Totarol (English Wikipedia)

Short WF, Stromberg H (1937). "116. Totarol. Part I.". Journal of the Chemical Society (Resumed): 516–520. doi:10.1039/JR9370000516.
Bendall JG, Cambie RC (1995). "Totarol: a Non-Conventional Diterpenoid". Australian Journal of Chemistry. 48 (5): 883. doi:10.1071/ch9950883. ISSN 0004-9425.
Short WF, Wang H (1951). "662. Totarol. Part II". Journal of the Chemical Society (Resumed): 2979–2987. doi:10.1039/jr9510002979. ISSN 0368-1769.
Sharp H, Latif Z, Bartholomew B, Bright C, Jones CD, Sarker SD, et al. (February 2001). "Totarol, totaradiol and ferruginol: three diterpenes from Thuja plicata (Cupressaceae)". Biochemical Systematics and Ecology. 29 (2): 215–217. Bibcode:2001BioSE..29..215S. doi:10.1016/s0305-1978(00)00047-8. PMID 11106853.
Le Métayer P, Schaeffer P, Adam P, Albrecht P, Roussé S, Duringer P (June 2008). "An unprecedented condensation pathway leading to the formation of phenolic C40 bis-diterpenoids in sediments from the Lower Oligocene of the Rhine Rift Valley". Organic Geochemistry. 39 (6): 658–675. Bibcode:2008OrGeo..39..658L. doi:10.1016/j.orggeochem.2008.02.020.
Bendall JG, Cambie RC (1995). "Totarol: A non-conventional diterpenoid". Australian Journal of Chemistry. 48 (5): 883–917. doi:10.1071/CH9950883.
Mossa JS, El-Feraly FS, Muhammad I (November 2004). "Antimycobacterial constituents from Juniperus procera, Ferula communis and Plumbago zeylanica and their in vitro synergistic activity with isonicotinic acid hydrazide". Phytotherapy Research. 18 (11): 934–7. doi:10.1002/ptr.1420. PMID 15597311. S2CID 33772478.
Gibbons S (January 2005). "Plants as a source of bacterial resistance modulators and anti-infective agents". Phytochemistry Reviews. 4 (1): 63–78. Bibcode:2005PChRv...4...63G. doi:10.1007/s11101-005-2494-9. S2CID 24225316.
Kubo I, Muroi H, Himejima M (October 1992). "Antibacterial activity of totarol and its potentiation". Journal of Natural Products. 55 (10): 1436–40. doi:10.1021/np50088a008. PMID 1453180.
Smith EC, Kaatz GW, Seo SM, Wareham N, Williamson EM, Gibbons S (December 2007). "The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus". Antimicrobial Agents and Chemotherapy. 51 (12): 4480–3. doi:10.1128/AAC.00216-07. PMC 2168009. PMID 17664318.
Samoylenko V, Dunbar DC, Gafur MA, Khan SI, Ross SA, Mossa JS, et al. (December 2008). "Antiparasitic, nematicidal and antifouling constituents from Juniperus berries". Phytotherapy Research. 22 (12): 1570–1576. doi:10.1002/ptr.2460. PMID 19067375. S2CID 10379153.
Evans GB, Furneaux RH, Gravestock MB, Lynch GP, Scott GK (September 1999). "The synthesis and antibacterial activity of totarol derivatives. Part 1: modifications of ring-C and pro-drugs". Bioorganic & Medicinal Chemistry. 7 (9): 1953–1964. doi:10.1016/s0968-0896(99)00162-5. PMID 10530944.
Gordien AY, Gray AI, Franzblau SG, Seidel V (December 2009). "Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae)". Journal of Ethnopharmacology. 126 (3): 500–5. doi:10.1016/j.jep.2009.09.007. PMID 19755141.
Muroi H, Kubo I (April 1996). "Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus". The Journal of Applied Bacteriology. 80 (4): 387–94. doi:10.1111/j.1365-2672.1996.tb03233.x. PMID 8849640.
Haraguchi H, Ishikawa H, Sakai S, Ying BP, Kubo I (June 1996). "Inhibition of lipid peroxidation by diterpenoid from Podocarpus nagi". Experientia. 52 (6): 573–6. doi:10.1007/BF01969731. PMID 8698092. S2CID 31273106.
Shapiro S, Guggenheim B (August 1998). "Inhibition of oral bacteria by phenolic compounds. Part 1. QSAR analysis using molecular connectivity". Quantitative Structure-Activity Relationships. 17 (4): 327–337. doi:10.1002/(SICI)1521-3838(199808)17:04<327::AID-QSAR327>3.0.CO;2-O.
Jaiswal R, Beuria TK, Mohan R, Mahajan SK, Panda D (April 2007). "Totarol inhibits bacterial cytokinesis by perturbing the assembly dynamics of FtsZ". Biochemistry. 46 (14): 4211–20. doi:10.1021/bi602573e. PMID 17348691.
Micol V, Mateo CR, Shapiro S, Aranda FJ, Villalaín J (April 2001). "Effects of (+)-totarol, a diterpenoid antibacterial agent, on phospholipid model membranes". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1511 (2): 281–90. doi:10.1016/s0005-2736(01)00284-x. PMID 11286971.
Mateo CR, Prieto M, Micol V, Shapiro S, Villalaín J (December 2000). "A fluorescence study of the interaction and location of (+)-totarol, a diterpenoid bioactive molecule, in model membranes". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1509 (1–2): 167–175. doi:10.1016/s0005-2736(00)00291-1. PMID 11118528.
Bernabeu A, Shapiro S, Villalaín J (October 2002). "A MAS-NMR study of the location of (+)-totarol, a diterpenoid bioactive molecule, in phospholipid model membranes". Chemistry and Physics of Lipids. 119 (1–2): 33–9. doi:10.1016/s0009-3084(02)00050-6. PMID 12270671.
Evans GB, Furneaux RH, Gainsford GJ, Murphy MP (July 2000). "The synthesis and antibacterial activity of totarol derivatives. Part 3: Modification of ring-B". Bioorganic & Medicinal Chemistry. 8 (7): 1663–75. doi:10.1016/s0968-0896(00)00096-1. PMID 10976514.
Abdillahi HS, Stafford GI, Finnie JF, Van Staden J (January 2010). "Ethnobotany, phytochemistry and pharmacology of Podocarpus sensu latissimo (sl)". South African Journal of Botany. 76 (1): 1–24. doi:10.1016/j.sajb.2009.09.002. S2CID 85271055.
Connor H (2021). "Ko te Rākau Hei Tohu Mō te Rangahau Me te Tuhi Whakapapa: Tree Symbolism as a Method for Researching and Writing Genealogy". Genealogy. 5 (2): 29. doi:10.3390/genealogy5020029. hdl:2292/54952. This article incorporates text from this source, which is available under the CC BY 4.0 license.
Cuevas-Cianca SI, Leal AC, Hernández LR, Arreola ES, Bach H (October 13, 2022). "Antimicrobial, toxicity, and anti-inflammatory activities of Buddleja perfoliata Kunth". Phytomedicine Plus. 2 (4). doi:10.1016/j.phyplu.2022.100357.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Belahcene S (February 14, 2024). "Chemical Composition Antioxidant and Anti-Inflammatory Activities of Myrtus communis L. Leaf Extract: Forecasting ADMET Profiling and Anti-Inflammatory Targets Using Molecular Docking Tools". Molecules. 29 (4): 849. doi:10.3390/molecules29040849. PMC 10893115. PMID 38398601.
Minami T, Iwamoto M, Ohtsu H, Ohishi H, Tanaka R, Yoshitake A (August 2002). "Aromatase inhibitory activities of standishinal and the diterpenoids from the bark of Thuja standishii". Planta Medica. 68 (8): 742–5. doi:10.1055/s-2002-33787. PMID 12221600. S2CID 26017116.
Lee MK, Yang H, Yoon JS, Jeong EJ, Kim DY, Ha NR, et al. (July 2008). "Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells". Archives of Pharmacal Research. 31 (7): 866–71. doi:10.1007/s12272-001-1239-9. PMID 18704328. S2CID 22860187.
Van De Water RW, Pettus TR (July 2002). "o-Quinone methides: intermediates underdeveloped and underutilized in organic synthesis". Tetrahedron. 58 (27): 5367–5406. doi:10.1016/S0040-4020(02)00496-9.
Bailly C (2020-12-01). "Anticancer Activities and Mechanism of Action of Nagilactones, a Group of Terpenoid Lactones Isolated from Podocarpus Species". Natural Products and Bioprospecting. 10 (6): 367–375. doi:10.1007/s13659-020-00268-8. ISSN 2192-2195. PMC 7648843. PMID 33034879.
Kubo I, Muroi H, Kubo A (December 1993). "Antibacterial activity of long-chain alcohols against Streptococcus mutans". Journal of Agricultural and Food Chemistry. 41 (12): 2447–2450. doi:10.1021/jf00036a045.
Short WF, Wang H (1951). "662. Totarol. Part II". Journal of the Chemical Society (Resumed): 2979–2987. doi:10.1039/JR9510002979.
Barltrop JA, Rogers NA (1958). "520. Experiments on the synthesis of diterpenes. Part I. A total synthesis of (±)-totarol". Journal of the Chemical Society (Resumed): 2566–2572. doi:10.1039/JR9580002566.
Matsumoto T, Suetsugu A (May 1979). "The Total Synthesis of (+)-Totarol and (+)-Podototarin". Bulletin of the Chemical Society of Japan. 52 (5): 1450–1453. doi:10.1246/bcsj.52.1450.
Das S, Sukanta B, Debabrata M (January 1992). "Stereocontrolled total synthesis of (±)-totaryl methyl ether and (±)-semperviryl methyl ether". Tetrahedron. 48 (41): 9101–9110. doi:10.1016/S0040-4020(01)82004-4.
Marcos IS, Cubillo MA, Moro RF, Dıez D, Basabe P, Sanz F, et al. (December 2003). "Synthesis of (+)-totarol". Tetrahedron Letters. 44 (49): 8831–8835. doi:10.1016/j.tetlet.2003.09.193.
Miyake T, Kigoshi H, Akita H (December 2007). "Chemoenzymatic synthesis of (+)-totarol,(+)-podototarin,(+)-sempervirol, and (+)-jolkinolides E and D.". Tetrahedron: Asymmetry. 18 (24): 2915–2922. doi:10.1016/j.tetasy.2007.11.024.
CR Bennett, RC Cambie (21 February 1966). "Chemistry of the podocarpaceae—XI: Reductions of totarol". Tetrahedron. 22 (8): 2845–2860. doi:10.1016/S0040-4020(01)99076-3.
Kubo I, Muroi H, Himejima M (October 1992). "Antibacterial activity of totarol and its potentiation". Journal of Natural Products. 55 (10): 1436–1440. doi:10.1021/np50088a008. PMID 1453180.
Muroi H, Kubo I (April 1996). "Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus". The Journal of Applied Bacteriology. 80 (4): 387–394. doi:10.1111/j.1365-2672.1996.tb03233.x. PMID 8849640.
Haraguchi H, Ishikawa H, Kubo I (1997-06-01). "Antioxidative Action of Diterpenoids from Podocarpus nagi". Planta Medica. 63 (3): 213–215. doi:10.1055/s-2006-957655. ISSN 0032-0943. PMID 9225601. S2CID 260248488.
Evans GB, Furneaux RH, Gravestock MB, Lynch GP, Scott GK (September 1999). "The synthesis and antibacterial activity of totarol derivatives. Part 1: modifications of ring-C and pro-drugs". Bioorganic & Medicinal Chemistry. 7 (9): 1953–1964. doi:10.1016/S0968-0896(99)00162-5. PMID 10530944.
Nicolson K, Evans G, O'Toole PW (1999-10-01). "Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes". FEMS Microbiology Letters. 179 (2): 233–239. doi:10.1111/j.1574-6968.1999.tb08733.x. PMID 10518721.
Lee SE, Park EK, Kim JG (October 2000). "A Mosquito Larvicidal Diterpenoid Isolated from Podocarpus totara D. Don ex Lambert" (PDF). Journal of Entomological Science. 35 (4): 474–477. doi:10.18474/0749-8004-35.4.474. ISSN 0749-8004.
Gordien AY, Gray AI, Franzblau SG, Seidel V (December 2009). "Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae)". Journal of Ethnopharmacology. 126 (3): 500–505. doi:10.1016/j.jep.2009.09.007. PMID 19755141.
Micol V, Mateo CR, Shapiro S, Aranda FJ, Villalaín J (April 2001). "Effects of (+)-totarol, a diterpenoid antibacterial agent, on phospholipid model membranes". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1511 (2): 281–290. doi:10.1016/S0005-2736(01)00284-X. PMID 11286971.
Patricio EF, Cruz-López L, Maile R, Tentschert J, Jones GR, Morgan ED (February 2002). "The propolis of stingless bees: terpenes from the tibia of three Frieseomelitta species". Journal of Insect Physiology. 48 (2): 249–254. Bibcode:2002JInsP..48..249P. doi:10.1016/S0022-1910(01)00170-6. PMID 12770125.
Clarkson C, Musonda CC, Chibale K, Campbell WE, Smith P (October 2003). "Synthesis of totarol amino alcohol derivatives and their antiplasmodial activity and cytotoxicity". Bioorganic & Medicinal Chemistry. 11 (20): 4417–4422. doi:10.1016/S0968-0896(03)00491-7. PMID 13129578.
Yamaji K, Mori S, Akiyama M, Kato A, Nakashima T (2007-12-05). "The Antifungal Compound Totarol of Thujopsis dolabrata var. hondai Seeds Selects for Fungi on Seedling Root Surfaces". Journal of Chemical Ecology. 33 (12): 2254–2265. Bibcode:2007JCEco..33.2254Y. doi:10.1007/s10886-007-9390-2. ISSN 0098-0331. PMID 18026796. S2CID 20883003.
Smith EC, Kaatz GW, Seo SM, Wareham N, Williamson EM, Gibbons S (December 2007). "The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus". Antimicrobial Agents and Chemotherapy. 51 (12): 4480–4483. doi:10.1128/AAC.00216-07. PMC 2168009. PMID 17664318.
Jaiswal R, Beuria TK, Mohan R, Mahajan SK, Panda D (April 2007). "Totarol inhibits bacterial cytokinesis by perturbing the assembly dynamics of FtsZ". Biochemistry. 46 (14): 4211–4220. doi:10.1021/bi602573e. PMID 17348691.
Gao Y, Xu X, Chang S, Wang Y, Xu Y, Ran S, et al. (December 2015). "Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction". Toxicology and Applied Pharmacology. 289 (2): 142–154. Bibcode:2015ToxAP.289..142G. doi:10.1016/j.taap.2015.10.001. PMID 26440581.
Reddy PJ, Ray S, Sathe GJ, Gajbhiye A, Prasad TS, Rapole S, et al. (January 2015). "A comprehensive proteomic analysis of totarol induced alterations in Bacillus subtilis by multipronged quantitative proteomics". Journal of Proteomics. 114: 247–262. doi:10.1016/j.jprot.2014.10.025. PMID 25464363.
Ma S, Shi C, Wang C, Guo M (October 2017). "Effects of Ultrasound Treatment on Physiochemical Properties and Antimicrobial Activities of Whey Protein-Totarol Nanoparticles". Journal of Food Protection. 80 (10): 1657–1665. doi:10.4315/0362-028X.JFP-17-078. PMID 28876131.
Reinbold J, Uhde AK, Müller I, Weindl T, Geis-Gerstorfer J, Schlensak C, et al. (September 2017). "Preventing Surgical Site Infections Using a Natural, Biodegradable, Antibacterial Coating on Surgical Sutures". Molecules. 22 (9): 1570. doi:10.3390/molecules22091570. PMC 6151728. PMID 28925959.
Qazi SS, Lombardo DA, Abou-Zaid MM (October 2018). "A Metabolomic and HPLC-MS/MS Analysis of the Foliar Phenolics, Flavonoids and Coumarins of the Fraxinus Species Resistant and Susceptible to Emerald Ash Borer". Molecules. 23 (11): 2734. doi:10.3390/molecules23112734. PMC 6278661. PMID 30360500.
Shi C, Che M, Zhang X, Liu Z, Meng R, Bu X, et al. (March 2018). "Antibacterial activity and mode of action of totarol against Staphylococcus aureus in carrot juice". Journal of Food Science and Technology. 55 (3): 924–934. doi:10.1007/s13197-017-3000-2. PMC 5821648. PMID 29487434.
Xu Z, Krajewski S, Weindl T, Han X, Kimmerle-Müller E, Schweizer E, et al. (September 25, 2019). "The application of natural antibacterial coating for the surface modification of dental implants and abutments". Clinical Oral Implants Research. 30 (S19): 132. doi:10.1111/clr.90_13509. ISSN 0905-7161. S2CID 204052249.
Hou Y, Zhang X, Wang C, Guo M (2020-04-24). "Formulation and Functional Properties of Whey Protein-Based Tissue Adhesive Using Totarol as an Antimicrobial Agent". Processes. 8 (4): 496. doi:10.3390/pr8040496. ISSN 2227-9717.
Velathanthiri N, Balmer T, Grinberg A (March 2020). Minimum Inhibitory and Bactericidal Concentrations of a Totarol™ formulation against Staphylococcus aureus strains obtained from bovine intramammary infections in New Zealand. Antimicrobials 2020. doi:10.13140/RG.2.2.29327.33449.
Laamari Y, Oubella A, Bimoussa A, El Mansouri AE, Ketatni EM, Mentre O, et al. (October 2021). "Design, Hemisynthesis, crystal structure and anticancer activity of 1, 2, 3-triazoles derivatives of totarol" (PDF). Bioorganic Chemistry. 115: 105165. doi:10.1016/j.bioorg.2021.105165. PMID 34298240.
Shariati A, Chegini Z, Ghaznavi-Rad E, Zare EN, Hosseini SM (2022-06-21). "PLGA-Based Nanoplatforms in Drug Delivery for Inhibition and Destruction of Microbial Biofilm". Frontiers in Cellular and Infection Microbiology. 12: 926363. doi:10.3389/fcimb.2022.926363. PMC 9253276. PMID 35800390.
Cuevas-Cianca SI, Leal AC, Hernández LR, Arreola ES, Bach H (October 13, 2022). "Antimicrobial, toxicity, and anti-inflammatory activities of Buddleja perfoliata Kunth". Phytomedicine Plus. 2 (4): 100357. doi:10.1016/j.phyplu.2022.100357. S2CID 252728375.
Bosly HA (November 3, 2022). "Larvicidal potential of Thuja orientalis leaves and fruits extracts against Culex pipiens (Diptera: Culicidae)". Journal of King Saud University - Science. 35 (1): 102396. doi:10.1016/j.jksus.2022.102396. S2CID 253198996.
Abdullahi M, Uzairu A, Shallangwa GA, Mamza PA, Ibrahim MT (December 8, 2022). "Computational modelling of some phenolic diterpenoid compounds as anti-influenza A virus agents". Scientific African. 19: e01462. doi:10.1016/j.sciaf.2022.e01462. S2CID 253944227.
Lu Y, Cui Y, Yang W, Meng F (July 11, 2023). "Design and synthesis of novel totarol derivatives bearing carbamate moiety as potential fungicides". Monatshefte für Chemie - Chemical Monthly. 154 (8): 915–923. doi:10.1007/s00706-023-03102-2.
Han X, Sharma N, Xu Z, Krajewski S, Li P, Spintzyk S, et al. (22 February 2024). "A balance of biocompatibility and antibacterial capability of 3D printed PEEK implants with natural totarol coating". Dental Materials. 40 (4): 674–688. doi:10.1016/j.dental.2024.02.011. PMID 38388252.
Tsunoi M, Iyori K, Harada K (2024). "Efficacy of totarol against Staphylococcus pseudintermedius and Staphylococcus coagulans in dogs and cats: An in vitro study". Japanese Journal of Veterinary Research. 71. doi:10.57494/jjvr.71.4_117.
Haidar S, Amesty Á, Oramas-Royo S, Götz C, El-Awaad E, Kaiser J, et al. (2024). "1,2,3-Triazole-totarol conjugates as potent PIP5K1α lipid kinase inhibitors". Bioorganic & Medicinal Chemistry. 105. doi:10.1016/j.bmc.2024.117727. PMID 38669736.
Hyeon G, Eom Y (July 29, 2024). "Totarol exhibits antibacterial effects through antibiofilm and combined interaction against vancomycin-resistant Enterococcus faecalis". Canadian Journal of Microbiology. 70 (10): 426–432. doi:10.1139/cjm-2024-0014. PMID 39058360.
Hoisang, Jitpean, Seesupa, Kamlangchai, Makpunpol, Ngowwatana, Chaimongkol, Khunbutsri, Khlongkhlaeo, Kampa (2024). "Evaluation of Totarol for Promoting Open Wound Healing in Dogs". Veterinary Sciences. 11 (9): 437. doi:10.3390/vetsci11090437. PMC 11435550. PMID 39330816.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Vichi S, Aumatell MR, Buxaderas S, López-Tamames E (November 2008). "Assessment of some diterpenoids in commercial distilled gin". Analytica Chimica Acta. 628 (2): 222–9. Bibcode:2008AcAC..628..222V. doi:10.1016/j.aca.2008.09.005. PMID 18929011.
Patricio EF, Cruz-López L, Maile R, Tentschert J, Jones GR, Morgan ED (February 2002). "The propolis of stingless bees: terpenes from the tibia of three Frieseomelitta species". Journal of Insect Physiology. 48 (2): 249–254. Bibcode:2002JInsP..48..249P. doi:10.1016/s0022-1910(01)00170-6. PMID 12770125.

essentiallynz.com

Nixon D, Hobbs D (August 15, 2006). "The use of totarol to treat acne in an adolescent: A case study" (PDF). NZFP. 33 (4): 253–255 – via Essentially New Zealand Ltd.

hal.science

Laamari Y, Oubella A, Bimoussa A, El Mansouri AE, Ketatni EM, Mentre O, et al. (October 2021). "Design, Hemisynthesis, crystal structure and anticancer activity of 1, 2, 3-triazoles derivatives of totarol" (PDF). Bioorganic Chemistry. 115: 105165. doi:10.1016/j.bioorg.2021.105165. PMID 34298240.

handle.net

hdl.handle.net

Connor H (2021). "Ko te Rākau Hei Tohu Mō te Rangahau Me te Tuhi Whakapapa: Tree Symbolism as a Method for Researching and Writing Genealogy". Genealogy. 5 (2): 29. doi:10.3390/genealogy5020029. hdl:2292/54952. This article incorporates text from this source, which is available under the CC BY 4.0 license.

harvard.edu

ui.adsabs.harvard.edu

Sharp H, Latif Z, Bartholomew B, Bright C, Jones CD, Sarker SD, et al. (February 2001). "Totarol, totaradiol and ferruginol: three diterpenes from Thuja plicata (Cupressaceae)". Biochemical Systematics and Ecology. 29 (2): 215–217. Bibcode:2001BioSE..29..215S. doi:10.1016/s0305-1978(00)00047-8. PMID 11106853.
Le Métayer P, Schaeffer P, Adam P, Albrecht P, Roussé S, Duringer P (June 2008). "An unprecedented condensation pathway leading to the formation of phenolic C40 bis-diterpenoids in sediments from the Lower Oligocene of the Rhine Rift Valley". Organic Geochemistry. 39 (6): 658–675. Bibcode:2008OrGeo..39..658L. doi:10.1016/j.orggeochem.2008.02.020.
Gibbons S (January 2005). "Plants as a source of bacterial resistance modulators and anti-infective agents". Phytochemistry Reviews. 4 (1): 63–78. Bibcode:2005PChRv...4...63G. doi:10.1007/s11101-005-2494-9. S2CID 24225316.
Patricio EF, Cruz-López L, Maile R, Tentschert J, Jones GR, Morgan ED (February 2002). "The propolis of stingless bees: terpenes from the tibia of three Frieseomelitta species". Journal of Insect Physiology. 48 (2): 249–254. Bibcode:2002JInsP..48..249P. doi:10.1016/S0022-1910(01)00170-6. PMID 12770125.
Yamaji K, Mori S, Akiyama M, Kato A, Nakashima T (2007-12-05). "The Antifungal Compound Totarol of Thujopsis dolabrata var. hondai Seeds Selects for Fungi on Seedling Root Surfaces". Journal of Chemical Ecology. 33 (12): 2254–2265. Bibcode:2007JCEco..33.2254Y. doi:10.1007/s10886-007-9390-2. ISSN 0098-0331. PMID 18026796. S2CID 20883003.
Gao Y, Xu X, Chang S, Wang Y, Xu Y, Ran S, et al. (December 2015). "Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction". Toxicology and Applied Pharmacology. 289 (2): 142–154. Bibcode:2015ToxAP.289..142G. doi:10.1016/j.taap.2015.10.001. PMID 26440581.
Vichi S, Aumatell MR, Buxaderas S, López-Tamames E (November 2008). "Assessment of some diterpenoids in commercial distilled gin". Analytica Chimica Acta. 628 (2): 222–9. Bibcode:2008AcAC..628..222V. doi:10.1016/j.aca.2008.09.005. PMID 18929011.
Patricio EF, Cruz-López L, Maile R, Tentschert J, Jones GR, Morgan ED (February 2002). "The propolis of stingless bees: terpenes from the tibia of three Frieseomelitta species". Journal of Insect Physiology. 48 (2): 249–254. Bibcode:2002JInsP..48..249P. doi:10.1016/s0022-1910(01)00170-6. PMID 12770125.

healthypets.org.nz

Bell A, Jones B, Bridges J, Ward-McGrath H (December 2021). "Some observations on the treatment of superficial pyoderma in dogs with totarol" (PDF). Healthy Pets.{{cite web}}: CS1 maint: multiple names: authors list (link)

incidecoder.com

"Products with Totarol". INCIDecoder.

landcareresearch.co.nz

rauropiwhakaoranga.landcareresearch.co.nz

"Podocarpus Totara". Landcare Research. July 1, 2020.

massey.ac.nz

mro.massey.ac.nz

Nicolson K (1998). Antibacterial properties of diterpenes and their derivatives: a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Microbiology at Massey University (Thesis thesis). Massey University.[1]

natlib.govt.nz

paperspast.natlib.govt.nz

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nature.com

Maxime Rageot, Ramadan B. Hussein, Susanne Beck, Victoria Altmann-Wendling, Mohammed I. M. Ibrahim, Mahmoud M. Bahgat, Ahmed M. Yousef, Katja Mittelstaedt, Jean-Jacques Filippi, Stephen Buckley, Cynthianne Spiteri & Philipp W. Stockhammer (February 1, 2023). "Biomolecular analyses enable new insights into ancient Egyptian embalming". Nature.com. Retrieved December 5, 2024.{{cite web}}: CS1 maint: multiple names: authors list (link)

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pubmed.ncbi.nlm.nih.gov

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Samoylenko V, Dunbar DC, Gafur MA, Khan SI, Ross SA, Mossa JS, et al. (December 2008). "Antiparasitic, nematicidal and antifouling constituents from Juniperus berries". Phytotherapy Research. 22 (12): 1570–1576. doi:10.1002/ptr.2460. PMID 19067375. S2CID 10379153.
Evans GB, Furneaux RH, Gravestock MB, Lynch GP, Scott GK (September 1999). "The synthesis and antibacterial activity of totarol derivatives. Part 1: modifications of ring-C and pro-drugs". Bioorganic & Medicinal Chemistry. 7 (9): 1953–1964. doi:10.1016/s0968-0896(99)00162-5. PMID 10530944.
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Evans GB, Furneaux RH, Gainsford GJ, Murphy MP (July 2000). "The synthesis and antibacterial activity of totarol derivatives. Part 3: Modification of ring-B". Bioorganic & Medicinal Chemistry. 8 (7): 1663–75. doi:10.1016/s0968-0896(00)00096-1. PMID 10976514.
Belahcene S (February 14, 2024). "Chemical Composition Antioxidant and Anti-Inflammatory Activities of Myrtus communis L. Leaf Extract: Forecasting ADMET Profiling and Anti-Inflammatory Targets Using Molecular Docking Tools". Molecules. 29 (4): 849. doi:10.3390/molecules29040849. PMC 10893115. PMID 38398601.
Minami T, Iwamoto M, Ohtsu H, Ohishi H, Tanaka R, Yoshitake A (August 2002). "Aromatase inhibitory activities of standishinal and the diterpenoids from the bark of Thuja standishii". Planta Medica. 68 (8): 742–5. doi:10.1055/s-2002-33787. PMID 12221600. S2CID 26017116.
Lee MK, Yang H, Yoon JS, Jeong EJ, Kim DY, Ha NR, et al. (July 2008). "Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells". Archives of Pharmacal Research. 31 (7): 866–71. doi:10.1007/s12272-001-1239-9. PMID 18704328. S2CID 22860187.
Bailly C (2020-12-01). "Anticancer Activities and Mechanism of Action of Nagilactones, a Group of Terpenoid Lactones Isolated from Podocarpus Species". Natural Products and Bioprospecting. 10 (6): 367–375. doi:10.1007/s13659-020-00268-8. ISSN 2192-2195. PMC 7648843. PMID 33034879.
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Muroi H, Kubo I (April 1996). "Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus". The Journal of Applied Bacteriology. 80 (4): 387–394. doi:10.1111/j.1365-2672.1996.tb03233.x. PMID 8849640.
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Evans GB, Furneaux RH, Gravestock MB, Lynch GP, Scott GK (September 1999). "The synthesis and antibacterial activity of totarol derivatives. Part 1: modifications of ring-C and pro-drugs". Bioorganic & Medicinal Chemistry. 7 (9): 1953–1964. doi:10.1016/S0968-0896(99)00162-5. PMID 10530944.
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Gordien AY, Gray AI, Franzblau SG, Seidel V (December 2009). "Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae)". Journal of Ethnopharmacology. 126 (3): 500–505. doi:10.1016/j.jep.2009.09.007. PMID 19755141.
Micol V, Mateo CR, Shapiro S, Aranda FJ, Villalaín J (April 2001). "Effects of (+)-totarol, a diterpenoid antibacterial agent, on phospholipid model membranes". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1511 (2): 281–290. doi:10.1016/S0005-2736(01)00284-X. PMID 11286971.
Patricio EF, Cruz-López L, Maile R, Tentschert J, Jones GR, Morgan ED (February 2002). "The propolis of stingless bees: terpenes from the tibia of three Frieseomelitta species". Journal of Insect Physiology. 48 (2): 249–254. Bibcode:2002JInsP..48..249P. doi:10.1016/S0022-1910(01)00170-6. PMID 12770125.
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Yamaji K, Mori S, Akiyama M, Kato A, Nakashima T (2007-12-05). "The Antifungal Compound Totarol of Thujopsis dolabrata var. hondai Seeds Selects for Fungi on Seedling Root Surfaces". Journal of Chemical Ecology. 33 (12): 2254–2265. Bibcode:2007JCEco..33.2254Y. doi:10.1007/s10886-007-9390-2. ISSN 0098-0331. PMID 18026796. S2CID 20883003.
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Jaiswal R, Beuria TK, Mohan R, Mahajan SK, Panda D (April 2007). "Totarol inhibits bacterial cytokinesis by perturbing the assembly dynamics of FtsZ". Biochemistry. 46 (14): 4211–4220. doi:10.1021/bi602573e. PMID 17348691.
Gao Y, Xu X, Chang S, Wang Y, Xu Y, Ran S, et al. (December 2015). "Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction". Toxicology and Applied Pharmacology. 289 (2): 142–154. Bibcode:2015ToxAP.289..142G. doi:10.1016/j.taap.2015.10.001. PMID 26440581.
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Ma S, Shi C, Wang C, Guo M (October 2017). "Effects of Ultrasound Treatment on Physiochemical Properties and Antimicrobial Activities of Whey Protein-Totarol Nanoparticles". Journal of Food Protection. 80 (10): 1657–1665. doi:10.4315/0362-028X.JFP-17-078. PMID 28876131.
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Qazi SS, Lombardo DA, Abou-Zaid MM (October 2018). "A Metabolomic and HPLC-MS/MS Analysis of the Foliar Phenolics, Flavonoids and Coumarins of the Fraxinus Species Resistant and Susceptible to Emerald Ash Borer". Molecules. 23 (11): 2734. doi:10.3390/molecules23112734. PMC 6278661. PMID 30360500.
Shi C, Che M, Zhang X, Liu Z, Meng R, Bu X, et al. (March 2018). "Antibacterial activity and mode of action of totarol against Staphylococcus aureus in carrot juice". Journal of Food Science and Technology. 55 (3): 924–934. doi:10.1007/s13197-017-3000-2. PMC 5821648. PMID 29487434.
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Shariati A, Chegini Z, Ghaznavi-Rad E, Zare EN, Hosseini SM (2022-06-21). "PLGA-Based Nanoplatforms in Drug Delivery for Inhibition and Destruction of Microbial Biofilm". Frontiers in Cellular and Infection Microbiology. 12: 926363. doi:10.3389/fcimb.2022.926363. PMC 9253276. PMID 35800390.
Han X, Sharma N, Xu Z, Krajewski S, Li P, Spintzyk S, et al. (22 February 2024). "A balance of biocompatibility and antibacterial capability of 3D printed PEEK implants with natural totarol coating". Dental Materials. 40 (4): 674–688. doi:10.1016/j.dental.2024.02.011. PMID 38388252.
Haidar S, Amesty Á, Oramas-Royo S, Götz C, El-Awaad E, Kaiser J, et al. (2024). "1,2,3-Triazole-totarol conjugates as potent PIP5K1α lipid kinase inhibitors". Bioorganic & Medicinal Chemistry. 105. doi:10.1016/j.bmc.2024.117727. PMID 38669736.
Hyeon G, Eom Y (July 29, 2024). "Totarol exhibits antibacterial effects through antibiofilm and combined interaction against vancomycin-resistant Enterococcus faecalis". Canadian Journal of Microbiology. 70 (10): 426–432. doi:10.1139/cjm-2024-0014. PMID 39058360.
Hoisang, Jitpean, Seesupa, Kamlangchai, Makpunpol, Ngowwatana, Chaimongkol, Khunbutsri, Khlongkhlaeo, Kampa (2024). "Evaluation of Totarol for Promoting Open Wound Healing in Dogs". Veterinary Sciences. 11 (9): 437. doi:10.3390/vetsci11090437. PMC 11435550. PMID 39330816.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Vichi S, Aumatell MR, Buxaderas S, López-Tamames E (November 2008). "Assessment of some diterpenoids in commercial distilled gin". Analytica Chimica Acta. 628 (2): 222–9. Bibcode:2008AcAC..628..222V. doi:10.1016/j.aca.2008.09.005. PMID 18929011.
Patricio EF, Cruz-López L, Maile R, Tentschert J, Jones GR, Morgan ED (February 2002). "The propolis of stingless bees: terpenes from the tibia of three Frieseomelitta species". Journal of Insect Physiology. 48 (2): 249–254. Bibcode:2002JInsP..48..249P. doi:10.1016/s0022-1910(01)00170-6. PMID 12770125.

ncbi.nlm.nih.gov

Smith EC, Kaatz GW, Seo SM, Wareham N, Williamson EM, Gibbons S (December 2007). "The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus". Antimicrobial Agents and Chemotherapy. 51 (12): 4480–3. doi:10.1128/AAC.00216-07. PMC 2168009. PMID 17664318.
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Bailly C (2020-12-01). "Anticancer Activities and Mechanism of Action of Nagilactones, a Group of Terpenoid Lactones Isolated from Podocarpus Species". Natural Products and Bioprospecting. 10 (6): 367–375. doi:10.1007/s13659-020-00268-8. ISSN 2192-2195. PMC 7648843. PMID 33034879.
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Reinbold J, Uhde AK, Müller I, Weindl T, Geis-Gerstorfer J, Schlensak C, et al. (September 2017). "Preventing Surgical Site Infections Using a Natural, Biodegradable, Antibacterial Coating on Surgical Sutures". Molecules. 22 (9): 1570. doi:10.3390/molecules22091570. PMC 6151728. PMID 28925959.
Qazi SS, Lombardo DA, Abou-Zaid MM (October 2018). "A Metabolomic and HPLC-MS/MS Analysis of the Foliar Phenolics, Flavonoids and Coumarins of the Fraxinus Species Resistant and Susceptible to Emerald Ash Borer". Molecules. 23 (11): 2734. doi:10.3390/molecules23112734. PMC 6278661. PMID 30360500.
Shi C, Che M, Zhang X, Liu Z, Meng R, Bu X, et al. (March 2018). "Antibacterial activity and mode of action of totarol against Staphylococcus aureus in carrot juice". Journal of Food Science and Technology. 55 (3): 924–934. doi:10.1007/s13197-017-3000-2. PMC 5821648. PMID 29487434.
Shariati A, Chegini Z, Ghaznavi-Rad E, Zare EN, Hosseini SM (2022-06-21). "PLGA-Based Nanoplatforms in Drug Delivery for Inhibition and Destruction of Microbial Biofilm". Frontiers in Cellular and Infection Microbiology. 12: 926363. doi:10.3389/fcimb.2022.926363. PMC 9253276. PMID 35800390.
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Lee MK, Yang H, Yoon JS, Jeong EJ, Kim DY, Ha NR, et al. (July 2008). "Antifibrotic activity of diterpenes from Biota orientalis leaves on hepatic stellate cells". Archives of Pharmacal Research. 31 (7): 866–71. doi:10.1007/s12272-001-1239-9. PMID 18704328. S2CID 22860187.
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