Cita orixinal: "Variations neither useful nor injurious would not be affected by natural selection, and would be left either a fluctuating element, as perhaps we see in certain polymorphic species, or would ultimately become fixed, owing to the nature of the organism and the nature of the conditions." Darwin online. Origin of species Variorum
Venetianer, Pál (1 January 2012). "Are synonymous codons indeed synonymous?". BioMolecular Concepts3 (1). doi:10.1515/bmc.2011.050.
Duret, L (December 2002). "Evolution of synonymous codon usage in metazoans". Current opinion in genetics & development12 (6): 640–9. PMID12433576. doi:10.1016/s0959-437x(02)00353-2.
Nakamoto T (March 2009). "Evolution and the universality of the mechanism of initiation of protein synthesis". Gene432 (1–2): 1–6. PMID19056476. doi:10.1016/j.gene.2008.11.001.
Ng, PC; Henikoff, S (2006). "Predicting the effects of amino acid substitutions on protein function". Annual Review of Genomics and Human Genetics7: 61–80. PMID16824020. doi:10.1146/annurev.genom.7.080505.115630.
Guo, HH; Choe, J; Loeb, LA (22 June 2004). "Protein tolerance to random amino acid change". Proc. Natl. Acad. Sci. U.S.A.101 (25): 9205–10. PMID15197260. doi:10.1073/pnas.0403255101.
Nei, M; Graur, D (1984). "Extent of protein polymorphism and the neutral mutation theory". Evolutionary Biology17: 73–118. doi:10.1007/978-1-4615-6974-9_3.
Dickerson, RE (1971). "The structures of cytochrome c and the rates of molecular evolution". Journal of Molecular Evolution1 (1): 26–45. PMID4377446. doi:10.1007/bf01659392.
Duret, L (December 2002). "Evolution of synonymous codon usage in metazoans". Current opinion in genetics & development12 (6): 640–9. PMID12433576. doi:10.1016/s0959-437x(02)00353-2.
Nakamoto T (March 2009). "Evolution and the universality of the mechanism of initiation of protein synthesis". Gene432 (1–2): 1–6. PMID19056476. doi:10.1016/j.gene.2008.11.001.
Ng, PC; Henikoff, S (2006). "Predicting the effects of amino acid substitutions on protein function". Annual Review of Genomics and Human Genetics7: 61–80. PMID16824020. doi:10.1146/annurev.genom.7.080505.115630.
Guo, HH; Choe, J; Loeb, LA (22 June 2004). "Protein tolerance to random amino acid change". Proc. Natl. Acad. Sci. U.S.A.101 (25): 9205–10. PMID15197260. doi:10.1073/pnas.0403255101.
Dickerson, RE (1971). "The structures of cytochrome c and the rates of molecular evolution". Journal of Molecular Evolution1 (1): 26–45. PMID4377446. doi:10.1007/bf01659392.