(en) Li Sui, Jing Wang et Bao-Ming Li, « Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex », Learning & Memory, vol. 15, no 10, , p. 762–776 (ISSN1072-0502 et 1549-5485, PMID18832563, DOI10.1101/lm.1067808, lire en ligne, consulté le )
doi.org
dx.doi.org
(en-US) David King, Daniel Yeomanson et Helen E. Bryant, « PI3King the Lock: Targeting the PI3K/Akt/mTOR Pathway as a Novel Therapeutic Strategy in Neuroblastoma », Journal of Pediatric Hematology/Oncology, vol. 37, no 4, , p. 245 (ISSN1077-4114, DOI10.1097/MPH.0000000000000329, lire en ligne, consulté le )
(en) Joseph Peltier, Analeah O'Neill et David V. Schaffer, « PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation », Developmental Neurobiology, vol. 67, no 10, , p. 1348–1361 (ISSN1932-8451 et 1932-846X, DOI10.1002/dneu.20506, lire en ligne, consulté le )
Heng-Ye Man, Qinhua Wang, Wei-Yang Lu et William Ju, « Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons », Neuron, vol. 38, no 4, , p. 611–624 (ISSN0896-6273, DOI10.1016/s0896-6273(03)00228-9, lire en ligne, consulté le )
(en) Lindsey A. Wyatt, Marie T. Filbin et Hans S. Keirstead, « PTEN inhibition enhances neurite outgrowth in human embryonic stem cell–derived neuronal progenitor cells », Journal of Comparative Neurology, vol. 522, no 12, , p. 2741–2755 (ISSN0021-9967 et 1096-9861, DOI10.1002/cne.23580, lire en ligne, consulté le )
(en) Li Sui, Jing Wang et Bao-Ming Li, « Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex », Learning & Memory, vol. 15, no 10, , p. 762–776 (ISSN1072-0502 et 1549-5485, PMID18832563, DOI10.1101/lm.1067808, lire en ligne, consulté le )
(en) Aziz Ur Rehman Aziz, Sumbal Farid, Kairong Qin et Hanqin Wang, « PIM Kinases and Their Relevance to the PI3K/AKT/mTOR Pathway in the Regulation of Ovarian Cancer », Biomolecules, vol. 8, no 1, , p. 7 (ISSN2218-273X, PMID29401696, PMCIDPMC5871976, DOI10.3390/biom8010007, lire en ligne, consulté le )
(en) Marcia A. Ciccone, Asaf Maoz, Jennifer K. Casabar et Hiroko Machida, « Clinical outcome of treatment with serine-threonine kinase inhibitors in recurrent epithelial ovarian cancer: a systematic review of literature », Expert Opinion on Investigational Drugs, vol. 25, no 7, , p. 781–796 (ISSN1354-3784 et 1744-7658, PMID27101098, PMCIDPMC7534810, DOI10.1080/13543784.2016.1181748, lire en ligne, consulté le )
Jacques Raphael, Danielle Desautels, Kathleen I. Pritchard et Ekaterina Petkova, « Phosphoinositide 3-kinase inhibitors in advanced breast cancer: A systematic review and meta-analysis », European Journal of Cancer, vol. 91, , p. 38–46 (ISSN0959-8049, DOI10.1016/j.ejca.2017.12.010, lire en ligne, consulté le )
(en) Ricardo L. B. Costa, Hyo Sook Han et William J. Gradishar, « Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review », Breast Cancer Research and Treatment, vol. 169, no 3, , p. 397–406 (ISSN1573-7217, DOI10.1007/s10549-018-4697-y, lire en ligne, consulté le )
Violeta Serra, Ben Markman, Maurizio Scaltriti et Pieter J.A. Eichhorn, « NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations », Cancer Research, vol. 68, no 19, , p. 8022–8030 (ISSN0008-5472 et 1538-7445, DOI10.1158/0008-5472.can-08-1385, lire en ligne, consulté le )
Sandy T. Liu, Gavin Hui, Colleen Mathis et Karim Chamie, « The Current Status and Future Role of the Phosphoinositide 3 Kinase/AKT Signaling Pathway in Urothelial Cancer: An Old Pathway in the New Immunotherapy Era », Clinical Genitourinary Cancer, vol. 16, no 2, , e269–e276 (ISSN1938-0682, PMID29199023, DOI10.1016/j.clgc.2017.10.011, lire en ligne, consulté le )
David G. Winkler, Kerrie L. Faia, Jonathan P. DiNitto et Janid A. Ali, « PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models », Chemistry & Biology, vol. 20, no 11, , p. 1364–1374 (ISSN1074-5521, DOI10.1016/j.chembiol.2013.09.017, lire en ligne, consulté le )
Soonbum Park, Young Sik Kim, Davis Yeon Kim et Insuk So, « PI3K pathway in prostate cancer: All resistant roads lead to PI3K », Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol. 1870, no 2, , p. 198–206 (ISSN0304-419X, DOI10.1016/j.bbcan.2018.09.001, lire en ligne, consulté le )
Brett S. Carver, Caren Chapinski, John Wongvipat et Haley Hieronymus, « Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer », Cancer Cell, vol. 19, no 5, , p. 575–586 (ISSN1535-6108, PMID21575859, PMCIDPMC3142785, DOI10.1016/j.ccr.2011.04.008, lire en ligne, consulté le )
Helen B. Pearson, Jason Li, Valerie S. Meniel et Christina M. Fennell, « Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth », Cancer Discovery, vol. 8, no 6, , p. 764–779 (ISSN2159-8274 et 2159-8290, DOI10.1158/2159-8290.cd-17-0867, lire en ligne, consulté le )
Laia Agell, Silvia Hernández, Marta Salido et Silvia de Muga, « PI3K signaling pathway is activated by PIK3CA mRNA overexpression and copy gain in prostate tumors, but PIK3CA, BRAF, KRAS and AKT1 mutations are infrequent events », Modern Pathology, vol. 24, no 3, , p. 443–452 (ISSN0893-3952, DOI10.1038/modpathol.2010.208, lire en ligne, consulté le )
Johann de Bono, Hendrik-Tobias Arkenau, Joaquin Mateo et Jeffrey R. Infante, « Abstract CT328: Exploratory genetic analysis of tumors from a phase I/II dose escalation study of GSK2636771 in patients (pts) with PTEN deficient advanced tumors », Cancer Research, vol. 75, no 15_Supplement, , CT328–CT328 (ISSN0008-5472 et 1538-7445, DOI10.1158/1538-7445.am2015-ct328, lire en ligne, consulté le )
(en) Hieab H. H. Adams, Derrek P. Hibar, Vincent Chouraki et Jason L. Stein, « Novel genetic loci underlying human intracranial volume identified through genome-wide association », Nature Neuroscience, vol. 19, no 12, , p. 1569–1582 (ISSN1546-1726, PMID27694991, PMCIDPMC5227112, DOI10.1038/nn.4398, lire en ligne, consulté le )
(en) Negin P. Martin, Ezequiel Marron, Fernandez de Velasco, Fengxia Mizuno, Erica L. Scappini, Bernd Gloss, Christian Erxleben, Jason G. Williams, Heather M. Stapleton, Saverio Gentile et David L. Armstrong, « A Rapid Cytoplasmic Mechanism for PI3 Kinase Regulation by the Nuclear Thyroid Hormone Receptor, TRβ, and Genetic Evidence for Its Role in the Maturation of Mouse Hippocampal Synapses In Vivo », Endocrinology, vol. 155, no 9, , p. 3713-3724 (PMID24932806, PMCIDPMC4138568, DOI10.1210/en.2013-2058, lire en ligne, consulté le )
Bayard R. Huck et Igor Mochalkin, « Recent progress towards clinically relevant ATP-competitive Akt inhibitors », Bioorganic & Medicinal Chemistry Letters, vol. 27, no 13, , p. 2838–2848 (ISSN0960-894X, DOI10.1016/j.bmcl.2017.04.090, lire en ligne, consulté le )
(en) Anindita Chakrabarty, Violeta Sánchez, María G. Kuba et Cammie Rinehart, « Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors », Proceedings of the National Academy of Sciences, vol. 109, no 8, , p. 2718–2723 (ISSN0027-8424 et 1091-6490, PMID21368164, PMCIDPMC3286932, DOI10.1073/pnas.1018001108, lire en ligne, consulté le )
(en) David Cappellen, Sixtina Gil Diez de Medina, Dominique Chopin et Jean Paul Thiery, « Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional cell carcinomas of the bladder », Oncogene, vol. 14, no 25, , p. 3059–3066 (ISSN1476-5594, DOI10.1038/sj.onc.1201154, lire en ligne, consulté le )
Susan Heavey, Kenneth J. O’Byrne et Kathy Gately, « Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC », Cancer Treatment Reviews, vol. 40, no 3, , p. 445–456 (ISSN0305-7372, DOI10.1016/j.ctrv.2013.08.006, lire en ligne, consulté le )
(en) Sabina Luszczak, Christopher Kumar, Vignesh Krishna Sathyadevan et Benjamin S. Simpson, « PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer », Signal Transduction and Targeted Therapy, vol. 5, no 1, , p. 1–10 (ISSN2059-3635, PMID32296034, PMCIDPMC6992635, DOI10.1038/s41392-020-0109-y, lire en ligne, consulté le )
Tom Malone, Lea Schäfer, Nathalie Simon et Susan Heavey, « Current perspectives on targeting PIM kinases to overcome mechanisms of drug resistance and immune evasion in cancer », Pharmacology & Therapeutics, vol. 207, , p. 107454 (ISSN0163-7258, DOI10.1016/j.pharmthera.2019.107454, lire en ligne, consulté le )
(en) Susan Heavey, Paul Dowling, Gillian Moore et Martin P. Barr, « Development and characterisation of a panel of phosphatidylinositide 3-kinase – mammalian target of rapamycin inhibitor resistant lung cancer cell lines », Scientific Reports, vol. 8, no 1, , p. 1652 (ISSN2045-2322, PMID29374181, PMCIDPMC5786033, DOI10.1038/s41598-018-19688-1, lire en ligne, consulté le )
(en) Annette C. Schmid, Richard D. Byrne, Ramón Vilar et Rüdiger Woscholski, « Bisperoxovanadium compounds are potent PTEN inhibitors », FEBS Letters, vol. 566, nos 1-3, , p. 35–38 (ISSN0014-5793 et 1873-3468, DOI10.1016/j.febslet.2004.03.102, lire en ligne, consulté le )
(en) Cosmin Mihai, Shengying Bao, Ju-Ping Lai et Samir N. Ghadiali, « PTEN inhibition improves wound healing in lung epithelia through changes in cellular mechanics that enhance migration », American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 302, no 3, , L287–L299 (ISSN1040-0605 et 1522-1504, PMID22037358, PMCIDPMC3289272, DOI10.1152/ajplung.00037.2011, lire en ligne, consulté le )
(en) Chandler L. Walker, Melissa J. Walker, Nai-Kui Liu et Emelie C. Risberg, « Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury », PLOS ONE, vol. 7, no 1, , e30012 (ISSN1932-6203, PMID22253859, PMCIDPMC3254642, DOI10.1371/journal.pone.0030012, lire en ligne, consulté le )
doi.org
Heng-Ye Man, Qinhua Wang, Wei-Yang Lu et William Ju, « Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons », Neuron, vol. 38, no 4, , p. 611–624 (ISSN0896-6273, DOI10.1016/s0896-6273(03)00228-9, lire en ligne, consulté le )
Jacques Raphael, Danielle Desautels, Kathleen I. Pritchard et Ekaterina Petkova, « Phosphoinositide 3-kinase inhibitors in advanced breast cancer: A systematic review and meta-analysis », European Journal of Cancer, vol. 91, , p. 38–46 (ISSN0959-8049, DOI10.1016/j.ejca.2017.12.010, lire en ligne, consulté le )
(en) Ricardo L. B. Costa, Hyo Sook Han et William J. Gradishar, « Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review », Breast Cancer Research and Treatment, vol. 169, no 3, , p. 397–406 (ISSN1573-7217, DOI10.1007/s10549-018-4697-y, lire en ligne, consulté le )
Violeta Serra, Ben Markman, Maurizio Scaltriti et Pieter J.A. Eichhorn, « NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations », Cancer Research, vol. 68, no 19, , p. 8022–8030 (ISSN0008-5472 et 1538-7445, DOI10.1158/0008-5472.can-08-1385, lire en ligne, consulté le )
Brett S. Carver, Caren Chapinski, John Wongvipat et Haley Hieronymus, « Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer », Cancer Cell, vol. 19, no 5, , p. 575–586 (ISSN1535-6108, PMID21575859, PMCIDPMC3142785, DOI10.1016/j.ccr.2011.04.008, lire en ligne, consulté le )
Helen B. Pearson, Jason Li, Valerie S. Meniel et Christina M. Fennell, « Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth », Cancer Discovery, vol. 8, no 6, , p. 764–779 (ISSN2159-8274 et 2159-8290, DOI10.1158/2159-8290.cd-17-0867, lire en ligne, consulté le )
Laia Agell, Silvia Hernández, Marta Salido et Silvia de Muga, « PI3K signaling pathway is activated by PIK3CA mRNA overexpression and copy gain in prostate tumors, but PIK3CA, BRAF, KRAS and AKT1 mutations are infrequent events », Modern Pathology, vol. 24, no 3, , p. 443–452 (ISSN0893-3952, DOI10.1038/modpathol.2010.208, lire en ligne, consulté le )
Johann de Bono, Hendrik-Tobias Arkenau, Joaquin Mateo et Jeffrey R. Infante, « Abstract CT328: Exploratory genetic analysis of tumors from a phase I/II dose escalation study of GSK2636771 in patients (pts) with PTEN deficient advanced tumors », Cancer Research, vol. 75, no 15_Supplement, , CT328–CT328 (ISSN0008-5472 et 1538-7445, DOI10.1158/1538-7445.am2015-ct328, lire en ligne, consulté le )
Susan Heavey, Kenneth J. O’Byrne et Kathy Gately, « Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC », Cancer Treatment Reviews, vol. 40, no 3, , p. 445–456 (ISSN0305-7372, DOI10.1016/j.ctrv.2013.08.006, lire en ligne, consulté le )
fda.gov
(en) Center for Drug Evaluation and Research, « duvelisib (COPIKTRA, Verastem, Inc.) for adult patients with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) », FDA, (lire en ligne, consulté le )
issn.org
portal.issn.org
(en-US) David King, Daniel Yeomanson et Helen E. Bryant, « PI3King the Lock: Targeting the PI3K/Akt/mTOR Pathway as a Novel Therapeutic Strategy in Neuroblastoma », Journal of Pediatric Hematology/Oncology, vol. 37, no 4, , p. 245 (ISSN1077-4114, DOI10.1097/MPH.0000000000000329, lire en ligne, consulté le )
(en) Joseph Peltier, Analeah O'Neill et David V. Schaffer, « PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation », Developmental Neurobiology, vol. 67, no 10, , p. 1348–1361 (ISSN1932-8451 et 1932-846X, DOI10.1002/dneu.20506, lire en ligne, consulté le )
Heng-Ye Man, Qinhua Wang, Wei-Yang Lu et William Ju, « Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons », Neuron, vol. 38, no 4, , p. 611–624 (ISSN0896-6273, DOI10.1016/s0896-6273(03)00228-9, lire en ligne, consulté le )
(en) Lindsey A. Wyatt, Marie T. Filbin et Hans S. Keirstead, « PTEN inhibition enhances neurite outgrowth in human embryonic stem cell–derived neuronal progenitor cells », Journal of Comparative Neurology, vol. 522, no 12, , p. 2741–2755 (ISSN0021-9967 et 1096-9861, DOI10.1002/cne.23580, lire en ligne, consulté le )
(en) Li Sui, Jing Wang et Bao-Ming Li, « Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex », Learning & Memory, vol. 15, no 10, , p. 762–776 (ISSN1072-0502 et 1549-5485, PMID18832563, DOI10.1101/lm.1067808, lire en ligne, consulté le )
(en) Aziz Ur Rehman Aziz, Sumbal Farid, Kairong Qin et Hanqin Wang, « PIM Kinases and Their Relevance to the PI3K/AKT/mTOR Pathway in the Regulation of Ovarian Cancer », Biomolecules, vol. 8, no 1, , p. 7 (ISSN2218-273X, PMID29401696, PMCIDPMC5871976, DOI10.3390/biom8010007, lire en ligne, consulté le )
(en) Marcia A. Ciccone, Asaf Maoz, Jennifer K. Casabar et Hiroko Machida, « Clinical outcome of treatment with serine-threonine kinase inhibitors in recurrent epithelial ovarian cancer: a systematic review of literature », Expert Opinion on Investigational Drugs, vol. 25, no 7, , p. 781–796 (ISSN1354-3784 et 1744-7658, PMID27101098, PMCIDPMC7534810, DOI10.1080/13543784.2016.1181748, lire en ligne, consulté le )
Jacques Raphael, Danielle Desautels, Kathleen I. Pritchard et Ekaterina Petkova, « Phosphoinositide 3-kinase inhibitors in advanced breast cancer: A systematic review and meta-analysis », European Journal of Cancer, vol. 91, , p. 38–46 (ISSN0959-8049, DOI10.1016/j.ejca.2017.12.010, lire en ligne, consulté le )
(en) Ricardo L. B. Costa, Hyo Sook Han et William J. Gradishar, « Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review », Breast Cancer Research and Treatment, vol. 169, no 3, , p. 397–406 (ISSN1573-7217, DOI10.1007/s10549-018-4697-y, lire en ligne, consulté le )
Violeta Serra, Ben Markman, Maurizio Scaltriti et Pieter J.A. Eichhorn, « NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations », Cancer Research, vol. 68, no 19, , p. 8022–8030 (ISSN0008-5472 et 1538-7445, DOI10.1158/0008-5472.can-08-1385, lire en ligne, consulté le )
Sandy T. Liu, Gavin Hui, Colleen Mathis et Karim Chamie, « The Current Status and Future Role of the Phosphoinositide 3 Kinase/AKT Signaling Pathway in Urothelial Cancer: An Old Pathway in the New Immunotherapy Era », Clinical Genitourinary Cancer, vol. 16, no 2, , e269–e276 (ISSN1938-0682, PMID29199023, DOI10.1016/j.clgc.2017.10.011, lire en ligne, consulté le )
David G. Winkler, Kerrie L. Faia, Jonathan P. DiNitto et Janid A. Ali, « PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models », Chemistry & Biology, vol. 20, no 11, , p. 1364–1374 (ISSN1074-5521, DOI10.1016/j.chembiol.2013.09.017, lire en ligne, consulté le )
Soonbum Park, Young Sik Kim, Davis Yeon Kim et Insuk So, « PI3K pathway in prostate cancer: All resistant roads lead to PI3K », Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol. 1870, no 2, , p. 198–206 (ISSN0304-419X, DOI10.1016/j.bbcan.2018.09.001, lire en ligne, consulté le )
Brett S. Carver, Caren Chapinski, John Wongvipat et Haley Hieronymus, « Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer », Cancer Cell, vol. 19, no 5, , p. 575–586 (ISSN1535-6108, PMID21575859, PMCIDPMC3142785, DOI10.1016/j.ccr.2011.04.008, lire en ligne, consulté le )
Helen B. Pearson, Jason Li, Valerie S. Meniel et Christina M. Fennell, « Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth », Cancer Discovery, vol. 8, no 6, , p. 764–779 (ISSN2159-8274 et 2159-8290, DOI10.1158/2159-8290.cd-17-0867, lire en ligne, consulté le )
Laia Agell, Silvia Hernández, Marta Salido et Silvia de Muga, « PI3K signaling pathway is activated by PIK3CA mRNA overexpression and copy gain in prostate tumors, but PIK3CA, BRAF, KRAS and AKT1 mutations are infrequent events », Modern Pathology, vol. 24, no 3, , p. 443–452 (ISSN0893-3952, DOI10.1038/modpathol.2010.208, lire en ligne, consulté le )
Johann de Bono, Hendrik-Tobias Arkenau, Joaquin Mateo et Jeffrey R. Infante, « Abstract CT328: Exploratory genetic analysis of tumors from a phase I/II dose escalation study of GSK2636771 in patients (pts) with PTEN deficient advanced tumors », Cancer Research, vol. 75, no 15_Supplement, , CT328–CT328 (ISSN0008-5472 et 1538-7445, DOI10.1158/1538-7445.am2015-ct328, lire en ligne, consulté le )
(en) Hieab H. H. Adams, Derrek P. Hibar, Vincent Chouraki et Jason L. Stein, « Novel genetic loci underlying human intracranial volume identified through genome-wide association », Nature Neuroscience, vol. 19, no 12, , p. 1569–1582 (ISSN1546-1726, PMID27694991, PMCIDPMC5227112, DOI10.1038/nn.4398, lire en ligne, consulté le )
I. Brian Greenwell, Andrew Ip et Jonathon B. Cohen, « PI3K Inhibitors: Understanding Toxicity Mechanisms and Management », Oncology (Williston Park, N.Y.), vol. 31, no 11, , p. 821–828 (ISSN0890-9091, PMID29179250, lire en ligne, consulté le )
Bayard R. Huck et Igor Mochalkin, « Recent progress towards clinically relevant ATP-competitive Akt inhibitors », Bioorganic & Medicinal Chemistry Letters, vol. 27, no 13, , p. 2838–2848 (ISSN0960-894X, DOI10.1016/j.bmcl.2017.04.090, lire en ligne, consulté le )
(en) Anindita Chakrabarty, Violeta Sánchez, María G. Kuba et Cammie Rinehart, « Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors », Proceedings of the National Academy of Sciences, vol. 109, no 8, , p. 2718–2723 (ISSN0027-8424 et 1091-6490, PMID21368164, PMCIDPMC3286932, DOI10.1073/pnas.1018001108, lire en ligne, consulté le )
(en) David Cappellen, Sixtina Gil Diez de Medina, Dominique Chopin et Jean Paul Thiery, « Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional cell carcinomas of the bladder », Oncogene, vol. 14, no 25, , p. 3059–3066 (ISSN1476-5594, DOI10.1038/sj.onc.1201154, lire en ligne, consulté le )
Susan Heavey, Kenneth J. O’Byrne et Kathy Gately, « Strategies for co-targeting the PI3K/AKT/mTOR pathway in NSCLC », Cancer Treatment Reviews, vol. 40, no 3, , p. 445–456 (ISSN0305-7372, DOI10.1016/j.ctrv.2013.08.006, lire en ligne, consulté le )
(en) Sabina Luszczak, Christopher Kumar, Vignesh Krishna Sathyadevan et Benjamin S. Simpson, « PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer », Signal Transduction and Targeted Therapy, vol. 5, no 1, , p. 1–10 (ISSN2059-3635, PMID32296034, PMCIDPMC6992635, DOI10.1038/s41392-020-0109-y, lire en ligne, consulté le )
Tom Malone, Lea Schäfer, Nathalie Simon et Susan Heavey, « Current perspectives on targeting PIM kinases to overcome mechanisms of drug resistance and immune evasion in cancer », Pharmacology & Therapeutics, vol. 207, , p. 107454 (ISSN0163-7258, DOI10.1016/j.pharmthera.2019.107454, lire en ligne, consulté le )
(en) Susan Heavey, Paul Dowling, Gillian Moore et Martin P. Barr, « Development and characterisation of a panel of phosphatidylinositide 3-kinase – mammalian target of rapamycin inhibitor resistant lung cancer cell lines », Scientific Reports, vol. 8, no 1, , p. 1652 (ISSN2045-2322, PMID29374181, PMCIDPMC5786033, DOI10.1038/s41598-018-19688-1, lire en ligne, consulté le )
(en) Annette C. Schmid, Richard D. Byrne, Ramón Vilar et Rüdiger Woscholski, « Bisperoxovanadium compounds are potent PTEN inhibitors », FEBS Letters, vol. 566, nos 1-3, , p. 35–38 (ISSN0014-5793 et 1873-3468, DOI10.1016/j.febslet.2004.03.102, lire en ligne, consulté le )
(en) Cosmin Mihai, Shengying Bao, Ju-Ping Lai et Samir N. Ghadiali, « PTEN inhibition improves wound healing in lung epithelia through changes in cellular mechanics that enhance migration », American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 302, no 3, , L287–L299 (ISSN1040-0605 et 1522-1504, PMID22037358, PMCIDPMC3289272, DOI10.1152/ajplung.00037.2011, lire en ligne, consulté le )
(en) Chandler L. Walker, Melissa J. Walker, Nai-Kui Liu et Emelie C. Risberg, « Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury », PLOS ONE, vol. 7, no 1, , e30012 (ISSN1932-6203, PMID22253859, PMCIDPMC3254642, DOI10.1371/journal.pone.0030012, lire en ligne, consulté le )
lww.com
journals.lww.com
(en-US) David King, Daniel Yeomanson et Helen E. Bryant, « PI3King the Lock: Targeting the PI3K/Akt/mTOR Pathway as a Novel Therapeutic Strategy in Neuroblastoma », Journal of Pediatric Hematology/Oncology, vol. 37, no 4, , p. 245 (ISSN1077-4114, DOI10.1097/MPH.0000000000000329, lire en ligne, consulté le )
mdpi.com
(en) Aziz Ur Rehman Aziz, Sumbal Farid, Kairong Qin et Hanqin Wang, « PIM Kinases and Their Relevance to the PI3K/AKT/mTOR Pathway in the Regulation of Ovarian Cancer », Biomolecules, vol. 8, no 1, , p. 7 (ISSN2218-273X, PMID29401696, PMCIDPMC5871976, DOI10.3390/biom8010007, lire en ligne, consulté le )
(en) Hieab H. H. Adams, Derrek P. Hibar, Vincent Chouraki et Jason L. Stein, « Novel genetic loci underlying human intracranial volume identified through genome-wide association », Nature Neuroscience, vol. 19, no 12, , p. 1569–1582 (ISSN1546-1726, PMID27694991, PMCIDPMC5227112, DOI10.1038/nn.4398, lire en ligne, consulté le )
(en) David Cappellen, Sixtina Gil Diez de Medina, Dominique Chopin et Jean Paul Thiery, « Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional cell carcinomas of the bladder », Oncogene, vol. 14, no 25, , p. 3059–3066 (ISSN1476-5594, DOI10.1038/sj.onc.1201154, lire en ligne, consulté le )
(en) Sabina Luszczak, Christopher Kumar, Vignesh Krishna Sathyadevan et Benjamin S. Simpson, « PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer », Signal Transduction and Targeted Therapy, vol. 5, no 1, , p. 1–10 (ISSN2059-3635, PMID32296034, PMCIDPMC6992635, DOI10.1038/s41392-020-0109-y, lire en ligne, consulté le )
(en) Susan Heavey, Paul Dowling, Gillian Moore et Martin P. Barr, « Development and characterisation of a panel of phosphatidylinositide 3-kinase – mammalian target of rapamycin inhibitor resistant lung cancer cell lines », Scientific Reports, vol. 8, no 1, , p. 1652 (ISSN2045-2322, PMID29374181, PMCIDPMC5786033, DOI10.1038/s41598-018-19688-1, lire en ligne, consulté le )
(en) Li Sui, Jing Wang et Bao-Ming Li, « Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex », Learning & Memory, vol. 15, no 10, , p. 762–776 (ISSN1072-0502 et 1549-5485, PMID18832563, DOI10.1101/lm.1067808, lire en ligne, consulté le )
(en) Aziz Ur Rehman Aziz, Sumbal Farid, Kairong Qin et Hanqin Wang, « PIM Kinases and Their Relevance to the PI3K/AKT/mTOR Pathway in the Regulation of Ovarian Cancer », Biomolecules, vol. 8, no 1, , p. 7 (ISSN2218-273X, PMID29401696, PMCIDPMC5871976, DOI10.3390/biom8010007, lire en ligne, consulté le )
(en) Marcia A. Ciccone, Asaf Maoz, Jennifer K. Casabar et Hiroko Machida, « Clinical outcome of treatment with serine-threonine kinase inhibitors in recurrent epithelial ovarian cancer: a systematic review of literature », Expert Opinion on Investigational Drugs, vol. 25, no 7, , p. 781–796 (ISSN1354-3784 et 1744-7658, PMID27101098, PMCIDPMC7534810, DOI10.1080/13543784.2016.1181748, lire en ligne, consulté le )
Sandy T. Liu, Gavin Hui, Colleen Mathis et Karim Chamie, « The Current Status and Future Role of the Phosphoinositide 3 Kinase/AKT Signaling Pathway in Urothelial Cancer: An Old Pathway in the New Immunotherapy Era », Clinical Genitourinary Cancer, vol. 16, no 2, , e269–e276 (ISSN1938-0682, PMID29199023, DOI10.1016/j.clgc.2017.10.011, lire en ligne, consulté le )
Brett S. Carver, Caren Chapinski, John Wongvipat et Haley Hieronymus, « Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer », Cancer Cell, vol. 19, no 5, , p. 575–586 (ISSN1535-6108, PMID21575859, PMCIDPMC3142785, DOI10.1016/j.ccr.2011.04.008, lire en ligne, consulté le )
(en) Hieab H. H. Adams, Derrek P. Hibar, Vincent Chouraki et Jason L. Stein, « Novel genetic loci underlying human intracranial volume identified through genome-wide association », Nature Neuroscience, vol. 19, no 12, , p. 1569–1582 (ISSN1546-1726, PMID27694991, PMCIDPMC5227112, DOI10.1038/nn.4398, lire en ligne, consulté le )
(en) Negin P. Martin, Ezequiel Marron, Fernandez de Velasco, Fengxia Mizuno, Erica L. Scappini, Bernd Gloss, Christian Erxleben, Jason G. Williams, Heather M. Stapleton, Saverio Gentile et David L. Armstrong, « A Rapid Cytoplasmic Mechanism for PI3 Kinase Regulation by the Nuclear Thyroid Hormone Receptor, TRβ, and Genetic Evidence for Its Role in the Maturation of Mouse Hippocampal Synapses In Vivo », Endocrinology, vol. 155, no 9, , p. 3713-3724 (PMID24932806, PMCIDPMC4138568, DOI10.1210/en.2013-2058, lire en ligne, consulté le )
I. Brian Greenwell, Andrew Ip et Jonathon B. Cohen, « PI3K Inhibitors: Understanding Toxicity Mechanisms and Management », Oncology (Williston Park, N.Y.), vol. 31, no 11, , p. 821–828 (ISSN0890-9091, PMID29179250, lire en ligne, consulté le )
(en) Anindita Chakrabarty, Violeta Sánchez, María G. Kuba et Cammie Rinehart, « Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors », Proceedings of the National Academy of Sciences, vol. 109, no 8, , p. 2718–2723 (ISSN0027-8424 et 1091-6490, PMID21368164, PMCIDPMC3286932, DOI10.1073/pnas.1018001108, lire en ligne, consulté le )
(en) Sabina Luszczak, Christopher Kumar, Vignesh Krishna Sathyadevan et Benjamin S. Simpson, « PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer », Signal Transduction and Targeted Therapy, vol. 5, no 1, , p. 1–10 (ISSN2059-3635, PMID32296034, PMCIDPMC6992635, DOI10.1038/s41392-020-0109-y, lire en ligne, consulté le )
(en) Susan Heavey, Paul Dowling, Gillian Moore et Martin P. Barr, « Development and characterisation of a panel of phosphatidylinositide 3-kinase – mammalian target of rapamycin inhibitor resistant lung cancer cell lines », Scientific Reports, vol. 8, no 1, , p. 1652 (ISSN2045-2322, PMID29374181, PMCIDPMC5786033, DOI10.1038/s41598-018-19688-1, lire en ligne, consulté le )
(en) Cosmin Mihai, Shengying Bao, Ju-Ping Lai et Samir N. Ghadiali, « PTEN inhibition improves wound healing in lung epithelia through changes in cellular mechanics that enhance migration », American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 302, no 3, , L287–L299 (ISSN1040-0605 et 1522-1504, PMID22037358, PMCIDPMC3289272, DOI10.1152/ajplung.00037.2011, lire en ligne, consulté le )
(en) Chandler L. Walker, Melissa J. Walker, Nai-Kui Liu et Emelie C. Risberg, « Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury », PLOS ONE, vol. 7, no 1, , e30012 (ISSN1932-6203, PMID22253859, PMCIDPMC3254642, DOI10.1371/journal.pone.0030012, lire en ligne, consulté le )
pubmed.ncbi.nlm.nih.gov
Sandy T. Liu, Gavin Hui, Colleen Mathis et Karim Chamie, « The Current Status and Future Role of the Phosphoinositide 3 Kinase/AKT Signaling Pathway in Urothelial Cancer: An Old Pathway in the New Immunotherapy Era », Clinical Genitourinary Cancer, vol. 16, no 2, , e269–e276 (ISSN1938-0682, PMID29199023, DOI10.1016/j.clgc.2017.10.011, lire en ligne, consulté le )
I. Brian Greenwell, Andrew Ip et Jonathon B. Cohen, « PI3K Inhibitors: Understanding Toxicity Mechanisms and Management », Oncology (Williston Park, N.Y.), vol. 31, no 11, , p. 821–828 (ISSN0890-9091, PMID29179250, lire en ligne, consulté le )
(en) Negin P. Martin, Ezequiel Marron, Fernandez de Velasco, Fengxia Mizuno, Erica L. Scappini, Bernd Gloss, Christian Erxleben, Jason G. Williams, Heather M. Stapleton, Saverio Gentile et David L. Armstrong, « A Rapid Cytoplasmic Mechanism for PI3 Kinase Regulation by the Nuclear Thyroid Hormone Receptor, TRβ, and Genetic Evidence for Its Role in the Maturation of Mouse Hippocampal Synapses In Vivo », Endocrinology, vol. 155, no 9, , p. 3713-3724 (PMID24932806, PMCIDPMC4138568, DOI10.1210/en.2013-2058, lire en ligne, consulté le )
physiology.org
(en) Cosmin Mihai, Shengying Bao, Ju-Ping Lai et Samir N. Ghadiali, « PTEN inhibition improves wound healing in lung epithelia through changes in cellular mechanics that enhance migration », American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 302, no 3, , L287–L299 (ISSN1040-0605 et 1522-1504, PMID22037358, PMCIDPMC3289272, DOI10.1152/ajplung.00037.2011, lire en ligne, consulté le )
(en) Chandler L. Walker, Melissa J. Walker, Nai-Kui Liu et Emelie C. Risberg, « Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury », PLOS ONE, vol. 7, no 1, , e30012 (ISSN1932-6203, PMID22253859, PMCIDPMC3254642, DOI10.1371/journal.pone.0030012, lire en ligne, consulté le )
pnas.org
(en) Anindita Chakrabarty, Violeta Sánchez, María G. Kuba et Cammie Rinehart, « Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors », Proceedings of the National Academy of Sciences, vol. 109, no 8, , p. 2718–2723 (ISSN0027-8424 et 1091-6490, PMID21368164, PMCIDPMC3286932, DOI10.1073/pnas.1018001108, lire en ligne, consulté le )
David G. Winkler, Kerrie L. Faia, Jonathan P. DiNitto et Janid A. Ali, « PI3K-δ and PI3K-γ Inhibition by IPI-145 Abrogates Immune Responses and Suppresses Activity in Autoimmune and Inflammatory Disease Models », Chemistry & Biology, vol. 20, no 11, , p. 1364–1374 (ISSN1074-5521, DOI10.1016/j.chembiol.2013.09.017, lire en ligne, consulté le )
Soonbum Park, Young Sik Kim, Davis Yeon Kim et Insuk So, « PI3K pathway in prostate cancer: All resistant roads lead to PI3K », Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol. 1870, no 2, , p. 198–206 (ISSN0304-419X, DOI10.1016/j.bbcan.2018.09.001, lire en ligne, consulté le )
Bayard R. Huck et Igor Mochalkin, « Recent progress towards clinically relevant ATP-competitive Akt inhibitors », Bioorganic & Medicinal Chemistry Letters, vol. 27, no 13, , p. 2838–2848 (ISSN0960-894X, DOI10.1016/j.bmcl.2017.04.090, lire en ligne, consulté le )
Tom Malone, Lea Schäfer, Nathalie Simon et Susan Heavey, « Current perspectives on targeting PIM kinases to overcome mechanisms of drug resistance and immune evasion in cancer », Pharmacology & Therapeutics, vol. 207, , p. 107454 (ISSN0163-7258, DOI10.1016/j.pharmthera.2019.107454, lire en ligne, consulté le )
tandfonline.com
(en) Marcia A. Ciccone, Asaf Maoz, Jennifer K. Casabar et Hiroko Machida, « Clinical outcome of treatment with serine-threonine kinase inhibitors in recurrent epithelial ovarian cancer: a systematic review of literature », Expert Opinion on Investigational Drugs, vol. 25, no 7, , p. 781–796 (ISSN1354-3784 et 1744-7658, PMID27101098, PMCIDPMC7534810, DOI10.1080/13543784.2016.1181748, lire en ligne, consulté le )
(en) Joseph Peltier, Analeah O'Neill et David V. Schaffer, « PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation », Developmental Neurobiology, vol. 67, no 10, , p. 1348–1361 (ISSN1932-8451 et 1932-846X, DOI10.1002/dneu.20506, lire en ligne, consulté le )
(en) Lindsey A. Wyatt, Marie T. Filbin et Hans S. Keirstead, « PTEN inhibition enhances neurite outgrowth in human embryonic stem cell–derived neuronal progenitor cells », Journal of Comparative Neurology, vol. 522, no 12, , p. 2741–2755 (ISSN0021-9967 et 1096-9861, DOI10.1002/cne.23580, lire en ligne, consulté le )
febs.onlinelibrary.wiley.com
(en) Annette C. Schmid, Richard D. Byrne, Ramón Vilar et Rüdiger Woscholski, « Bisperoxovanadium compounds are potent PTEN inhibitors », FEBS Letters, vol. 566, nos 1-3, , p. 35–38 (ISSN0014-5793 et 1873-3468, DOI10.1016/j.febslet.2004.03.102, lire en ligne, consulté le )