Toxic shock syndrome (English Wikipedia)

Rupp CM. "The Times Goes Computer". In Ditlea S (ed.). Digital Deli. Atari Archives. Archived from the original on 27 August 2013. Retrieved 12 October 2013.

books.google.com

Talevski N (7 April 2010). Rock Obituaries – Knocking On Heaven's Door. Omnibus Press. ISBN 978-0-85712-117-2. Retrieved 29 January 2015.
Mercer B (2007). Play-by-Play: Tales from a Sportscasting Insider. Taylor Trade Publishing. pp. 277–. ISBN 978-1-4617-3474-1. Archived from the original on 15 October 2013. Retrieved 12 October 2013.

cdc.gov

stacks.cdc.gov

CDC (23 May 1980). "Toxic-shock syndrome—United States". Morbidity and Mortality Weekly Report. 29 (20): 229–230. Archived from the original on 20 October 2014.
CDC (19 September 1980). "Follow-up on toxic-shock syndrome". Morbidity and Mortality Weekly Report. 29 (37): 441–5. Archived from the original on 4 March 2016.

wwwn.cdc.gov

"Toxic shock syndrome (other than Streptococcal) (TSS): 2011 Case Definition". Centers for Disease Control and Prevention. 8 May 2014. Archived from the original on 2 November 2020. Retrieved 9 February 2021.

cdc.gov

"Streptococcal Toxic Shock Syndrome: For Clinicians | CDC". www.cdc.gov. 23 November 2021. Archived from the original on 23 December 2022. Retrieved 2 April 2022.

clevelandclinic.org

my.clevelandclinic.org

"Toxic Shock Syndrome (TSS): Causes, Symptoms & Treatment". Cleveland Clinic. Archived from the original on 24 March 2022. Retrieved 1 April 2022.

crossref.org

chooser.crossref.org

Vostral SL (27 November 2018). "5. Health Activism and the Limits of Labeling". Toxic Shock: A Social History. New York City: New York University Press. p. 140. doi:10.18574/nyu/9781479877843.001.0001. ISBN 978-1-4798-7784-3. LCCN 2018012210. OCLC 1031956695. Pursettes blossom out to absorb more fully, more effectively.

doi.org

Low DE (July 2013). "Toxic Shock Syndrome: Major Advances in Pathogenesis, But Not Treatment". Critical Care Clinics. 29 (3): 651–675. doi:10.1016/j.ccc.2013.03.012. PMID 23830657 – via Elsevier.
Gottlieb M, Long B, Koyfman A (June 2018). "The Evaluation and Management of Toxic Shock Syndrome in the Emergency Department: A Review of the Literature". The Journal of Emergency Medicine. 54 (6): 807–814. doi:10.1016/j.jemermed.2017.12.048. PMID 29366615. S2CID 1812988.
Khajuria A, Nadam HH, Gallagher M, Jones I, Atkins J (2020). "Pediatric Toxic Shock Syndrome After a 7% Burn: A Case Study and Systematic Literature Review". Ann. Plast. Surg. 84 (1): 35–42. doi:10.1097/SAP.0000000000001990. PMID 31192868. S2CID 189815024.
Wilkins AL, Steer AC, Smeesters PR, Curtis N (2017). "Toxic shock syndrome – the seven Rs of management and treatment". Journal of Infection. 74: S147–S152. doi:10.1016/S0163-4453(17)30206-2. PMID 28646955.
Burnham J, Kollef M (May 2015). "Understanding toxic shock syndrome". Intensive Care Medicine. 41: 1707–1710. doi:10.1007/s00134-015-3861-7.
Lindsay JA, Ruzin, A, Ross, HF, Kurepina, N, Novick, RP (July 1998). "The gene for toxic shock toxin is carried by a family of mobile pathogenicity islands in Staphylococcus aureus". Molecular Microbiology. 29 (2): 527–43. doi:10.1046/j.1365-2958.1998.00947.x. PMID 9720870. S2CID 30680160.
Groisman EA, ed. (2001). "15. Pathogenic Mechanisms in Streptococcal Diseases". Principles of Bacterial Pathogenesis. San Diego, Calif: Academic Press. p. 740. doi:10.1016/B978-0-12-304220-0.X5000-6. ISBN 978-0-12-304220-0. Archived from the original on 22 June 2024. Retrieved 22 June 2024. Superantigens are proteins that have the ability to bind to an invariant region of the class II major histocompatibility complex (MHC) on an antigen-presenting cell and to crosslink this receptor to a T cell through binding to the variable region of the β-chain of the T cell antigen receptor.
Zimbelman J, Palmer A, Todd J (1999). "Improved outcome of clindamycin compared with beta-lactam antibiotic treatment for invasive Streptococcus pyogenes infection". The Pediatric Infectious Disease Journal. 18 (12): 1096–1100. doi:10.1097/00006454-199912000-00014. PMID 10608632. Archived from the original on 11 January 2020. Retrieved 16 February 2009.
Schlievert PM, Kelly JA (1984). "Clindamycin-induced suppression of toxic-shock syndrome-associated exotoxin production". The Journal of Infectious Diseases. 149 (3): 471. doi:10.1093/infdis/149.3.471. PMID 6715902.
van Langevelde P, van Dissel JT, Meurs CJ, Renz J, Groeneveld PH (1 August 1997). "Combination of flucloxacillin and gentamicin inhibits toxic shock syndrome toxin 1 production by Staphylococcus aureus in both logarithmic and stationary phases of growth". Antimicrobial Agents and Chemotherapy. 41 (8): 1682–5. doi:10.1128/AAC.41.8.1682. PMC 163985. PMID 9257741.
Mishra G (2014). "Australian Longitudinal Study on Women's Health". UQ eSpace. doi:10.14264/uql.2016.448. Retrieved 2 April 2022.
Todd J, Fishaut M, Kapral F, Welch T (1978). "Toxic-shock syndrome associated with phage-group-I staphylococci". The Lancet. 2 (8100): 1116–8. doi:10.1016/S0140-6736(78)92274-2. PMID 82681. S2CID 54231145.
Todd J (1981). "Toxic shock syndrome—scientific uncertainty and the public media". Pediatrics. 67 (6): 921–3. doi:10.1542/peds.67.6.921. PMID 7232057. S2CID 3051129.
Hanrahan S, Submission HC (1994). "Historical review of menstrual toxic shock syndrome". Women & Health. 21 (2–3): 141–65. doi:10.1300/J013v21n02_09. PMID 8073784.
Vostral SL (27 November 2018). "5. Health Activism and the Limits of Labeling". Toxic Shock: A Social History. New York City: New York University Press. p. 140. doi:10.18574/nyu/9781479877843.001.0001. ISBN 978-1-4798-7784-3. LCCN 2018012210. OCLC 1031956695. Pursettes blossom out to absorb more fully, more effectively.
Hanrahan S, Submission HC (1994). "Historical review of menstrual toxic shock syndrome". Women & Health. 21 (2–3): 141–165. doi:10.1300/J013v21n02_09. PMID 8073784.
Petitti D, Reingold A, Chin J (1986). "The incidence of toxic shock syndrome in Northern California. 1972 through 1983". JAMA. 255 (3): 368–72. doi:10.1001/jama.255.3.368. PMID 3941516.
Berkley S, Hightower A, Broome C, Reingold A (1987). "The relationship of tampon characteristics to menstrual toxic shock syndrome". JAMA. 258 (7): 917–20. doi:10.1001/jama.258.7.917. PMID 3613021.

dx.doi.org

Mishra G (2014). "Australian Longitudinal Study on Women's Health". UQ eSpace. doi:10.14264/uql.2016.448. Retrieved 2 April 2022.

ew.com

news-briefs.ew.com

"Clive Barker recovering from 'near fatal' case of toxic shock syndrome". Entertainment Weekly. 7 February 2012. Archived from the original on 11 November 2014. Retrieved 11 November 2014.

harvard.edu

dash.harvard.edu

Kohen, Jamie (2001). "The History of the Regulation of Menstrual Tampons". LEDA at Harvard Law School. Archived from the original on 20 October 2016. Retrieved 5 March 2017.

hopkinsmedicine.org

"Toxic Shock Syndrome (TSS)". Johns Hopkins School of Medicine. 19 November 2019. Archived from the original on 29 January 2022. Retrieved 31 March 2022.

io.com

Vitale, Sidra (1997). "Toxic Shock Syndrome". Web by Women, for Women. Archived from the original on 16 March 2006. Retrieved 20 March 2006.

loc.gov

lccn.loc.gov

Vostral SL (27 November 2018). "5. Health Activism and the Limits of Labeling". Toxic Shock: A Social History. New York City: New York University Press. p. 140. doi:10.18574/nyu/9781479877843.001.0001. ISBN 978-1-4798-7784-3. LCCN 2018012210. OCLC 1031956695. Pursettes blossom out to absorb more fully, more effectively.

mayoclinic.org

"Toxic shock syndrome". Mayo Clinic. 23 March 2022. Archived from the original on 6 March 2023. Retrieved 15 March 2023.
"Staph infections – Symptoms and causes". Mayo Clinic. Archived from the original on 1 June 2021. Retrieved 1 April 2022.

msdmanuals.com

Bush LM (March 2023). "Toxic Shock Syndrome". The Merck Manuals. Archived from the original on 23 March 2024. Retrieved 23 June 2024.

mum.org

Finley, Harry. "Rely Tampon: It Even Absorbed the Worry!". Museum of Menstruation. Archived from the original on 14 April 2006. Retrieved 20 March 2006.

nih.gov

pubmed.ncbi.nlm.nih.gov

Low DE (July 2013). "Toxic Shock Syndrome: Major Advances in Pathogenesis, But Not Treatment". Critical Care Clinics. 29 (3): 651–675. doi:10.1016/j.ccc.2013.03.012. PMID 23830657 – via Elsevier.
Gottlieb M, Long B, Koyfman A (June 2018). "The Evaluation and Management of Toxic Shock Syndrome in the Emergency Department: A Review of the Literature". The Journal of Emergency Medicine. 54 (6): 807–814. doi:10.1016/j.jemermed.2017.12.048. PMID 29366615. S2CID 1812988.
Khajuria A, Nadam HH, Gallagher M, Jones I, Atkins J (2020). "Pediatric Toxic Shock Syndrome After a 7% Burn: A Case Study and Systematic Literature Review". Ann. Plast. Surg. 84 (1): 35–42. doi:10.1097/SAP.0000000000001990. PMID 31192868. S2CID 189815024.
Wilkins AL, Steer AC, Smeesters PR, Curtis N (2017). "Toxic shock syndrome – the seven Rs of management and treatment". Journal of Infection. 74: S147–S152. doi:10.1016/S0163-4453(17)30206-2. PMID 28646955.
Lindsay JA, Ruzin, A, Ross, HF, Kurepina, N, Novick, RP (July 1998). "The gene for toxic shock toxin is carried by a family of mobile pathogenicity islands in Staphylococcus aureus". Molecular Microbiology. 29 (2): 527–43. doi:10.1046/j.1365-2958.1998.00947.x. PMID 9720870. S2CID 30680160.
Zimbelman J, Palmer A, Todd J (1999). "Improved outcome of clindamycin compared with beta-lactam antibiotic treatment for invasive Streptococcus pyogenes infection". The Pediatric Infectious Disease Journal. 18 (12): 1096–1100. doi:10.1097/00006454-199912000-00014. PMID 10608632. Archived from the original on 11 January 2020. Retrieved 16 February 2009.
Schlievert PM, Kelly JA (1984). "Clindamycin-induced suppression of toxic-shock syndrome-associated exotoxin production". The Journal of Infectious Diseases. 149 (3): 471. doi:10.1093/infdis/149.3.471. PMID 6715902.
van Langevelde P, van Dissel JT, Meurs CJ, Renz J, Groeneveld PH (1 August 1997). "Combination of flucloxacillin and gentamicin inhibits toxic shock syndrome toxin 1 production by Staphylococcus aureus in both logarithmic and stationary phases of growth". Antimicrobial Agents and Chemotherapy. 41 (8): 1682–5. doi:10.1128/AAC.41.8.1682. PMC 163985. PMID 9257741.
Todd J, Fishaut M, Kapral F, Welch T (1978). "Toxic-shock syndrome associated with phage-group-I staphylococci". The Lancet. 2 (8100): 1116–8. doi:10.1016/S0140-6736(78)92274-2. PMID 82681. S2CID 54231145.
Todd J (1981). "Toxic shock syndrome—scientific uncertainty and the public media". Pediatrics. 67 (6): 921–3. doi:10.1542/peds.67.6.921. PMID 7232057. S2CID 3051129.
Hanrahan S, Submission HC (1994). "Historical review of menstrual toxic shock syndrome". Women & Health. 21 (2–3): 141–65. doi:10.1300/J013v21n02_09. PMID 8073784.
Hanrahan S, Submission HC (1994). "Historical review of menstrual toxic shock syndrome". Women & Health. 21 (2–3): 141–165. doi:10.1300/J013v21n02_09. PMID 8073784.
Petitti D, Reingold A, Chin J (1986). "The incidence of toxic shock syndrome in Northern California. 1972 through 1983". JAMA. 255 (3): 368–72. doi:10.1001/jama.255.3.368. PMID 3941516.
Berkley S, Hightower A, Broome C, Reingold A (1987). "The relationship of tampon characteristics to menstrual toxic shock syndrome". JAMA. 258 (7): 917–20. doi:10.1001/jama.258.7.917. PMID 3613021.

ncbi.nlm.nih.gov

van Langevelde P, van Dissel JT, Meurs CJ, Renz J, Groeneveld PH (1 August 1997). "Combination of flucloxacillin and gentamicin inhibits toxic shock syndrome toxin 1 production by Staphylococcus aureus in both logarithmic and stationary phases of growth". Antimicrobial Agents and Chemotherapy. 41 (8): 1682–5. doi:10.1128/AAC.41.8.1682. PMC 163985. PMID 9257741.

nytimes.com

Dennis Hevesi (10 September 2011). "Bruce Dan, Who Helped Link Toxic Shock and Tampons, Is Dead at 64". The New York Times. Archived from the original on 11 September 2011. Retrieved 12 September 2011.
Robertson N (19 September 1982). "Toxic Shock". The New York Times. Archived from the original on 9 November 2022. Retrieved 9 November 2022.

query.nytimes.com

Altman L (29 May 1990). "The Doctor's World; Henson Death Shows Danger of Pneumonia". The New York Times. Archived from the original on 16 October 2007. Retrieved 10 June 2017.

nzherald.co.nz

Lang S (15 February 2009). "Lana's leap outside her comfort zone". The New Zealand Herald. Archived from the original on 23 February 2013. Retrieved 26 January 2010.

pidj.org

Zimbelman J, Palmer A, Todd J (1999). "Improved outcome of clindamycin compared with beta-lactam antibiotic treatment for invasive Streptococcus pyogenes infection". The Pediatric Infectious Disease Journal. 18 (12): 1096–1100. doi:10.1097/00006454-199912000-00014. PMID 10608632. Archived from the original on 11 January 2020. Retrieved 16 February 2009.

psu.edu

collegian.psu.edu

Citrinbaum, Joanna (14 October 2003). "The question's absorbing: 'Are tampons little white lies?'". The Daily Collegian. Archived from the original on 20 June 2017. Retrieved 27 December 2015.

rarediseases.org

"Toxic Shock Syndrome". National Organization for Rare Disorders. 8 April 2009. Archived from the original on 24 March 2022. Retrieved 31 March 2022.

sciencedirect.com

Groisman EA, ed. (2001). "15. Pathogenic Mechanisms in Streptococcal Diseases". Principles of Bacterial Pathogenesis. San Diego, Calif: Academic Press. p. 740. doi:10.1016/B978-0-12-304220-0.X5000-6. ISBN 978-0-12-304220-0. Archived from the original on 22 June 2024. Retrieved 22 June 2024. Superantigens are proteins that have the ability to bind to an invariant region of the class II major histocompatibility complex (MHC) on an antigen-presenting cell and to crosslink this receptor to a T cell through binding to the variable region of the β-chain of the T cell antigen receptor.

seattletimes.com

Lyons JS (25 January 2005). "A New Generation Faces Toxic Shock Syndrome". The Seattle Times. Knight Ridder Newspapers. Archived from the original on 11 September 2017. Retrieved 11 September 2017. first published as "Lingering Risk", San Jose Mercury News, 13 December 2004

semanticscholar.org

api.semanticscholar.org

Gottlieb M, Long B, Koyfman A (June 2018). "The Evaluation and Management of Toxic Shock Syndrome in the Emergency Department: A Review of the Literature". The Journal of Emergency Medicine. 54 (6): 807–814. doi:10.1016/j.jemermed.2017.12.048. PMID 29366615. S2CID 1812988.
Khajuria A, Nadam HH, Gallagher M, Jones I, Atkins J (2020). "Pediatric Toxic Shock Syndrome After a 7% Burn: A Case Study and Systematic Literature Review". Ann. Plast. Surg. 84 (1): 35–42. doi:10.1097/SAP.0000000000001990. PMID 31192868. S2CID 189815024.
Lindsay JA, Ruzin, A, Ross, HF, Kurepina, N, Novick, RP (July 1998). "The gene for toxic shock toxin is carried by a family of mobile pathogenicity islands in Staphylococcus aureus". Molecular Microbiology. 29 (2): 527–43. doi:10.1046/j.1365-2958.1998.00947.x. PMID 9720870. S2CID 30680160.
Todd J, Fishaut M, Kapral F, Welch T (1978). "Toxic-shock syndrome associated with phage-group-I staphylococci". The Lancet. 2 (8100): 1116–8. doi:10.1016/S0140-6736(78)92274-2. PMID 82681. S2CID 54231145.
Todd J (1981). "Toxic shock syndrome—scientific uncertainty and the public media". Pediatrics. 67 (6): 921–3. doi:10.1542/peds.67.6.921. PMID 7232057. S2CID 3051129.

sepsis.org

"Sepsis and Toxic Shock Syndrome". Sepsis Alliance. 18 June 2024. Archived from the original on 24 June 2024. Retrieved 24 June 2024.

stayfree.com

"Stayfree — FAQ About Toxic Shock Syndrome (TSS)". 2006. Archived from the original on 23 March 2007. Retrieved 13 October 2006.

theclinics.com

criticalcare.theclinics.com

Low DE (July 2013). "Toxic Shock Syndrome: Major Advances in Pathogenesis, But Not Treatment". Critical Care Clinics. 29 (3): 651–675. doi:10.1016/j.ccc.2013.03.012. PMID 23830657 – via Elsevier.

theguardian.com

Lindsey E (6 November 2003). "Welcome to the cotton club". The Guardian. Archived from the original on 9 November 2016.

washingtonpost.com

Masih N, Vinall F (19 June 2024). "A deadly bacterial infection is on the rise in Japan. What is STSS?". The Washington Post. Archived from the original on 19 June 2024. Retrieved 21 June 2024.

web.archive.org

"Toxic shock syndrome". Mayo Clinic. 23 March 2022. Archived from the original on 6 March 2023. Retrieved 15 March 2023.
"Toxic shock syndrome (other than Streptococcal) (TSS): 2011 Case Definition". Centers for Disease Control and Prevention. 8 May 2014. Archived from the original on 2 November 2020. Retrieved 9 February 2021.
Bush LM (March 2023). "Toxic Shock Syndrome". The Merck Manuals. Archived from the original on 23 March 2024. Retrieved 23 June 2024.
Groisman EA, ed. (2001). "15. Pathogenic Mechanisms in Streptococcal Diseases". Principles of Bacterial Pathogenesis. San Diego, Calif: Academic Press. p. 740. doi:10.1016/B978-0-12-304220-0.X5000-6. ISBN 978-0-12-304220-0. Archived from the original on 22 June 2024. Retrieved 22 June 2024. Superantigens are proteins that have the ability to bind to an invariant region of the class II major histocompatibility complex (MHC) on an antigen-presenting cell and to crosslink this receptor to a T cell through binding to the variable region of the β-chain of the T cell antigen receptor.
"Sepsis and Toxic Shock Syndrome". Sepsis Alliance. 18 June 2024. Archived from the original on 24 June 2024. Retrieved 24 June 2024.
"The Basics of Toxic Shock Syndrome". WebMD. Archived from the original on 27 December 2023. Retrieved 27 December 2023.
Zimbelman J, Palmer A, Todd J (1999). "Improved outcome of clindamycin compared with beta-lactam antibiotic treatment for invasive Streptococcus pyogenes infection". The Pediatric Infectious Disease Journal. 18 (12): 1096–1100. doi:10.1097/00006454-199912000-00014. PMID 10608632. Archived from the original on 11 January 2020. Retrieved 16 February 2009.
"Streptococcal Toxic Shock Syndrome: For Clinicians | CDC". www.cdc.gov. 23 November 2021. Archived from the original on 23 December 2022. Retrieved 2 April 2022.
"Toxic Shock Syndrome (TSS)". Johns Hopkins School of Medicine. 19 November 2019. Archived from the original on 29 January 2022. Retrieved 31 March 2022.
"Toxic Shock Syndrome". National Organization for Rare Disorders. 8 April 2009. Archived from the original on 24 March 2022. Retrieved 31 March 2022.
"Toxic Shock Syndrome (TSS): Causes, Symptoms & Treatment". Cleveland Clinic. Archived from the original on 24 March 2022. Retrieved 1 April 2022.
"Staph infections – Symptoms and causes". Mayo Clinic. Archived from the original on 1 June 2021. Retrieved 1 April 2022.
Lyons JS (25 January 2005). "A New Generation Faces Toxic Shock Syndrome". The Seattle Times. Knight Ridder Newspapers. Archived from the original on 11 September 2017. Retrieved 11 September 2017. first published as "Lingering Risk", San Jose Mercury News, 13 December 2004
"Stayfree — FAQ About Toxic Shock Syndrome (TSS)". 2006. Archived from the original on 23 March 2007. Retrieved 13 October 2006.
Lindsey E (6 November 2003). "Welcome to the cotton club". The Guardian. Archived from the original on 9 November 2016.
Masih N, Vinall F (19 June 2024). "A deadly bacterial infection is on the rise in Japan. What is STSS?". The Washington Post. Archived from the original on 19 June 2024. Retrieved 21 June 2024.
Finley, Harry. "Rely Tampon: It Even Absorbed the Worry!". Museum of Menstruation. Archived from the original on 14 April 2006. Retrieved 20 March 2006.
Citrinbaum, Joanna (14 October 2003). "The question's absorbing: 'Are tampons little white lies?'". The Daily Collegian. Archived from the original on 20 June 2017. Retrieved 27 December 2015.
Vitale, Sidra (1997). "Toxic Shock Syndrome". Web by Women, for Women. Archived from the original on 16 March 2006. Retrieved 20 March 2006.
CDC (23 May 1980). "Toxic-shock syndrome—United States". Morbidity and Mortality Weekly Report. 29 (20): 229–230. Archived from the original on 20 October 2014.
Dennis Hevesi (10 September 2011). "Bruce Dan, Who Helped Link Toxic Shock and Tampons, Is Dead at 64". The New York Times. Archived from the original on 11 September 2011. Retrieved 12 September 2011.
CDC (19 September 1980). "Follow-up on toxic-shock syndrome". Morbidity and Mortality Weekly Report. 29 (37): 441–5. Archived from the original on 4 March 2016.
Kohen, Jamie (2001). "The History of the Regulation of Menstrual Tampons". LEDA at Harvard Law School. Archived from the original on 20 October 2016. Retrieved 5 March 2017.
"Clive Barker recovering from 'near fatal' case of toxic shock syndrome". Entertainment Weekly. 7 February 2012. Archived from the original on 11 November 2014. Retrieved 11 November 2014.
Altman L (29 May 1990). "The Doctor's World; Henson Death Shows Danger of Pneumonia". The New York Times. Archived from the original on 16 October 2007. Retrieved 10 June 2017.
Robertson N (19 September 1982). "Toxic Shock". The New York Times. Archived from the original on 9 November 2022. Retrieved 9 November 2022.
Rupp CM. "The Times Goes Computer". In Ditlea S (ed.). Digital Deli. Atari Archives. Archived from the original on 27 August 2013. Retrieved 12 October 2013.
Mercer B (2007). Play-by-Play: Tales from a Sportscasting Insider. Taylor Trade Publishing. pp. 277–. ISBN 978-1-4617-3474-1. Archived from the original on 15 October 2013. Retrieved 12 October 2013.

webmd.com

"The Basics of Toxic Shock Syndrome". WebMD. Archived from the original on 27 December 2023. Retrieved 27 December 2023.

worldcat.org

search.worldcat.org

Vostral SL (27 November 2018). "5. Health Activism and the Limits of Labeling". Toxic Shock: A Social History. New York City: New York University Press. p. 140. doi:10.18574/nyu/9781479877843.001.0001. ISBN 978-1-4798-7784-3. LCCN 2018012210. OCLC 1031956695. Pursettes blossom out to absorb more fully, more effectively.