References analysis of the Wikipedia article "Proteína precursora amiloide" in the Galician version

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PDB 1RW6; Wang Y, Ha Y (August 2004). "The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain". Mol. Cell 15 (3): 343–53. PMID 15304215. doi:10.1016/j.molcel.2004.06.037.

Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, Herms J (July 2006). "Synapse formation and function is modulated by the amyloid precursor protein". J. Neurosci. 26 (27): 7212–21. PMID 16822978. doi:10.1523/JNEUROSCI.1450-06.2006.

Turner PR, O'Connor K, Tate WP, Abraham WC (May 2003). "Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory". Prog. Neurobiol. 70 (1): 1–32. PMID 12927332. doi:10.1016/S0301-0082(03)00089-3.

Duce JA; et al. (2010). "Iron-Export Ferroxidase Activity of β- Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease". Cell 142 (6): 857–67. PMC 2943017. PMID 20817278. doi:10.1016/j.cell.2010.08.014.

Sarkar IN, Tharp G (April 2013). "Origins of amyloid-beta.". BMC Genomics 14 (1): 290. PMID 23627794. doi:10.1186/1471-2164-14-290.

Yoshikai S, Sasaki H, Doh-ura K, Furuya H, Sakaki Y (March 1990). "Genomic organization of the human amyloid beta-protein precursor gene". Gene 87 (2): 257–63. PMID 2110105. doi:10.1016/0378-1119(90)90310-N.

Lamb BT, Sisodia SS, Lawler AM, Slunt HH, Kitt CA, Kearns WG, Pearson PL, Price DL, Gearhart JD (September 1993). "Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]". Nat. Genet. 5 (1): 22–30. PMID 8220418. doi:10.1038/ng0993-22.

Matsui T, Ingelsson M, Fukumoto H, Ramasamy K, Kowa H, Frosch MP, Irizarry MC, Hyman BT (August 2007). "Expression of APP pathway mRNAs and proteins in Alzheimer's disease". Brain Res. 1161: 116–23. PMID 17586478. doi:10.1016/j.brainres.2007.05.050.

Zheng H, Koo EH (2006). "The amyloid precursor protein: beyond amyloid". Mol Neurodegener 1 (1): 5. PMC 1538601. PMID 16930452. doi:10.1186/1750-1326-1-5.

Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L (February 1991). "Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease". Nature 349 (6311): 704–6. PMID 1671712. doi:10.1038/349704a0.

Murrell J, Farlow M, Ghetti B, Benson MD (October 1991). "A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease". Science 254 (5028): 97–9. PMID 1925564. doi:10.1126/science.1925564.

Chartier-Harlin MC, Crawford F, Houlden H, Warren A, Hughes D, Fidani L, Goate A, Rossor M, Roques P, Hardy J (October 1991). "Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene". Nature 353 (6347): 844–6. PMID 1944558. doi:10.1038/353844a0.

Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ (December 1992). "Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production". Nature 360 (6405): 672–4. PMID 1465129. doi:10.1038/360672a0.

Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, Graham RR, Huttenlocher J, Bjornsdottir G, Andreassen OA, Jönsson EG, Palotie A, Behrens TW, Magnusson OT, Kong A, Thorsteinsdottir U, Watts RJ, Stefansson K (July 2012). "A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline". Nature 487. doi:10.1038/nature11283. Resumo divulgativo – The New York Times.

Dahms SO, Hoefgen S, Roeser D, Schlott B, Gührs KH, Than ME (March 2010). "Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein". Proc Natl Acad Sci U S A 107 (12): 5381–6. PMC 2851805. PMID 20212142. doi:10.1073/pnas.0911326107.; ver tamén PDB ID 3KTM

Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW (April 1999). "Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein". Nat Struct Biol 6 (4): 327–31. PMID 10201399. doi:10.1038/7562.; ver tamén PDB ID 1MWP

Kong GK, Adams JJ, Harris HH, Boas JF, Curtain CC, Galatis D, Masters CL, Barnham KJ, McKinstry WJ, Cappai R, Parker MW (March 2007). "Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions". J Mol Biol 367 (1): 148–61. PMID 17239395. doi:10.1016/j.jmb.2006.12.041.; Ver tamén 2007 PDB IDs 2FJZ, 2FK2, 2FKL.

Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P (April 2006). "TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity". Nature 440 (7088): 1208–12. PMID 16641999. doi:10.1038/nature04667.

Ehehalt R, Keller P, Haass C, Thiele C, Simons K (January 2003). "Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts". J. Cell Biol. 160 (1): 113–23. PMC 2172747. PMID 12515826. doi:10.1083/jcb.200207113.

Vetrivel KS, Cheng H, Lin W, Sakurai T, Li T, Nukina N, Wong PC, Xu H, Thinakaran G (October 2004). "Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes". J. Biol. Chem. 279 (43): 44945–54. PMC 1201506. PMID 15322084. doi:10.1074/jbc.M407986200.

Riddell DR, Christie G, Hussain I, Dingwall C (August 2001). "Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts". Curr. Biol. 11 (16): 1288–93. PMID 11525745. doi:10.1016/S0960-9822(01)00394-3.

Selkoe D, Kopan R (2003). "Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration". Annu. Rev. Neurosci. 26 (1): 565–97. PMID 12730322. doi:10.1146/annurev.neuro.26.041002.131334.

Phinney AL, Calhoun ME, Wolfer DP, Lipp HP, Zheng H, Jucker M (1999). "No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice". Neuroscience 90 (4): 1207–16. PMID 10338291. doi:10.1016/S0306-4522(98)00645-9.

Barger SW, DeWall KM, Liu L, Mrak RE, Griffin WS (August 2008). "Relationships between expression of apolipoprotein E and beta-amyloid precursor protein are altered in proximity to Alzheimer beta-amyloid plaques: potential explanations from cell culture studies". J. Neuropathol. Exp. Neurol. 67 (8): 773–83. PMID 18648325. doi:10.1097/NEN.0b013e318180ec47.

Rogers JT, Bush AI, Cho HH, Smith DH, Thomson AM, Friedlich AL, Lahiri DK, Leedman PJ, Huang X, Cahill CM (December 2008). "Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease". Biochem. Soc. Trans. 36 (Pt 6): 1282–7. PMC 2746665. PMID 19021541. doi:10.1042/BST0361282.

Ebrahimi KH, Hagedoorn PL, Hagen WR (2012). "A synthetic peptide with the putative iron binding motif of amyloid precursor protein (APP) does not catalytically oxidize iron". PLoS ONE 7 (8): e40287. PMC 3419245. PMID 22916096. doi:10.1371/journal.pone.0040287.

Honarmand Ebrahimi K, Dienemann C, Hoefgen S, Than ME, Hagedoorn PL, Hagen WR (2013). "The Amyloid Precursor Protein (APP) Does Not Have a Ferroxidase Site in Its E2 Domain". PLoS ONE 8 (8): e72177. PMID 23977245. doi:10.1371/journal.pone.0072177.

Porayette P, Gallego MJ, Kaltcheva MM, Meethal SV, Atwood CS (December 2007). "Amyloid-beta precursor protein expression and modulation in human embryonic stem cells: a novel role for human chorionic gonadotropin". Biochem. Biophys. Res. Commun. 364 (3): 522–7. PMID 17959150. doi:10.1016/j.bbrc.2007.10.021.

Porayette P, Gallego MJ, Kaltcheva MM, Bowen RL, Vadakkadath Meethal S, Atwood CS (August 2009). "Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells". J. Biol. Chem. 284 (35): 23806–17. PMC 2749153. PMID 19542221. doi:10.1074/jbc.M109.026328.

Gallego MJ, Porayette P, Kaltcheva MM, Meethal SV, Atwood CS (June 2009). "Opioid and progesterone signaling is obligatory for early human embryogenesis". Stem Cells Dev. 18 (5): 737–40. PMC 2891507. PMID 18803462. doi:10.1089/scd.2008.0190.

Gallego MJ, Porayette P, Kaltcheva MM, Bowen RL, Vadakkadath Meethal S, Atwood CS (2010). "The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and differentiation into neuroectodermal rosettes". Stem Cell Res Ther 1 (4): 28. PMC 2983441. PMID 20836886. doi:10.1186/scrt28.

Bowen RL, Verdile G, Liu T, Parlow AF, Perry G, Smith MA, Martins RN, Atwood CS (May 2004). "Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition". J. Biol. Chem. 279 (19): 20539–45. PMID 14871891. doi:10.1074/jbc.M311993200.

Araki Y, Tomita Susumu, Yamaguchi Haruyasu, Miyagi Naomi, Sumioka Akio, Kirino Yutaka, Suzuki Toshiharu (Dec 2003). "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". J. Biol. Chem. 278 (49): 49448–58. PMID 12972431. doi:10.1074/jbc.M306024200.

Tomita S, Ozaki T, Taru H, Oguchi S, Takeda S, Yagi Y, Sakiyama S, Kirino Y, Suzuki T (January 1999). "Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein". J. Biol. Chem. 274 (4): 2243–54. PMID 9890987. doi:10.1074/jbc.274.4.2243.

Tanahashi H, Tabira T (February 1999). "X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein". Biochem. Biophys. Res. Commun. 255 (3): 663–7. PMID 10049767. doi:10.1006/bbrc.1999.0265.

Zambrano N, Buxbaum J D, Minopoli G, Fiore F, De Candia P, De Renzis S, Faraonio R, Sabo S, Cheetham J, Sudol M, Russo T (March 1997). "Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins". J. Biol. Chem. 272 (10): 6399–405. PMID 9045663. doi:10.1074/jbc.272.10.6399.

Guénette SY, Chen J, Jondro P D, Tanzi R E (October 1996). "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein". PNAS 93 (20): 10832–7. PMC 38241. PMID 8855266. doi:10.1073/pnas.93.20.10832.

Tanahashi H, Tabira T (February 1999). "Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein". Neurosci. Lett. 261 (3): 143–6. PMID 10081969. doi:10.1016/S0304-3940(98)00995-1.

Trommsdorff M, Borg J P, Margolis B, Herz J (Dec 1998). "Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein". J. Biol. Chem. 273 (50): 33556–60. PMID 9837937. doi:10.1074/jbc.273.50.33556.

Chow N, Korenberg J R, Chen X N, Neve R L (May 1996). "APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein". J. Biol. Chem. 271 (19): 11339–46. PMID 8626687. doi:10.1074/jbc.271.19.11339.

Zheng P, Eastman J, Vande Pol S, Pimplikar S W (Dec 1998). "PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein". PNAS 95 (25): 14745–50. PMC 24520. PMID 9843960. doi:10.1073/pnas.95.25.14745.

Wang B, Nguyen Mai, Breckenridge David G, Stojanovic Marina, Clemons Paul A, Kuppig Stephan, Shore Gordon C (April 2003). "Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria". J. Biol. Chem. 278 (16): 14461–8. PMID 12529377. doi:10.1074/jbc.M209684200.

Lefterov IM, Koldamova R P, Lazo J S (September 2000). "Human bleomycin hydrolase regulates the secretion of amyloid precursor protein". FASEB J. 14 (12): 1837–47. PMID 10973933. doi:10.1096/fj.99-0938com.

Araki Y, Miyagi Naomi, Kato Naoko, Yoshida Tomohiro, Wada Sachiyo, Nishimura Masaki, Komano Hiroto, Yamamoto Tohru, De Strooper Bart, Yamamoto Kazuo, Suzuki Toshiharu (June 2004). "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". J. Biol. Chem. 279 (23): 24343–54. PMID 15037614. doi:10.1074/jbc.M401925200.

Ikezu T, Trapp B D, Song K S, Schlegel A, Lisanti M P, Okamoto T (April 1998). "Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein". J. Biol. Chem. 273 (17): 10485–95. PMID 9553108. doi:10.1074/jbc.273.17.10485.

Hashimoto T, Wakabayashi Tomoko, Watanabe Atsushi, Kowa Hisatomo, Hosoda Ritsuko, Nakamura Atsushi, Kanazawa Ichiro, Arai Takao, Takio Koji, Mann David M A, Iwatsubo Takeshi (April 2002). "CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV". EMBO J. 21 (7): 1524–34. PMC 125364. PMID 11927537. doi:10.1093/emboj/21.7.1524.

Ohsawa I, Takamura C, Kohsaka S (March 2001). "Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function". J. Neurochem. 76 (5): 1411–20. PMID 11238726. doi:10.1046/j.1471-4159.2001.00144.x.

Chauhan VP, Ray I, Chauhan A, Wisniewski H M (May 1999). "Binding of gelsolin, a secretory protein, to amyloid beta-protein". Biochem. Biophys. Res. Commun. 258 (2): 241–6. PMID 10329371. doi:10.1006/bbrc.1999.0623.

Yan SD, Fu J, Soto C, Chen X, Zhu H, Al-Mohanna F, Collison K, Zhu A, Stern E, Saido T, Tohyama M, Ogawa S, Roher A, Stern D (October 1997). "An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease". Nature 389 (6652): 689–95. PMID 9338779. doi:10.1038/39522.

Tarr PE, Roncarati Roberta, Pelicci Giuliana, Pelicci Pier Giuseppe, D'Adamio Luciano (May 2002). "Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc". J. Biol. Chem. 277 (19): 16798–804. PMID 11877420. doi:10.1074/jbc.M110286200.

Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW (June 2009). "Interaction of reelin with amyloid precursor protein promotes neurite outgrowth". J. Neurosci. 29 (23): 7459–73. PMC 2759694. PMID 19515914. doi:10.1523/JNEUROSCI.4872-08.2009. Resumo divulgativo – Alzheimer Research Forum.

nih.gov

ncbi.nlm.nih.gov

Sarkar IN, Tharp G (April 2013). "Origins of amyloid-beta.". BMC Genomics 14 (1): 290. PMID 23627794. doi:10.1186/1471-2164-14-290.

Zheng H, Koo EH (2006). "The amyloid precursor protein: beyond amyloid". Mol Neurodegener 1 (1): 5. PMC 1538601. PMID 16930452. doi:10.1186/1750-1326-1-5.

Sisodia SS, Koo EH, Hoffman PN, Perry G, Price DL (July 1993). "Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system". J. Neurosci. 13 (7): 3136–42. PMID 8331390.

De Strooper B, Annaert W (June 2000). "Proteolytic processing and cell biological functions of the amyloid precursor protein". J. Cell. Sci. ( Pt 11): 1857–70. PMID 10806097.

Matsuyama S, Teraoka R, Mori H, Tomiyama T. (2007). Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice. Neuroreport 18(10):1083-7. PMID 17558301

McPhie DL, Coopersmith R, Hines-Peralta A, Chen Y, Ivins KJ, Manly SP, Kozlowski MR, Neve KA, Neve RL (July 2003). "DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3". J. Neurosci. 23 (17): 6914–27. PMID 12890786.

Biederer T, Cao Xinwei, Südhof Thomas C, Liu Xinran (September 2002). "Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms". J. Neurosci. 22 (17): 7340–51. PMID 12196555.

Borg JP, Ooi J, Levy E, Margolis B (November 1996). "The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein". Mol. Cell. Biol. 16 (11): 6229–41. PMC 231626. PMID 8887653.

nytimes.com

rcsb.org

Proteína precursora amiloide (Galician Wikipedia)

alzforum.org

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