Clinical trial number NCT01015118 for "LUME-Ovar 1: Nintedanib (BIBF 1120) or Placebo in Combination With Paclitaxel and Carboplatin in First Line Treatment of Ovarian Cancer" at ClinicalTrials.gov
doi.org
dx.doi.org
Ahluwalia, N; Shea, BS; Tager, AM (15 de octubre de 2014). «New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses.». American journal of respiratory and critical care medicine190 (8): 867-78. PMID25090037. doi:10.1164/rccm.201403-0509pp.
Mazzei, ME; Richeldi, L; Collard, HR (junio de 2015). «Nintedanib in the treatment of idiopathic pulmonary fibrosis.». Therapeutic advances in respiratory disease9 (3): 121-9. PMID25862013. doi:10.1177/1753465815579365.
Popat, S; Mellemgaard, A; Fahrbach, K; Martin, A; Rizzo, M; Kaiser, R; Griebsch, I; Reck, M (5 de diciembre de 2014). «Nintedanib plus docetaxel as second-line therapy in patients with non-small-cell lung cancer: a network meta-analysis». Future oncology (London, England)11 (3): 1-12. PMID25478720. doi:10.2217/fon.14.290.
Hilberg, F.; G. J. Roth, M. Krssak, S. Kautschitsch, W. Sommergruber, U. Tontsch-Grunt, P. Garin-Chesa, G. Bader, A. Zoephel, J. Quant, A. Heckel, W. J. Rettig (2008). «BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy». Cancer Res68 (12): 4774-82. ISSN1538-7445. PMID18559524. doi:10.1158/0008-5472.CAN-07-6307.
Okamoto, I.; H. Kaneda; T. Satoh; W. Okamoto; M. Miyazaki; R. Morinaga; S. Ueda; M. Terashima; A. Tsuya; A. Sarashina; K. Konishi; T. Arao; K. Nishio; R. Kaiser; K. Nakagawa (2010). «Phase I safety, pharmacokinetic, and biomarker study of BIBF 1120, an oral triple tyrosine kinase inhibitor in patients with advanced solid tumors». Mol Cancer Ther9 (10): 2825-33. ISSN1538-8514. PMID20688946. doi:10.1158/1535-7163.MCT-10-0379.
Mross, K.; M. Stefanic, D. Gmehling, A. Frost, F. Baas, C. Unger, R. Strecker, J. Henning, B. Gaschler-Markefski, P. Stopfer, L. de Rossi, R. Kaiser (2010). «Phase I study of the angiogenesis inhibitor BIBF 1120 in patients with advanced solid tumors». Clin Cancer Res16 (1): 311-9. ISSN1078-0432. PMID20028771. doi:10.1158/1078-0432.CCR-09-0694.
Ellis, P. M.; R. Kaiser; Y. Zhao; P. Stopfer; S. Gyorffy; N. Hanna (2010). «Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients». Clin Cancer Res16 (10): 2881-9. ISSN1078-0432. PMID20460487. doi:10.1158/1078-0432.CCR-09-2944.
du Bois, A.; J. Huober; P. Stopfer; J. Pfisterer; P. Wimberger; S. Loibl; V. L. Reichardt; P. Harter (2010). «A phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignancies». Ann Oncol21 (2): 370-5. ISSN1569-8041. PMID19889612. doi:10.1093/annonc/mdp506.
Selman, M; King, T. E.; Pardo, A; American Thoracic, Society; European Respiratory, Society; American College of Chest Physicians (2001). «Idiopathic pulmonary fibrosis: Prevailing and evolving hypotheses about its pathogenesis and implications for therapy». Annals of internal medicine134 (2): 136-51. PMID11177318. doi:10.7326/0003-4819-134-2-200101160-00015.
Wollin, L; Maillet, I; Quesniaux, V; Holweg, A; Ryffel, B (2014). «Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis». Journal of Pharmacology and Experimental Therapeutics349 (2): 209-20. PMID24556663. doi:10.1124/jpet.113.208223.
Hilberg, F.; G. J. Roth, M. Krssak, S. Kautschitsch, W. Sommergruber, U. Tontsch-Grunt, P. Garin-Chesa, G. Bader, A. Zoephel, J. Quant, A. Heckel, W. J. Rettig (2008). «BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy». Cancer Res68 (12): 4774-82. ISSN1538-7445. PMID18559524. doi:10.1158/0008-5472.CAN-07-6307.
Reck, M.; R. Kaiser; C. Eschbach; M. Stefanic; J. Love; U. Gatzemeier; P. Stopfer; J. von Pawel (2011). «A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer». Ann Oncol. ISSN1569-8041.
Okamoto, I.; H. Kaneda; T. Satoh; W. Okamoto; M. Miyazaki; R. Morinaga; S. Ueda; M. Terashima; A. Tsuya; A. Sarashina; K. Konishi; T. Arao; K. Nishio; R. Kaiser; K. Nakagawa (2010). «Phase I safety, pharmacokinetic, and biomarker study of BIBF 1120, an oral triple tyrosine kinase inhibitor in patients with advanced solid tumors». Mol Cancer Ther9 (10): 2825-33. ISSN1538-8514. PMID20688946. doi:10.1158/1535-7163.MCT-10-0379.
Mross, K.; M. Stefanic, D. Gmehling, A. Frost, F. Baas, C. Unger, R. Strecker, J. Henning, B. Gaschler-Markefski, P. Stopfer, L. de Rossi, R. Kaiser (2010). «Phase I study of the angiogenesis inhibitor BIBF 1120 in patients with advanced solid tumors». Clin Cancer Res16 (1): 311-9. ISSN1078-0432. PMID20028771. doi:10.1158/1078-0432.CCR-09-0694.
Kropff, M.; J. Kienast; G. Bisping; W. E. Berdel; B. Gaschler-Markefski; P. Stopfer; M. Stefanic; G. Munzert (2009). «An open-label dose-escalation study of BIBF 1120 in patients with relapsed or refractory multiple myeloma». Anticancer Res29 (10): 4233-8. ISSN1791-7530. PMID19846979.
Ellis, P. M.; R. Kaiser; Y. Zhao; P. Stopfer; S. Gyorffy; N. Hanna (2010). «Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients». Clin Cancer Res16 (10): 2881-9. ISSN1078-0432. PMID20460487. doi:10.1158/1078-0432.CCR-09-2944.
du Bois, A.; J. Huober; P. Stopfer; J. Pfisterer; P. Wimberger; S. Loibl; V. L. Reichardt; P. Harter (2010). «A phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignancies». Ann Oncol21 (2): 370-5. ISSN1569-8041. PMID19889612. doi:10.1093/annonc/mdp506.
nih.gov
ncbi.nlm.nih.gov
Ahluwalia, N; Shea, BS; Tager, AM (15 de octubre de 2014). «New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses.». American journal of respiratory and critical care medicine190 (8): 867-78. PMID25090037. doi:10.1164/rccm.201403-0509pp.
Mazzei, ME; Richeldi, L; Collard, HR (junio de 2015). «Nintedanib in the treatment of idiopathic pulmonary fibrosis.». Therapeutic advances in respiratory disease9 (3): 121-9. PMID25862013. doi:10.1177/1753465815579365.
Popat, S; Mellemgaard, A; Fahrbach, K; Martin, A; Rizzo, M; Kaiser, R; Griebsch, I; Reck, M (5 de diciembre de 2014). «Nintedanib plus docetaxel as second-line therapy in patients with non-small-cell lung cancer: a network meta-analysis». Future oncology (London, England)11 (3): 1-12. PMID25478720. doi:10.2217/fon.14.290.
Hilberg, F.; G. J. Roth, M. Krssak, S. Kautschitsch, W. Sommergruber, U. Tontsch-Grunt, P. Garin-Chesa, G. Bader, A. Zoephel, J. Quant, A. Heckel, W. J. Rettig (2008). «BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy». Cancer Res68 (12): 4774-82. ISSN1538-7445. PMID18559524. doi:10.1158/0008-5472.CAN-07-6307.
Okamoto, I.; H. Kaneda; T. Satoh; W. Okamoto; M. Miyazaki; R. Morinaga; S. Ueda; M. Terashima; A. Tsuya; A. Sarashina; K. Konishi; T. Arao; K. Nishio; R. Kaiser; K. Nakagawa (2010). «Phase I safety, pharmacokinetic, and biomarker study of BIBF 1120, an oral triple tyrosine kinase inhibitor in patients with advanced solid tumors». Mol Cancer Ther9 (10): 2825-33. ISSN1538-8514. PMID20688946. doi:10.1158/1535-7163.MCT-10-0379.
Mross, K.; M. Stefanic, D. Gmehling, A. Frost, F. Baas, C. Unger, R. Strecker, J. Henning, B. Gaschler-Markefski, P. Stopfer, L. de Rossi, R. Kaiser (2010). «Phase I study of the angiogenesis inhibitor BIBF 1120 in patients with advanced solid tumors». Clin Cancer Res16 (1): 311-9. ISSN1078-0432. PMID20028771. doi:10.1158/1078-0432.CCR-09-0694.
Kropff, M.; J. Kienast; G. Bisping; W. E. Berdel; B. Gaschler-Markefski; P. Stopfer; M. Stefanic; G. Munzert (2009). «An open-label dose-escalation study of BIBF 1120 in patients with relapsed or refractory multiple myeloma». Anticancer Res29 (10): 4233-8. ISSN1791-7530. PMID19846979.
Ellis, P. M.; R. Kaiser; Y. Zhao; P. Stopfer; S. Gyorffy; N. Hanna (2010). «Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patients». Clin Cancer Res16 (10): 2881-9. ISSN1078-0432. PMID20460487. doi:10.1158/1078-0432.CCR-09-2944.
du Bois, A.; J. Huober; P. Stopfer; J. Pfisterer; P. Wimberger; S. Loibl; V. L. Reichardt; P. Harter (2010). «A phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignancies». Ann Oncol21 (2): 370-5. ISSN1569-8041. PMID19889612. doi:10.1093/annonc/mdp506.
Selman, M; King, T. E.; Pardo, A; American Thoracic, Society; European Respiratory, Society; American College of Chest Physicians (2001). «Idiopathic pulmonary fibrosis: Prevailing and evolving hypotheses about its pathogenesis and implications for therapy». Annals of internal medicine134 (2): 136-51. PMID11177318. doi:10.7326/0003-4819-134-2-200101160-00015.
Wollin, L; Maillet, I; Quesniaux, V; Holweg, A; Ryffel, B (2014). «Antifibrotic and anti-inflammatory activity of the tyrosine kinase inhibitor nintedanib in experimental models of lung fibrosis». Journal of Pharmacology and Experimental Therapeutics349 (2): 209-20. PMID24556663. doi:10.1124/jpet.113.208223.