 2018). "Prion-like properties of disease-relevant proteins in amyotrophic lateral sclerosis". Journal of Neural Transmission. 125 (4): 591–613. doi:10.1007/s00702-018-1851-y. PMID 29417336. S2CID 3895544.
Lau DH, Hartopp N, Welsh NJ, Mueller S, Glennon EB, Mórotz GM, et al. (February 2018). "Disruption of ER-mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis". Cell Death & Disease. 9 (3): 327. doi:10.1038/s41419-017-0022-7. PMC 5832427. PMID 29491392.
Tremblay C, St-Amour I, Schneider J, Bennett DA, Calon F (September 2011). "Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease". Journal of Neuropathology and Experimental Neurology. 70 (9): 788–798. doi:10.1097/nen.0b013e31822c62cf. PMC 3197017. PMID 21865887.
Trejo-Lopez JA, Sorrentino ZA, Riffe CJ, Lloyd GM, Labuzan SA, Dickson DW, et al. (November 2020). "Novel monoclonal antibodies targeting the RRM2 domain of human TDP-43 protein". Neuroscience Letters. 738: 135353. doi:10.1016/j.neulet.2020.135353. PMC 7924408. PMID 32905837.
Kwong LK, Neumann M, Sampathu DM, Lee VM, Trojanowski JQ (July 2007). "TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease". Acta Neuropathologica. 114 (1): 63–70. doi:10.1007/s00401-007-0226-5. PMID 17492294. S2CID 20773388.
Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, et al. (March 2008). "TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis". Science. 319 (5870): 1668–1672. Bibcode:2008Sci...319.1668S. doi:10.1126/science.1154584. PMC 7116650. PMID 18309045. S2CID 28744172.
Gendron TF, Rademakers R, Petrucelli L (2013). "TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43". Journal of Alzheimer's Disease. 33 (Suppl 1): S35–S45. doi:10.3233/JAD-2012-129036. PMC 3532959. PMID 22751173.
Babić Leko M, Župunski V, Kirincich J, Smilović D, Hortobágyi T, Hof PR, Šimić G (2019). "Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion". Behavioural Neurology. 2019: 2909168. doi:10.1155/2019/2909168. PMC 6350563. PMID 30774737.
Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, et al. (May 2022). "Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43". Nature. 605 (7909): 304–309. doi:10.1038/s41586-022-04670-9. PMC 9844993. PMID 35344984.
Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, et al. (March 2013). "Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS". Nature. 495 (7442): 467–473. Bibcode:2013Natur.495..467K. doi:10.1038/nature11922. PMC 3756911. PMID 23455423.
.Mompeán M, Romano V, Pantoja-Uceda D, Stuani C, Baralle FE, Buratti E, Laurents DV (April 2016). "The TDP-43 N-terminal domain structure at high resolution". The FEBS Journal. 283 (7): 1242–1260. doi:10.1111/febs.13651. hdl:10261/162654. PMID 26756435.
Svahn AJ, Don EK, Badrock AP, Cole NJ, Graeber MB, Yerbury JJ, et al. (September 2018). "Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons". Acta Neuropathologica. 136 (3): 445–459. doi:10.1007/s00401-018-1875-2. PMC 6096729. PMID 29943193.
de Boer EM, Orie VK, Williams T, Baker MR, De Oliveira HM, Polvikoski T, Silsby M, Menon P, van den Bos M, Halliday GM, van den Berg LH, Van Den Bosch L, van Damme P, Kiernan MC, van Es MA, Vucic S (November 2020). "TDP-43 proteinopathies: a new wave of neurodegenerative diseases". Journal of Neurology, Neurosurgery, and Psychiatry. 92 (1): 86–95. doi:10.1136/jnnp-2020-322983. PMC 7803890. PMID 33177049.

ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ou SH, Wu F, Harrich D, García-Martínez LF, Gaynor RB (June 1995). "Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs". Journal of Virology. 69 (6): 3584–3596. doi:10.1128/JVI.69.6.3584-3596.1995. PMC 189073. PMID 7745706.
Afroz T, Hock EM, Ernst P, Foglieni C, Jambeau M, Gilhespy LA, et al. (June 2017). "Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation". Nature Communications. 8 (1): 45. Bibcode:2017NatCo...8...45A. doi:10.1038/s41467-017-00062-0. PMC 5491494. PMID 28663553.
Wang A, Conicella AE, Schmidt HB, Martin EW, Rhoads SN, Reeb AN, et al. (March 2018). "A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing". The EMBO Journal. 37 (5): e97452. doi:10.15252/embj.201797452. PMC 5830921. PMID 29438978.
Conicella AE, Zerze GH, Mittal J, Fawzi NL (September 2016). "ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain". Structure. 24 (9): 1537–1549. doi:10.1016/j.str.2016.07.007. PMC 5014597. PMID 27545621.
Arseni D, Hasegawa M, Murzin AG, Kametani F, Arai M, Yoshida M, Ryskeldi-Falcon B (January 2022). "Structure of pathological TDP-43 filaments from ALS with FTLD". Nature. 601 (7891): 139–143. Bibcode:2022Natur.601..139A. doi:10.1038/s41586-021-04199-3. PMC 7612255. PMID 34880495.
Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, et al. (March 2022). "Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43". Nature. 605 (7909): 304–309. doi:10.1038/s41586-022-04670-9. PMC 9844993. PMID 35344984. S2CID 247777613.
Qin H, Lim LZ, Wei Y, Song J (December 2014). "TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA". Proceedings of the National Academy of Sciences of the United States of America. 111 (52): 18619–18624. Bibcode:2014PNAS..11118619Q. doi:10.1073/pnas.1413994112. PMC 4284588. PMID 25503365.
Prasad A, Bharathi V, Sivalingam V, Girdhar A, Patel BK (2019-02-14). "Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis". Frontiers in Molecular Neuroscience. 12: 25. doi:10.3389/fnmol.2019.00025. PMC 6382748. PMID 30837838.
"TARDBP TAR DNA binding protein [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-12-13.
Qin H, Lim LZ, Wei Y, Song J (December 2014). "TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA". Proceedings of the National Academy of Sciences of the United States of America. 111 (52): 18619–18624. Bibcode:2014PNAS..11118619Q. doi:10.1073/pnas.1413994112. PMC 4284588. PMID 25503365.
Huang C, Yan S, Zhang Z (October 2020). "Maintaining the balance of TDP-43, mitochondria, and autophagy: a promising therapeutic strategy for neurodegenerative diseases". Translational Neurodegeneration. 9 (1): 40. doi:10.1186/s40035-020-00219-w. PMC 7597011. PMID 33126923.
Pozzi S, Thammisetty SS, Codron P, Rahimian R, Plourde KV, Soucy G, et al. (February 2019). "Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology". The Journal of Clinical Investigation. 129 (4): 1581–1595. doi:10.1172/JCI123931. PMC 6436898. PMID 30667370.
Fan AC, Leung AK (2016). "RNA Granules and Diseases: A Case Study of Stress Granules in ALS and FTLD". In Yeo GW (ed.). RNA Processing. Advances in Experimental Medicine and Biology. Vol. 907. Cham: Springer International Publishing. pp. 263–296. doi:10.1007/978-3-319-29073-7_11. ISBN 978-3-319-29071-3. PMC 5247449. PMID 27256390.
Suk TR, Rousseaux MW (August 2020). "The role of TDP-43 mislocalization in amyotrophic lateral sclerosis". Molecular Neurodegeneration. 15 (1): 45. doi:10.1186/s13024-020-00397-1. PMC 7429473. PMID 32799899. S2CID 221129473.
Hennig S, Kong G, Mannen T, Sadowska A, Kobelke S, Blythe A, et al. (August 2015). "Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles". The Journal of Cell Biology. 210 (4): 529–539. doi:10.1083/jcb.201504117. PMC 4539981. PMID 26283796.
Buratti E, Dörk T, Zuccato E, Pagani F, Romano M, Baralle FE (April 2001). "Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping". The EMBO Journal. 20 (7): 1774–1784. doi:10.1093/emboj/20.7.1774. PMC 145463. PMID 11285240.
Kuo PH, Doudeva LG, Wang YT, Shen CK, Yuan HS (April 2009). "Structural insights into TDP-43 in nucleic-acid binding and domain interactions". Nucleic Acids Research. 37 (6): 1799–1808. doi:10.1093/nar/gkp013. PMC 2665213. PMID 19174564.
Gene Result
Sephton CF, Cenik C, Kucukural A, Dammer EB, Cenik B, Han Y, et al. (January 2011). "Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes". The Journal of Biological Chemistry. 286 (2): 1204–1215. doi:10.1074/jbc.M110.190884. PMC 3020728. PMID 21051541.
Mercado PA, Ayala YM, Romano M, Buratti E, Baralle FE (2005-10-12). "Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene". Nucleic Acids Research. 33 (18): 6000–6010. doi:10.1093/nar/gki897. PMC 1270946. PMID 16254078.
Garnier C, Devred F, Byrne D, Puppo R, Roman AY, Malesinski S, et al. (July 2017). "Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates". Scientific Reports. 7 (1): 6812. Bibcode:2017NatSR...7.6812G. doi:10.1038/s41598-017-07215-7. PMC 5533730. PMID 28754988.
Mitra J, Guerrero EN, Hegde PM, Liachko NF, Wang H, Vasquez V, et al. (March 2019). "Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects". Proceedings of the National Academy of Sciences of the United States of America. 116 (10): 4696–4705. Bibcode:2019PNAS..116.4696M. doi:10.1073/pnas.1818415116. PMC 6410842. PMID 30770445.
Mackenzie IR, Neumann M, Baborie A, Sampathu DM, Du Plessis D, Jaros E, et al. (July 2011). "A harmonized classification system for FTLD-TDP pathology". Acta Neuropathologica. 122 (1): 111–113. doi:10.1007/s00401-011-0845-8. PMC 3285143. PMID 21644037.
Lau DH, Hartopp N, Welsh NJ, Mueller S, Glennon EB, Mórotz GM, et al. (February 2018). "Disruption of ER-mitochondria signalling in fronto-temporal dementia and related amyotrophic lateral sclerosis". Cell Death & Disease. 9 (3): 327. doi:10.1038/s41419-017-0022-7. PMC 5832427. PMID 29491392.
Tremblay C, St-Amour I, Schneider J, Bennett DA, Calon F (September 2011). "Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease". Journal of Neuropathology and Experimental Neurology. 70 (9): 788–798. doi:10.1097/nen.0b013e31822c62cf. PMC 3197017. PMID 21865887.
Trejo-Lopez JA, Sorrentino ZA, Riffe CJ, Lloyd GM, Labuzan SA, Dickson DW, et al. (November 2020). "Novel monoclonal antibodies targeting the RRM2 domain of human TDP-43 protein". Neuroscience Letters. 738: 135353. doi:10.1016/j.neulet.2020.135353. PMC 7924408. PMID 32905837.
Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, et al. (March 2008). "TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis". Science. 319 (5870): 1668–1672. Bibcode:2008Sci...319.1668S. doi:10.1126/science.1154584. PMC 7116650. PMID 18309045. S2CID 28744172.
Gendron TF, Rademakers R, Petrucelli L (2013). "TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43". Journal of Alzheimer's Disease. 33 (Suppl 1): S35–S45. doi:10.3233/JAD-2012-129036. PMC 3532959. PMID 22751173.
Babić Leko M, Župunski V, Kirincich J, Smilović D, Hortobágyi T, Hof PR, Šimić G (2019). "Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion". Behavioural Neurology. 2019: 2909168. doi:10.1155/2019/2909168. PMC 6350563. PMID 30774737.
Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, et al. (May 2022). "Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43". Nature. 605 (7909): 304–309. doi:10.1038/s41586-022-04670-9. PMC 9844993. PMID 35344984.
Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, et al. (March 2013). "Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS". Nature. 495 (7442): 467–473. Bibcode:2013Natur.495..467K. doi:10.1038/nature11922. PMC 3756911. PMID 23455423.
Svahn AJ, Don EK, Badrock AP, Cole NJ, Graeber MB, Yerbury JJ, et al. (September 2018). "Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons". Acta Neuropathologica. 136 (3): 445–459. doi:10.1007/s00401-018-1875-2. PMC 6096729. PMID 29943193.
de Boer EM, Orie VK, Williams T, Baker MR, De Oliveira HM, Polvikoski T, Silsby M, Menon P, van den Bos M, Halliday GM, van den Berg LH, Van Den Bosch L, van Damme P, Kiernan MC, van Es MA, Vucic S (November 2020). "TDP-43 proteinopathies: a new wave of neurodegenerative diseases". Journal of Neurology, Neurosurgery, and Psychiatry. 92 (1): 86–95. doi:10.1136/jnnp-2020-322983. PMC 7803890. PMID 33177049.

nytimes.com

Schwarz, Alan. "Study Says Brain Trauma Can Mimic A.L.S.", The New York Times, August 18, 2010. Accessed August 18, 2010.

science.org

"An ALS Protein, Revealed". www.science.org. Retrieved 2022-04-04.
"Frontotemporal Dementia: Not the Protein We Thought". www.science.org. Retrieved 2022-04-04.

semanticscholar.org

api.semanticscholar.org

Alcalde AI, Barcina Y, Larralde J, Ilundain A (March 1986). "Role of calcium in the phloretin effects on sugar transport in rat small intestine". Revista Espanola de Fisiologia. 42 (1): 23–28. doi:10.1038/nsmb.2698. PMID 2424061. S2CID 13783277.
Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, et al. (March 2022). "Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43". Nature. 605 (7909): 304–309. doi:10.1038/s41586-022-04670-9. PMC 9844993. PMID 35344984. S2CID 247777613.
Ratti A, Buratti E (August 2016). "Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins". Journal of Neurochemistry. 138 (Suppl 1): 95–111. doi:10.1111/jnc.13625. PMID 27015757. S2CID 12679353.
Strong MJ, Volkening K, Hammond R, Yang W, Strong W, Leystra-Lantz C, Shoesmith C (June 2007). "TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein". Molecular and Cellular Neurosciences. 35 (2): 320–327. doi:10.1016/j.mcn.2007.03.007. PMID 17481916. S2CID 42553015.
Suk TR, Rousseaux MW (August 2020). "The role of TDP-43 mislocalization in amyotrophic lateral sclerosis". Molecular Neurodegeneration. 15 (1): 45. doi:10.1186/s13024-020-00397-1. PMC 7429473. PMID 32799899. S2CID 221129473.
Wang IF, Wu LS, Chang HY, Shen CK (May 2008). "TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor". Journal of Neurochemistry. 105 (3): 797–806. doi:10.1111/j.1471-4159.2007.05190.x. PMID 18088371. S2CID 41139555.
Bräuer S, Zimyanin V, Hermann A (April 2018). "Prion-like properties of disease-relevant proteins in amyotrophic lateral sclerosis". Journal of Neural Transmission. 125 (4): 591–613. doi:10.1007/s00702-018-1851-y. PMID 29417336. S2CID 3895544.
Kwong LK, Neumann M, Sampathu DM, Lee VM, Trojanowski JQ (July 2007). "TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease". Acta Neuropathologica. 114 (1): 63–70. doi:10.1007/s00401-007-0226-5. PMID 17492294. S2CID 20773388.
Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, et al. (March 2008). "TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis". Science. 319 (5870): 1668–1672. Bibcode:2008Sci...319.1668S. doi:10.1126/science.1154584. PMC 7116650. PMID 18309045. S2CID 28744172.