Hiltunen M, van Groen T, Jolkkonen J (2009). "Functional roles of amyloid-beta protein precursor and amyloid-beta peptides: evidence from experimental studies". J. Alzheimers Dis.18 (2): 401–12. PMID19584429. doi:10.3233/JAD-2009-1154.
Luo Y, Bolon B, Damore MA, Fitzpatrick D, Liu H, Zhang J, Yan Q, Vassar R, Citron M (October 2003). "BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time". Neurobiol. Dis.14 (1): 81–8. PMID13678669. doi:10.1016/S0969-9961(03)00104-9.
Bogoyevitch MA, Boehm I, Oakley A, Ketterman AJ, Barr RK (March 2004). "Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential". Biochim. Biophys. Acta1697 (1–2): 89–101. PMID15023353. doi:10.1016/j.bbapap.2003.11.016.
Baruch-Suchodolsky R, Fischer B (May 2009). "Abeta40, either soluble or aggregated, is a remarkably potent antioxidant in cell-free oxidative systems". Biochemistry48 (20): 4354–70. PMID19320465. doi:10.1021/bi802361k.
Prelli F, Castaño E, Glenner GG, Frangione B (August 1988). "Differences between vascular and plaque core amyloid in Alzheimer's disease". J. Neurochem.51 (2): 648–51. PMID3292706. doi:10.1111/j.1471-4159.1988.tb01087.x.
Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M (September 1998). "Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau". Nat. Neurosci.1 (5): 355–8. PMID10196523. doi:10.1038/1565.
Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM (December 1999). "Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch". J. Biol. Chem.274 (51): 36801–7. PMID10593990. doi:10.1074/jbc.274.51.36801.
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M (October 1999). "Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE". Science286 (5440): 735–41. PMID10531052. doi:10.1126/science.286.5440.735.
Vassar R (December 2002). "Beta-secretase (BACE) as a drug target for Alzheimer's disease". Adv. Drug Deliv. Rev.54 (12): 1589–602. PMID12453676. doi:10.1016/S0169-409X(02)00157-6.
Castaño EM, Prelli F, Soto C, Beavis R, Matsubara E, Shoji M, Frangione B (December 1996). "The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid-beta 1-42 in Alzheimer's disease". J. Biol. Chem.271 (50): 32185–91. PMID8943274. doi:10.1074/jbc.271.50.32185.
Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS (December 2001). "Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP". Nature414 (6864): 643–8. PMID11740561. doi:10.1038/414643a.
Hartmann T, Bieger SC, Brühl B, Tienari PJ, Ida N, Allsop D, Roberts GW, Masters CL, Dotti CG, Unsicker K, Beyreuther K (September 1997). "Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides". Nat. Med.3 (9): 1016–20. PMID9288729. doi:10.1038/nm0997-1016.
Yin YI, Bassit B, Zhu L, Yang X, Wang C, Li YM (August 2007). "γ-Secretase Substrate Concentration Modulates the Aβ42/Aβ40 Ratio: Implications for Alzheimer's disease". J. Biol. Chem.282 (32): 23639–44. PMID17556361. doi:10.1074/jbc.M704601200.
Zhang S, Iwata K, Lachenmann MJ, Peng JW, Li S, Stimson ER, Lu Y, Felix AM, Maggio JE, Lee JP (June 2000). "The Alzheimer's peptide a beta adopts a collapsed coil structure in water". J. Struct. Biol.130 (2-3): 130–41. PMID10940221. doi:10.1006/jsbi.2000.4288.
Yu L, Edalji R, Harlan JE, Holzman TF, Lopez AP, Labkovsky B, Hillen H, Barghorn S, Ebert U, Richardson PL, Miesbauer L, Solomon L, Bartley D, Walter K, Johnson RW, Hajduk PJ, Olejniczak ET (March 2009). "Structural characterization of a soluble amyloid beta-peptide oligomer". Biochemistry48 (9): 1870–7. PMID19216516. doi:10.1021/bi802046n.
Strodel B, Lee JW, Whittleston CS, Wales DJ (September 2010). "Transmembrane structures for Alzheimer's Aβ(1-42) oligomers". J. Am. Chem. Soc.132 (38): 13300–12. PMID20822103. doi:10.1021/ja103725c.
Lashuel, H. A.; Hartley, D. M.; Balakhaneh, D.; Aggarwal A.; Teichberg S.; Callaway, D. J. E. (November 2002). "New class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer's disease". J. Biol. Chem.277 (45): 42881–90. PMID12167652. doi:10.1074/jbc.M206593200.
Parker MH, Chen R, Conway KA, Lee DH, Luo C, Boyd RE, Nortey SO, Ross TM, Scott MK, Reitz AB (November 2002). "Synthesis of (-)-5,8-dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: an inhibitor of beta-amyloid(1-42) aggregation". Bioorg. Med. Chem.10 (11): 3565–9. PMID12213471. doi:10.1016/S0968-0896(02)00251-1.
finder, v; glockshuber (2009). "The Recombinant Amyloid-β Peptide Aβ1–42 Aggregates Faster and Is More Neurotoxic than Synthetic Aβ1–42". journal of molecular biology396: 9–18. doi:10.1016/j.jmb.2009.12.016.
Pappolla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Frangione B, Ghiso J (March 1998). "Inhibition of Alzheimer's beta fibrillogenesis by melatonin". J Biol Chem273 (13): 7185–7188. PMID9516407. doi:10.1074/jbc.273.13.7185.
Lahiri DK, Chen DM, Lahiri P, Bondy S, Greig NH (November 2005). "Amyloid, cholinesterase, melatonin, and metals and their roles in aging and neurodegenerative diseases". Ann. N. Y. Acad. Sci.1056: 430–49. Bibcode:2005NYASA1056..430L. PMID16387707. doi:10.1196/annals.1352.008.
Wang XC, Zhang YC, Chatterjie N, Grundke-Iqbal I, Iqbal K, Wang JZ (June 2008). "Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells". Neurochem. Res.33 (6): 1138–44. PMID18231852. doi:10.1007/s11064-007-9563-y.
Ramírez BG, Blázquez C, Gómez del Pulgar T, Guzmán M, de Ceballos ML (February 2005). "Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation". J. Neurosci.25 (8): 1904–13. PMID15728830. doi:10.1523/JNEUROSCI.4540-04.2005.
Milton NG (October 2002). "Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide". Neurosci. Lett.332 (2): 127–30. PMID12384227. doi:10.1016/S0304-3940(02)00936-9.
Schneider JS, Pioli EY, Jianzhong Y, Li Q, Bezard E (April 2013). "Effects of memantine and galantamine on cognitive performance in aged rhesus macaques". Neurobiol. Aging34 (4): 1126–32. PMID23158762. doi:10.1016/j.neurobiolaging.2012.10.020.
McClean, P., Parthsarathy, V., Faivre, E., and Hölscher, C (November 2011). "The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease". The Journal of Neuroscience31 (17): 6587–6594. PMID12213471. doi:10.1016/S0968-0896(02)00251-1.
Stine WB, Dahlgren KN, Krafft GA, LaDu MJ (March 2003). "In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis". J. Biol. Chem.278 (13): 11612–22. PMID12499373. doi:10.1074/jbc.M210207200.
Gengler S, Gault VA, Harriott P, Hölscher C (June 2007). "Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid (25-35) are dependent on stimulation-protocol and genetic background". Exp Brain Res179 (4): 621–30. PMID17171334. doi:10.1007/s00221-006-0819-6.
Rekas A, Jankova L, Thorn DC, Cappai R, Carver JA (December 2007). "Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the aggregating species". FEBS J.274 (24): 6290–304. PMID18005258. doi:10.1111/j.1742-4658.2007.06144.x.
Sanghera N, Swann MJ, Ronan G, Pinheiro TJ (October 2009). "Insight into early events in the aggregation of the prion protein on lipid membranes". Biochim. Biophys. Acta1788 (10): 2245–51. PMID19703409. doi:10.1016/j.bbamem.2009.08.005.
Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG (April 2003). "Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis". Science300 (5618): 486–9. Bibcode:2003Sci...300..486K. PMID12702875. doi:10.1126/science.1079469.
Lahiri DK, Chen DM, Lahiri P, Bondy S, Greig NH (November 2005). "Amyloid, cholinesterase, melatonin, and metals and their roles in aging and neurodegenerative diseases". Ann. N. Y. Acad. Sci.1056: 430–49. Bibcode:2005NYASA1056..430L. PMID16387707. doi:10.1196/annals.1352.008.
Nussbaum, J. M.; Seward, M. E.; Bloom, G. S. (2013). "Alzheimer disease: A tale of two prions". Prion 7 (1): 14–9. doi:10.4161/pri.22118. PMC 3609044. PMID 22965142.
Hiltunen M, van Groen T, Jolkkonen J (2009). "Functional roles of amyloid-beta protein precursor and amyloid-beta peptides: evidence from experimental studies". J. Alzheimers Dis.18 (2): 401–12. PMID19584429. doi:10.3233/JAD-2009-1154.
Luo Y, Bolon B, Damore MA, Fitzpatrick D, Liu H, Zhang J, Yan Q, Vassar R, Citron M (October 2003). "BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time". Neurobiol. Dis.14 (1): 81–8. PMID13678669. doi:10.1016/S0969-9961(03)00104-9.
Bogoyevitch MA, Boehm I, Oakley A, Ketterman AJ, Barr RK (March 2004). "Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential". Biochim. Biophys. Acta1697 (1–2): 89–101. PMID15023353. doi:10.1016/j.bbapap.2003.11.016.
Zou K, Gong JS, Yanagisawa K, Michikawa M (June 2002). "A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage". J. Neurosci.22 (12): 4833–41. PMID12077180.
Baruch-Suchodolsky R, Fischer B (May 2009). "Abeta40, either soluble or aggregated, is a remarkably potent antioxidant in cell-free oxidative systems". Biochemistry48 (20): 4354–70. PMID19320465. doi:10.1021/bi802361k.
Prelli F, Castaño E, Glenner GG, Frangione B (August 1988). "Differences between vascular and plaque core amyloid in Alzheimer's disease". J. Neurochem.51 (2): 648–51. PMID3292706. doi:10.1111/j.1471-4159.1988.tb01087.x.
Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M (September 1998). "Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau". Nat. Neurosci.1 (5): 355–8. PMID10196523. doi:10.1038/1565.
Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM (December 1999). "Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch". J. Biol. Chem.274 (51): 36801–7. PMID10593990. doi:10.1074/jbc.274.51.36801.
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M (October 1999). "Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE". Science286 (5440): 735–41. PMID10531052. doi:10.1126/science.286.5440.735.
Vassar R (December 2002). "Beta-secretase (BACE) as a drug target for Alzheimer's disease". Adv. Drug Deliv. Rev.54 (12): 1589–602. PMID12453676. doi:10.1016/S0169-409X(02)00157-6.
Castaño EM, Prelli F, Soto C, Beavis R, Matsubara E, Shoji M, Frangione B (December 1996). "The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid-beta 1-42 in Alzheimer's disease". J. Biol. Chem.271 (50): 32185–91. PMID8943274. doi:10.1074/jbc.271.50.32185.
Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS (December 2001). "Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP". Nature414 (6864): 643–8. PMID11740561. doi:10.1038/414643a.
Hartmann T, Bieger SC, Brühl B, Tienari PJ, Ida N, Allsop D, Roberts GW, Masters CL, Dotti CG, Unsicker K, Beyreuther K (September 1997). "Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides". Nat. Med.3 (9): 1016–20. PMID9288729. doi:10.1038/nm0997-1016.
Yin YI, Bassit B, Zhu L, Yang X, Wang C, Li YM (August 2007). "γ-Secretase Substrate Concentration Modulates the Aβ42/Aβ40 Ratio: Implications for Alzheimer's disease". J. Biol. Chem.282 (32): 23639–44. PMID17556361. doi:10.1074/jbc.M704601200.
Zhang S, Iwata K, Lachenmann MJ, Peng JW, Li S, Stimson ER, Lu Y, Felix AM, Maggio JE, Lee JP (June 2000). "The Alzheimer's peptide a beta adopts a collapsed coil structure in water". J. Struct. Biol.130 (2-3): 130–41. PMID10940221. doi:10.1006/jsbi.2000.4288.
Yu L, Edalji R, Harlan JE, Holzman TF, Lopez AP, Labkovsky B, Hillen H, Barghorn S, Ebert U, Richardson PL, Miesbauer L, Solomon L, Bartley D, Walter K, Johnson RW, Hajduk PJ, Olejniczak ET (March 2009). "Structural characterization of a soluble amyloid beta-peptide oligomer". Biochemistry48 (9): 1870–7. PMID19216516. doi:10.1021/bi802046n.
Strodel B, Lee JW, Whittleston CS, Wales DJ (September 2010). "Transmembrane structures for Alzheimer's Aβ(1-42) oligomers". J. Am. Chem. Soc.132 (38): 13300–12. PMID20822103. doi:10.1021/ja103725c.
Lashuel, H. A.; Hartley, D. M.; Balakhaneh, D.; Aggarwal A.; Teichberg S.; Callaway, D. J. E. (November 2002). "New class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer's disease". J. Biol. Chem.277 (45): 42881–90. PMID12167652. doi:10.1074/jbc.M206593200.
Parker MH, Chen R, Conway KA, Lee DH, Luo C, Boyd RE, Nortey SO, Ross TM, Scott MK, Reitz AB (November 2002). "Synthesis of (-)-5,8-dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: an inhibitor of beta-amyloid(1-42) aggregation". Bioorg. Med. Chem.10 (11): 3565–9. PMID12213471. doi:10.1016/S0968-0896(02)00251-1.
Pappolla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Frangione B, Ghiso J (March 1998). "Inhibition of Alzheimer's beta fibrillogenesis by melatonin". J Biol Chem273 (13): 7185–7188. PMID9516407. doi:10.1074/jbc.273.13.7185.
Lahiri DK, Chen DM, Lahiri P, Bondy S, Greig NH (November 2005). "Amyloid, cholinesterase, melatonin, and metals and their roles in aging and neurodegenerative diseases". Ann. N. Y. Acad. Sci.1056: 430–49. Bibcode:2005NYASA1056..430L. PMID16387707. doi:10.1196/annals.1352.008.
Wang XC, Zhang YC, Chatterjie N, Grundke-Iqbal I, Iqbal K, Wang JZ (June 2008). "Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells". Neurochem. Res.33 (6): 1138–44. PMID18231852. doi:10.1007/s11064-007-9563-y.
Ramírez BG, Blázquez C, Gómez del Pulgar T, Guzmán M, de Ceballos ML (February 2005). "Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation". J. Neurosci.25 (8): 1904–13. PMID15728830. doi:10.1523/JNEUROSCI.4540-04.2005.
Milton NG (October 2002). "Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide". Neurosci. Lett.332 (2): 127–30. PMID12384227. doi:10.1016/S0304-3940(02)00936-9.
Schneider JS, Pioli EY, Jianzhong Y, Li Q, Bezard E (April 2013). "Effects of memantine and galantamine on cognitive performance in aged rhesus macaques". Neurobiol. Aging34 (4): 1126–32. PMID23158762. doi:10.1016/j.neurobiolaging.2012.10.020.
McClean, P., Parthsarathy, V., Faivre, E., and Hölscher, C (November 2011). "The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease". The Journal of Neuroscience31 (17): 6587–6594. PMID12213471. doi:10.1016/S0968-0896(02)00251-1.
Stine WB, Dahlgren KN, Krafft GA, LaDu MJ (March 2003). "In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis". J. Biol. Chem.278 (13): 11612–22. PMID12499373. doi:10.1074/jbc.M210207200.
Gengler S, Gault VA, Harriott P, Hölscher C (June 2007). "Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid (25-35) are dependent on stimulation-protocol and genetic background". Exp Brain Res179 (4): 621–30. PMID17171334. doi:10.1007/s00221-006-0819-6.
Rekas A, Jankova L, Thorn DC, Cappai R, Carver JA (December 2007). "Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the aggregating species". FEBS J.274 (24): 6290–304. PMID18005258. doi:10.1111/j.1742-4658.2007.06144.x.
Sanghera N, Swann MJ, Ronan G, Pinheiro TJ (October 2009). "Insight into early events in the aggregation of the prion protein on lipid membranes". Biochim. Biophys. Acta1788 (10): 2245–51. PMID19703409. doi:10.1016/j.bbamem.2009.08.005.