Analysis of information sources in references of the Wikipedia article "Trazodone" in English language version.
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Table 1 Trip-killers recommended by Reddit users [...] Antidepressants, n=100 [...] Drug Name: Trazodone; N: 77. [...] Table 2 Trip-killer doses recommended by Reddit users: Drug name: Trazodone. Dose range: 50–150 mg.
{{cite journal}}: CS1 maint: periodical has ISBN (link)Although the exact underlying mechanism causing parkinsonism after the exposure of trazodone in this or any of the previously described cases remains elusive, it likely involves trazodone's inhibitory effect, either directly or via the serotonergic system on striatal dopaminergic neurotransmission.7,8,12–16 It is known that serotonin (5-hydroxytryptamine [5-HT]), via stimulation of 5-HT2C receptors, exerts a tonic inhibitory influence on dopaminergic neurotransmission, whereas activation of 5-HT2A receptors enhances dopaminergic neurotransmission. The antidepressant trazodone is a 5-HT2A and 5-HT2C receptor antagonist.7,16 However, its antagonism at 5-HT2A receptors is more robust than that at 5-HT2C receptors (15-fold difference).7,8 Hence, the differential antagonist effect of trazodone on 5-HT2A versus 5-HT2C receptors "at a certain dose point" could potentially result in the inhibition of dopaminergic neurotransmission in the striatonigral region. In addition, a direct dose-dependent blocking effect of trazodone on postsynaptic striatal D2 dopamine receptors has been demonstrated in the rat model.8
{{cite journal}}: CS1 maint: periodical has ISBN (link){{cite journal}}: CS1 maint: DOI inactive as of September 2025 (link)Following oral administration, the absolute bioavailability of trazodone is estimated between 63% and 80%, primarily limited by first-pass metabolism.
Trazodone hydrochloride is well absorbed after oral administration, with an average absolute bioavailability of approximately 65%. Peak plasma concentrations are reached within one to two hours.
Table 1 Trip-killers recommended by Reddit users [...] Antidepressants, n=100 [...] Drug Name: Trazodone; N: 77. [...] Table 2 Trip-killer doses recommended by Reddit users: Drug name: Trazodone. Dose range: 50–150 mg.
Table 1 Trip-killers recommended by Reddit users [...] Antidepressants, n=100 [...] Drug Name: Trazodone; N: 77. [...] Table 2 Trip-killer doses recommended by Reddit users: Drug name: Trazodone. Dose range: 50–150 mg.
{{cite journal}}: CS1 maint: periodical has ISBN (link)Although the exact underlying mechanism causing parkinsonism after the exposure of trazodone in this or any of the previously described cases remains elusive, it likely involves trazodone's inhibitory effect, either directly or via the serotonergic system on striatal dopaminergic neurotransmission.7,8,12–16 It is known that serotonin (5-hydroxytryptamine [5-HT]), via stimulation of 5-HT2C receptors, exerts a tonic inhibitory influence on dopaminergic neurotransmission, whereas activation of 5-HT2A receptors enhances dopaminergic neurotransmission. The antidepressant trazodone is a 5-HT2A and 5-HT2C receptor antagonist.7,16 However, its antagonism at 5-HT2A receptors is more robust than that at 5-HT2C receptors (15-fold difference).7,8 Hence, the differential antagonist effect of trazodone on 5-HT2A versus 5-HT2C receptors "at a certain dose point" could potentially result in the inhibition of dopaminergic neurotransmission in the striatonigral region. In addition, a direct dose-dependent blocking effect of trazodone on postsynaptic striatal D2 dopamine receptors has been demonstrated in the rat model.8
{{cite journal}}: CS1 maint: periodical has ISBN (link){{cite journal}}: CS1 maint: DOI inactive as of September 2025 (link)