Biochemistry, Mary K. Campbell, Shawn O. Farrell, pp. 15, Cengage Learning, 2011, ISBN 978-0-8400-6858-3, ... The word eukaryote means “true nucleus.” Eukaryotes are more complex organisms and can be multicellular or single-celled. A well-defined nucleus, set off from the rest of the cell by a membrane, is one of the chief features distinguishing a eukaryote from a prokaryote ...