Α-Ketoglutaric acid (English Wikipedia)

Analysis of information sources in references of the Wikipedia article "Α-Ketoglutaric acid" in English language version.

refsWebsite

Global rank English rank

63nih.gov

4^th place

38doi.org

2^nd place

2handle.net

102^nd place

76^th place

1wikipathways.org

low place

1harvard.edu

18^th place

17^th place

1sciencedirect.com

149^th place

178^th place

1worldcat.org

5^th place

doi.org

Chinopoulos C (August 2013). "Which way does the citric acid cycle turn during hypoxia? The critical role of α-ketoglutarate dehydrogenase complex". Journal of Neuroscience Research. 91 (8): 1030–43. doi:10.1002/jnr.23196. PMID 23378250.
Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D (January 2016). "Alpha-Ketoglutarate: Physiological Functions and Applications". Biomolecules & Therapeutics. 24 (1): 1–8. doi:10.4062/biomolther.2015.078. PMC 4703346. PMID 26759695.
Liu S, He L, Yao K (2018). "The Antioxidative Function of Alpha-Ketoglutarate and Its Applications". BioMed Research International. 2018: 3408467. doi:10.1155/2018/3408467. PMC 5884300. PMID 29750149.
Kroupina K, Bémeur C, Rose CF (July 2022). "Amino acids, ammonia, and hepatic encephalopathy". Analytical Biochemistry. 649: 114696. doi:10.1016/j.ab.2022.114696. hdl:1866/26644. PMID 35500655.
Kaneko T, Mizuno N (August 1994). "Glutamate-synthesizing enzymes in GABAergic neurons of the neocortex: a double immunofluorescence study in the rat". Neuroscience. 61 (4): 839–49. doi:10.1016/0306-4522(94)90407-3. PMID 7838383.
Tokonami N, Morla L, Centeno G, Mordasini D, Ramakrishnan SK, Nikolaeva S, Wagner CA, Bonny O, Houillier P, Doucet A, Firsov D (July 2013). "α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism". The Journal of Clinical Investigation. 123 (7): 3166–71. doi:10.1172/JCI67562. PMC 3696567. PMID 23934124.
Yuan Y, Xu P, Jiang Q, Cai X, Wang T, Peng W, Sun J, Zhu C, Zhang C, Yue D, He Z, Yang J, Zeng Y, Du M, Zhang F, Ibrahimi L, Schaul S, Jiang Y, Wang J, Sun J, Wang Q, Liu L, Wang S, Wang L, Zhu X, Gao P, Xi Q, Yin C, Li F, Xu G, Zhang Y, Shu G (April 2020). "Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation". The EMBO Journal. 39 (7): e103304. doi:10.15252/embj.2019103304. PMC 7110140. PMID 32104923.
Yuan Y, Zhu C, Wang Y, Sun J, Feng J, Ma Z, Li P, Peng W, Yin C, Xu G, Xu P, Jiang Y, Jiang Q, Shu G (May 2022). "α-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling". Science Advances. 8 (18): eabn2879. Bibcode:2022SciA....8N2879Y. doi:10.1126/sciadv.abn2879. PMC 9067931. PMID 35507647.
Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ (September 2020). "Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice". Cell Metabolism. 32 (3): 447–456.e6. doi:10.1016/j.cmet.2020.08.004. PMC 8508957. PMID 32877690.
Manni W, Jianxin X, Weiqi H, Siyuan C, Huashan S (September 2022). "JMJD family proteins in cancer and inflammation". Signal Transduction and Targeted Therapy. 7 (1): 304. doi:10.1038/s41392-022-01145-1. PMC 9434538. PMID 36050314.
Klysz D, Tai X, Robert PA, Craveiro M, Cretenet G, Oburoglu L, Mongellaz C, Floess S, Fritz V, Matias MI, Yong C, Surh N, Marie JC, Huehn J, Zimmermann V, Kinet S, Dardalhon V, Taylor N (September 2015). "Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation". Science Signaling. 8 (396): ra97. doi:10.1126/scisignal.aab2610. PMID 26420908.
Kamzolova SV, Shamin RV, Stepanova NN, Morgunov GI, Lunina JN, Allayarov RK, Samoilenko VA, Morgunov IG (2018). "Fermentation Conditions and Media Optimization for Isocitric Acid Production from Ethanol by Yarrowia lipolytica". BioMed Research International. 2018: 2543210. doi:10.1155/2018/2543210. PMC 5820659. PMID 29568744.
Yang RZ, Park S, Reagan WJ, Goldstein R, Zhong S, Lawton M, Rajamohan F, Qian K, Liu L, Gong DW (February 2009). "Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity". Hepatology. 49 (2): 598–607. doi:10.1002/hep.22657. PMC 2917112. PMID 19085960.
Gyanwali B, Lim ZX, Soh J, Lim C, Guan SP, Goh J, Maier AB, Kennedy BK (February 2022). "Alpha-Ketoglutarate dietary supplementation to improve health in humans". Trends in Endocrinology and Metabolism. 33 (2): 136–146. doi:10.1016/j.tem.2021.11.003. hdl:1871.1/4ada9cac-6437-44d5-ad2b-c0ee6431df3b. PMID 34952764.
Katayama, Kazuhiro (2004-12-01). "Ammonia metabolism and hepatic encephalopathy". Hepatology Research. 30: 73–80. doi:10.1016/j.hepres.2004.08.013. ISSN 1386-6346. PMID 15607143.
Robinson MB, Lee ML, DaSilva S (March 2020). "Glutamate Transporters and Mitochondria: Signaling, Co-compartmentalization, Functional Coupling, and Future Directions". Neurochemical Research. 45 (3): 526–540. doi:10.1007/s11064-020-02974-8. PMC 7060825. PMID 32002773.
Zeng YR, Song JB, Wang D, Huang ZX, Zhang C, Sun YP, Shu G, Xiong Y, Guan KL, Ye D, Wang P (March 2023). "The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response". The Journal of Clinical Investigation. 133 (6). doi:10.1172/JCI160463. PMC 10014103. PMID 36919698.
Ye D, Wang P, Chen LL, Guan KL, Xiong Y (March 2024). "Itaconate in host inflammation and defense". Trends in Endocrinology and Metabolism. doi:10.1016/j.tem.2024.02.004. PMID 38448252.
Kanaoka Y, Maekawa A, Austen KF (April 2013). "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand". The Journal of Biological Chemistry. 288 (16): 10967–72. doi:10.1074/jbc.C113.453704. PMC 3630866. PMID 23504326.
Sasaki F, Yokomizo T (August 2019). "The leukotriene receptors as therapeutic targets of inflammatory diseases". International Immunology. 31 (9): 607–615. doi:10.1093/intimm/dxz044. PMID 31135881.
Guerrero A, Visniauskas B, Cárdenas P, Figueroa SM, Vivanco J, Salinas-Parra N, Araos P, Nguyen QM, Kassan M, Amador CA, Prieto MC, Gonzalez AA (2021). "α-Ketoglutarate Upregulates Collecting Duct (Pro)renin Receptor Expression, Tubular Angiotensin II Formation, and Na+ Reabsorption During High Glucose Conditions". Frontiers in Cardiovascular Medicine. 8: 644797. doi:10.3389/fcvm.2021.644797. PMC 8220822. PMID 34179130.
Brazier F, Cornière N, Picard N, Chambrey R, Eladari D (April 2024). "Pendrin: linking acid base to blood pressure". Pflügers Archiv. 476 (4): 533–543. doi:10.1007/s00424-023-02897-7. PMID 38110744.
Grimm PR, Welling PA (September 2017). "α-Ketoglutarate drives electroneutral NaCl reabsorption in intercalated cells by activating a G-protein coupled receptor, Oxgr1". Current Opinion in Nephrology and Hypertension. 26 (5): 426–433. doi:10.1097/MNH.0000000000000353. PMID 28771454.
Cai X, Yuan Y, Liao Z, Xing K, Zhu C, Xu Y, Yu L, Wang L, Wang S, Zhu X, Gao P, Zhang Y, Jiang Q, Xu P, Shu G (January 2018). "α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway". FASEB Journal. 32 (1): 488–499. doi:10.1096/fj.201700670R. PMC 6266637. PMID 28939592.
Tian Q, Zhao J, Yang Q, Wang B, Deavila JM, Zhu MJ, Du M (January 2020). "Dietary alpha-ketoglutarate promotes beige adipogenesis and prevents obesity in middle-aged mice". Aging Cell. 19 (1): e13059. doi:10.1111/acel.13059. PMC 6974731. PMID 31691468.
Tekwe CD, Yao K, Lei J, Li X, Gupta A, Luan Y, Meininger CJ, Bazer FW, Wu G (October 2019). "Oral administration of α-ketoglutarate enhances nitric oxide synthesis by endothelial cells and whole-body insulin sensitivity in diet-induced obese rats". Experimental Biology and Medicine. 244 (13): 1081–1088. doi:10.1177/1535370219865229. PMC 6775570. PMID 31357871.
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J (June 2014). "The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR". Nature. 510 (7505): 397–401. doi:10.1038/nature13264. PMC 4263271. PMID 24828042.
Islam MT, Tuday E, Allen S, Kim J, Trott DW, Holland WL, Donato AJ, Lesniewski LA (February 2023). "Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age". Aging Cell. 22 (2): e13767. doi:10.1111/acel.13767. PMC 9924942. PMID 36637079.
Soto-Palma C, Niedernhofer LJ, Faulk CD, Dong X (August 2022). "Epigenetics, DNA damage, and aging". The Journal of Clinical Investigation. 132 (16). doi:10.1172/JCI158446. PMC 9374376. PMID 35968782.
Chen L, Ganz PA, Sehl ME (2022). "DNA Methylation, Aging, and Cancer Risk: A Mini-Review". Frontiers in Bioinformatics. 2: 847629. doi:10.3389/fbinf.2022.847629. PMC 9580889. PMID 36304336.
Moqri M, Herzog C, Poganik JR, Justice J, Belsky DW, Higgins-Chen A, Moskalev A, Fuellen G, Cohen AA, Bautmans I, Widschwendter M, Ding J, Fleming A, Mannick J, Han JJ, Zhavoronkov A, Barzilai N, Kaeberlein M, Cummings S, Kennedy BK, Ferrucci L, Horvath S, Verdin E, Maier AB, Snyder MP, Sebastiano V, Gladyshev VN (August 2023). "Biomarkers of aging for the identification and evaluation of longevity interventions". Cell. 186 (18): 3758–3775. doi:10.1016/j.cell.2023.08.003. PMC 11088934. PMID 37657418.
Demidenko O, Barardo D, Budovskii V, Finnemore R, Palmer FR, Kennedy BK, Budovskaya YV (November 2021). "Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test". Aging. 13 (22): 24485–24499. doi:10.18632/aging.203736. PMC 8660611. PMID 34847066.
Park SY, Park JW, Chun YS (March 2016). "Jumonji histone demethylases as emerging therapeutic targets". Pharmacological Research. 105: 146–51. doi:10.1016/j.phrs.2016.01.026. PMID 26816087.
Staehle HF, Pahl HL, Jutzi JS (December 2021). "The Cross Marks the Spot: The Emerging Role of JmjC Domain-Containing Proteins in Myeloid Malignancies". Biomolecules. 11 (12): 1911. doi:10.3390/biom11121911. PMC 8699298. PMID 34944554.
Maity J, Majumder S, Pal R, Saha B, Mukhopadhyay PK (November 2023). "Ascorbic acid modulates immune responses through Jumonji-C domain containing histone demethylases and Ten eleven translocation methylcytosine dioxygenase". BioEssays. 45 (11): e2300035. doi:10.1002/bies.202300035. PMID 37694689.
Joshi K, Liu S, Breslin SJ, Zhang J (June 2022). "Mechanisms that regulate the activities of TET proteins". Cellular and Molecular Life Sciences. 79 (7): 363. doi:10.1007/s00018-022-04396-x. PMC 9756640. PMID 35705880.
López-Moyado IF, Ko M, Hogan PG, Rao A (February 2024). "TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer". Annual Review of Immunology. 42. doi:10.1146/annurev-immunol-080223-044610. PMID 38360546.
Bhatkar D, Ananda N, Lokhande KB, Khunteta K, Jain P, Hebale A, Sarode SC, Sharma NK (September 2023). "Organic Acids Derived from Saliva-amalgamated Betel Quid Filtrate Are Predicted as a Ten-eleven Translocation-2 Inhibitor". Journal of Cancer Prevention. 28 (3): 115–130. doi:10.15430/JCP.2023.28.3.115. PMC 10564634. PMID 37830116.

handle.net

hdl.handle.net

Kroupina K, Bémeur C, Rose CF (July 2022). "Amino acids, ammonia, and hepatic encephalopathy". Analytical Biochemistry. 649: 114696. doi:10.1016/j.ab.2022.114696. hdl:1866/26644. PMID 35500655.
Gyanwali B, Lim ZX, Soh J, Lim C, Guan SP, Goh J, Maier AB, Kennedy BK (February 2022). "Alpha-Ketoglutarate dietary supplementation to improve health in humans". Trends in Endocrinology and Metabolism. 33 (2): 136–146. doi:10.1016/j.tem.2021.11.003. hdl:1871.1/4ada9cac-6437-44d5-ad2b-c0ee6431df3b. PMID 34952764.

harvard.edu

ui.adsabs.harvard.edu

Yuan Y, Zhu C, Wang Y, Sun J, Feng J, Ma Z, Li P, Peng W, Yin C, Xu G, Xu P, Jiang Y, Jiang Q, Shu G (May 2022). "α-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling". Science Advances. 8 (18): eabn2879. Bibcode:2022SciA....8N2879Y. doi:10.1126/sciadv.abn2879. PMC 9067931. PMID 35507647.

nih.gov

pubmed.ncbi.nlm.nih.gov

Chinopoulos C (August 2013). "Which way does the citric acid cycle turn during hypoxia? The critical role of α-ketoglutarate dehydrogenase complex". Journal of Neuroscience Research. 91 (8): 1030–43. doi:10.1002/jnr.23196. PMID 23378250.
Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D (January 2016). "Alpha-Ketoglutarate: Physiological Functions and Applications". Biomolecules & Therapeutics. 24 (1): 1–8. doi:10.4062/biomolther.2015.078. PMC 4703346. PMID 26759695.
Liu S, He L, Yao K (2018). "The Antioxidative Function of Alpha-Ketoglutarate and Its Applications". BioMed Research International. 2018: 3408467. doi:10.1155/2018/3408467. PMC 5884300. PMID 29750149.
Kroupina K, Bémeur C, Rose CF (July 2022). "Amino acids, ammonia, and hepatic encephalopathy". Analytical Biochemistry. 649: 114696. doi:10.1016/j.ab.2022.114696. hdl:1866/26644. PMID 35500655.
Kaneko T, Mizuno N (August 1994). "Glutamate-synthesizing enzymes in GABAergic neurons of the neocortex: a double immunofluorescence study in the rat". Neuroscience. 61 (4): 839–49. doi:10.1016/0306-4522(94)90407-3. PMID 7838383.
Tokonami N, Morla L, Centeno G, Mordasini D, Ramakrishnan SK, Nikolaeva S, Wagner CA, Bonny O, Houillier P, Doucet A, Firsov D (July 2013). "α-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism". The Journal of Clinical Investigation. 123 (7): 3166–71. doi:10.1172/JCI67562. PMC 3696567. PMID 23934124.
Yuan Y, Xu P, Jiang Q, Cai X, Wang T, Peng W, Sun J, Zhu C, Zhang C, Yue D, He Z, Yang J, Zeng Y, Du M, Zhang F, Ibrahimi L, Schaul S, Jiang Y, Wang J, Sun J, Wang Q, Liu L, Wang S, Wang L, Zhu X, Gao P, Xi Q, Yin C, Li F, Xu G, Zhang Y, Shu G (April 2020). "Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation". The EMBO Journal. 39 (7): e103304. doi:10.15252/embj.2019103304. PMC 7110140. PMID 32104923.
Yuan Y, Zhu C, Wang Y, Sun J, Feng J, Ma Z, Li P, Peng W, Yin C, Xu G, Xu P, Jiang Y, Jiang Q, Shu G (May 2022). "α-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling". Science Advances. 8 (18): eabn2879. Bibcode:2022SciA....8N2879Y. doi:10.1126/sciadv.abn2879. PMC 9067931. PMID 35507647.
Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ (September 2020). "Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice". Cell Metabolism. 32 (3): 447–456.e6. doi:10.1016/j.cmet.2020.08.004. PMC 8508957. PMID 32877690.
Manni W, Jianxin X, Weiqi H, Siyuan C, Huashan S (September 2022). "JMJD family proteins in cancer and inflammation". Signal Transduction and Targeted Therapy. 7 (1): 304. doi:10.1038/s41392-022-01145-1. PMC 9434538. PMID 36050314.
Klysz D, Tai X, Robert PA, Craveiro M, Cretenet G, Oburoglu L, Mongellaz C, Floess S, Fritz V, Matias MI, Yong C, Surh N, Marie JC, Huehn J, Zimmermann V, Kinet S, Dardalhon V, Taylor N (September 2015). "Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation". Science Signaling. 8 (396): ra97. doi:10.1126/scisignal.aab2610. PMID 26420908.
Kamzolova SV, Shamin RV, Stepanova NN, Morgunov GI, Lunina JN, Allayarov RK, Samoilenko VA, Morgunov IG (2018). "Fermentation Conditions and Media Optimization for Isocitric Acid Production from Ethanol by Yarrowia lipolytica". BioMed Research International. 2018: 2543210. doi:10.1155/2018/2543210. PMC 5820659. PMID 29568744.
Yang RZ, Park S, Reagan WJ, Goldstein R, Zhong S, Lawton M, Rajamohan F, Qian K, Liu L, Gong DW (February 2009). "Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity". Hepatology. 49 (2): 598–607. doi:10.1002/hep.22657. PMC 2917112. PMID 19085960.
Gyanwali B, Lim ZX, Soh J, Lim C, Guan SP, Goh J, Maier AB, Kennedy BK (February 2022). "Alpha-Ketoglutarate dietary supplementation to improve health in humans". Trends in Endocrinology and Metabolism. 33 (2): 136–146. doi:10.1016/j.tem.2021.11.003. hdl:1871.1/4ada9cac-6437-44d5-ad2b-c0ee6431df3b. PMID 34952764.
Katayama, Kazuhiro (2004-12-01). "Ammonia metabolism and hepatic encephalopathy". Hepatology Research. 30: 73–80. doi:10.1016/j.hepres.2004.08.013. ISSN 1386-6346. PMID 15607143.
Robinson MB, Lee ML, DaSilva S (March 2020). "Glutamate Transporters and Mitochondria: Signaling, Co-compartmentalization, Functional Coupling, and Future Directions". Neurochemical Research. 45 (3): 526–540. doi:10.1007/s11064-020-02974-8. PMC 7060825. PMID 32002773.
Zeng YR, Song JB, Wang D, Huang ZX, Zhang C, Sun YP, Shu G, Xiong Y, Guan KL, Ye D, Wang P (March 2023). "The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response". The Journal of Clinical Investigation. 133 (6). doi:10.1172/JCI160463. PMC 10014103. PMID 36919698.
Ye D, Wang P, Chen LL, Guan KL, Xiong Y (March 2024). "Itaconate in host inflammation and defense". Trends in Endocrinology and Metabolism. doi:10.1016/j.tem.2024.02.004. PMID 38448252.
Kanaoka Y, Maekawa A, Austen KF (April 2013). "Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand". The Journal of Biological Chemistry. 288 (16): 10967–72. doi:10.1074/jbc.C113.453704. PMC 3630866. PMID 23504326.
Sasaki F, Yokomizo T (August 2019). "The leukotriene receptors as therapeutic targets of inflammatory diseases". International Immunology. 31 (9): 607–615. doi:10.1093/intimm/dxz044. PMID 31135881.
Guerrero A, Visniauskas B, Cárdenas P, Figueroa SM, Vivanco J, Salinas-Parra N, Araos P, Nguyen QM, Kassan M, Amador CA, Prieto MC, Gonzalez AA (2021). "α-Ketoglutarate Upregulates Collecting Duct (Pro)renin Receptor Expression, Tubular Angiotensin II Formation, and Na+ Reabsorption During High Glucose Conditions". Frontiers in Cardiovascular Medicine. 8: 644797. doi:10.3389/fcvm.2021.644797. PMC 8220822. PMID 34179130.
Brazier F, Cornière N, Picard N, Chambrey R, Eladari D (April 2024). "Pendrin: linking acid base to blood pressure". Pflügers Archiv. 476 (4): 533–543. doi:10.1007/s00424-023-02897-7. PMID 38110744.
Grimm PR, Welling PA (September 2017). "α-Ketoglutarate drives electroneutral NaCl reabsorption in intercalated cells by activating a G-protein coupled receptor, Oxgr1". Current Opinion in Nephrology and Hypertension. 26 (5): 426–433. doi:10.1097/MNH.0000000000000353. PMID 28771454.
Cai X, Yuan Y, Liao Z, Xing K, Zhu C, Xu Y, Yu L, Wang L, Wang S, Zhu X, Gao P, Zhang Y, Jiang Q, Xu P, Shu G (January 2018). "α-Ketoglutarate prevents skeletal muscle protein degradation and muscle atrophy through PHD3/ADRB2 pathway". FASEB Journal. 32 (1): 488–499. doi:10.1096/fj.201700670R. PMC 6266637. PMID 28939592.
Tian Q, Zhao J, Yang Q, Wang B, Deavila JM, Zhu MJ, Du M (January 2020). "Dietary alpha-ketoglutarate promotes beige adipogenesis and prevents obesity in middle-aged mice". Aging Cell. 19 (1): e13059. doi:10.1111/acel.13059. PMC 6974731. PMID 31691468.
Tekwe CD, Yao K, Lei J, Li X, Gupta A, Luan Y, Meininger CJ, Bazer FW, Wu G (October 2019). "Oral administration of α-ketoglutarate enhances nitric oxide synthesis by endothelial cells and whole-body insulin sensitivity in diet-induced obese rats". Experimental Biology and Medicine. 244 (13): 1081–1088. doi:10.1177/1535370219865229. PMC 6775570. PMID 31357871.
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J (June 2014). "The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR". Nature. 510 (7505): 397–401. doi:10.1038/nature13264. PMC 4263271. PMID 24828042.
Islam MT, Tuday E, Allen S, Kim J, Trott DW, Holland WL, Donato AJ, Lesniewski LA (February 2023). "Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age". Aging Cell. 22 (2): e13767. doi:10.1111/acel.13767. PMC 9924942. PMID 36637079.
Soto-Palma C, Niedernhofer LJ, Faulk CD, Dong X (August 2022). "Epigenetics, DNA damage, and aging". The Journal of Clinical Investigation. 132 (16). doi:10.1172/JCI158446. PMC 9374376. PMID 35968782.
Chen L, Ganz PA, Sehl ME (2022). "DNA Methylation, Aging, and Cancer Risk: A Mini-Review". Frontiers in Bioinformatics. 2: 847629. doi:10.3389/fbinf.2022.847629. PMC 9580889. PMID 36304336.
Moqri M, Herzog C, Poganik JR, Justice J, Belsky DW, Higgins-Chen A, Moskalev A, Fuellen G, Cohen AA, Bautmans I, Widschwendter M, Ding J, Fleming A, Mannick J, Han JJ, Zhavoronkov A, Barzilai N, Kaeberlein M, Cummings S, Kennedy BK, Ferrucci L, Horvath S, Verdin E, Maier AB, Snyder MP, Sebastiano V, Gladyshev VN (August 2023). "Biomarkers of aging for the identification and evaluation of longevity interventions". Cell. 186 (18): 3758–3775. doi:10.1016/j.cell.2023.08.003. PMC 11088934. PMID 37657418.
Demidenko O, Barardo D, Budovskii V, Finnemore R, Palmer FR, Kennedy BK, Budovskaya YV (November 2021). "Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test". Aging. 13 (22): 24485–24499. doi:10.18632/aging.203736. PMC 8660611. PMID 34847066.
Park SY, Park JW, Chun YS (March 2016). "Jumonji histone demethylases as emerging therapeutic targets". Pharmacological Research. 105: 146–51. doi:10.1016/j.phrs.2016.01.026. PMID 26816087.
Staehle HF, Pahl HL, Jutzi JS (December 2021). "The Cross Marks the Spot: The Emerging Role of JmjC Domain-Containing Proteins in Myeloid Malignancies". Biomolecules. 11 (12): 1911. doi:10.3390/biom11121911. PMC 8699298. PMID 34944554.
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ncbi.nlm.nih.gov

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Bhatkar D, Ananda N, Lokhande KB, Khunteta K, Jain P, Hebale A, Sarode SC, Sharma NK (September 2023). "Organic Acids Derived from Saliva-amalgamated Betel Quid Filtrate Are Predicted as a Ten-eleven Translocation-2 Inhibitor". Journal of Cancer Prevention. 28 (3): 115–130. doi:10.15430/JCP.2023.28.3.115. PMC 10564634. PMID 37830116.

sciencedirect.com

Katayama, Kazuhiro (2004-12-01). "Ammonia metabolism and hepatic encephalopathy". Hepatology Research. 30: 73–80. doi:10.1016/j.hepres.2004.08.013. ISSN 1386-6346. PMID 15607143.

wikipathways.org

The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78".

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Katayama, Kazuhiro (2004-12-01). "Ammonia metabolism and hepatic encephalopathy". Hepatology Research. 30: 73–80. doi:10.1016/j.hepres.2004.08.013. ISSN 1386-6346. PMID 15607143.