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(Septembro 2020) “COVID-19 vaccine trials should seek worthwhile efficacy”, Lancet396 (10253), p. 741–743. doi:10.1016/S0140-6736(20)31821-3. “WHO recommends that successful vaccines should show an estimated risk reduction of at least one-half, with sufficient precision to conclude that the true vaccine efficacy is greater than 30%. This means that the 95% CI for the trial result should exclude efficacy less than 30%. Current US Food and Drug Administration guidance includes this lower limit of 30% as a criterion for vaccine licensure.”.