WNK4 (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "WNK4" in English language version.

refsWebsite

Global rank English rank

55nih.gov

4^th place

36doi.org

2^nd place

5semanticscholar.org

11^th place

8^th place

5harvard.edu

18^th place

17^th place

2ensembl.org

1,626^th place

1,007^th place

1worldcat.org

5^th place

doi.org (Global: 2^nd place; English: 2^nd place)

Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH (June 2000). "WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II". The Journal of Biological Chemistry. 275 (22): 16795–801. doi:10.1074/jbc.275.22.16795. PMID 10828064.
Wilson FH, Disse-Nicodème S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, et al. (August 2001). "Human hypertension caused by mutations in WNK kinases". Science. 293 (5532): 1107–12. doi:10.1126/science.1062844. PMID 11498583. S2CID 22700809.
Kahle KT, Gimenez I, Hassan H, Wilson FH, Wong RD, Forbush B, et al. (February 2004). "WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia". Proceedings of the National Academy of Sciences of the United States of America. 101 (7): 2064–9. doi:10.1073/pnas.0308434100. PMC 357052. PMID 14769928.
Veríssimo F, Jordan P (September 2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms". Oncogene. 20 (39): 5562–9. doi:10.1038/sj.onc.1204726. PMID 11571656.
Murillo-de-Ozores AR, Rodríguez-Gama A, Bazúa-Valenti S, Leyva-Ríos K, Vázquez N, Pacheco-Álvarez D, et al. (August 2018). "C-terminally truncated, kidney-specific variants of the WNK4 kinase lack several sites that regulate its activity". The Journal of Biological Chemistry. 293 (31): 12209–12221. doi:10.1074/jbc.RA118.003037. PMC 6078442. PMID 29921588.
Arnold JE, Healy JK (September 1969). "Hyperkalemia, hypertension and systemic acidosis without renal failure associated with a tubular defect in potassium excretion". The American Journal of Medicine. 47 (3): 461–72. doi:10.1016/0002-9343(69)90230-7. PMID 5808659.
Gordon RD, Geddes RA, Pawsey CG, O'Halloran MW (November 1970). "Hypertension and severe hyperkalaemia associated with suppression of renin and aldosterone and completely reversed by dietary sodium restriction". Australasian Annals of Medicine. 19 (4): 287–94. doi:10.1111/imj.1970.19.4.287. PMID 5490655.
Min X, Lee BH, Cobb MH, Goldsmith EJ (July 2004). "Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension". Structure. 12 (7): 1303–11. doi:10.1016/j.str.2004.04.014. PMID 15242606.
Piala AT, Moon TM, Akella R, He H, Cobb MH, Goldsmith EJ (May 2014). "Chloride sensing by WNK1 involves inhibition of autophosphorylation". Science Signaling. 7 (324): ra41. doi:10.1126/scisignal.2005050. PMC 4123527. PMID 24803536.
Xu BE, Min X, Stippec S, Lee BH, Goldsmith EJ, Cobb MH (December 2002). "Regulation of WNK1 by an autoinhibitory domain and autophosphorylation". The Journal of Biological Chemistry. 277 (50): 48456–62. doi:10.1074/jbc.M207917200. PMID 12374799.
Moon TM, Correa F, Kinch LN, Piala AT, Gardner KH, Goldsmith EJ (April 2013). "Solution structure of the WNK1 autoinhibitory domain, a WNK-specific PF2 domain". Journal of Molecular Biology. 425 (8): 1245–52. doi:10.1016/j.jmb.2013.01.031. PMID 23376100.
Vitari AC, Deak M, Morrice NA, Alessi DR (October 2005). "The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases". The Biochemical Journal. 391 (Pt 1): 17–24. doi:10.1042/BJ20051180. PMC 1237134. PMID 16083423.
Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, et al. (December 2005). "WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1". The Journal of Biological Chemistry. 280 (52): 42685–93. doi:10.1074/jbc.M510042200. PMID 16263722.
Gagnon KB, England R, Delpire E (January 2006). "Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4". American Journal of Physiology. Cell Physiology. 290 (1): C134-42. doi:10.1152/ajpcell.00037.2005. PMID 15930150.
Na T, Wu G, Peng JB (March 2012). "Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions". Biochemical and Biophysical Research Communications. 419 (2): 293–8. Bibcode:2012BBRC..419..293N. doi:10.1016/j.bbrc.2012.02.013. PMC 3358818. PMID 22342722.
Murillo-de-Ozores AR, Rodríguez-Gama A, Carbajal-Contreras H, Gamba G, Castañeda-Bueno M (March 2021). "WNK4 kinase: from structure to physiology". American Journal of Physiology. Renal Physiology. 320 (3): F378–F403. doi:10.1152/ajprenal.00634.2020. PMC 7988811. PMID 33491560.
Yu L, Cai H, Yue Q, Alli AA, Wang D, Al-Khalili O, et al. (July 2013). "WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination". American Journal of Physiology. Renal Physiology. 305 (1): F31-41. doi:10.1152/ajprenal.00652.2012. PMC 3725674. PMID 23594824.
Ring AM, Leng Q, Rinehart J, Wilson FH, Kahle KT, Hebert SC, et al. (March 2007). "An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis". Proceedings of the National Academy of Sciences of the United States of America. 104 (10): 4025–9. doi:10.1073/pnas.0611728104. PMC 1803763. PMID 17360471.
Fu Y, Subramanya A, Rozansky D, Cohen DM (June 2006). "WNK kinases influence TRPV4 channel function and localization". American Journal of Physiology. Renal Physiology. 290 (6): F1305-14. doi:10.1152/ajprenal.00391.2005. PMID 16403833.
Jiang Y, Ferguson WB, Peng JB (February 2007). "WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4". American Journal of Physiology. Renal Physiology. 292 (2): F545-54. doi:10.1152/ajprenal.00187.2006. PMID 17018846. S2CID 12884928.
Murthy M, Cope G, O'Shaughnessy KM (October 2008). "The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK". Biochemical and Biophysical Research Communications. 375 (4): 651–4. Bibcode:2008BBRC..375..651M. doi:10.1016/j.bbrc.2008.08.076. PMID 18755144.
Ponce-Coria J, Markadieu N, Austin TM, Flammang L, Rios K, Welling PA, et al. (June 2014). "A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters". The Journal of Biological Chemistry. 289 (25): 17680–8. doi:10.1074/jbc.M113.540518. PMC 4067202. PMID 24811174.
Brooks AM, Owens M, Sayer JA, Salzmann M, Ellard S, Vaidya B (August 2012). "Pseudohypoaldosteronism type 2 presenting with hypertension and hyperkalaemia due to a novel mutation in the WNK4 gene". QJM. 105 (8): 791–4. doi:10.1093/qjmed/hcr119. PMID 21764813.
Gong H, Tang Z, Yang Y, Sun L, Zhang W, Wang W, et al. (June 2008). "A patient with pseudohypoaldosteronism type II caused by a novel mutation in WNK4 gene". Endocrine. 33 (3): 230–4. doi:10.1007/s12020-008-9084-8. PMID 19016006. S2CID 45040268.
Golbang AP, Murthy M, Hamad A, Liu CH, Cope G, Van't Hoff W, et al. (August 2005). "A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene". Hypertension. 46 (2): 295–300. doi:10.1161/01.HYP.0000174326.96918.d6. PMID 15998707.
Zhang C, Wang Z, Xie J, Yan F, Wang W, Feng X, et al. (2011). "Identification of a novel WNK4 mutation in Chinese patients with pseudohypoaldosteronism type II". Nephron Physiology. 118 (3): 53–61. doi:10.1159/000321879. PMID 21196779. S2CID 11164311.
Na T, Wu G, Zhang W, Dong WJ, Peng JB (January 2013). "Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites". American Journal of Physiology. Renal Physiology. 304 (1): F8–F18. doi:10.1152/ajprenal.00284.2012. PMC 3543615. PMID 23054253.
San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, et al. (March 2009). "Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway". Proceedings of the National Academy of Sciences of the United States of America. 106 (11): 4384–9. Bibcode:2009PNAS..106.4384S. doi:10.1073/pnas.0813238106. PMC 2647339. PMID 19240212.
Castañeda-Bueno M, Cervantes-Pérez LG, Vázquez N, Uribe N, Kantesaria S, Morla L, et al. (May 2012). "Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process". Proceedings of the National Academy of Sciences of the United States of America. 109 (20): 7929–34. doi:10.1073/pnas.1200947109. PMC 3356635. PMID 22550170.
Chiga M, Rai T, Yang SS, Ohta A, Takizawa T, Sasaki S, et al. (December 2008). "Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone". Kidney International. 74 (11): 1403–9. doi:10.1038/ki.2008.451. PMID 18800028.
Rozansky DJ, Cornwall T, Subramanya AR, Rogers S, Yang YF, David LL, et al. (September 2009). "Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway". The Journal of Clinical Investigation. 119 (9): 2601–12. doi:10.1172/JCI38323. PMC 2735908. PMID 19690383.
Castañeda-Bueno M, Arroyo JP, Zhang J, Puthumana J, Yarborough O, Shibata S, et al. (January 2017). "Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4". Proceedings of the National Academy of Sciences of the United States of America. 114 (5): E879–E886. Bibcode:2017PNAS..114E.879C. doi:10.1073/pnas.1620315114. PMC 5293014. PMID 28096417.
Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, et al. (January 2012). "Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities". Nature. 482 (7383): 98–102. Bibcode:2012Natur.482...98B. doi:10.1038/nature10814. PMC 3278668. PMID 22266938.
Louis-Dit-Picard H, Barc J, Trujillano D, Miserey-Lenkei S, Bouatia-Naji N, Pylypenko O, et al. (March 2012). "KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron". Nature Genetics. 44 (4): 456–60, S1-3. doi:10.1038/ng.2218. PMID 22406640. S2CID 112724.
Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, et al. (March 2013). "Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension". Cell Reports. 3 (3): 858–68. doi:10.1016/j.celrep.2013.02.024. PMID 23453970.
Grimm PR, Coleman R, Delpire E, Welling PA (September 2017). "Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules". Journal of the American Society of Nephrology. 28 (9): 2597–2606. doi:10.1681/ASN.2016090948. ISSN 1046-6673. PMC 5576927. PMID 28442491.

ensembl.org (Global: 1,626^th place; English: 1,007^th place)

May2017.archive.ensembl.org

GRCh38: Ensembl release 89: ENSG00000126562 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035112 – Ensembl, May 2017

harvard.edu (Global: 18^th place; English: 17^th place)

ui.adsabs.harvard.edu

Na T, Wu G, Peng JB (March 2012). "Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions". Biochemical and Biophysical Research Communications. 419 (2): 293–8. Bibcode:2012BBRC..419..293N. doi:10.1016/j.bbrc.2012.02.013. PMC 3358818. PMID 22342722.
Murthy M, Cope G, O'Shaughnessy KM (October 2008). "The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK". Biochemical and Biophysical Research Communications. 375 (4): 651–4. Bibcode:2008BBRC..375..651M. doi:10.1016/j.bbrc.2008.08.076. PMID 18755144.
San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, et al. (March 2009). "Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway". Proceedings of the National Academy of Sciences of the United States of America. 106 (11): 4384–9. Bibcode:2009PNAS..106.4384S. doi:10.1073/pnas.0813238106. PMC 2647339. PMID 19240212.
Castañeda-Bueno M, Arroyo JP, Zhang J, Puthumana J, Yarborough O, Shibata S, et al. (January 2017). "Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4". Proceedings of the National Academy of Sciences of the United States of America. 114 (5): E879–E886. Bibcode:2017PNAS..114E.879C. doi:10.1073/pnas.1620315114. PMC 5293014. PMID 28096417.
Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, et al. (January 2012). "Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities". Nature. 482 (7383): 98–102. Bibcode:2012Natur.482...98B. doi:10.1038/nature10814. PMC 3278668. PMID 22266938.

nih.gov (Global: 4^th place; English: 4^th place)

pubmed.ncbi.nlm.nih.gov

Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH (June 2000). "WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II". The Journal of Biological Chemistry. 275 (22): 16795–801. doi:10.1074/jbc.275.22.16795. PMID 10828064.
Wilson FH, Disse-Nicodème S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, et al. (August 2001). "Human hypertension caused by mutations in WNK kinases". Science. 293 (5532): 1107–12. doi:10.1126/science.1062844. PMID 11498583. S2CID 22700809.
Kahle KT, Gimenez I, Hassan H, Wilson FH, Wong RD, Forbush B, et al. (February 2004). "WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia". Proceedings of the National Academy of Sciences of the United States of America. 101 (7): 2064–9. doi:10.1073/pnas.0308434100. PMC 357052. PMID 14769928.
Veríssimo F, Jordan P (September 2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms". Oncogene. 20 (39): 5562–9. doi:10.1038/sj.onc.1204726. PMID 11571656.
Murillo-de-Ozores AR, Rodríguez-Gama A, Bazúa-Valenti S, Leyva-Ríos K, Vázquez N, Pacheco-Álvarez D, et al. (August 2018). "C-terminally truncated, kidney-specific variants of the WNK4 kinase lack several sites that regulate its activity". The Journal of Biological Chemistry. 293 (31): 12209–12221. doi:10.1074/jbc.RA118.003037. PMC 6078442. PMID 29921588.
Arnold JE, Healy JK (September 1969). "Hyperkalemia, hypertension and systemic acidosis without renal failure associated with a tubular defect in potassium excretion". The American Journal of Medicine. 47 (3): 461–72. doi:10.1016/0002-9343(69)90230-7. PMID 5808659.
Gordon RD, Geddes RA, Pawsey CG, O'Halloran MW (November 1970). "Hypertension and severe hyperkalaemia associated with suppression of renin and aldosterone and completely reversed by dietary sodium restriction". Australasian Annals of Medicine. 19 (4): 287–94. doi:10.1111/imj.1970.19.4.287. PMID 5490655.
Min X, Lee BH, Cobb MH, Goldsmith EJ (July 2004). "Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension". Structure. 12 (7): 1303–11. doi:10.1016/j.str.2004.04.014. PMID 15242606.
Piala AT, Moon TM, Akella R, He H, Cobb MH, Goldsmith EJ (May 2014). "Chloride sensing by WNK1 involves inhibition of autophosphorylation". Science Signaling. 7 (324): ra41. doi:10.1126/scisignal.2005050. PMC 4123527. PMID 24803536.
Xu BE, Min X, Stippec S, Lee BH, Goldsmith EJ, Cobb MH (December 2002). "Regulation of WNK1 by an autoinhibitory domain and autophosphorylation". The Journal of Biological Chemistry. 277 (50): 48456–62. doi:10.1074/jbc.M207917200. PMID 12374799.
Moon TM, Correa F, Kinch LN, Piala AT, Gardner KH, Goldsmith EJ (April 2013). "Solution structure of the WNK1 autoinhibitory domain, a WNK-specific PF2 domain". Journal of Molecular Biology. 425 (8): 1245–52. doi:10.1016/j.jmb.2013.01.031. PMID 23376100.
Vitari AC, Deak M, Morrice NA, Alessi DR (October 2005). "The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases". The Biochemical Journal. 391 (Pt 1): 17–24. doi:10.1042/BJ20051180. PMC 1237134. PMID 16083423.
Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, et al. (December 2005). "WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1". The Journal of Biological Chemistry. 280 (52): 42685–93. doi:10.1074/jbc.M510042200. PMID 16263722.
Gagnon KB, England R, Delpire E (January 2006). "Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4". American Journal of Physiology. Cell Physiology. 290 (1): C134-42. doi:10.1152/ajpcell.00037.2005. PMID 15930150.
Na T, Wu G, Peng JB (March 2012). "Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions". Biochemical and Biophysical Research Communications. 419 (2): 293–8. Bibcode:2012BBRC..419..293N. doi:10.1016/j.bbrc.2012.02.013. PMC 3358818. PMID 22342722.
Murillo-de-Ozores AR, Rodríguez-Gama A, Carbajal-Contreras H, Gamba G, Castañeda-Bueno M (March 2021). "WNK4 kinase: from structure to physiology". American Journal of Physiology. Renal Physiology. 320 (3): F378–F403. doi:10.1152/ajprenal.00634.2020. PMC 7988811. PMID 33491560.
Yu L, Cai H, Yue Q, Alli AA, Wang D, Al-Khalili O, et al. (July 2013). "WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination". American Journal of Physiology. Renal Physiology. 305 (1): F31-41. doi:10.1152/ajprenal.00652.2012. PMC 3725674. PMID 23594824.
Ring AM, Leng Q, Rinehart J, Wilson FH, Kahle KT, Hebert SC, et al. (March 2007). "An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis". Proceedings of the National Academy of Sciences of the United States of America. 104 (10): 4025–9. doi:10.1073/pnas.0611728104. PMC 1803763. PMID 17360471.
Fu Y, Subramanya A, Rozansky D, Cohen DM (June 2006). "WNK kinases influence TRPV4 channel function and localization". American Journal of Physiology. Renal Physiology. 290 (6): F1305-14. doi:10.1152/ajprenal.00391.2005. PMID 16403833.
Jiang Y, Ferguson WB, Peng JB (February 2007). "WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4". American Journal of Physiology. Renal Physiology. 292 (2): F545-54. doi:10.1152/ajprenal.00187.2006. PMID 17018846. S2CID 12884928.
Murthy M, Cope G, O'Shaughnessy KM (October 2008). "The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK". Biochemical and Biophysical Research Communications. 375 (4): 651–4. Bibcode:2008BBRC..375..651M. doi:10.1016/j.bbrc.2008.08.076. PMID 18755144.
Ponce-Coria J, Markadieu N, Austin TM, Flammang L, Rios K, Welling PA, et al. (June 2014). "A novel Ste20-related proline/alanine-rich kinase (SPAK)-independent pathway involving calcium-binding protein 39 (Cab39) and serine threonine kinase with no lysine member 4 (WNK4) in the activation of Na-K-Cl cotransporters". The Journal of Biological Chemistry. 289 (25): 17680–8. doi:10.1074/jbc.M113.540518. PMC 4067202. PMID 24811174.
Brooks AM, Owens M, Sayer JA, Salzmann M, Ellard S, Vaidya B (August 2012). "Pseudohypoaldosteronism type 2 presenting with hypertension and hyperkalaemia due to a novel mutation in the WNK4 gene". QJM. 105 (8): 791–4. doi:10.1093/qjmed/hcr119. PMID 21764813.
Gong H, Tang Z, Yang Y, Sun L, Zhang W, Wang W, et al. (June 2008). "A patient with pseudohypoaldosteronism type II caused by a novel mutation in WNK4 gene". Endocrine. 33 (3): 230–4. doi:10.1007/s12020-008-9084-8. PMID 19016006. S2CID 45040268.
Golbang AP, Murthy M, Hamad A, Liu CH, Cope G, Van't Hoff W, et al. (August 2005). "A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene". Hypertension. 46 (2): 295–300. doi:10.1161/01.HYP.0000174326.96918.d6. PMID 15998707.
Zhang C, Wang Z, Xie J, Yan F, Wang W, Feng X, et al. (2011). "Identification of a novel WNK4 mutation in Chinese patients with pseudohypoaldosteronism type II". Nephron Physiology. 118 (3): 53–61. doi:10.1159/000321879. PMID 21196779. S2CID 11164311.
Na T, Wu G, Zhang W, Dong WJ, Peng JB (January 2013). "Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites". American Journal of Physiology. Renal Physiology. 304 (1): F8–F18. doi:10.1152/ajprenal.00284.2012. PMC 3543615. PMID 23054253.
San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, et al. (March 2009). "Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway". Proceedings of the National Academy of Sciences of the United States of America. 106 (11): 4384–9. Bibcode:2009PNAS..106.4384S. doi:10.1073/pnas.0813238106. PMC 2647339. PMID 19240212.
Castañeda-Bueno M, Cervantes-Pérez LG, Vázquez N, Uribe N, Kantesaria S, Morla L, et al. (May 2012). "Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process". Proceedings of the National Academy of Sciences of the United States of America. 109 (20): 7929–34. doi:10.1073/pnas.1200947109. PMC 3356635. PMID 22550170.
Chiga M, Rai T, Yang SS, Ohta A, Takizawa T, Sasaki S, et al. (December 2008). "Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone". Kidney International. 74 (11): 1403–9. doi:10.1038/ki.2008.451. PMID 18800028.
Rozansky DJ, Cornwall T, Subramanya AR, Rogers S, Yang YF, David LL, et al. (September 2009). "Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway". The Journal of Clinical Investigation. 119 (9): 2601–12. doi:10.1172/JCI38323. PMC 2735908. PMID 19690383.
Castañeda-Bueno M, Arroyo JP, Zhang J, Puthumana J, Yarborough O, Shibata S, et al. (January 2017). "Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4". Proceedings of the National Academy of Sciences of the United States of America. 114 (5): E879–E886. Bibcode:2017PNAS..114E.879C. doi:10.1073/pnas.1620315114. PMC 5293014. PMID 28096417.
Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, et al. (January 2012). "Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities". Nature. 482 (7383): 98–102. Bibcode:2012Natur.482...98B. doi:10.1038/nature10814. PMC 3278668. PMID 22266938.
Louis-Dit-Picard H, Barc J, Trujillano D, Miserey-Lenkei S, Bouatia-Naji N, Pylypenko O, et al. (March 2012). "KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron". Nature Genetics. 44 (4): 456–60, S1-3. doi:10.1038/ng.2218. PMID 22406640. S2CID 112724.
Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, et al. (March 2013). "Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension". Cell Reports. 3 (3): 858–68. doi:10.1016/j.celrep.2013.02.024. PMID 23453970.
Grimm PR, Coleman R, Delpire E, Welling PA (September 2017). "Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules". Journal of the American Society of Nephrology. 28 (9): 2597–2606. doi:10.1681/ASN.2016090948. ISSN 1046-6673. PMC 5576927. PMID 28442491.

ncbi.nlm.nih.gov

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: WNK4 WNK lysine deficient protein kinase 4".
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Na T, Wu G, Peng JB (March 2012). "Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions". Biochemical and Biophysical Research Communications. 419 (2): 293–8. Bibcode:2012BBRC..419..293N. doi:10.1016/j.bbrc.2012.02.013. PMC 3358818. PMID 22342722.
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Castañeda-Bueno M, Arroyo JP, Zhang J, Puthumana J, Yarborough O, Shibata S, et al. (January 2017). "Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4". Proceedings of the National Academy of Sciences of the United States of America. 114 (5): E879–E886. Bibcode:2017PNAS..114E.879C. doi:10.1073/pnas.1620315114. PMC 5293014. PMID 28096417.
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Wilson FH, Disse-Nicodème S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, et al. (August 2001). "Human hypertension caused by mutations in WNK kinases". Science. 293 (5532): 1107–12. doi:10.1126/science.1062844. PMID 11498583. S2CID 22700809.
Jiang Y, Ferguson WB, Peng JB (February 2007). "WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4". American Journal of Physiology. Renal Physiology. 292 (2): F545-54. doi:10.1152/ajprenal.00187.2006. PMID 17018846. S2CID 12884928.
Gong H, Tang Z, Yang Y, Sun L, Zhang W, Wang W, et al. (June 2008). "A patient with pseudohypoaldosteronism type II caused by a novel mutation in WNK4 gene". Endocrine. 33 (3): 230–4. doi:10.1007/s12020-008-9084-8. PMID 19016006. S2CID 45040268.
Zhang C, Wang Z, Xie J, Yan F, Wang W, Feng X, et al. (2011). "Identification of a novel WNK4 mutation in Chinese patients with pseudohypoaldosteronism type II". Nephron Physiology. 118 (3): 53–61. doi:10.1159/000321879. PMID 21196779. S2CID 11164311.
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Grimm PR, Coleman R, Delpire E, Welling PA (September 2017). "Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules". Journal of the American Society of Nephrology. 28 (9): 2597–2606. doi:10.1681/ASN.2016090948. ISSN 1046-6673. PMC 5576927. PMID 28442491.

WNK4 (English Wikipedia)

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