Arendt J (August 2005). «Melatonin: characteristics, concerns, and prospects». J. Biol. Rhythms20 (4): 291-303. PMID16077149. doi:10.1177/0748730405277492. «There is very little evidence in the short term for toxicity or undesirable effects in humans. The extensive promotion of the miraculous powers of melatonin in the recent past did a disservice to acceptance of its genuine benefits.»
Turek FW, Gillette MU (November 2004). "Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists". Sleep Med.5 (6): 523–32. doi:10.1016/j.sleep.2004.07.009. PMID15511698.
Larson J, Jessen RE, Uz T, Arslan AD, Kurtuncu M, Imbesi M, Manev H (Enero 2006). "Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice". Neurosci. Lett.393 (1): 23-6. doi:10.1016/j.neulet.2005.09.040. PMID16203090.
Pappolla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Frangione B, Ghiso J (March 1998). "Inhibition of Azlheimer beta-fibrillogenesis by melatonin". J. Biol. Chem. 273 (13): 7185-8. doi:10.1074/jbc.273.13.7185. PMID9516407.
Weishaupt JH, Bartels C, Pölking E, Dietrich J, Rohde G, Poeggeler B, Mertens N, Sperling S, Bohn M, Hüther G, Schneider A, Bach A, Sirén AL, Hardeland R, Bähr M, Nave KA, Ehrenreich H (November 2006). "Reduced oxidative damage in ALS by high-dose enteral melatonin treatment". J. Pineal Res.41 (4): 313–23. doi:10.1111/j.1600-079X.2006.00377.x.PMID17014688.
Al-Aama T, Brymer C, Gutmanis I, Woolmore-Goodwin SM, Esbaugh J, Dasgupta M (July 2011). "Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial". Int J Geriatr Psychiatry26 (7): 687–94. doi:10.1002/gps.2582.PMID20845391.
Tan D, Manchester LC, Reiter RJ, Qi W, Hanes MA, Farley NJ (October 1999). "High physiological levels of melatonin in the bile of mammals". Life Sci.65 (23): 2523–9. doi:10.1016/S0024-3205(99)00519-6.PMID10622237.
Wolden-Hanson T, Mitton DR, McCants RL, Yellon SM, Wilkinson CW, Matsumoto AM, Rasmussen DD (February 2000). "Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat".Endocrinology141 (2): 487–97.doi:10.1210/en.141.2.487. PMID10650927.
Tan DX, Manchester LC, Fuentes-Broto L, Paredes SD, Reiter RJ (March 2011). "Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity".Obes Rev12 (3): 167–88. doi:10.1111/j.1467-789X.2010.00756.x. PMID20557470.
Vijayalaxmi, Meltz ML, Reiter RJ, Herman TS, Kumar KS (March 1999). "Melatonin and protection from whole-body irradiation: survival studies in mice".Mutat. Res.425 (1): 21–7. doi:10.1016/S0027-5107(98)00246-2. PMID10082913.
Tan DX, Manchester LC, Terron MP, Flores LJ, Reiter RJ (January 2007). "One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?". J. Pineal Res.42 (1): 28–42. doi:10.1111/j.1600-079X.2006.00407.x.PMID17198536.
Shirazi A, Ghobadi G, Ghazi-Khansari M (July 2007). "A radiobiological review on melatonin: a novel radioprotector". J. Radiat. Res.48 (4): 263–72.doi:10.1269/jrr.06070. PMID17641465.
Megwalu UC, Finnell JE, Piccirillo JF (February 2006). "The effects of melatonin on tinnitus and sleep".Otolaryngol Head Neck Surg134 (2): 210–3.doi:10.1016/j.otohns.2005.10.007. PMID16455366.
Pirodda A, Raimondi MC, Ferri GG (August 2010). "Exploring the reasons why melatonin can improve tinnitus". Med. Hypotheses75 (2): 190–1.doi:10.1016/j.mehy.2010.02.018. PMID20207491.
dx.doi.org
Filadelfi AM, Castrucci AM (May 1996). «Comparative aspects of the pineal/melatonin system of poikilothermic vertebrates». J. Pineal Res.20 (4): 175-86. PMID8836950. doi:10.1111/j.1600-079X.1996.tb00256.x.
Sugden D, Davidson K, Hough KA, Teh MT (October 2004). «Melatonin, melatonin receptors and melanophores: a moving story». Pigment Cell Res.17 (5): 454-60. PMID15357831. doi:10.1111/j.1600-0749.2004.00185.x.
Poeggeler B, Reiter RJ, Tan DX, Chen LD, Manchester LC (May 1993). «Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis». J. Pineal Res.14 (4): 151-68. PMID8102180. doi:10.1111/j.1600-079X.1993.tb00498.x.
Arendt J (August 2005). «Melatonin: characteristics, concerns, and prospects». J. Biol. Rhythms20 (4): 291-303. PMID16077149. doi:10.1177/0748730405277492. «There is very little evidence in the short term for toxicity or undesirable effects in humans. The extensive promotion of the miraculous powers of melatonin in the recent past did a disservice to acceptance of its genuine benefits.»
Carrillo-Vico A, Guerrero JM, Lardone PJ, Reiter RJ (July 2005). «A review of the multiple actions of melatonin on the immune system». Endocrine27 (2): 189-200. PMID16217132. S2CID21133107. doi:10.1385/ENDO:27:2:189.
Mills E, Wu P, Seely D, Guyatt G (November 2005). «Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis». J. Pineal Res.39 (4): 360-66. PMID16207291. doi:10.1111/j.1600-079X.2005.00258.x.
Lemoine P, Zisapel N (2012). «Prolonged-release formulation of melatonin (Circadin) for the treatment of insomnia». Expert Opin Pharmacother13 (6): 895-905. PMID22429105. doi:10.1517/14656566.2012.667076.
Lyseng-Williamson KA (2012). «Melatonin prolonged release: in the treatment of insomnia in patients aged ≥55 years». Drugs Aging29 (11): 911-23. PMID23044640. doi:10.1007/s40266-012-0018-z.
European Medicines Agency. «Circadin, melatonin». European Public Assessment Report (EPAR). European Medicines Agency. Archivado desde el original el 21 de febrero de 2018. Consultado el 5 de junio de 2013.
Srinivasan V, Pandi-Perumal SR, Trahkt I, Spence DW, Poeggeler B, Hardeland R, Cardinali DP (2009). "Melatonin and melatonergic drugs on slep: possible mechanisms of action". Int. J. Neurosci.119 (6): 821-46. doi:10.1080/00207450802328607. PMID19326288.
Wade AG, Ford I, Crawford G, McMahon AD, Nir T, Laudon M, Zisapel N (Octubre 2007). "Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes". Curr Med Res Opin23 (10): 2597–605. doi:10.1185/030079907X233098. PMID17875243.
Topkan E, Tufan H, Yavuz AA, Bacanli D, Onal C, Kosdak S, Yavuz MN (October 2008). "Comparison of the protective effects of melatonin and amifostine on radiation-induced epiphyseal injury". Int. J. Radiat. Biol.84 (10): 796–802.doi:10.1080/09553000802389678. PMID18979313.
Uz T, Akhisaroglu M, Ahmed R, Manev H (December 2003). "The pineal gland is critical for circadian Period1 expression in the striatum and for circadian cocaine sensitization in mice". Neuropsychopharmacology28 (12): 2117-23. doi:10.1038/sj.npp.1300254. PMID12865893.
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Filadelfi AM, Castrucci AM (May 1996). «Comparative aspects of the pineal/melatonin system of poikilothermic vertebrates». J. Pineal Res.20 (4): 175-86. PMID8836950. doi:10.1111/j.1600-079X.1996.tb00256.x.
Sugden D, Davidson K, Hough KA, Teh MT (October 2004). «Melatonin, melatonin receptors and melanophores: a moving story». Pigment Cell Res.17 (5): 454-60. PMID15357831. doi:10.1111/j.1600-0749.2004.00185.x.
Poeggeler B, Reiter RJ, Tan DX, Chen LD, Manchester LC (May 1993). «Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis». J. Pineal Res.14 (4): 151-68. PMID8102180. doi:10.1111/j.1600-079X.1993.tb00498.x.
Arendt J (August 2005). «Melatonin: characteristics, concerns, and prospects». J. Biol. Rhythms20 (4): 291-303. PMID16077149. doi:10.1177/0748730405277492. «There is very little evidence in the short term for toxicity or undesirable effects in humans. The extensive promotion of the miraculous powers of melatonin in the recent past did a disservice to acceptance of its genuine benefits.»
Bellipanni G, DI Marzo F, Blasi F, Di Marzo A (2005). "Effects of melatonin in perimenopausal and menopausal women: our personal experience". Ann N Y Acad Sci1057 (Dec): 393–402. PMID 16399909.
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Carrillo-Vico A, Guerrero JM, Lardone PJ, Reiter RJ (July 2005). «A review of the multiple actions of melatonin on the immune system». Endocrine27 (2): 189-200. PMID16217132. S2CID21133107. doi:10.1385/ENDO:27:2:189.
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Turek FW, Gillette MU (November 2004). "Melatonin, sleep, and circadian rhythms: rationale for development of specific melatonin agonists". Sleep Med.5 (6): 523–32. doi:10.1016/j.sleep.2004.07.009. PMID15511698.
Wade AG, Ford I, Crawford G, McMahon AD, Nir T, Laudon M, Zisapel N (Octubre 2007). "Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes". Curr Med Res Opin23 (10): 2597–605. doi:10.1185/030079907X233098. PMID17875243.
Cassone VM (noviembre de 1990). "Efectos de la melatonina sobre los sistemas circadianos de vertebrados". Tendencias Neurosci. 13 (11): 457-64. doi:10.1016/0166-2236 (90) 90099-V. PMID1701579.
Uz T, Akhisaroglu M, Ahmed R, Manev H (December 2003). "The pineal gland is critical for circadian Period1 expression in the striatum and for circadian cocaine sensitization in mice". Neuropsychopharmacology28 (12): 2117-23. doi:10.1038/sj.npp.1300254. PMID12865893.
Anisimov VN, Popovich IG, Zabezhinski MA, Anisimov SV, Vesnushkin GM, Vinogradova IA (2006). "Melatonin as antioxidant geroprotector and anticarcinogen". Biochim. Biophys. Acta1757 (5-6): 573-89. doi:10.1016/j.bbabio.2006.03.012. PMID16678784.
Larson J, Jessen RE, Uz T, Arslan AD, Kurtuncu M, Imbesi M, Manev H (Enero 2006). "Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice". Neurosci. Lett.393 (1): 23-6. doi:10.1016/j.neulet.2005.09.040. PMID16203090.
Pappolla MA, Sos M, Omar RA, Bick RJ, Hickson-Bick DL, Reiter RJ, Efthimiopoulos S, Robakis NK (Marzo 1997). "Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide". J. Neurosci.17 (5): 1683-90. PMID9030627.
Pappolla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Frangione B, Ghiso J (March 1998). "Inhibition of Azlheimer beta-fibrillogenesis by melatonin". J. Biol. Chem. 273 (13): 7185-8. doi:10.1074/jbc.273.13.7185. PMID9516407.
Weishaupt JH, Bartels C, Pölking E, Dietrich J, Rohde G, Poeggeler B, Mertens N, Sperling S, Bohn M, Hüther G, Schneider A, Bach A, Sirén AL, Hardeland R, Bähr M, Nave KA, Ehrenreich H (November 2006). "Reduced oxidative damage in ALS by high-dose enteral melatonin treatment". J. Pineal Res.41 (4): 313–23. doi:10.1111/j.1600-079X.2006.00377.x.PMID17014688.
Al-Aama T, Brymer C, Gutmanis I, Woolmore-Goodwin SM, Esbaugh J, Dasgupta M (July 2011). "Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial". Int J Geriatr Psychiatry26 (7): 687–94. doi:10.1002/gps.2582.PMID20845391.
Tjon Pian Gi CV, Broeren JP, Starreveld JS, Versteegh FG (July 2003). "Melatonin for treatment of sleeping disorders in children with attention deficit/hyperactivity disorder: a preliminary open label study". Eur. J. Pediatr.162 (7–8): 554–5.doi:10.1007/s00431-003-1207-x. PMID12783318.
Dodick DW, Capobianco DJ (February 2001). "Treatment and management of cluster headache".Curr Pain Headache Rep5 (1): 83–91.doi:10.1007/s11916-001-0015-0. PMID11252143.
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Mills E, Wu P, Seely D, Guyatt G (November 2005). «Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis». J. Pineal Res.39 (4): 360-66. PMID16207291. doi:10.1111/j.1600-079X.2005.00258.x.
Tan D, Manchester LC, Reiter RJ, Qi W, Hanes MA, Farley NJ (October 1999). "High physiological levels of melatonin in the bile of mammals". Life Sci.65 (23): 2523–9. doi:10.1016/S0024-3205(99)00519-6.PMID10622237.
Wolden-Hanson T, Mitton DR, McCants RL, Yellon SM, Wilkinson CW, Matsumoto AM, Rasmussen DD (February 2000). "Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat".Endocrinology141 (2): 487–97.doi:10.1210/en.141.2.487. PMID10650927.
Tan DX, Manchester LC, Fuentes-Broto L, Paredes SD, Reiter RJ (March 2011). "Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity".Obes Rev12 (3): 167–88. doi:10.1111/j.1467-789X.2010.00756.x. PMID20557470.
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Vijayalaxmi, Meltz ML, Reiter RJ, Herman TS, Kumar KS (March 1999). "Melatonin and protection from whole-body irradiation: survival studies in mice".Mutat. Res.425 (1): 21–7. doi:10.1016/S0027-5107(98)00246-2. PMID10082913.
Vijayalaxmi, Reiter RJ, Herman TS, Meltz ML (December 1996). "Melatonin and radioprotection from genetic damage: in vivo/in vitro studies with human volunteers". Mutat. Res.371 (3–4): 221–8.doi:10.1016/S0165-1218(96)90110-X. PMID9008723.
Vijayalaxmi, Reiter RJ, Herman TS, Meltz ML (February 1998). "Melatonin reduces gamma radiation-induced primary DNA damage in human blood lymphocytes". Mutat. Res.397 (2): 203–8.doi:10.1016/S0027-5107(97)00211-X. PMID9541644.
Topkan E, Tufan H, Yavuz AA, Bacanli D, Onal C, Kosdak S, Yavuz MN (October 2008). "Comparison of the protective effects of melatonin and amifostine on radiation-induced epiphyseal injury". Int. J. Radiat. Biol.84 (10): 796–802.doi:10.1080/09553000802389678. PMID18979313.
Tan DX, Manchester LC, Terron MP, Flores LJ, Reiter RJ (January 2007). "One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?". J. Pineal Res.42 (1): 28–42. doi:10.1111/j.1600-079X.2006.00407.x.PMID17198536.
Shirazi A, Ghobadi G, Ghazi-Khansari M (July 2007). "A radiobiological review on melatonin: a novel radioprotector". J. Radiat. Res.48 (4): 263–72.doi:10.1269/jrr.06070. PMID17641465.
Hurtuk A, Dome C, Holloman CH, Wolfe K, Welling DB, Dodson EE, Jacob A (July 2011). "Melatonin: can it stop the ringing?". Ann. Otol. Rhinol. Laryngol.120(7): 433–40. PMID21859051.
Megwalu UC, Finnell JE, Piccirillo JF (February 2006). "The effects of melatonin on tinnitus and sleep".Otolaryngol Head Neck Surg134 (2): 210–3.doi:10.1016/j.otohns.2005.10.007. PMID16455366.
Pirodda A, Raimondi MC, Ferri GG (August 2010). "Exploring the reasons why melatonin can improve tinnitus". Med. Hypotheses75 (2): 190–1.doi:10.1016/j.mehy.2010.02.018. PMID20207491.
Lemoine P, Zisapel N (2012). «Prolonged-release formulation of melatonin (Circadin) for the treatment of insomnia». Expert Opin Pharmacother13 (6): 895-905. PMID22429105. doi:10.1517/14656566.2012.667076.
Lyseng-Williamson KA (2012). «Melatonin prolonged release: in the treatment of insomnia in patients aged ≥55 years». Drugs Aging29 (11): 911-23. PMID23044640. doi:10.1007/s40266-012-0018-z.
https://pubmed.ncbi.nlm.nih.gov/9218571/ Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes (en inglés).Publicado el 15 de julio de 1997.
https://pubmed.ncbi.nlm.nih.gov/14715696/ Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance (en inglés).Publicado el 15 de marzo de 2004.
https://pubmed.ncbi.nlm.nih.gov/1084274/ Morphological changes of thymus and the thyroid gland after postnatal extirpation of pineal body (en inglés).Publicado el 9 de Enero de 1975.
Cassone VM (noviembre de 1990). "Efectos de la melatonina sobre los sistemas circadianos de vertebrados". Tendencias Neurosci. 13 (11): 457-64. doi:10.1016/0166-2236 (90) 90099-V. PMID1701579.
Anisimov VN, Popovich IG, Zabezhinski MA, Anisimov SV, Vesnushkin GM, Vinogradova IA (2006). "Melatonin as antioxidant geroprotector and anticarcinogen". Biochim. Biophys. Acta1757 (5-6): 573-89. doi:10.1016/j.bbabio.2006.03.012. PMID16678784.
Vijayalaxmi, Reiter RJ, Herman TS, Meltz ML (December 1996). "Melatonin and radioprotection from genetic damage: in vivo/in vitro studies with human volunteers". Mutat. Res.371 (3–4): 221–8.doi:10.1016/S0165-1218(96)90110-X. PMID9008723.
Vijayalaxmi, Reiter RJ, Herman TS, Meltz ML (February 1998). "Melatonin reduces gamma radiation-induced primary DNA damage in human blood lymphocytes". Mutat. Res.397 (2): 203–8.doi:10.1016/S0027-5107(97)00211-X. PMID9541644.
Carrillo-Vico A, Guerrero JM, Lardone PJ, Reiter RJ (July 2005). «A review of the multiple actions of melatonin on the immune system». Endocrine27 (2): 189-200. PMID16217132. S2CID21133107. doi:10.1385/ENDO:27:2:189.
Tjon Pian Gi CV, Broeren JP, Starreveld JS, Versteegh FG (July 2003). "Melatonin for treatment of sleeping disorders in children with attention deficit/hyperactivity disorder: a preliminary open label study". Eur. J. Pediatr.162 (7–8): 554–5.doi:10.1007/s00431-003-1207-x. PMID12783318.
Dodick DW, Capobianco DJ (February 2001). "Treatment and management of cluster headache".Curr Pain Headache Rep5 (1): 83–91.doi:10.1007/s11916-001-0015-0. PMID11252143.
European Medicines Agency. «Circadin, melatonin». European Public Assessment Report (EPAR). European Medicines Agency. Archivado desde el original el 21 de febrero de 2018. Consultado el 5 de junio de 2013.