"Conformation-Dependent Design of Sequences in Copolymers I," Alexei R. Khokhlov, Springer Science & Business Media, 2006, ISBN 9783540295136, ... Hydrophilic compounds are well soluble in water, but hydrophobic ones are not. Amphiphilic compounds occupy an intermediate position, being able to level off the unprofitable interactions between water and hydrophobic compounds ...