Terminal deoxynucleotidyl transferase (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Terminal deoxynucleotidyl transferase" in English language version.

refsWebsite

Global rank English rank

35nih.gov

4^th place

25doi.org

2^nd place

5semanticscholar.org

11^th place

8^th place

2ensembl.org

1,626^th place

1,007^th place

2harvard.edu

18^th place

17^th place

1archives-ouvertes.fr

1,031^st place

879^th place

1unil.ch

9,112^th place

7,304^th place

1handle.net

102^nd place

76^th place

1escholarship.org

1,523^rd place

976^th place

1osti.gov

2,036^th place

1,254^th place

archives-ouvertes.fr

hal-pasteur.archives-ouvertes.fr

Loc'h J, Delarue M (December 2018). "Terminal deoxynucleotidyltransferase: the story of an untemplated DNA polymerase capable of DNA bridging and templated synthesis across strands" (PDF). Current Opinion in Structural Biology. 53: 22–31. doi:10.1016/j.sbi.2018.03.019. PMID 29656238. S2CID 4882661.

doi.org

Isobe M, Huebner K, Erikson J, Peterson RC, Bollum FJ, Chang LM, et al. (September 1985). "Chromosome localization of the gene for human terminal deoxynucleotidyltransferase to region 10q23-q25". Proceedings of the National Academy of Sciences of the United States of America. 82 (17): 5836–40. Bibcode:1985PNAS...82.5836I. doi:10.1073/pnas.82.17.5836. PMC 390648. PMID 3862101.
Yang-Feng TL, Landau NR, Baltimore D, Francke U (1986). "The terminal deoxynucleotidyltransferase gene is located on human chromosome 10 (10q23----q24) and on mouse chromosome 19". Cytogenetics and Cell Genetics. 43 (3–4): 121–6. doi:10.1159/000132309. PMID 3467897.
Motea EA, Berdis AJ (May 2010). "Terminal deoxynucleotidyl transferase: the story of a misguided DNA polymerase". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1804 (5): 1151–66. doi:10.1016/j.bbapap.2009.06.030. PMC 2846215. PMID 19596089.
Haeryfar SM, Hickman HD, Irvine KR, Tscharke DC, Bennink JR, Yewdell JW (July 2008). "Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies". Journal of Immunology. 181 (1): 649–59. doi:10.4049/jimmunol.181.1.649. PMC 2587314. PMID 18566432.
Bollum FJ (August 1960). "Calf thymus polymerase". The Journal of Biological Chemistry. 235 (8): 2399–403. doi:10.1016/S0021-9258(18)64634-4. PMID 13802334.
Gouge J, Rosario S, Romain F, Poitevin F, Béguin P, Delarue M (April 2015). "Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair". The EMBO Journal. 34 (8): 1126–42. doi:10.15252/embj.201489643. PMC 4406656. PMID 25762590.
Loc'h J, Delarue M (December 2018). "Terminal deoxynucleotidyltransferase: the story of an untemplated DNA polymerase capable of DNA bridging and templated synthesis across strands" (PDF). Current Opinion in Structural Biology. 53: 22–31. doi:10.1016/j.sbi.2018.03.019. PMID 29656238. S2CID 4882661.
Ramadan K, Shevelev IV, Maga G, Hübscher U (May 2004). "De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase". Journal of Molecular Biology. 339 (2): 395–404. doi:10.1016/j.jmb.2004.03.056. PMID 15136041.
Bollum FJ, Chang LM, Tsiapalis CM, Dorson JW (1974). "[8] Nucleotide polymerizing enzymes from calf thymus gland". Nucleotide polymerizing enzymes from calf thymus gland. Methods in Enzymology. Vol. 29. pp. 70–81. doi:10.1016/0076-6879(74)29010-4. ISBN 9780121818920. PMID 4853390.
Chang LM, Bollum FJ (April 1970). "Doxynucleotide-polymerizing enzymes of calf thymus gland. IV. Inhibition of terminal deoxynucleotidyl transferase by metal ligands". Proceedings of the National Academy of Sciences of the United States of America. 65 (4): 1041–8. Bibcode:1970PNAS...65.1041C. doi:10.1073/pnas.65.4.1041. PMC 283020. PMID 4985880.
Deibel MR, Coleman MS (May 1980). "Biochemical properties of purified human terminal deoxynucleotidyltransferase". The Journal of Biological Chemistry. 255 (9): 4206–12. doi:10.1016/S0021-9258(19)85653-3. PMID 7372675.
Cherrier M, D'Andon MF, Rougeon F, Doyen N (February 2008). "Identification of a new cis-regulatory element of the terminal deoxynucleotidyl transferase gene in the 5' region of the murine locus". Molecular Immunology. 45 (4): 1009–17. doi:10.1016/j.molimm.2007.07.027. PMID 17854898.
Kubota T, Maezawa S, Koiwai K, Hayano T, Koiwai O (August 2007). "Identification of functional domains in TdIF1 and its inhibitory mechanism for TdT activity". Genes to Cells. 12 (8): 941–59. doi:10.1111/j.1365-2443.2007.01105.x. PMID 17663723. S2CID 25530793.
Zhang Y, Shi M, Wen Q, Luo W, Yang Z, Zhou M, et al. (2012-01-01). "Antigenic stimulation induces recombination activating gene 1 and terminal deoxynucleotidyl transferase expression in a murine T-cell hybridoma". Cellular Immunology. 274 (1–2): 19–25. doi:10.1016/j.cellimm.2012.02.008. PMID 22464913.
Vashishtha AK, Wang J, Konigsberg WH (September 2016). "Different Divalent Cations Alter the Kinetics and Fidelity of DNA Polymerases". The Journal of Biological Chemistry. 291 (40): 20869–20875. doi:10.1074/jbc.R116.742494. PMC 5076500. PMID 27462081.
Delarue M, Boulé JB, Lescar J, Expert-Bezançon N, Jourdan N, Sukumar N, et al. (February 2002). "Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase". The EMBO Journal. 21 (3): 427–39. doi:10.1093/emboj/21.3.427. PMC 125842. PMID 11823435.{{cite journal}}: CS1 maint: overridden setting (link)
Steenberg ML, Lokhandwala MF, Jandhyala BS (1988). "Abnormalities in the sodium transport as the causative factor for enhanced norepinephrine overflow in the spontaneously hypertensive rat". Clinical & Experimental Hypertension, Part A. 10 (5): 833–41. doi:10.1080/07300077.1988.11878788. PMID 2846215.
Schmoldt A, Benthe HF, Haberland G (September 1975). "Digitoxin metabolism by rat liver microsomes". Biochemical Pharmacology. 24 (17): 1639–41. doi:10.1016/0006-2952(75)90094-5. hdl:10033/333424. PMID 10.
Thai TH, Kearney JF (September 2004). "Distinct and opposite activities of human terminal deoxynucleotidyltransferase splice variants". Journal of Immunology. 173 (6): 4009–19. doi:10.4049/jimmunol.173.6.4009. PMID 15356150. S2CID 40193319.
Thai TH, Kearney JF (2005). Isoforms of Terminal Deoxynucleotidyltransferase: Developmental Aspects and Function. Advances in Immunology. Vol. 86. pp. 113–36. doi:10.1016/S0065-2776(04)86003-6. ISBN 9780120044863. PMID 15705420.
Bland RD, Clarke TL, Harden LB (February 1976). "Rapid infusion of sodium bicarbonate and albumin into high-risk premature infants soon after birth: a controlled, prospective trial". American Journal of Obstetrics and Gynecology. 124 (3): 263–7. doi:10.1016/0002-9378(76)90154-x. PMID 2013.
Martin MJ, Blanco L (July 2014). "Decision-making during NHEJ: a network of interactions in human Polμ implicated in substrate recognition and end-bridging". Nucleic Acids Research. 42 (12): 7923–34. doi:10.1093/nar/gku475. PMC 4081086. PMID 24878922.
Maga G, Ramadan K, Locatelli GA, Shevelev I, Spadari S, Hübscher U (January 2005). "DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A". The Journal of Biological Chemistry. 280 (3): 1971–81. doi:10.1074/jbc.M411650200. PMID 15537631. S2CID 43322190.
Faber J, Kantarjian H, Roberts MW, Keating M, Freireich E, Albitar M (January 2000). "Terminal deoxynucleotidyl transferase-negative acute lymphoblastic leukemia". Archives of Pathology & Laboratory Medicine. 124 (1): 92–7. doi:10.5858/2000-124-0092-TDTNAL. PMID 10629138.
Palluk S, Arlow DH, de Rond T, Barthel S, Kang JS, Bector R, et al. (August 2018). "De novo DNA synthesis using polymerase-nucleotide conjugates". Nature Biotechnology. 36 (7): 645–650. doi:10.1038/nbt.4173. OSTI 1461176. PMID 29912208. S2CID 49271982.

ensembl.org

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000107447 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025014 – Ensembl, May 2017

escholarship.org

Palluk S, Arlow DH, de Rond T, Barthel S, Kang JS, Bector R, et al. (August 2018). "De novo DNA synthesis using polymerase-nucleotide conjugates". Nature Biotechnology. 36 (7): 645–650. doi:10.1038/nbt.4173. OSTI 1461176. PMID 29912208. S2CID 49271982.

handle.net

hdl.handle.net

Schmoldt A, Benthe HF, Haberland G (September 1975). "Digitoxin metabolism by rat liver microsomes". Biochemical Pharmacology. 24 (17): 1639–41. doi:10.1016/0006-2952(75)90094-5. hdl:10033/333424. PMID 10.

harvard.edu

ui.adsabs.harvard.edu

Isobe M, Huebner K, Erikson J, Peterson RC, Bollum FJ, Chang LM, et al. (September 1985). "Chromosome localization of the gene for human terminal deoxynucleotidyltransferase to region 10q23-q25". Proceedings of the National Academy of Sciences of the United States of America. 82 (17): 5836–40. Bibcode:1985PNAS...82.5836I. doi:10.1073/pnas.82.17.5836. PMC 390648. PMID 3862101.
Chang LM, Bollum FJ (April 1970). "Doxynucleotide-polymerizing enzymes of calf thymus gland. IV. Inhibition of terminal deoxynucleotidyl transferase by metal ligands". Proceedings of the National Academy of Sciences of the United States of America. 65 (4): 1041–8. Bibcode:1970PNAS...65.1041C. doi:10.1073/pnas.65.4.1041. PMC 283020. PMID 4985880.

nih.gov

pubmed.ncbi.nlm.nih.gov

Isobe M, Huebner K, Erikson J, Peterson RC, Bollum FJ, Chang LM, et al. (September 1985). "Chromosome localization of the gene for human terminal deoxynucleotidyltransferase to region 10q23-q25". Proceedings of the National Academy of Sciences of the United States of America. 82 (17): 5836–40. Bibcode:1985PNAS...82.5836I. doi:10.1073/pnas.82.17.5836. PMC 390648. PMID 3862101.
Yang-Feng TL, Landau NR, Baltimore D, Francke U (1986). "The terminal deoxynucleotidyltransferase gene is located on human chromosome 10 (10q23----q24) and on mouse chromosome 19". Cytogenetics and Cell Genetics. 43 (3–4): 121–6. doi:10.1159/000132309. PMID 3467897.
Motea EA, Berdis AJ (May 2010). "Terminal deoxynucleotidyl transferase: the story of a misguided DNA polymerase". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1804 (5): 1151–66. doi:10.1016/j.bbapap.2009.06.030. PMC 2846215. PMID 19596089.
Haeryfar SM, Hickman HD, Irvine KR, Tscharke DC, Bennink JR, Yewdell JW (July 2008). "Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies". Journal of Immunology. 181 (1): 649–59. doi:10.4049/jimmunol.181.1.649. PMC 2587314. PMID 18566432.
Bollum FJ (August 1960). "Calf thymus polymerase". The Journal of Biological Chemistry. 235 (8): 2399–403. doi:10.1016/S0021-9258(18)64634-4. PMID 13802334.
Gouge J, Rosario S, Romain F, Poitevin F, Béguin P, Delarue M (April 2015). "Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair". The EMBO Journal. 34 (8): 1126–42. doi:10.15252/embj.201489643. PMC 4406656. PMID 25762590.
Loc'h J, Delarue M (December 2018). "Terminal deoxynucleotidyltransferase: the story of an untemplated DNA polymerase capable of DNA bridging and templated synthesis across strands" (PDF). Current Opinion in Structural Biology. 53: 22–31. doi:10.1016/j.sbi.2018.03.019. PMID 29656238. S2CID 4882661.
Ramadan K, Shevelev IV, Maga G, Hübscher U (May 2004). "De novo DNA synthesis by human DNA polymerase lambda, DNA polymerase mu and terminal deoxyribonucleotidyl transferase". Journal of Molecular Biology. 339 (2): 395–404. doi:10.1016/j.jmb.2004.03.056. PMID 15136041.
Bollum FJ, Chang LM, Tsiapalis CM, Dorson JW (1974). "[8] Nucleotide polymerizing enzymes from calf thymus gland". Nucleotide polymerizing enzymes from calf thymus gland. Methods in Enzymology. Vol. 29. pp. 70–81. doi:10.1016/0076-6879(74)29010-4. ISBN 9780121818920. PMID 4853390.
Chang LM, Bollum FJ (April 1970). "Doxynucleotide-polymerizing enzymes of calf thymus gland. IV. Inhibition of terminal deoxynucleotidyl transferase by metal ligands". Proceedings of the National Academy of Sciences of the United States of America. 65 (4): 1041–8. Bibcode:1970PNAS...65.1041C. doi:10.1073/pnas.65.4.1041. PMC 283020. PMID 4985880.
Deibel MR, Coleman MS (May 1980). "Biochemical properties of purified human terminal deoxynucleotidyltransferase". The Journal of Biological Chemistry. 255 (9): 4206–12. doi:10.1016/S0021-9258(19)85653-3. PMID 7372675.
Cherrier M, D'Andon MF, Rougeon F, Doyen N (February 2008). "Identification of a new cis-regulatory element of the terminal deoxynucleotidyl transferase gene in the 5' region of the murine locus". Molecular Immunology. 45 (4): 1009–17. doi:10.1016/j.molimm.2007.07.027. PMID 17854898.
Kubota T, Maezawa S, Koiwai K, Hayano T, Koiwai O (August 2007). "Identification of functional domains in TdIF1 and its inhibitory mechanism for TdT activity". Genes to Cells. 12 (8): 941–59. doi:10.1111/j.1365-2443.2007.01105.x. PMID 17663723. S2CID 25530793.
Zhang Y, Shi M, Wen Q, Luo W, Yang Z, Zhou M, et al. (2012-01-01). "Antigenic stimulation induces recombination activating gene 1 and terminal deoxynucleotidyl transferase expression in a murine T-cell hybridoma". Cellular Immunology. 274 (1–2): 19–25. doi:10.1016/j.cellimm.2012.02.008. PMID 22464913.
Vashishtha AK, Wang J, Konigsberg WH (September 2016). "Different Divalent Cations Alter the Kinetics and Fidelity of DNA Polymerases". The Journal of Biological Chemistry. 291 (40): 20869–20875. doi:10.1074/jbc.R116.742494. PMC 5076500. PMID 27462081.
Delarue M, Boulé JB, Lescar J, Expert-Bezançon N, Jourdan N, Sukumar N, et al. (February 2002). "Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase". The EMBO Journal. 21 (3): 427–39. doi:10.1093/emboj/21.3.427. PMC 125842. PMID 11823435.{{cite journal}}: CS1 maint: overridden setting (link)
Steenberg ML, Lokhandwala MF, Jandhyala BS (1988). "Abnormalities in the sodium transport as the causative factor for enhanced norepinephrine overflow in the spontaneously hypertensive rat". Clinical & Experimental Hypertension, Part A. 10 (5): 833–41. doi:10.1080/07300077.1988.11878788. PMID 2846215.
Schmoldt A, Benthe HF, Haberland G (September 1975). "Digitoxin metabolism by rat liver microsomes". Biochemical Pharmacology. 24 (17): 1639–41. doi:10.1016/0006-2952(75)90094-5. hdl:10033/333424. PMID 10.
Thai TH, Kearney JF (September 2004). "Distinct and opposite activities of human terminal deoxynucleotidyltransferase splice variants". Journal of Immunology. 173 (6): 4009–19. doi:10.4049/jimmunol.173.6.4009. PMID 15356150. S2CID 40193319.
Thai TH, Kearney JF (2005). Isoforms of Terminal Deoxynucleotidyltransferase: Developmental Aspects and Function. Advances in Immunology. Vol. 86. pp. 113–36. doi:10.1016/S0065-2776(04)86003-6. ISBN 9780120044863. PMID 15705420.
Bland RD, Clarke TL, Harden LB (February 1976). "Rapid infusion of sodium bicarbonate and albumin into high-risk premature infants soon after birth: a controlled, prospective trial". American Journal of Obstetrics and Gynecology. 124 (3): 263–7. doi:10.1016/0002-9378(76)90154-x. PMID 2013.
Martin MJ, Blanco L (July 2014). "Decision-making during NHEJ: a network of interactions in human Polμ implicated in substrate recognition and end-bridging". Nucleic Acids Research. 42 (12): 7923–34. doi:10.1093/nar/gku475. PMC 4081086. PMID 24878922.
Maga G, Ramadan K, Locatelli GA, Shevelev I, Spadari S, Hübscher U (January 2005). "DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A". The Journal of Biological Chemistry. 280 (3): 1971–81. doi:10.1074/jbc.M411650200. PMID 15537631. S2CID 43322190.
Faber J, Kantarjian H, Roberts MW, Keating M, Freireich E, Albitar M (January 2000). "Terminal deoxynucleotidyl transferase-negative acute lymphoblastic leukemia". Archives of Pathology & Laboratory Medicine. 124 (1): 92–7. doi:10.5858/2000-124-0092-TDTNAL. PMID 10629138.
Palluk S, Arlow DH, de Rond T, Barthel S, Kang JS, Bector R, et al. (August 2018). "De novo DNA synthesis using polymerase-nucleotide conjugates". Nature Biotechnology. 36 (7): 645–650. doi:10.1038/nbt.4173. OSTI 1461176. PMID 29912208. S2CID 49271982.

ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Isobe M, Huebner K, Erikson J, Peterson RC, Bollum FJ, Chang LM, et al. (September 1985). "Chromosome localization of the gene for human terminal deoxynucleotidyltransferase to region 10q23-q25". Proceedings of the National Academy of Sciences of the United States of America. 82 (17): 5836–40. Bibcode:1985PNAS...82.5836I. doi:10.1073/pnas.82.17.5836. PMC 390648. PMID 3862101.
Motea EA, Berdis AJ (May 2010). "Terminal deoxynucleotidyl transferase: the story of a misguided DNA polymerase". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1804 (5): 1151–66. doi:10.1016/j.bbapap.2009.06.030. PMC 2846215. PMID 19596089.
Haeryfar SM, Hickman HD, Irvine KR, Tscharke DC, Bennink JR, Yewdell JW (July 2008). "Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies". Journal of Immunology. 181 (1): 649–59. doi:10.4049/jimmunol.181.1.649. PMC 2587314. PMID 18566432.
Gouge J, Rosario S, Romain F, Poitevin F, Béguin P, Delarue M (April 2015). "Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair". The EMBO Journal. 34 (8): 1126–42. doi:10.15252/embj.201489643. PMC 4406656. PMID 25762590.
Chang LM, Bollum FJ (April 1970). "Doxynucleotide-polymerizing enzymes of calf thymus gland. IV. Inhibition of terminal deoxynucleotidyl transferase by metal ligands". Proceedings of the National Academy of Sciences of the United States of America. 65 (4): 1041–8. Bibcode:1970PNAS...65.1041C. doi:10.1073/pnas.65.4.1041. PMC 283020. PMID 4985880.
Vashishtha AK, Wang J, Konigsberg WH (September 2016). "Different Divalent Cations Alter the Kinetics and Fidelity of DNA Polymerases". The Journal of Biological Chemistry. 291 (40): 20869–20875. doi:10.1074/jbc.R116.742494. PMC 5076500. PMID 27462081.
Delarue M, Boulé JB, Lescar J, Expert-Bezançon N, Jourdan N, Sukumar N, et al. (February 2002). "Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase". The EMBO Journal. 21 (3): 427–39. doi:10.1093/emboj/21.3.427. PMC 125842. PMID 11823435.{{cite journal}}: CS1 maint: overridden setting (link)
Martin MJ, Blanco L (July 2014). "Decision-making during NHEJ: a network of interactions in human Polμ implicated in substrate recognition and end-bridging". Nucleic Acids Research. 42 (12): 7923–34. doi:10.1093/nar/gku475. PMC 4081086. PMID 24878922.

osti.gov

Palluk S, Arlow DH, de Rond T, Barthel S, Kang JS, Bector R, et al. (August 2018). "De novo DNA synthesis using polymerase-nucleotide conjugates". Nature Biotechnology. 36 (7): 645–650. doi:10.1038/nbt.4173. OSTI 1461176. PMID 29912208. S2CID 49271982.

semanticscholar.org

api.semanticscholar.org

Loc'h J, Delarue M (December 2018). "Terminal deoxynucleotidyltransferase: the story of an untemplated DNA polymerase capable of DNA bridging and templated synthesis across strands" (PDF). Current Opinion in Structural Biology. 53: 22–31. doi:10.1016/j.sbi.2018.03.019. PMID 29656238. S2CID 4882661.
Kubota T, Maezawa S, Koiwai K, Hayano T, Koiwai O (August 2007). "Identification of functional domains in TdIF1 and its inhibitory mechanism for TdT activity". Genes to Cells. 12 (8): 941–59. doi:10.1111/j.1365-2443.2007.01105.x. PMID 17663723. S2CID 25530793.
Thai TH, Kearney JF (September 2004). "Distinct and opposite activities of human terminal deoxynucleotidyltransferase splice variants". Journal of Immunology. 173 (6): 4009–19. doi:10.4049/jimmunol.173.6.4009. PMID 15356150. S2CID 40193319.
Maga G, Ramadan K, Locatelli GA, Shevelev I, Spadari S, Hübscher U (January 2005). "DNA elongation by the human DNA polymerase lambda polymerase and terminal transferase activities are differentially coordinated by proliferating cell nuclear antigen and replication protein A". The Journal of Biological Chemistry. 280 (3): 1971–81. doi:10.1074/jbc.M411650200. PMID 15537631. S2CID 43322190.
Palluk S, Arlow DH, de Rond T, Barthel S, Kang JS, Bector R, et al. (August 2018). "De novo DNA synthesis using polymerase-nucleotide conjugates". Nature Biotechnology. 36 (7): 645–650. doi:10.1038/nbt.4173. OSTI 1461176. PMID 29912208. S2CID 49271982.

unil.ch

serval.unil.ch

Schmoldt A, Benthe HF, Haberland G (September 1975). "Digitoxin metabolism by rat liver microsomes". Biochemical Pharmacology. 24 (17): 1639–41. doi:10.1016/0006-2952(75)90094-5. hdl:10033/333424. PMID 10.