Pertwee RG (April 2006). «The pharmacology of cannabinoid receptors and their ligands: an overview». Int J Obes (Lond)30 (Suppl 1): S13-8. PMID16570099. doi:10.1038/sj.ijo.0803272.
Fortin DA, Levine ES (2007). «Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons». Cereb. Cortex17 (1): 163-74. PMID16467564. doi:10.1093/cercor/bhj133.
Good CH (2007). «Endocannabinoid-dependent regulation of feedforward inhibition in cerebellar Purkinje cells». J. Neurosci.27 (1): 1-3. PMID17205618. doi:10.1523/JNEUROSCI.4842-06.2007.
Hashimotodani Y, Ohno-Shosaku T, Kano M (2007). «Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus». J. Neurosci.27 (5): 1211-9. PMID17267577. doi:10.1523/JNEUROSCI.4159-06.2007.
Kishimoto Y, Kano M (2006). «Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning». J. Neurosci.26 (34): 8829-37. PMID16928872. doi:10.1523/JNEUROSCI.1236-06.2006.
Di Marzo V, Goparaju SK, Wang L, Liu J, Bátkai S, Járai Z, Fezza F, Miura GI, Palmiter RD, Sugiura T, Kunos G (April 2001). «Leptin-regulated endocannabinoids are involved in maintaining food intake». Nature410 (6830): 822-5. PMID11298451. doi:10.1038/35071088.
Watkins BA, Kim J (2014). «The endocannabinoid system: directing eating behavior and macronutrient metabolism». Front Psychol5: 1506. PMC4285050. PMID25610411. doi:10.3389/fpsyg.2014.01506. «CB1 is present in neurons of the enteric nervous system and in sensory terminals of vagal and spinal neurons in the gastrointestinal tract (Massa et al., 2005). Activation of CB1 is shown to modulate nutrient processing, such as gastric secretion, gastric emptying, and intestinal motility. ... CB1 is shown to co-localize with the food intake inhibiting neuropeptide, corticotrophin-releasing hormone, in the paraventricular nucleus of the hypothalamus, and with the two orexigenic peptides, melanin-concentrating hormone in the lateral hypothalamus and with pre-pro-orexin in the ventromedial hypothalamus (Inui, 1999; Horvath, 2003). CB1 knockout mice showed higher levels of CRH mRNA, suggesting that hypothalamic EC receptors are involved in energy balance and may be able to mediate food intake (Cota et al., 2003). ... The ECS works through many anorexigenic and orexigenic pathways where ghrelin, leptin, adiponectin, endogenous opioids, and corticotropin-releasing hormones are involved (Viveros et al., 2008).»
Thompson MD, Xhaard H, Sakurai T, Rainero I, Kukkonen JP (2014). «OX1 and OX2 orexin/hypocretin receptor pharmacogenetics». Front Neurosci8: 57. PMC4018553. PMID24834023. doi:10.3389/fnins.2014.00057. «OX1–CB1 dimerization was suggested to strongly potentiate orexin receptor signaling, but a likely explanation for the signal potentiation is, instead, offered by the ability of OX1 receptor signaling to produce 2-arachidonoyl glycerol, a CB1 receptor ligand, and a subsequent co-signaling of the receptors (Haj-Dahmane and Shen, 2005; Turunen et al., 2012; Jäntti et al., 2013). However, this does not preclude dimerization.»
Jäntti MH, Mandrika I, Kukkonen JP (2014). «Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors». Biochem. Biophys. Res. Commun.445 (2): 486-90. PMID24530395. doi:10.1016/j.bbrc.2014.02.026. «Orexin receptor subtypes readily formed homo- and hetero(di)mers, as suggested by significant BRET signals. CB1 receptors formed homodimers, and they also heterodimerized with both orexin receptors. ... In conclusion, orexin receptors have a significant propensity to make homo- and heterodi-/oligomeric complexes. However, it is unclear whether this affects their signaling. As orexin receptors efficiently signal via endocannabinoid production to CB1 receptors, dimerization could be an effective way of forming signal complexes with optimal cannabinoid concentrations available for cannabinoid receptors.»
Puente N, Cui Y, Lassalle O, Lafourcade M, Georges F, Venance L, Grandes P, Manzoni OJ (December 2011). «Polymodal activation of the endocannabinoid system in the extended amygdala». Nat. Neurosci.14 (12): 1542-7. PMID22057189. doi:10.1038/nn.2974.
Ibrahim BM, Abdel-Rahman AA (2015). «A pivotal role for enhanced brainstem Orexin receptor 1 signaling in the central cannabinoid receptor 1-mediated pressor response in conscious rats». Brain Res.1622: 51-63. PMID26096126. doi:10.1016/j.brainres.2015.06.011. «Orexin receptor 1 (OX1R) signaling is implicated in cannabinoid receptor 1 (CB1R) modulation of feeding. Further, our studies established the dependence of the central CB1R-mediated pressor response on neuronal nitric oxide synthase (nNOS) and extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylation in the RVLM. We tested the novel hypothesis that brainstem orexin-A/OX1R signaling plays a pivotal role in the central CB1R-mediated pressor response. Our multiple labeling immunofluorescence findings revealed co-localization of CB1R, OX1R and the peptide orexin-A within the C1 area of the rostral ventrolateral medulla (RVLM). Activation of central CB1R following intracisternal (i.c.) WIN55,212-2 (15μg/rat) in conscious rats caused significant increases in BP and orexin-A level in RVLM neuronal tissue. Additional studies established a causal role for orexin-A in the central CB1R-mediated pressor response».
Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N (February 2004). «Molecular characterization of a phospholipase D generating anandamide and its congeners». J. Biol. Chem.279 (7): 5298-305. PMID14634025. doi:10.1074/jbc.M306642200.
Magotti P, Bauer I, Igarashi M, Babagoli M, Marotta R, Piomelli D, Garau G (2014). «Structure of Human N-Acylphosphatidylethanolamine-Hydrolyzing Phospholipase D: Regulation of Fatty Acid Ethanolamide Biosynthesis by Bile Acids». Structure24 (3): 598-604. PMID25684574. doi:10.1016/j.str.2014.12.018.
Pazos MR, Núñez E, Benito C, Tolón RM, Romero J (June 2005). «Functional neuroanatomy of the endocannabinoid system». Pharmacol. Biochem. Behav.81 (2): 239-47. PMID15936805. doi:10.1016/j.pbb.2005.01.030.
Yamaguchi T, Shoyama Y, Watanabe S, Yamamoto T (January 2001). «Behavioral suppression induced by cannabinoids is due to activation of the arachidonic acid cascade in rats». Brain Res.889 (1–2): 149-54. PMID11166698. doi:10.1016/S0006-8993(00)03127-9.
Brock TG (December 2005). «Regulating leukotriene synthesis: the role of nuclear 5-lipoxygenase». J. Cell. Biochem.96 (6): 1203-11. PMID16215982. doi:10.1002/jcb.20662.
Guo J, Ikeda SR (2004). «Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons». Mol. Pharmacol.65 (3): 665-74. PMID14978245. doi:10.1124/mol.65.3.665.
Binzen U, Greffrath W, Hennessy S, Bausen M, Saaler-Reinhardt S, Treede RD (2006). «Co-expression of the voltage-gated potassium channel Kv1.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons». Neuroscience142 (2): 527-39. PMID16889902. doi:10.1016/j.neuroscience.2006.06.020.
Aguado T, Monory K, Palazuelos J, Stella N, Cravatt B, Lutz B, Marsicano G, Kokaia Z, Guzmán M, Galve-Roperh I (2005). «The endocannabinoid system drives neural progenitor proliferation». FASEB J.19 (12): 1704-6. PMID16037095. doi:10.1096/fj.05-3995fje.
Christie BR, Cameron HA (2006). «Neurogenesis in the adult hippocampus». Hippocampus16 (3): 199-207. PMID16411231. doi:10.1002/hipo.20151.
Kirkham TC, Tucci SA (2006). «Endocannabinoids in appetite control and the treatment of obesity». CNS Neurol Disord Drug Targets5 (3): 272-92. PMID16787229. doi:10.2174/187152706777452272.
Di Marzo V, Sepe N, De Petrocellis L, Berger A, Crozier G, Fride E, Mechoulam R (December 1998). «Trick or treat from food endocannabinoids?». Nature396 (6712): 636-7. Bibcode:1998Natur.396..636D. PMID9872309. doi:10.1038/25267.
Bellocchio L, Cervino C, Pasquali R, Pagotto U (June 2008). «The endocannabinoid system and energy metabolism». J. Neuroendocrinol.20 (6): 850-7. PMID18601709. doi:10.1111/j.1365-2826.2008.01728.x.
Baker D, Pryce G, Croxford JL, Brown P, Pertwee RG, Huffman JW, Layward L (2000). «Cannabinoids control spasticity and tremor in a multiple sclerosis model». Nature404 (6773): 84-7. PMID10716447. doi:10.1038/35003583.
Baker D, Pryce G, Croxford JL, Brown P, Pertwee RG, Makriyannis A, Khanolkar A, Layward L, Fezza F, Bisogno T, Di Marzo V (2001). «Endocannabinoids control spasticity in a multiple sclerosis model». FASEB J.15 (2): 300-2. PMID11156943. doi:10.1096/fj.00-0399fje.
Cabranes A, Pryce G, Baker D, Fernández-Ruiz J (August 2006). «Changes in CB1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis mice». Brain Res.1107 (1): 199-205. PMID16822488. doi:10.1016/j.brainres.2006.06.001.
Carrier EJ, Kearn CS, Barkmeier AJ, Breese NM, Yang W, Nithipatikom K, Pfister SL, Campbell WB, Hillard CJ (April 2004). «Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism». Mol. Pharmacol.65 (4): 999-1007. PMID15044630. doi:10.1124/mol.65.4.999.
Maccarrone M, Valensise H, Bari M, Lazzarin N, Romanini C, Finazzi-Agrò A (2000). «Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage». Lancet355 (9212): 1326-9. PMID10776746. doi:10.1016/S0140-6736(00)02115-2.
Hesselink JM (2012). «New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide». The Open Pain Journal5 (1): 12-23. doi:10.2174/1876386301205010012.
Murillo-Rodríguez E, Sánchez-Alavez M, Navarro L, Martínez-González D, Drucker-Colín R, Prospéro-García O (November 1998). «Anandamide modulates sleep and memory in rats». Brain Res.812 (1–2): 270-4. PMID9813364. doi:10.1016/S0006-8993(98)00969-X.
Santucci V, Storme JJ, Soubrié P, Le Fur G (1996). «Arousal-enhancing properties of the CB1 cannabinoid receptor antagonist SR 141716A in rats as assessed by electroencephalographic spectral and sleep-waking cycle analysis». Life Sci.58 (6): PL103-10. PMID8569415. doi:10.1016/0024-3205(95)02319-4.
Wang L, Yang T, Qian W, Hou X (January 2011). «The role of endocannabinoids in visceral hyposensitivity induced by rapid eye movement sleep deprivation in rats: regional differences». Int. J. Mol. Med.27 (1): 119-26. PMID21057766. doi:10.3892/ijmm.2010.547.
Murillo-Rodriguez E, Désarnaud F, Prospéro-García O (May 2006). «Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat». Life Sci.79 (1): 30-7. PMID16434061. doi:10.1016/j.lfs.2005.12.028.
Ravinet Trillou C, Delgorge C, Menet C, Arnone M, Soubrié P (2004). «CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity». Int. J. Obes. Relat. Metab. Disord.28 (4): 640-8. PMID14770190. doi:10.1038/sj.ijo.0802583.
Varvel SA, Lichtman AH (2002). «Evaluation of CB1 receptor knockout mice in the Morris water maze». J. Pharmacol. Exp. Ther.301 (3): 915-24. PMID12023519. doi:10.1124/jpet.301.3.915.
Niyuhire F, Varvel SA, Martin BR, Lichtman AH (2007). «Exposure to marijuana smoke impairs memory retrieval in mice». J. Pharmacol. Exp. Ther.322 (3): 1067-75. PMID17586723. doi:10.1124/jpet.107.119594.
Marsicano G, Goodenough S, Monory K, Hermann H, Eder M, Cannich A, Azad SC, Cascio MG, Gutiérrez SO, van der Stelt M, López-Rodriguez ML, Casanova E, Schütz G, Zieglgänsberger W, Di Marzo V, Behl C, Lutz B (October 2003). «CB1 cannabinoid receptors and on-demand defense against excitotoxicity». Science302 (5642): 84-8. Bibcode:2003Sci...302...84M. PMID14526074. doi:10.1126/science.1088208.
Di Marzo V, Sepe N, De Petrocellis L, Berger A, Crozier G, Fride E, Mechoulam R (December 1998). «Trick or treat from food endocannabinoids?». Nature396 (6712): 636-7. Bibcode:1998Natur.396..636D. PMID9872309. doi:10.1038/25267.
Marsicano G, Goodenough S, Monory K, Hermann H, Eder M, Cannich A, Azad SC, Cascio MG, Gutiérrez SO, van der Stelt M, López-Rodriguez ML, Casanova E, Schütz G, Zieglgänsberger W, Di Marzo V, Behl C, Lutz B (October 2003). «CB1 cannabinoid receptors and on-demand defense against excitotoxicity». Science302 (5642): 84-8. Bibcode:2003Sci...302...84M. PMID14526074. doi:10.1126/science.1088208.
Pertwee RG (April 2006). «The pharmacology of cannabinoid receptors and their ligands: an overview». Int J Obes (Lond)30 (Suppl 1): S13-8. PMID16570099. doi:10.1038/sj.ijo.0803272.
Fortin DA, Levine ES (2007). «Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons». Cereb. Cortex17 (1): 163-74. PMID16467564. doi:10.1093/cercor/bhj133.
Good CH (2007). «Endocannabinoid-dependent regulation of feedforward inhibition in cerebellar Purkinje cells». J. Neurosci.27 (1): 1-3. PMID17205618. doi:10.1523/JNEUROSCI.4842-06.2007.
Hashimotodani Y, Ohno-Shosaku T, Kano M (2007). «Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus». J. Neurosci.27 (5): 1211-9. PMID17267577. doi:10.1523/JNEUROSCI.4159-06.2007.
Kishimoto Y, Kano M (2006). «Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning». J. Neurosci.26 (34): 8829-37. PMID16928872. doi:10.1523/JNEUROSCI.1236-06.2006.
Di Marzo V, Goparaju SK, Wang L, Liu J, Bátkai S, Járai Z, Fezza F, Miura GI, Palmiter RD, Sugiura T, Kunos G (April 2001). «Leptin-regulated endocannabinoids are involved in maintaining food intake». Nature410 (6830): 822-5. PMID11298451. doi:10.1038/35071088.
Watkins BA, Kim J (2014). «The endocannabinoid system: directing eating behavior and macronutrient metabolism». Front Psychol5: 1506. PMC4285050. PMID25610411. doi:10.3389/fpsyg.2014.01506. «CB1 is present in neurons of the enteric nervous system and in sensory terminals of vagal and spinal neurons in the gastrointestinal tract (Massa et al., 2005). Activation of CB1 is shown to modulate nutrient processing, such as gastric secretion, gastric emptying, and intestinal motility. ... CB1 is shown to co-localize with the food intake inhibiting neuropeptide, corticotrophin-releasing hormone, in the paraventricular nucleus of the hypothalamus, and with the two orexigenic peptides, melanin-concentrating hormone in the lateral hypothalamus and with pre-pro-orexin in the ventromedial hypothalamus (Inui, 1999; Horvath, 2003). CB1 knockout mice showed higher levels of CRH mRNA, suggesting that hypothalamic EC receptors are involved in energy balance and may be able to mediate food intake (Cota et al., 2003). ... The ECS works through many anorexigenic and orexigenic pathways where ghrelin, leptin, adiponectin, endogenous opioids, and corticotropin-releasing hormones are involved (Viveros et al., 2008).»
Thompson MD, Xhaard H, Sakurai T, Rainero I, Kukkonen JP (2014). «OX1 and OX2 orexin/hypocretin receptor pharmacogenetics». Front Neurosci8: 57. PMC4018553. PMID24834023. doi:10.3389/fnins.2014.00057. «OX1–CB1 dimerization was suggested to strongly potentiate orexin receptor signaling, but a likely explanation for the signal potentiation is, instead, offered by the ability of OX1 receptor signaling to produce 2-arachidonoyl glycerol, a CB1 receptor ligand, and a subsequent co-signaling of the receptors (Haj-Dahmane and Shen, 2005; Turunen et al., 2012; Jäntti et al., 2013). However, this does not preclude dimerization.»
Jäntti MH, Mandrika I, Kukkonen JP (2014). «Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors». Biochem. Biophys. Res. Commun.445 (2): 486-90. PMID24530395. doi:10.1016/j.bbrc.2014.02.026. «Orexin receptor subtypes readily formed homo- and hetero(di)mers, as suggested by significant BRET signals. CB1 receptors formed homodimers, and they also heterodimerized with both orexin receptors. ... In conclusion, orexin receptors have a significant propensity to make homo- and heterodi-/oligomeric complexes. However, it is unclear whether this affects their signaling. As orexin receptors efficiently signal via endocannabinoid production to CB1 receptors, dimerization could be an effective way of forming signal complexes with optimal cannabinoid concentrations available for cannabinoid receptors.»
Puente N, Cui Y, Lassalle O, Lafourcade M, Georges F, Venance L, Grandes P, Manzoni OJ (December 2011). «Polymodal activation of the endocannabinoid system in the extended amygdala». Nat. Neurosci.14 (12): 1542-7. PMID22057189. doi:10.1038/nn.2974.
Ibrahim BM, Abdel-Rahman AA (2015). «A pivotal role for enhanced brainstem Orexin receptor 1 signaling in the central cannabinoid receptor 1-mediated pressor response in conscious rats». Brain Res.1622: 51-63. PMID26096126. doi:10.1016/j.brainres.2015.06.011. «Orexin receptor 1 (OX1R) signaling is implicated in cannabinoid receptor 1 (CB1R) modulation of feeding. Further, our studies established the dependence of the central CB1R-mediated pressor response on neuronal nitric oxide synthase (nNOS) and extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylation in the RVLM. We tested the novel hypothesis that brainstem orexin-A/OX1R signaling plays a pivotal role in the central CB1R-mediated pressor response. Our multiple labeling immunofluorescence findings revealed co-localization of CB1R, OX1R and the peptide orexin-A within the C1 area of the rostral ventrolateral medulla (RVLM). Activation of central CB1R following intracisternal (i.c.) WIN55,212-2 (15μg/rat) in conscious rats caused significant increases in BP and orexin-A level in RVLM neuronal tissue. Additional studies established a causal role for orexin-A in the central CB1R-mediated pressor response».
Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N (February 2004). «Molecular characterization of a phospholipase D generating anandamide and its congeners». J. Biol. Chem.279 (7): 5298-305. PMID14634025. doi:10.1074/jbc.M306642200.
Magotti P, Bauer I, Igarashi M, Babagoli M, Marotta R, Piomelli D, Garau G (2014). «Structure of Human N-Acylphosphatidylethanolamine-Hydrolyzing Phospholipase D: Regulation of Fatty Acid Ethanolamide Biosynthesis by Bile Acids». Structure24 (3): 598-604. PMID25684574. doi:10.1016/j.str.2014.12.018.
Pazos MR, Núñez E, Benito C, Tolón RM, Romero J (June 2005). «Functional neuroanatomy of the endocannabinoid system». Pharmacol. Biochem. Behav.81 (2): 239-47. PMID15936805. doi:10.1016/j.pbb.2005.01.030.
Yamaguchi T, Shoyama Y, Watanabe S, Yamamoto T (January 2001). «Behavioral suppression induced by cannabinoids is due to activation of the arachidonic acid cascade in rats». Brain Res.889 (1–2): 149-54. PMID11166698. doi:10.1016/S0006-8993(00)03127-9.
Brock TG (December 2005). «Regulating leukotriene synthesis: the role of nuclear 5-lipoxygenase». J. Cell. Biochem.96 (6): 1203-11. PMID16215982. doi:10.1002/jcb.20662.
Twitchell W, Brown S, Mackie K (1997). «Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons». J. Neurophysiol.78 (1): 43-50. PMID9242259.
Guo J, Ikeda SR (2004). «Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons». Mol. Pharmacol.65 (3): 665-74. PMID14978245. doi:10.1124/mol.65.3.665.
Binzen U, Greffrath W, Hennessy S, Bausen M, Saaler-Reinhardt S, Treede RD (2006). «Co-expression of the voltage-gated potassium channel Kv1.4 with transient receptor potential channels (TRPV1 and TRPV2) and the cannabinoid receptor CB1 in rat dorsal root ganglion neurons». Neuroscience142 (2): 527-39. PMID16889902. doi:10.1016/j.neuroscience.2006.06.020.
Freund TF, Katona I, Piomelli D (2003). «Role of endogenous cannabinoids in synaptic signaling». Physiol. Rev.83 (3): 1017-66. PMID12843414. doi:10.1152/physrev.00004.2003 (inactivo 2015-01-09).
Aguado T, Monory K, Palazuelos J, Stella N, Cravatt B, Lutz B, Marsicano G, Kokaia Z, Guzmán M, Galve-Roperh I (2005). «The endocannabinoid system drives neural progenitor proliferation». FASEB J.19 (12): 1704-6. PMID16037095. doi:10.1096/fj.05-3995fje.
Christie BR, Cameron HA (2006). «Neurogenesis in the adult hippocampus». Hippocampus16 (3): 199-207. PMID16411231. doi:10.1002/hipo.20151.
Kirkham TC, Tucci SA (2006). «Endocannabinoids in appetite control and the treatment of obesity». CNS Neurol Disord Drug Targets5 (3): 272-92. PMID16787229. doi:10.2174/187152706777452272.
Di Marzo V, Sepe N, De Petrocellis L, Berger A, Crozier G, Fride E, Mechoulam R (December 1998). «Trick or treat from food endocannabinoids?». Nature396 (6712): 636-7. Bibcode:1998Natur.396..636D. PMID9872309. doi:10.1038/25267.
Bellocchio L, Cervino C, Pasquali R, Pagotto U (June 2008). «The endocannabinoid system and energy metabolism». J. Neuroendocrinol.20 (6): 850-7. PMID18601709. doi:10.1111/j.1365-2826.2008.01728.x.
Baker D, Pryce G, Croxford JL, Brown P, Pertwee RG, Huffman JW, Layward L (2000). «Cannabinoids control spasticity and tremor in a multiple sclerosis model». Nature404 (6773): 84-7. PMID10716447. doi:10.1038/35003583.
Baker D, Pryce G, Croxford JL, Brown P, Pertwee RG, Makriyannis A, Khanolkar A, Layward L, Fezza F, Bisogno T, Di Marzo V (2001). «Endocannabinoids control spasticity in a multiple sclerosis model». FASEB J.15 (2): 300-2. PMID11156943. doi:10.1096/fj.00-0399fje.
Cabranes A, Pryce G, Baker D, Fernández-Ruiz J (August 2006). «Changes in CB1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis mice». Brain Res.1107 (1): 199-205. PMID16822488. doi:10.1016/j.brainres.2006.06.001.
Carrier EJ, Kearn CS, Barkmeier AJ, Breese NM, Yang W, Nithipatikom K, Pfister SL, Campbell WB, Hillard CJ (April 2004). «Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism». Mol. Pharmacol.65 (4): 999-1007. PMID15044630. doi:10.1124/mol.65.4.999.
Maccarrone M, Valensise H, Bari M, Lazzarin N, Romanini C, Finazzi-Agrò A (2000). «Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage». Lancet355 (9212): 1326-9. PMID10776746. doi:10.1016/S0140-6736(00)02115-2.
Murillo-Rodríguez E, Sánchez-Alavez M, Navarro L, Martínez-González D, Drucker-Colín R, Prospéro-García O (November 1998). «Anandamide modulates sleep and memory in rats». Brain Res.812 (1–2): 270-4. PMID9813364. doi:10.1016/S0006-8993(98)00969-X.
Santucci V, Storme JJ, Soubrié P, Le Fur G (1996). «Arousal-enhancing properties of the CB1 cannabinoid receptor antagonist SR 141716A in rats as assessed by electroencephalographic spectral and sleep-waking cycle analysis». Life Sci.58 (6): PL103-10. PMID8569415. doi:10.1016/0024-3205(95)02319-4.
Wang L, Yang T, Qian W, Hou X (January 2011). «The role of endocannabinoids in visceral hyposensitivity induced by rapid eye movement sleep deprivation in rats: regional differences». Int. J. Mol. Med.27 (1): 119-26. PMID21057766. doi:10.3892/ijmm.2010.547.
Murillo-Rodriguez E, Désarnaud F, Prospéro-García O (May 2006). «Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat». Life Sci.79 (1): 30-7. PMID16434061. doi:10.1016/j.lfs.2005.12.028.
Ravinet Trillou C, Delgorge C, Menet C, Arnone M, Soubrié P (2004). «CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity». Int. J. Obes. Relat. Metab. Disord.28 (4): 640-8. PMID14770190. doi:10.1038/sj.ijo.0802583.
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