(en) Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, O'Dwyer PJ, Lee RJ, Grippo JF, Nolop K, Chapman PB, « Inhibition of mutated, activated BRAF in metastatic melanoma », N. Engl. J. Med., vol. 363, no 9, , p. 809–19 (PMID20818844, DOI10.1056/NEJMoa1002011, résumé)
doi.org
dx.doi.org
PDB3OG7; (en) Bollag G, Hirth P, Tsai J, et al., « Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma », Nature, vol. 467, no 7315, , p. 596–599 (PMID20823850, PMCID2948082, DOI10.1038/nature09454)
(en) Sala E, Mologni L, Truffa S, Gaetano C, Bollag GE, Gambacorti-Passerini C, « BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells », Mol. Cancer Res., vol. 6, no 5, , p. 751–9 (PMID18458053, DOI10.1158/1541-7786.MCR-07-2001)
(en) Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S, « RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth », Nature, vol. 464, no 7287, , p. 431–5 (PMID20130576, DOI10.1038/nature08833)
(en) Halaban R, Zhang W, Bacchiocchi A, Cheng E, Parisi F, Ariyan S, Krauthammer M, McCusker JP, Kluger Y, Sznol M, « PLX4032, a Selective BRAF(V600E) Kinase Inhibitor, Activates the ERK Pathway and Enhances Cell Migration and Proliferation of BRAF(WT) Melanoma Cells », Pigment Cell Melanoma Res, vol. 23, no 2, , p. 190–200 (PMID20149136, PMCID2848976, DOI10.1111/j.1755-148X.2010.00685.x)
(en) Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS, « Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation », Nature, vol. 468, no 7326, , p. 973–977 (PMID21107323, DOI10.1038/nature09626, résumé)
(en) Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, O'Dwyer PJ, Lee RJ, Grippo JF, Nolop K, Chapman PB, « Inhibition of mutated, activated BRAF in metastatic melanoma », N. Engl. J. Med., vol. 363, no 9, , p. 809–19 (PMID20818844, DOI10.1056/NEJMoa1002011, résumé)
PDB3OG7; (en) Bollag G, Hirth P, Tsai J, et al., « Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma », Nature, vol. 467, no 7315, , p. 596–599 (PMID20823850, PMCID2948082, DOI10.1038/nature09454)
genengnews.com
(en) Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS, « Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation », Nature, vol. 468, no 7326, , p. 973–977 (PMID21107323, DOI10.1038/nature09626, résumé)
PDB3OG7; (en) Bollag G, Hirth P, Tsai J, et al., « Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma », Nature, vol. 467, no 7315, , p. 596–599 (PMID20823850, PMCID2948082, DOI10.1038/nature09454)
(en) Sala E, Mologni L, Truffa S, Gaetano C, Bollag GE, Gambacorti-Passerini C, « BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells », Mol. Cancer Res., vol. 6, no 5, , p. 751–9 (PMID18458053, DOI10.1158/1541-7786.MCR-07-2001)
(en) Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S, « RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth », Nature, vol. 464, no 7287, , p. 431–5 (PMID20130576, DOI10.1038/nature08833)
(en) Halaban R, Zhang W, Bacchiocchi A, Cheng E, Parisi F, Ariyan S, Krauthammer M, McCusker JP, Kluger Y, Sznol M, « PLX4032, a Selective BRAF(V600E) Kinase Inhibitor, Activates the ERK Pathway and Enhances Cell Migration and Proliferation of BRAF(WT) Melanoma Cells », Pigment Cell Melanoma Res, vol. 23, no 2, , p. 190–200 (PMID20149136, PMCID2848976, DOI10.1111/j.1755-148X.2010.00685.x)
(en) Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS, « Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation », Nature, vol. 468, no 7326, , p. 973–977 (PMID21107323, DOI10.1038/nature09626, résumé)
(en) Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, O'Dwyer PJ, Lee RJ, Grippo JF, Nolop K, Chapman PB, « Inhibition of mutated, activated BRAF in metastatic melanoma », N. Engl. J. Med., vol. 363, no 9, , p. 809–19 (PMID20818844, DOI10.1056/NEJMoa1002011, résumé)
