Thrombotic thrombocytopenic purpura (English Wikipedia)

Clinical trial number NCT05468320 for "Caplacizumab and Immunosuppressive Therapy Without Firstline Therapeutic Plasma Exchange in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura (MAYARI)" at ClinicalTrials.gov

cmaj.ca

Arnold DM, Patriquin CJ, Nazy I (January 2017). "Thrombotic microangiopathies: a general approach to diagnosis and management". CMAJ. 189 (4): E153 – E159. doi:10.1503/cmaj.160142. ISSN 0820-3946. PMC 5266569. PMID 27754896.

doi.org

Kremer Hovinga JA, Coppo P, Lämmle B, Moake JL, Miyata T, Vanhoorelbeke K (April 2017). "Thrombotic thrombocytopenic purpura". Nature Reviews Disease Primers. 3 17020: 17020. doi:10.1038/nrdp.2017.20. ISSN 2056-676X. PMID 28382967. S2CID 11960153.
Joly BS, Coppo P, Veyradier A (May 2017). "Thrombotic thrombocytopenic purpura". Blood. 129 (21): 2836–46. doi:10.1182/blood-2016-10-709857. ISSN 0006-4971. PMID 28416507. S2CID 2543348.
George JN (November 2010). "How I treat patients with thrombotic thrombocytopenic purpura: 2010". Blood. 116 (20): 4060–9. doi:10.1182/blood-2010-07-271445. ISSN 0006-4971. PMID 20686117. S2CID 26844964.
Moake JL (January 2004). "Von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura". Seminars in Hematology. 41 (1): 4–14. doi:10.1053/j.seminhematol.2003.10.003. ISSN 0037-1963. PMID 14727254.
Shatzel JJ, Taylor JA (March 2017). "Syndromes of Thrombotic Microangiopathy". Medical Clinics of North America. 101 (2): 395–415. doi:10.1016/j.mcna.2016.09.010. ISSN 0025-7125. PMID 28189178. S2CID 24123004.
Shibagaki Y, Fujita T (January 2005). "Thrombotic Microangiopathy in Malignant Hypertension and Hemolytic Uremic Syndrome (HUS)/Thrombotic Thrombocytopenic Purpura (TTP): Can We Differentiate One from the Other?". Hypertension Research. 28 (1): 89–95. doi:10.1291/hypres.28.89. ISSN 1348-4214. PMID 15969259. S2CID 139098502.
Chiasakul T, Cuker A (November 2018). "Clinical and laboratory diagnosis of TTP: an integrated approach". Hematology. 2018 (1): 530–8. doi:10.1182/asheducation-2018.1.530. ISSN 1520-4391. PMC 6246034. PMID 30504354. S2CID 54564230.
Moake JL (August 2022). "Thrombotic Microangiopathies". New England Journal of Medicine. 347 (8): 589–600. doi:10.1056/NEJMra020528. ISSN 0028-4793. PMID 12192020. S2CID 40055198.
Moake JL (November 1998). "Moschcowitz, Multimers, and Metalloprotease". New England Journal of Medicine. 339 (22): 1629–31. doi:10.1056/NEJM199811263392210. ISSN 0028-4793. PMID 9828253.
Conboy E, Partain PI, Warad D, Kluge ML, Arndt C, Chen D, Rodriguez V (January 2018). "A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting From Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant". Journal of Pediatric Hematology/Oncology. 40 (1): 60–62. doi:10.1097/MPH.0000000000000895. ISSN 1077-4114. PMID 28678087. S2CID 3470460.
Lämmle B, Hovinga JA, George JN (February 2008). "Acquired thrombotic thrombocytopenic purpura: ADAMTS13 activity, anti-ADAMTS13 autoantibodies and risk of recurrent disease". Haematologica. 93 (2): 172–7. doi:10.3324/haematol.12701. ISSN 1592-8721. PMID 18245649. S2CID 17777111.
Kremer Hovinga JA, George JN (October 2019). Longo DL (ed.). "Hereditary Thrombotic Thrombocytopenic Purpura". New England Journal of Medicine. 381 (17): 1653–62. doi:10.1056/NEJMra1813013. ISSN 0028-4793. PMID 31644845. S2CID 204864996.
Chapman K, Seldon M, Richards R (February 2012). "Thrombotic Microangiopathies, Thrombotic Thrombocytopenic Purpura, and ADAMTS-13". Seminars in Thrombosis and Hemostasis. 38 (1): 47–54. doi:10.1055/s-0031-1300951. ISSN 0094-6176. PMID 22314603. S2CID 13963783.
Levy GG, Nichols WC, Lian EC, Foroud T, McClintick JN, McGee BM, Yang AY, Siemieniak DR, Stark KR, Gruppo R, Sarode R, Shurin SB, Chandrasekaran V, Stabler SP, Sabio H (October 2001). "Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura". Nature. 413 (6855): 488–494. Bibcode:2001Natur.413..488L. doi:10.1038/35097008. hdl:2027.42/62592. ISSN 1476-4687. PMID 11586351. S2CID 4380010.
Kokame K, Matsumoto M, Soejima K, Yagi H, Ishizashi H, Funato M, Tamai H, Konno M, Kamide K, Kawano Y, Miyata T, Fujimura Y (September 2002). "Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity". Proceedings of the National Academy of Sciences. 99 (18): 11902–7. Bibcode:2002PNAS...9911902K. doi:10.1073/pnas.172277399. ISSN 0027-8424. PMC 129366. PMID 12181489. S2CID 20496927.
Seidizadeh O, Cairo A, Mancini I, George JN, Peyvandi F (August 2024). "Global prevalence of hereditary thrombotic thrombocytopenic purpura determined by genetic analysis". Blood Adv. 8 (16): 4386–96. doi:10.1182/bloodadvances.2024013421. PMC 11375255. PMID 38935915.
van Mourik JA, Boertjes R, Huisveld IA, Fijnvandraat K, Pajkrt D, van Genderen PJ, Fijnheer R (1999-07-01). "von Willebrand Factor Propeptide in Vascular Disorders: A Tool to Distinguish Between Acute and Chronic Endothelial Cell Perturbation". Blood. 94 (1): 179–185. doi:10.1182/blood.V94.1.179.413k18_179_185. ISSN 1528-0020. PMID 10381511.
Tsai HM (January 2010). "Pathophysiology of thrombotic thrombocytopenic purpura". International Journal of Hematology. 91 (1): 1–19. doi:10.1007/s12185-009-0476-1. ISSN 1865-3774. PMC 3159000. PMID 20058209.
Han B, Page EE, Stewart LM, Deford CC, Scott JG, Schwartz LH, Perdue JJ, Terrell DR, Vesely SK, George JN (August 2018). "Depression and cognitive impairment following recovery from thrombotic thrombocytopenic purpura: Depression and Cognitive Impairment Following TTP". American Journal of Hematology. 90 (8): 709–714. doi:10.1002/ajh.24060. PMC 4509840. PMID 25975932.
Bendapudi PK, Hurwitz S, Fry A, Marques MB, Waldo SW, Li A, Sun L, Upadhyay V, Hamdan A, Brunner AM, Gansner JM, Viswanathan S, Kaufman RM, Uhl L, Stowell CP, Dzik WH, Makar RS (April 2017). "Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study". Lancet Haematol. 4 (4): e157 – e164. doi:10.1016/S2352-3026(17)30026-1. PMID 28259520.
Bentley MJ, Lehman CM, Blaylock RC, Wilson AR, Rodgers GM (August 2010). "The utility of patient characteristics in predicting severe ADAMTS13 deficiency and response to plasma exchange". Transfusion. 50 (8): 1654–64. doi:10.1111/j.1537-2995.2010.02653.x. PMID 20412532.
Coppo P, Schwarzinger M, Buffet M, Wynckel A, Clabault K, Presne C, Poullin P, Malot S, Vanhille P, Azoulay E, Galicier L, Lemiale V, Mira JP, Ridel C, Rondeau E, Pourrat J, Girault S, Bordessoule D, Saheb S, Ramakers M, Hamidou M, Vernant JP, Guidet B, Wolf M, Veyradier A (April 2010). "Predictive features of severe acquired ADAMTS13 deficiency in idiopathic thrombotic microangiopathies: the French TMA reference center experience". PLOS ONE. 5 (4): e10208. Bibcode:2010PLoSO...510208C. doi:10.1371/journal.pone.0010208. PMC 2859048. PMID 20436664.
Park SH, Kim HK, Jeong J, Lee SH, Lee YJ, Kim YJ, Jo JC, Lim JH (September 2023). "Performance Validation of Three Scoring Systems for the Prediction of Thrombotic Microangiopathy Due to Severe ADAMTS13 Deficiency and the Response to Therapeutic Plasma Exchange: First Study in Korea". Ann Lab Med. 43 (5): 485–492. doi:10.3343/alm.2023.43.5.485. PMC 10151285. PMID 37080750.
Zheng XL, Vesely SK, Cataland SR, Coppo P, Geldziler B, Iorio A, Matsumoto M, Mustafa RA, Pai M, Rock G, Russell L, Tarawneh R, Valdes J, Peyvandi F (October 2020). "ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura". J Thromb Haemost. 18 (10): 2486–95. doi:10.1111/jth.15006. PMC 8146131. PMID 32914582.
Arnold DM, Patriquin CJ, Nazy I (January 2017). "Thrombotic microangiopathies: a general approach to diagnosis and management". CMAJ. 189 (4): E153 – E159. doi:10.1503/cmaj.160142. ISSN 0820-3946. PMC 5266569. PMID 27754896.
Abrams CS (2012). "Thrombocytopenia". In Goldman L, Schafer AI (eds.). Goldman's Cecil Medicine. Vol. 1 (24th ed.). Elsevier. pp. 1124–31. doi:10.1016/B978-1-4377-1604-7.00175-5. ISBN 978-1437716047. In contrast to TTP, HUS is not caused by a deficiency of ADAMTS13.
Feng S, Eyler SJ, Zhang Y, Maga T, Nester CM, Kroll MH, Smith RJ, Afshar-Kharghan V (August 2013). "Partial ADAMTS13 deficiency in atypical hemolytic uremic syndrome". Blood. 122 (8): 1487–93. doi:10.1182/blood-2013-03-492421. ISSN 1528-0020. PMC 3750341. PMID 23847193. Complement dysregulation leads to atypical hemolytic uremic syndrome (aHUS), while ADAMTS13 deficiency causes thrombotic thrombocytopenic purpura.
Cataland, Spero R.; Wu, Haifeng M. (April 2014). "How I treat: the clinical differentiation and initial treatment of adult patients with atypical hemolytic uremic syndrome". Blood. 123 (16): 2478–84. doi:10.1182/blood-2013-11-516237. ISSN 0006-4971. PMID 24599547.
Bitzan M, Schaefer F, Reymond D (September 2010). "Treatment of typical (enteropathic) hemolytic uremic syndrome". Seminars in Thrombosis and Hemostasis. 36 (6): 594–610. doi:10.1055/s-0030-1262881. ISSN 1098-9064. PMID 20865636. S2CID 6129618.
Michael, M; Elliott, EJ; Ridley, GF; Hodson, EM; Craig, JC (January 2009). "Interventions for haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura". The Cochrane Database of Systematic Reviews. 1 (1): CD003595–CD003595–63. doi:10.1002/14651858.CD003595.pub2. hdl:10072/61440. PMC 7154575. PMID 19160220.
Lim W, Vesely SK, George JN (March 2015). "The role of rituximab in the management of patients with acquired thrombotic thrombocytopenic purpura". Blood. 125 (10): 1526–31. doi:10.1182/blood-2014-10-559211. PMC 4351502. PMID 25573992.
Allford SL, Hunt BJ, Rose P, Machin SJ (February 2003). "Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias". British Journal of Haematology. 120 (4): 556–73. doi:10.1046/j.1365-2141.2003.04049.x. PMID 12588343. S2CID 38774829.
Peyvandi F, Scully M, Kremer Hovinga JA, Cataland S, Knöbl P, Wu H, Artoni A, Westwood JP, Mansouri Taleghani M (February 2016). "Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura". New England Journal of Medicine. 374 (6): 511–522. doi:10.1056/NEJMoa1505533. hdl:2434/829303. ISSN 0028-4793. PMID 26863353. S2CID 19482364.
Goshua G, Bendapudi PK (December 2022). "Evidence-Based Minireview: Should caplacizumab be used routinely in unselected patients with immune thrombotic thrombocytopenic purpura?". Hematology. 2022 (1): 491–4. doi:10.1182/hematology.2022000412. ISSN 1520-4391. PMC 9820987. PMID 36485149.
Goshua G, Sinha P, Hendrickson JE, Tormey C, Bendapudi PK, Lee AI (February 2021). "Cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura". Blood. 137 (7): 969–976. doi:10.1182/blood.2020006052. PMC 7918179. PMID 33280030.
Völker LA, Brinkkoetter PT, Knöbl PN, Krstic M, Kaufeld J, Menne J, Buxhofer-Ausch V, Miesbach W (November 2020). "Treatment of acquired thrombotic thrombocytopenic purpura without plasma exchange in selected patients under caplacizumab". J Thromb Haemost. 18 (11): 3061–6. doi:10.1111/jth.15045. PMC 7692904. PMID 32757435.
Zheng XL, Vesely SK, Cataland SR, Coppo P, Geldziler B, Iorio A, Matsumoto M, Mustafa RA, Pai M, Rock G, Russell L, Tarawneh R, Valdes J, Peyvandi F (October 2020). "ISTH guidelines for treatment of thrombotic thrombocytopenic purpura". J Thromb Haemost. 18 (10): 2496–2502. doi:10.1111/jth.15010. PMC 8091490. PMID 32914526.
Loirat C, Girma JP, Desconclois C, Coppo P, Veyradier A (January 2009). "Thrombotic thrombocytopenic purpura related to severe ADAMTS13 deficiency in children". Pediatric Nephrology. 24 (1): 19–29. doi:10.1007/s00467-008-0863-5. ISSN 1432-198X. PMID 18574602. S2CID 22209831.
Saha M, McDaniel J, Zheng X (October 2010). "Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics". Journal of Thrombosis and Haemostasis. 15 (10): 1889–1900. doi:10.1111/jth.13764. ISSN 1538-7836. PMC 5630501. PMID 28662310. S2CID 40493167.
Scully M, Antun A, Cataland SR, Coppo P, Dossier C, Biebuyck N, Hassenpflug WA, Kentouche K, Knöbl P, Kremer Hovinga JA, López-Fernández MF, Matsumoto M, Ortel TL, Windyga J, Bhattacharya I, Cronin M, Li H, Mellgård B, Patel M, Patwari P, Xiao S, Zhang P, Wang LT (May 2024). "Recombinant ADAMTS13 in Congenital Thrombotic Thrombocytopenic Purpura". N Engl J Med. 390 (17): 1584–96. doi:10.1056/NEJMoa2314793. PMID 38692292.
Tsai HM (February 2006). "Current Concepts in Thrombotic Thrombocytopenic Purpura". Annual Review of Medicine. 57: 419–436. doi:10.1146/annurev.med.57.061804.084505. PMC 2426955. PMID 16409158.
Terrell DR, Williams LA, Vesely SK, Lämmle B, Hovinga JA, George JN (July 2005). "The incidence of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: all patients, idiopathic patients, and patients with severe ADAMTS-13 deficiency". Journal of Thrombosis and Haemostasis. 3 (7): 1432–6. doi:10.1111/j.1538-7836.2005.01436.x. PMID 15978100. S2CID 24914279.
Terrell DR, Vesely SK, Kremer Hovinga JA, Lämmle B, George JN (November 2010). "Different disparities of gender and race among the thrombotic thrombocytopenic purpura and hemolytic-uremic syndromes". American Journal of Hematology. 85 (11): 844–7. doi:10.1002/ajh.21833. PMC 3420337. PMID 20799358. S2CID 23118040.
Martino, Suella; Jamme, Mathieu; Deligny, Christophe; Busson, Marc; Loiseau, Pascale; Azoulay, Elie; Galicier, Lionel; Pène, Frédéric; Provôt, François; Dossier, Antoine; Saheb, Samir; Veyradier, Agnès; Coppo, Paul; Microangiopathies, French Reference Center for Thrombotic (2016-07-06). "Thrombotic Thrombocytopenic Purpura in Black People: Impact of Ethnicity on Survival and Genetic Risk Factors". PLOS ONE. 11 (7): e0156679. Bibcode:2016PLoSO..1156679M. doi:10.1371/journal.pone.0156679. ISSN 1932-6203. PMC 4934773. PMID 27383202.
Zheng XL, Sadler JE (2008). "Pathogenesis of Thrombotic Microangiopathies". Annual Review of Pathology. 3: 249–277. doi:10.1146/annurev.pathmechdis.3.121806.154311. PMC 2582586. PMID 18215115.
Sukumar S, Lämmle B, Cataland SR (January 2021). "Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, and Management". Journal of Clinical Medicine. 10 (3): 536. doi:10.3390/jcm10030536. ISSN 2077-0383. PMC 7867179. PMID 33540569.
Moschcowitz E (1924). "Hyaline Thrombosis of the Terminal Arterioles and Capillaries: A Hitherto Undescribed Disease". Proceedings of the New York Pathological Society. 24: 21–24.
- —— (1925). "An Acute Febrile Pleiochromic Anemia with Hyaline Thrombosis of the Terminal Arterioles and Capillaries: An Undescribed Disease". Archives of Internal Medicine. 36 (1): 89–93. doi:10.1001/archinte.1925.00120130092009. ISSN 0730-188X:
- Amorosi EL, Ultmann JE (March 1966). "Thrombotic thrombocytopenic purpura: report of 16 cases and review of the literature". Medicine. 45 (2): 139. doi:10.1097/00005792-196603000-00003. S2CID 71943329.
- Sadler, JE (2008). "Von Willerbrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura". Blood. 112 (1): 11–18. doi:10.1182/blood-2008-02-078170. PMC 2435681. PMID 18574040.
- Rock GA, Shumak KH, Buskard NA, et al. (August 1991). "Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group". New England Journal of Medicine. 325 (6): 393–7. doi:10.1056/NEJM199108083250604. PMID 2062330.

fda.gov

"FDA Approves First Treatment for Patients with Rare Inherited Blood Clotting Disorder". U.S. Food and Drug Administration (Press release). 9 November 2023. Retrieved 30 November 2023.

haematologica.org

Lämmle B, Hovinga JA, George JN (February 2008). "Acquired thrombotic thrombocytopenic purpura: ADAMTS13 activity, anti-ADAMTS13 autoantibodies and risk of recurrent disease". Haematologica. 93 (2): 172–7. doi:10.3324/haematol.12701. ISSN 1592-8721. PMID 18245649. S2CID 17777111.
Iwata H, Kami M, Hori A, Hamaki T, Takeuchi K, Mutou Y (June 2001). "An autopsy-based retrospective study of secondary thrombotic thrombocytopenic purpura". Haematologica. 86 (6): 669–70. PMID 11418383.

handle.net

hdl.handle.net

Levy GG, Nichols WC, Lian EC, Foroud T, McClintick JN, McGee BM, Yang AY, Siemieniak DR, Stark KR, Gruppo R, Sarode R, Shurin SB, Chandrasekaran V, Stabler SP, Sabio H (October 2001). "Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura". Nature. 413 (6855): 488–494. Bibcode:2001Natur.413..488L. doi:10.1038/35097008. hdl:2027.42/62592. ISSN 1476-4687. PMID 11586351. S2CID 4380010.
Michael, M; Elliott, EJ; Ridley, GF; Hodson, EM; Craig, JC (January 2009). "Interventions for haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura". The Cochrane Database of Systematic Reviews. 1 (1): CD003595–CD003595–63. doi:10.1002/14651858.CD003595.pub2. hdl:10072/61440. PMC 7154575. PMID 19160220.
Peyvandi F, Scully M, Kremer Hovinga JA, Cataland S, Knöbl P, Wu H, Artoni A, Westwood JP, Mansouri Taleghani M (February 2016). "Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura". New England Journal of Medicine. 374 (6): 511–522. doi:10.1056/NEJMoa1505533. hdl:2434/829303. ISSN 0028-4793. PMID 26863353. S2CID 19482364.

harvard.edu

ui.adsabs.harvard.edu

Levy GG, Nichols WC, Lian EC, Foroud T, McClintick JN, McGee BM, Yang AY, Siemieniak DR, Stark KR, Gruppo R, Sarode R, Shurin SB, Chandrasekaran V, Stabler SP, Sabio H (October 2001). "Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura". Nature. 413 (6855): 488–494. Bibcode:2001Natur.413..488L. doi:10.1038/35097008. hdl:2027.42/62592. ISSN 1476-4687. PMID 11586351. S2CID 4380010.
Kokame K, Matsumoto M, Soejima K, Yagi H, Ishizashi H, Funato M, Tamai H, Konno M, Kamide K, Kawano Y, Miyata T, Fujimura Y (September 2002). "Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity". Proceedings of the National Academy of Sciences. 99 (18): 11902–7. Bibcode:2002PNAS...9911902K. doi:10.1073/pnas.172277399. ISSN 0027-8424. PMC 129366. PMID 12181489. S2CID 20496927.
Coppo P, Schwarzinger M, Buffet M, Wynckel A, Clabault K, Presne C, Poullin P, Malot S, Vanhille P, Azoulay E, Galicier L, Lemiale V, Mira JP, Ridel C, Rondeau E, Pourrat J, Girault S, Bordessoule D, Saheb S, Ramakers M, Hamidou M, Vernant JP, Guidet B, Wolf M, Veyradier A (April 2010). "Predictive features of severe acquired ADAMTS13 deficiency in idiopathic thrombotic microangiopathies: the French TMA reference center experience". PLOS ONE. 5 (4): e10208. Bibcode:2010PLoSO...510208C. doi:10.1371/journal.pone.0010208. PMC 2859048. PMID 20436664.
Martino, Suella; Jamme, Mathieu; Deligny, Christophe; Busson, Marc; Loiseau, Pascale; Azoulay, Elie; Galicier, Lionel; Pène, Frédéric; Provôt, François; Dossier, Antoine; Saheb, Samir; Veyradier, Agnès; Coppo, Paul; Microangiopathies, French Reference Center for Thrombotic (2016-07-06). "Thrombotic Thrombocytopenic Purpura in Black People: Impact of Ethnicity on Survival and Genetic Risk Factors". PLOS ONE. 11 (7): e0156679. Bibcode:2016PLoSO..1156679M. doi:10.1371/journal.pone.0156679. ISSN 1932-6203. PMC 4934773. PMID 27383202.

jthjournal.org

Terrell DR, Williams LA, Vesely SK, Lämmle B, Hovinga JA, George JN (July 2005). "The incidence of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: all patients, idiopathic patients, and patients with severe ADAMTS-13 deficiency". Journal of Thrombosis and Haemostasis. 3 (7): 1432–6. doi:10.1111/j.1538-7836.2005.01436.x. PMID 15978100. S2CID 24914279.

lww.com

journals.lww.com

Conboy E, Partain PI, Warad D, Kluge ML, Arndt C, Chen D, Rodriguez V (January 2018). "A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting From Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant". Journal of Pediatric Hematology/Oncology. 40 (1): 60–62. doi:10.1097/MPH.0000000000000895. ISSN 1077-4114. PMID 28678087. S2CID 3470460.
Amorosi EL, Ultmann JE (March 1966). "Thrombotic thrombocytopenic purpura: report of 16 cases and review of the literature". Medicine. 45 (2): 139. doi:10.1097/00005792-196603000-00003. S2CID 71943329.

medlineplus.gov

"Thrombotic thrombocytopenic purpura". MedlinePlus Genetics. National Library of Medicine.

nature.com

Kremer Hovinga JA, Coppo P, Lämmle B, Moake JL, Miyata T, Vanhoorelbeke K (April 2017). "Thrombotic thrombocytopenic purpura". Nature Reviews Disease Primers. 3 17020: 17020. doi:10.1038/nrdp.2017.20. ISSN 2056-676X. PMID 28382967. S2CID 11960153.

nejm.org

Moake JL (August 2022). "Thrombotic Microangiopathies". New England Journal of Medicine. 347 (8): 589–600. doi:10.1056/NEJMra020528. ISSN 0028-4793. PMID 12192020. S2CID 40055198.
Moake JL (November 1998). "Moschcowitz, Multimers, and Metalloprotease". New England Journal of Medicine. 339 (22): 1629–31. doi:10.1056/NEJM199811263392210. ISSN 0028-4793. PMID 9828253.
Kremer Hovinga JA, George JN (October 2019). Longo DL (ed.). "Hereditary Thrombotic Thrombocytopenic Purpura". New England Journal of Medicine. 381 (17): 1653–62. doi:10.1056/NEJMra1813013. ISSN 0028-4793. PMID 31644845. S2CID 204864996.

nih.gov

pubmed.ncbi.nlm.nih.gov

Kremer Hovinga JA, Coppo P, Lämmle B, Moake JL, Miyata T, Vanhoorelbeke K (April 2017). "Thrombotic thrombocytopenic purpura". Nature Reviews Disease Primers. 3 17020: 17020. doi:10.1038/nrdp.2017.20. ISSN 2056-676X. PMID 28382967. S2CID 11960153.
Joly BS, Coppo P, Veyradier A (May 2017). "Thrombotic thrombocytopenic purpura". Blood. 129 (21): 2836–46. doi:10.1182/blood-2016-10-709857. ISSN 0006-4971. PMID 28416507. S2CID 2543348.
George JN (November 2010). "How I treat patients with thrombotic thrombocytopenic purpura: 2010". Blood. 116 (20): 4060–9. doi:10.1182/blood-2010-07-271445. ISSN 0006-4971. PMID 20686117. S2CID 26844964.
Moake JL (January 2004). "Von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura". Seminars in Hematology. 41 (1): 4–14. doi:10.1053/j.seminhematol.2003.10.003. ISSN 0037-1963. PMID 14727254.
Shatzel JJ, Taylor JA (March 2017). "Syndromes of Thrombotic Microangiopathy". Medical Clinics of North America. 101 (2): 395–415. doi:10.1016/j.mcna.2016.09.010. ISSN 0025-7125. PMID 28189178. S2CID 24123004.
Shibagaki Y, Fujita T (January 2005). "Thrombotic Microangiopathy in Malignant Hypertension and Hemolytic Uremic Syndrome (HUS)/Thrombotic Thrombocytopenic Purpura (TTP): Can We Differentiate One from the Other?". Hypertension Research. 28 (1): 89–95. doi:10.1291/hypres.28.89. ISSN 1348-4214. PMID 15969259. S2CID 139098502.
Chiasakul T, Cuker A (November 2018). "Clinical and laboratory diagnosis of TTP: an integrated approach". Hematology. 2018 (1): 530–8. doi:10.1182/asheducation-2018.1.530. ISSN 1520-4391. PMC 6246034. PMID 30504354. S2CID 54564230.
Moake JL (August 2022). "Thrombotic Microangiopathies". New England Journal of Medicine. 347 (8): 589–600. doi:10.1056/NEJMra020528. ISSN 0028-4793. PMID 12192020. S2CID 40055198.
Stanley M, Killeen RB, Michalski JM (January 2023). "Thrombotic Thrombocytopenic Purpura". StatPearls. StatPearls Publishing. PMID 28613472.
Moake JL (November 1998). "Moschcowitz, Multimers, and Metalloprotease". New England Journal of Medicine. 339 (22): 1629–31. doi:10.1056/NEJM199811263392210. ISSN 0028-4793. PMID 9828253.
Conboy E, Partain PI, Warad D, Kluge ML, Arndt C, Chen D, Rodriguez V (January 2018). "A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting From Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant". Journal of Pediatric Hematology/Oncology. 40 (1): 60–62. doi:10.1097/MPH.0000000000000895. ISSN 1077-4114. PMID 28678087. S2CID 3470460.
Lämmle B, Hovinga JA, George JN (February 2008). "Acquired thrombotic thrombocytopenic purpura: ADAMTS13 activity, anti-ADAMTS13 autoantibodies and risk of recurrent disease". Haematologica. 93 (2): 172–7. doi:10.3324/haematol.12701. ISSN 1592-8721. PMID 18245649. S2CID 17777111.
Kremer Hovinga JA, George JN (October 2019). Longo DL (ed.). "Hereditary Thrombotic Thrombocytopenic Purpura". New England Journal of Medicine. 381 (17): 1653–62. doi:10.1056/NEJMra1813013. ISSN 0028-4793. PMID 31644845. S2CID 204864996.
Chapman K, Seldon M, Richards R (February 2012). "Thrombotic Microangiopathies, Thrombotic Thrombocytopenic Purpura, and ADAMTS-13". Seminars in Thrombosis and Hemostasis. 38 (1): 47–54. doi:10.1055/s-0031-1300951. ISSN 0094-6176. PMID 22314603. S2CID 13963783.
Levy GG, Nichols WC, Lian EC, Foroud T, McClintick JN, McGee BM, Yang AY, Siemieniak DR, Stark KR, Gruppo R, Sarode R, Shurin SB, Chandrasekaran V, Stabler SP, Sabio H (October 2001). "Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura". Nature. 413 (6855): 488–494. Bibcode:2001Natur.413..488L. doi:10.1038/35097008. hdl:2027.42/62592. ISSN 1476-4687. PMID 11586351. S2CID 4380010.
Kokame K, Matsumoto M, Soejima K, Yagi H, Ishizashi H, Funato M, Tamai H, Konno M, Kamide K, Kawano Y, Miyata T, Fujimura Y (September 2002). "Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity". Proceedings of the National Academy of Sciences. 99 (18): 11902–7. Bibcode:2002PNAS...9911902K. doi:10.1073/pnas.172277399. ISSN 0027-8424. PMC 129366. PMID 12181489. S2CID 20496927.
Seidizadeh O, Cairo A, Mancini I, George JN, Peyvandi F (August 2024). "Global prevalence of hereditary thrombotic thrombocytopenic purpura determined by genetic analysis". Blood Adv. 8 (16): 4386–96. doi:10.1182/bloodadvances.2024013421. PMC 11375255. PMID 38935915.
van Mourik JA, Boertjes R, Huisveld IA, Fijnvandraat K, Pajkrt D, van Genderen PJ, Fijnheer R (1999-07-01). "von Willebrand Factor Propeptide in Vascular Disorders: A Tool to Distinguish Between Acute and Chronic Endothelial Cell Perturbation". Blood. 94 (1): 179–185. doi:10.1182/blood.V94.1.179.413k18_179_185. ISSN 1528-0020. PMID 10381511.
Iwata H, Kami M, Hori A, Hamaki T, Takeuchi K, Mutou Y (June 2001). "An autopsy-based retrospective study of secondary thrombotic thrombocytopenic purpura". Haematologica. 86 (6): 669–70. PMID 11418383.
Tsai HM (January 2010). "Pathophysiology of thrombotic thrombocytopenic purpura". International Journal of Hematology. 91 (1): 1–19. doi:10.1007/s12185-009-0476-1. ISSN 1865-3774. PMC 3159000. PMID 20058209.
Han B, Page EE, Stewart LM, Deford CC, Scott JG, Schwartz LH, Perdue JJ, Terrell DR, Vesely SK, George JN (August 2018). "Depression and cognitive impairment following recovery from thrombotic thrombocytopenic purpura: Depression and Cognitive Impairment Following TTP". American Journal of Hematology. 90 (8): 709–714. doi:10.1002/ajh.24060. PMC 4509840. PMID 25975932.
Bendapudi PK, Hurwitz S, Fry A, Marques MB, Waldo SW, Li A, Sun L, Upadhyay V, Hamdan A, Brunner AM, Gansner JM, Viswanathan S, Kaufman RM, Uhl L, Stowell CP, Dzik WH, Makar RS (April 2017). "Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study". Lancet Haematol. 4 (4): e157 – e164. doi:10.1016/S2352-3026(17)30026-1. PMID 28259520.
Bentley MJ, Lehman CM, Blaylock RC, Wilson AR, Rodgers GM (August 2010). "The utility of patient characteristics in predicting severe ADAMTS13 deficiency and response to plasma exchange". Transfusion. 50 (8): 1654–64. doi:10.1111/j.1537-2995.2010.02653.x. PMID 20412532.
Coppo P, Schwarzinger M, Buffet M, Wynckel A, Clabault K, Presne C, Poullin P, Malot S, Vanhille P, Azoulay E, Galicier L, Lemiale V, Mira JP, Ridel C, Rondeau E, Pourrat J, Girault S, Bordessoule D, Saheb S, Ramakers M, Hamidou M, Vernant JP, Guidet B, Wolf M, Veyradier A (April 2010). "Predictive features of severe acquired ADAMTS13 deficiency in idiopathic thrombotic microangiopathies: the French TMA reference center experience". PLOS ONE. 5 (4): e10208. Bibcode:2010PLoSO...510208C. doi:10.1371/journal.pone.0010208. PMC 2859048. PMID 20436664.
Park SH, Kim HK, Jeong J, Lee SH, Lee YJ, Kim YJ, Jo JC, Lim JH (September 2023). "Performance Validation of Three Scoring Systems for the Prediction of Thrombotic Microangiopathy Due to Severe ADAMTS13 Deficiency and the Response to Therapeutic Plasma Exchange: First Study in Korea". Ann Lab Med. 43 (5): 485–492. doi:10.3343/alm.2023.43.5.485. PMC 10151285. PMID 37080750.
Zheng XL, Vesely SK, Cataland SR, Coppo P, Geldziler B, Iorio A, Matsumoto M, Mustafa RA, Pai M, Rock G, Russell L, Tarawneh R, Valdes J, Peyvandi F (October 2020). "ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura". J Thromb Haemost. 18 (10): 2486–95. doi:10.1111/jth.15006. PMC 8146131. PMID 32914582.
Arnold DM, Patriquin CJ, Nazy I (January 2017). "Thrombotic microangiopathies: a general approach to diagnosis and management". CMAJ. 189 (4): E153 – E159. doi:10.1503/cmaj.160142. ISSN 0820-3946. PMC 5266569. PMID 27754896.
Feng S, Eyler SJ, Zhang Y, Maga T, Nester CM, Kroll MH, Smith RJ, Afshar-Kharghan V (August 2013). "Partial ADAMTS13 deficiency in atypical hemolytic uremic syndrome". Blood. 122 (8): 1487–93. doi:10.1182/blood-2013-03-492421. ISSN 1528-0020. PMC 3750341. PMID 23847193. Complement dysregulation leads to atypical hemolytic uremic syndrome (aHUS), while ADAMTS13 deficiency causes thrombotic thrombocytopenic purpura.
Cataland, Spero R.; Wu, Haifeng M. (April 2014). "How I treat: the clinical differentiation and initial treatment of adult patients with atypical hemolytic uremic syndrome". Blood. 123 (16): 2478–84. doi:10.1182/blood-2013-11-516237. ISSN 0006-4971. PMID 24599547.
Bitzan M, Schaefer F, Reymond D (September 2010). "Treatment of typical (enteropathic) hemolytic uremic syndrome". Seminars in Thrombosis and Hemostasis. 36 (6): 594–610. doi:10.1055/s-0030-1262881. ISSN 1098-9064. PMID 20865636. S2CID 6129618.
Michael, M; Elliott, EJ; Ridley, GF; Hodson, EM; Craig, JC (January 2009). "Interventions for haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura". The Cochrane Database of Systematic Reviews. 1 (1): CD003595–CD003595–63. doi:10.1002/14651858.CD003595.pub2. hdl:10072/61440. PMC 7154575. PMID 19160220.
Lim W, Vesely SK, George JN (March 2015). "The role of rituximab in the management of patients with acquired thrombotic thrombocytopenic purpura". Blood. 125 (10): 1526–31. doi:10.1182/blood-2014-10-559211. PMC 4351502. PMID 25573992.
Allford SL, Hunt BJ, Rose P, Machin SJ (February 2003). "Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias". British Journal of Haematology. 120 (4): 556–73. doi:10.1046/j.1365-2141.2003.04049.x. PMID 12588343. S2CID 38774829.
Peyvandi F, Scully M, Kremer Hovinga JA, Cataland S, Knöbl P, Wu H, Artoni A, Westwood JP, Mansouri Taleghani M (February 2016). "Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura". New England Journal of Medicine. 374 (6): 511–522. doi:10.1056/NEJMoa1505533. hdl:2434/829303. ISSN 0028-4793. PMID 26863353. S2CID 19482364.
Goshua G, Bendapudi PK (December 2022). "Evidence-Based Minireview: Should caplacizumab be used routinely in unselected patients with immune thrombotic thrombocytopenic purpura?". Hematology. 2022 (1): 491–4. doi:10.1182/hematology.2022000412. ISSN 1520-4391. PMC 9820987. PMID 36485149.
Goshua G, Sinha P, Hendrickson JE, Tormey C, Bendapudi PK, Lee AI (February 2021). "Cost effectiveness of caplacizumab in acquired thrombotic thrombocytopenic purpura". Blood. 137 (7): 969–976. doi:10.1182/blood.2020006052. PMC 7918179. PMID 33280030.
Völker LA, Brinkkoetter PT, Knöbl PN, Krstic M, Kaufeld J, Menne J, Buxhofer-Ausch V, Miesbach W (November 2020). "Treatment of acquired thrombotic thrombocytopenic purpura without plasma exchange in selected patients under caplacizumab". J Thromb Haemost. 18 (11): 3061–6. doi:10.1111/jth.15045. PMC 7692904. PMID 32757435.
Zheng XL, Vesely SK, Cataland SR, Coppo P, Geldziler B, Iorio A, Matsumoto M, Mustafa RA, Pai M, Rock G, Russell L, Tarawneh R, Valdes J, Peyvandi F (October 2020). "ISTH guidelines for treatment of thrombotic thrombocytopenic purpura". J Thromb Haemost. 18 (10): 2496–2502. doi:10.1111/jth.15010. PMC 8091490. PMID 32914526.
Loirat C, Girma JP, Desconclois C, Coppo P, Veyradier A (January 2009). "Thrombotic thrombocytopenic purpura related to severe ADAMTS13 deficiency in children". Pediatric Nephrology. 24 (1): 19–29. doi:10.1007/s00467-008-0863-5. ISSN 1432-198X. PMID 18574602. S2CID 22209831.
Saha M, McDaniel J, Zheng X (October 2010). "Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics". Journal of Thrombosis and Haemostasis. 15 (10): 1889–1900. doi:10.1111/jth.13764. ISSN 1538-7836. PMC 5630501. PMID 28662310. S2CID 40493167.
Scully M, Antun A, Cataland SR, Coppo P, Dossier C, Biebuyck N, Hassenpflug WA, Kentouche K, Knöbl P, Kremer Hovinga JA, López-Fernández MF, Matsumoto M, Ortel TL, Windyga J, Bhattacharya I, Cronin M, Li H, Mellgård B, Patel M, Patwari P, Xiao S, Zhang P, Wang LT (May 2024). "Recombinant ADAMTS13 in Congenital Thrombotic Thrombocytopenic Purpura". N Engl J Med. 390 (17): 1584–96. doi:10.1056/NEJMoa2314793. PMID 38692292.
Tsai HM (February 2006). "Current Concepts in Thrombotic Thrombocytopenic Purpura". Annual Review of Medicine. 57: 419–436. doi:10.1146/annurev.med.57.061804.084505. PMC 2426955. PMID 16409158.
Terrell DR, Williams LA, Vesely SK, Lämmle B, Hovinga JA, George JN (July 2005). "The incidence of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: all patients, idiopathic patients, and patients with severe ADAMTS-13 deficiency". Journal of Thrombosis and Haemostasis. 3 (7): 1432–6. doi:10.1111/j.1538-7836.2005.01436.x. PMID 15978100. S2CID 24914279.
Terrell DR, Vesely SK, Kremer Hovinga JA, Lämmle B, George JN (November 2010). "Different disparities of gender and race among the thrombotic thrombocytopenic purpura and hemolytic-uremic syndromes". American Journal of Hematology. 85 (11): 844–7. doi:10.1002/ajh.21833. PMC 3420337. PMID 20799358. S2CID 23118040.
Martino, Suella; Jamme, Mathieu; Deligny, Christophe; Busson, Marc; Loiseau, Pascale; Azoulay, Elie; Galicier, Lionel; Pène, Frédéric; Provôt, François; Dossier, Antoine; Saheb, Samir; Veyradier, Agnès; Coppo, Paul; Microangiopathies, French Reference Center for Thrombotic (2016-07-06). "Thrombotic Thrombocytopenic Purpura in Black People: Impact of Ethnicity on Survival and Genetic Risk Factors". PLOS ONE. 11 (7): e0156679. Bibcode:2016PLoSO..1156679M. doi:10.1371/journal.pone.0156679. ISSN 1932-6203. PMC 4934773. PMID 27383202.
Zheng XL, Sadler JE (2008). "Pathogenesis of Thrombotic Microangiopathies". Annual Review of Pathology. 3: 249–277. doi:10.1146/annurev.pathmechdis.3.121806.154311. PMC 2582586. PMID 18215115.
Sukumar S, Lämmle B, Cataland SR (January 2021). "Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, and Management". Journal of Clinical Medicine. 10 (3): 536. doi:10.3390/jcm10030536. ISSN 2077-0383. PMC 7867179. PMID 33540569.
Sadler, JE (2008). "Von Willerbrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura". Blood. 112 (1): 11–18. doi:10.1182/blood-2008-02-078170. PMC 2435681. PMID 18574040.
Rock GA, Shumak KH, Buskard NA, et al. (August 1991). "Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. Canadian Apheresis Study Group". New England Journal of Medicine. 325 (6): 393–7. doi:10.1056/NEJM199108083250604. PMID 2062330.

omim.org

"THROMBOTIC THROMBOCYTOPENIC PURPURA, HEREDITARY; TTP". OMIM.

orpha.net

"Thrombotic thrombocytopenic purpura". Orphanet.

sciencedirect.com

Moake JL (January 2004). "Von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura". Seminars in Hematology. 41 (1): 4–14. doi:10.1053/j.seminhematol.2003.10.003. ISSN 0037-1963. PMID 14727254.
Shatzel JJ, Taylor JA (March 2017). "Syndromes of Thrombotic Microangiopathy". Medical Clinics of North America. 101 (2): 395–415. doi:10.1016/j.mcna.2016.09.010. ISSN 0025-7125. PMID 28189178. S2CID 24123004.
van Mourik JA, Boertjes R, Huisveld IA, Fijnvandraat K, Pajkrt D, van Genderen PJ, Fijnheer R (1999-07-01). "von Willebrand Factor Propeptide in Vascular Disorders: A Tool to Distinguish Between Acute and Chronic Endothelial Cell Perturbation". Blood. 94 (1): 179–185. doi:10.1182/blood.V94.1.179.413k18_179_185. ISSN 1528-0020. PMID 10381511.
Abrams CS (2012). "Thrombocytopenia". In Goldman L, Schafer AI (eds.). Goldman's Cecil Medicine. Vol. 1 (24th ed.). Elsevier. pp. 1124–31. doi:10.1016/B978-1-4377-1604-7.00175-5. ISBN 978-1437716047. In contrast to TTP, HUS is not caused by a deficiency of ADAMTS13.

semanticscholar.org

api.semanticscholar.org

Kremer Hovinga JA, Coppo P, Lämmle B, Moake JL, Miyata T, Vanhoorelbeke K (April 2017). "Thrombotic thrombocytopenic purpura". Nature Reviews Disease Primers. 3 17020: 17020. doi:10.1038/nrdp.2017.20. ISSN 2056-676X. PMID 28382967. S2CID 11960153.
Joly BS, Coppo P, Veyradier A (May 2017). "Thrombotic thrombocytopenic purpura". Blood. 129 (21): 2836–46. doi:10.1182/blood-2016-10-709857. ISSN 0006-4971. PMID 28416507. S2CID 2543348.
George JN (November 2010). "How I treat patients with thrombotic thrombocytopenic purpura: 2010". Blood. 116 (20): 4060–9. doi:10.1182/blood-2010-07-271445. ISSN 0006-4971. PMID 20686117. S2CID 26844964.
Shatzel JJ, Taylor JA (March 2017). "Syndromes of Thrombotic Microangiopathy". Medical Clinics of North America. 101 (2): 395–415. doi:10.1016/j.mcna.2016.09.010. ISSN 0025-7125. PMID 28189178. S2CID 24123004.
Shibagaki Y, Fujita T (January 2005). "Thrombotic Microangiopathy in Malignant Hypertension and Hemolytic Uremic Syndrome (HUS)/Thrombotic Thrombocytopenic Purpura (TTP): Can We Differentiate One from the Other?". Hypertension Research. 28 (1): 89–95. doi:10.1291/hypres.28.89. ISSN 1348-4214. PMID 15969259. S2CID 139098502.
Chiasakul T, Cuker A (November 2018). "Clinical and laboratory diagnosis of TTP: an integrated approach". Hematology. 2018 (1): 530–8. doi:10.1182/asheducation-2018.1.530. ISSN 1520-4391. PMC 6246034. PMID 30504354. S2CID 54564230.
Moake JL (August 2022). "Thrombotic Microangiopathies". New England Journal of Medicine. 347 (8): 589–600. doi:10.1056/NEJMra020528. ISSN 0028-4793. PMID 12192020. S2CID 40055198.
Conboy E, Partain PI, Warad D, Kluge ML, Arndt C, Chen D, Rodriguez V (January 2018). "A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting From Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant". Journal of Pediatric Hematology/Oncology. 40 (1): 60–62. doi:10.1097/MPH.0000000000000895. ISSN 1077-4114. PMID 28678087. S2CID 3470460.
Lämmle B, Hovinga JA, George JN (February 2008). "Acquired thrombotic thrombocytopenic purpura: ADAMTS13 activity, anti-ADAMTS13 autoantibodies and risk of recurrent disease". Haematologica. 93 (2): 172–7. doi:10.3324/haematol.12701. ISSN 1592-8721. PMID 18245649. S2CID 17777111.
Kremer Hovinga JA, George JN (October 2019). Longo DL (ed.). "Hereditary Thrombotic Thrombocytopenic Purpura". New England Journal of Medicine. 381 (17): 1653–62. doi:10.1056/NEJMra1813013. ISSN 0028-4793. PMID 31644845. S2CID 204864996.
Chapman K, Seldon M, Richards R (February 2012). "Thrombotic Microangiopathies, Thrombotic Thrombocytopenic Purpura, and ADAMTS-13". Seminars in Thrombosis and Hemostasis. 38 (1): 47–54. doi:10.1055/s-0031-1300951. ISSN 0094-6176. PMID 22314603. S2CID 13963783.
Levy GG, Nichols WC, Lian EC, Foroud T, McClintick JN, McGee BM, Yang AY, Siemieniak DR, Stark KR, Gruppo R, Sarode R, Shurin SB, Chandrasekaran V, Stabler SP, Sabio H (October 2001). "Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura". Nature. 413 (6855): 488–494. Bibcode:2001Natur.413..488L. doi:10.1038/35097008. hdl:2027.42/62592. ISSN 1476-4687. PMID 11586351. S2CID 4380010.
Kokame K, Matsumoto M, Soejima K, Yagi H, Ishizashi H, Funato M, Tamai H, Konno M, Kamide K, Kawano Y, Miyata T, Fujimura Y (September 2002). "Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity". Proceedings of the National Academy of Sciences. 99 (18): 11902–7. Bibcode:2002PNAS...9911902K. doi:10.1073/pnas.172277399. ISSN 0027-8424. PMC 129366. PMID 12181489. S2CID 20496927.
Bitzan M, Schaefer F, Reymond D (September 2010). "Treatment of typical (enteropathic) hemolytic uremic syndrome". Seminars in Thrombosis and Hemostasis. 36 (6): 594–610. doi:10.1055/s-0030-1262881. ISSN 1098-9064. PMID 20865636. S2CID 6129618.
Allford SL, Hunt BJ, Rose P, Machin SJ (February 2003). "Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias". British Journal of Haematology. 120 (4): 556–73. doi:10.1046/j.1365-2141.2003.04049.x. PMID 12588343. S2CID 38774829.
Peyvandi F, Scully M, Kremer Hovinga JA, Cataland S, Knöbl P, Wu H, Artoni A, Westwood JP, Mansouri Taleghani M (February 2016). "Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura". New England Journal of Medicine. 374 (6): 511–522. doi:10.1056/NEJMoa1505533. hdl:2434/829303. ISSN 0028-4793. PMID 26863353. S2CID 19482364.
Loirat C, Girma JP, Desconclois C, Coppo P, Veyradier A (January 2009). "Thrombotic thrombocytopenic purpura related to severe ADAMTS13 deficiency in children". Pediatric Nephrology. 24 (1): 19–29. doi:10.1007/s00467-008-0863-5. ISSN 1432-198X. PMID 18574602. S2CID 22209831.
Saha M, McDaniel J, Zheng X (October 2010). "Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics". Journal of Thrombosis and Haemostasis. 15 (10): 1889–1900. doi:10.1111/jth.13764. ISSN 1538-7836. PMC 5630501. PMID 28662310. S2CID 40493167.
Terrell DR, Williams LA, Vesely SK, Lämmle B, Hovinga JA, George JN (July 2005). "The incidence of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: all patients, idiopathic patients, and patients with severe ADAMTS-13 deficiency". Journal of Thrombosis and Haemostasis. 3 (7): 1432–6. doi:10.1111/j.1538-7836.2005.01436.x. PMID 15978100. S2CID 24914279.
Terrell DR, Vesely SK, Kremer Hovinga JA, Lämmle B, George JN (November 2010). "Different disparities of gender and race among the thrombotic thrombocytopenic purpura and hemolytic-uremic syndromes". American Journal of Hematology. 85 (11): 844–7. doi:10.1002/ajh.21833. PMC 3420337. PMID 20799358. S2CID 23118040.
Amorosi EL, Ultmann JE (March 1966). "Thrombotic thrombocytopenic purpura: report of 16 cases and review of the literature". Medicine. 45 (2): 139. doi:10.1097/00005792-196603000-00003. S2CID 71943329.

tampaemergencymedicine.org

"MAHA, TTP, HUS, DIC... Oh My! Understanding Microangiopathic Hemolytic Anemias". Tampa Emergency Medicine Blog. University of South Florida. 2023-04-26. Retrieved 2023-08-23.

thieme-connect.com

Bitzan M, Schaefer F, Reymond D (September 2010). "Treatment of typical (enteropathic) hemolytic uremic syndrome". Seminars in Thrombosis and Hemostasis. 36 (6): 594–610. doi:10.1055/s-0030-1262881. ISSN 1098-9064. PMID 20865636. S2CID 6129618.

unimi.it

air.unimi.it

Peyvandi F, Scully M, Kremer Hovinga JA, Cataland S, Knöbl P, Wu H, Artoni A, Westwood JP, Mansouri Taleghani M (February 2016). "Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura". New England Journal of Medicine. 374 (6): 511–522. doi:10.1056/NEJMoa1505533. hdl:2434/829303. ISSN 0028-4793. PMID 26863353. S2CID 19482364.

web.archive.org

"Immune-mediated thrombotic thrombocytopenic purpura". Genetic and Rare Diseases Information Center. U.S. Department of Health & Human Services. Archived from the original on 2018-10-20. Retrieved 2018-10-10.

worldcat.org

search.worldcat.org

Kremer Hovinga JA, Coppo P, Lämmle B, Moake JL, Miyata T, Vanhoorelbeke K (April 2017). "Thrombotic thrombocytopenic purpura". Nature Reviews Disease Primers. 3 17020: 17020. doi:10.1038/nrdp.2017.20. ISSN 2056-676X. PMID 28382967. S2CID 11960153.
Joly BS, Coppo P, Veyradier A (May 2017). "Thrombotic thrombocytopenic purpura". Blood. 129 (21): 2836–46. doi:10.1182/blood-2016-10-709857. ISSN 0006-4971. PMID 28416507. S2CID 2543348.
George JN (November 2010). "How I treat patients with thrombotic thrombocytopenic purpura: 2010". Blood. 116 (20): 4060–9. doi:10.1182/blood-2010-07-271445. ISSN 0006-4971. PMID 20686117. S2CID 26844964.
Moake JL (January 2004). "Von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura". Seminars in Hematology. 41 (1): 4–14. doi:10.1053/j.seminhematol.2003.10.003. ISSN 0037-1963. PMID 14727254.
Shatzel JJ, Taylor JA (March 2017). "Syndromes of Thrombotic Microangiopathy". Medical Clinics of North America. 101 (2): 395–415. doi:10.1016/j.mcna.2016.09.010. ISSN 0025-7125. PMID 28189178. S2CID 24123004.
Shibagaki Y, Fujita T (January 2005). "Thrombotic Microangiopathy in Malignant Hypertension and Hemolytic Uremic Syndrome (HUS)/Thrombotic Thrombocytopenic Purpura (TTP): Can We Differentiate One from the Other?". Hypertension Research. 28 (1): 89–95. doi:10.1291/hypres.28.89. ISSN 1348-4214. PMID 15969259. S2CID 139098502.
Chiasakul T, Cuker A (November 2018). "Clinical and laboratory diagnosis of TTP: an integrated approach". Hematology. 2018 (1): 530–8. doi:10.1182/asheducation-2018.1.530. ISSN 1520-4391. PMC 6246034. PMID 30504354. S2CID 54564230.
Moake JL (August 2022). "Thrombotic Microangiopathies". New England Journal of Medicine. 347 (8): 589–600. doi:10.1056/NEJMra020528. ISSN 0028-4793. PMID 12192020. S2CID 40055198.
Moake JL (November 1998). "Moschcowitz, Multimers, and Metalloprotease". New England Journal of Medicine. 339 (22): 1629–31. doi:10.1056/NEJM199811263392210. ISSN 0028-4793. PMID 9828253.
Conboy E, Partain PI, Warad D, Kluge ML, Arndt C, Chen D, Rodriguez V (January 2018). "A Severe Case of Congenital Thrombotic Thrombocytopenia Purpura Resulting From Compound Heterozygosity Involving a Novel ADAMTS13 Pathogenic Variant". Journal of Pediatric Hematology/Oncology. 40 (1): 60–62. doi:10.1097/MPH.0000000000000895. ISSN 1077-4114. PMID 28678087. S2CID 3470460.
Lämmle B, Hovinga JA, George JN (February 2008). "Acquired thrombotic thrombocytopenic purpura: ADAMTS13 activity, anti-ADAMTS13 autoantibodies and risk of recurrent disease". Haematologica. 93 (2): 172–7. doi:10.3324/haematol.12701. ISSN 1592-8721. PMID 18245649. S2CID 17777111.
Kremer Hovinga JA, George JN (October 2019). Longo DL (ed.). "Hereditary Thrombotic Thrombocytopenic Purpura". New England Journal of Medicine. 381 (17): 1653–62. doi:10.1056/NEJMra1813013. ISSN 0028-4793. PMID 31644845. S2CID 204864996.
Chapman K, Seldon M, Richards R (February 2012). "Thrombotic Microangiopathies, Thrombotic Thrombocytopenic Purpura, and ADAMTS-13". Seminars in Thrombosis and Hemostasis. 38 (1): 47–54. doi:10.1055/s-0031-1300951. ISSN 0094-6176. PMID 22314603. S2CID 13963783.
Levy GG, Nichols WC, Lian EC, Foroud T, McClintick JN, McGee BM, Yang AY, Siemieniak DR, Stark KR, Gruppo R, Sarode R, Shurin SB, Chandrasekaran V, Stabler SP, Sabio H (October 2001). "Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura". Nature. 413 (6855): 488–494. Bibcode:2001Natur.413..488L. doi:10.1038/35097008. hdl:2027.42/62592. ISSN 1476-4687. PMID 11586351. S2CID 4380010.
Kokame K, Matsumoto M, Soejima K, Yagi H, Ishizashi H, Funato M, Tamai H, Konno M, Kamide K, Kawano Y, Miyata T, Fujimura Y (September 2002). "Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity". Proceedings of the National Academy of Sciences. 99 (18): 11902–7. Bibcode:2002PNAS...9911902K. doi:10.1073/pnas.172277399. ISSN 0027-8424. PMC 129366. PMID 12181489. S2CID 20496927.
van Mourik JA, Boertjes R, Huisveld IA, Fijnvandraat K, Pajkrt D, van Genderen PJ, Fijnheer R (1999-07-01). "von Willebrand Factor Propeptide in Vascular Disorders: A Tool to Distinguish Between Acute and Chronic Endothelial Cell Perturbation". Blood. 94 (1): 179–185. doi:10.1182/blood.V94.1.179.413k18_179_185. ISSN 1528-0020. PMID 10381511.
Tsai HM (January 2010). "Pathophysiology of thrombotic thrombocytopenic purpura". International Journal of Hematology. 91 (1): 1–19. doi:10.1007/s12185-009-0476-1. ISSN 1865-3774. PMC 3159000. PMID 20058209.
Arnold DM, Patriquin CJ, Nazy I (January 2017). "Thrombotic microangiopathies: a general approach to diagnosis and management". CMAJ. 189 (4): E153 – E159. doi:10.1503/cmaj.160142. ISSN 0820-3946. PMC 5266569. PMID 27754896.
Feng S, Eyler SJ, Zhang Y, Maga T, Nester CM, Kroll MH, Smith RJ, Afshar-Kharghan V (August 2013). "Partial ADAMTS13 deficiency in atypical hemolytic uremic syndrome". Blood. 122 (8): 1487–93. doi:10.1182/blood-2013-03-492421. ISSN 1528-0020. PMC 3750341. PMID 23847193. Complement dysregulation leads to atypical hemolytic uremic syndrome (aHUS), while ADAMTS13 deficiency causes thrombotic thrombocytopenic purpura.
Cataland, Spero R.; Wu, Haifeng M. (April 2014). "How I treat: the clinical differentiation and initial treatment of adult patients with atypical hemolytic uremic syndrome". Blood. 123 (16): 2478–84. doi:10.1182/blood-2013-11-516237. ISSN 0006-4971. PMID 24599547.
Bitzan M, Schaefer F, Reymond D (September 2010). "Treatment of typical (enteropathic) hemolytic uremic syndrome". Seminars in Thrombosis and Hemostasis. 36 (6): 594–610. doi:10.1055/s-0030-1262881. ISSN 1098-9064. PMID 20865636. S2CID 6129618.
Peyvandi F, Scully M, Kremer Hovinga JA, Cataland S, Knöbl P, Wu H, Artoni A, Westwood JP, Mansouri Taleghani M (February 2016). "Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura". New England Journal of Medicine. 374 (6): 511–522. doi:10.1056/NEJMoa1505533. hdl:2434/829303. ISSN 0028-4793. PMID 26863353. S2CID 19482364.
Goshua G, Bendapudi PK (December 2022). "Evidence-Based Minireview: Should caplacizumab be used routinely in unselected patients with immune thrombotic thrombocytopenic purpura?". Hematology. 2022 (1): 491–4. doi:10.1182/hematology.2022000412. ISSN 1520-4391. PMC 9820987. PMID 36485149.
Loirat C, Girma JP, Desconclois C, Coppo P, Veyradier A (January 2009). "Thrombotic thrombocytopenic purpura related to severe ADAMTS13 deficiency in children". Pediatric Nephrology. 24 (1): 19–29. doi:10.1007/s00467-008-0863-5. ISSN 1432-198X. PMID 18574602. S2CID 22209831.
Saha M, McDaniel J, Zheng X (October 2010). "Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics". Journal of Thrombosis and Haemostasis. 15 (10): 1889–1900. doi:10.1111/jth.13764. ISSN 1538-7836. PMC 5630501. PMID 28662310. S2CID 40493167.
Martino, Suella; Jamme, Mathieu; Deligny, Christophe; Busson, Marc; Loiseau, Pascale; Azoulay, Elie; Galicier, Lionel; Pène, Frédéric; Provôt, François; Dossier, Antoine; Saheb, Samir; Veyradier, Agnès; Coppo, Paul; Microangiopathies, French Reference Center for Thrombotic (2016-07-06). "Thrombotic Thrombocytopenic Purpura in Black People: Impact of Ethnicity on Survival and Genetic Risk Factors". PLOS ONE. 11 (7): e0156679. Bibcode:2016PLoSO..1156679M. doi:10.1371/journal.pone.0156679. ISSN 1932-6203. PMC 4934773. PMID 27383202.
Sukumar S, Lämmle B, Cataland SR (January 2021). "Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, and Management". Journal of Clinical Medicine. 10 (3): 536. doi:10.3390/jcm10030536. ISSN 2077-0383. PMC 7867179. PMID 33540569.
Moschcowitz E (1924). "Hyaline Thrombosis of the Terminal Arterioles and Capillaries: A Hitherto Undescribed Disease". Proceedings of the New York Pathological Society. 24: 21–24.
- —— (1925). "An Acute Febrile Pleiochromic Anemia with Hyaline Thrombosis of the Terminal Arterioles and Capillaries: An Undescribed Disease". Archives of Internal Medicine. 36 (1): 89–93. doi:10.1001/archinte.1925.00120130092009. ISSN 0730-188X:

Thrombotic thrombocytopenic purpura (English Wikipedia)

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