(2011. augusztus 1.) „Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects”. British Journal of Pharmacology163 (7), 1344–1364. o. DOI:10.1111/j.1476-5381.2011.01238.x. PMID21749363. PMC3165946.
(2006. április 1.) „The pharmacology of cannabinoid receptors and their ligands: an overview”. Int J Obes (Lond)30 (Suppl 1), S13–8. o. DOI:10.1038/sj.ijo.0803272. PMID16570099.
(2007) „Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons”. Cereb. Cortex17 (1), 163–74. o. DOI:10.1093/cercor/bhj133. PMID16467564.
(2007) „Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus”. J. Neurosci.27 (5), 1211–9. o. DOI:10.1523/JNEUROSCI.4159-06.2007. PMID17267577.
(2006) „Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning”. J. Neurosci.26 (34), 8829–37. o. DOI:10.1523/JNEUROSCI.1236-06.2006. PMID16928872.
(2001. július 1.) „Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase”. Proc. Natl. Acad. Sci. U.S.A.98 (16), 9371–6. o. DOI:10.1073/pnas.161191698. JSTOR3056353. PMID11470906. PMC55427.
(2014) „The endocannabinoid system: helps to direct eating behavior and macronutrient metabolism”. Front Psychol5, 1506. o. DOI:10.3389/fpsyg.2014.01506. PMID25610411. PMC4285050. „CB1 is present in neurons of the enteric nervous system and in sensory terminals of vagal and spinal neurons in the gastrointestinal tract (Massa et al., 2005). Activation of CB1 is shown to modulate nutrient processing, such as gastric secretion, gastric emptying, and intestinal motility. ... CB1 is shown to co-localize with the food intake inhibiting neuropeptide, corticotrophin-releasing hormone, in the paraventricular nucleus of the hypothalamus, and with the two orexigenic peptides, melanin-concentrating hormone in the lateral hypothalamus and with pre-pro-orexin in the ventromedial hypothalamus (Inui, 1999; Horvath, 2003). CB1 knockout mice showed higher levels of CRH mRNA, suggesting that hypothalamic EC receptors are involved in energy balance and may be able to mediate food intake (Cota et al., 2003). ... The ECS works through many anorexigenic and orexigenic pathways where ghrelin, leptin, adiponectin, endogenous opioids, and corticotropin-releasing hormones are involved (Viveros et al., 2008).”
(2013) „Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far”. Front Neurosci7, 256. o. DOI:10.3389/fnins.2013.00256. PMID24391536. PMC3868890. „Direct CB1-HcrtR1 interaction was first proposed in 2003 (Hilairet et al., 2003). Indeed, a 100-fold increase in the potency of hypocretin-1 to activate the ERK signaling was observed when CB1 and HcrtR1 were co-expressed ... In this study, a higher potency of hypocretin-1 to regulate CB1-HcrtR1 heteromer compared with the HcrtR1-HcrtR1 homomer was reported (Ward et al., 2011b). These data provide unambiguous identification of CB1-HcrtR1 heteromerization, which has a substantial functional impact. ... The existence of a cross-talk between the hypocretinergic and endocannabinoid systems is strongly supported by their partially overlapping anatomical distribution and common role in several physiological and pathological processes. However, little is known about the mechanisms underlying this interaction.”
(2014) „OX1 and OX2 orexin/hypocretin receptor pharmacogenetics”. Front Neurosci8, 57. o. DOI:10.3389/fnins.2014.00057. PMID24834023. PMC4018553. „OX1–CB1 dimerization was suggested to strongly potentiate orexin receptor signaling, but a likely explanation for the signal potentiation is, instead, offered by the ability of OX1 receptor signaling to produce 2-arachidonoyl glycerol, a CB1 receptor ligand, and a subsequent co-signaling of the receptors (Haj-Dahmane and Shen, 2005; Turunen et al., 2012; Jäntti et al., 2013). However, this does not preclude dimerization.”
(2014) „Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors”. Biochem. Biophys. Res. Commun.445 (2), 486–90. o. DOI:10.1016/j.bbrc.2014.02.026. PMID24530395. „Orexin receptor subtypes readily formed homo- and hetero(di)mers, as suggested by significant BRET signals. CB1 receptors formed homodimers, and they also heterodimerized with both orexin receptors. ... In conclusion, orexin receptors have a significant propensity to make homo- and heterodi-/oligomeric complexes. However, it is unclear whether this affects their signaling. As orexin receptors efficiently signal via endocannabinoid production to CB1 receptors, dimerization could be an effective way of forming signal complexes with optimal cannabinoid concentrations available for cannabinoid receptors.”
(2008. január 1.) „The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin”. Br. J. Pharmacol.153 (2), 199–215. o. DOI:10.1038/sj.bjp.0707442. PMID17828291. PMC2219532.
(2001. március 1.) „The neurobiology and evolution of cannabinoid signalling”. Philos. Trans. R. Soc. Lond., B, Biol. Sci.356 (1407), 381–408. o. DOI:10.1098/rstb.2000.0787. PMID11316486. PMC1088434.
(2011. december 1.) „Polymodal activation of the endocannabinoid system in the extended amygdala”. Nat. Neurosci.14 (12), 1542–7. o. DOI:10.1038/nn.2974. PMID22057189.
(2006) „Endocannabinoids in appetite control and the treatment of obesity”. CNS Neurol Disord Drug Targets5 (3), 272–92. o. DOI:10.2174/187152706777452272. PMID16787229.
(1998. december 1.) „Trick or treat from food endocannabinoids?”. Nature396 (6712), 636–7. o. DOI:10.1038/25267. PMID9872309.
(2001. április 1.) „Leptin-regulated endocannabinoids are involved in maintaining food intake”. Nature410 (6830), 822–5. o. DOI:10.1038/35071088. PMID11298451.
(2010. május 1.) „Endogenous cannabinoid signaling is essential for stress adaptation”. Proc. Natl. Acad. Sci. U.S.A.107 (20), 9406–11. o. DOI:10.1073/pnas.0914661107. PMID20439721.
(2011. december 1.) „Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses”. J. Immunol.187 (11), 5720–32. o. DOI:10.4049/jimmunol.1102195. PMID22048769. PMC3226756.
(2000) „Cannabinoids control spasticity and tremor in a multiple sclerosis model”. Nature404 (6773), 84–7. o. DOI:10.1038/35003583. PMID10716447.
(2006. augusztus 1.) „Changes in CB1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis mice”. Brain Res.1107 (1), 199–205. o. DOI:10.1016/j.brainres.2006.06.001. PMID16822488.
(2004. április 1.) „Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism”. Mol. Pharmacol.65 (4), 999–1007. o. DOI:10.1124/mol.65.4.999. PMID15044630.
(2000) „Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage”. Lancet355 (9212), 1326–9. o. DOI:10.1016/S0140-6736(00)02115-2. PMID10776746.
(1995) „The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling”. Proc. Natl. Acad. Sci. U.S.A.92 (21), 9460–4. o. DOI:10.1073/pnas.92.21.9460. PMID7568154. PMC40821.
(2012) „New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide”. The Open Pain Journal5 (1), 12–23. o. DOI:10.2174/1876386301205010012.
(2002. június 1.) „An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors”. Proc. Natl. Acad. Sci. U.S.A.99 (12), 8400–5. o. DOI:10.1073/pnas.122196999. PMID12060783.
(1996) „Arousal-enhancing properties of the CB1 cannabinoid receptor antagonist SR 141716A in rats as assessed by electroencephalographic spectral and sleep-waking cycle analysis”. Life Sci.58 (6), PL103–10. o. DOI:10.1016/0024-3205(95)02319-4. PMID8569415.
(2011. január 1.) „The role of endocannabinoids in visceral hyposensitivity induced by rapid eye movement sleep deprivation in rats: regional differences”. Int. J. Mol. Med.27 (1), 119–26. o. DOI:10.3892/ijmm.2010.547. PMID21057766.
(2006. május 1.) „Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat”. Life Sci.79 (1), 30–7. o. DOI:10.1016/j.lfs.2005.12.028. PMID16434061.
(2001. július 1.) „Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase”. Proc. Natl. Acad. Sci. U.S.A.98 (16), 9371–6. o. DOI:10.1073/pnas.161191698. JSTOR3056353. PMID11470906. PMC55427.
(2011. augusztus 1.) „Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects”. British Journal of Pharmacology163 (7), 1344–1364. o. DOI:10.1111/j.1476-5381.2011.01238.x. PMID21749363. PMC3165946.
(2006. április 1.) „The pharmacology of cannabinoid receptors and their ligands: an overview”. Int J Obes (Lond)30 (Suppl 1), S13–8. o. DOI:10.1038/sj.ijo.0803272. PMID16570099.
(2007) „Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons”. Cereb. Cortex17 (1), 163–74. o. DOI:10.1093/cercor/bhj133. PMID16467564.
(2007) „Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus”. J. Neurosci.27 (5), 1211–9. o. DOI:10.1523/JNEUROSCI.4159-06.2007. PMID17267577.
(2006) „Endogenous cannabinoid signaling through the CB1 receptor is essential for cerebellum-dependent discrete motor learning”. J. Neurosci.26 (34), 8829–37. o. DOI:10.1523/JNEUROSCI.1236-06.2006. PMID16928872.
(2001. július 1.) „Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase”. Proc. Natl. Acad. Sci. U.S.A.98 (16), 9371–6. o. DOI:10.1073/pnas.161191698. JSTOR3056353. PMID11470906. PMC55427.
(2014) „The endocannabinoid system: helps to direct eating behavior and macronutrient metabolism”. Front Psychol5, 1506. o. DOI:10.3389/fpsyg.2014.01506. PMID25610411. PMC4285050. „CB1 is present in neurons of the enteric nervous system and in sensory terminals of vagal and spinal neurons in the gastrointestinal tract (Massa et al., 2005). Activation of CB1 is shown to modulate nutrient processing, such as gastric secretion, gastric emptying, and intestinal motility. ... CB1 is shown to co-localize with the food intake inhibiting neuropeptide, corticotrophin-releasing hormone, in the paraventricular nucleus of the hypothalamus, and with the two orexigenic peptides, melanin-concentrating hormone in the lateral hypothalamus and with pre-pro-orexin in the ventromedial hypothalamus (Inui, 1999; Horvath, 2003). CB1 knockout mice showed higher levels of CRH mRNA, suggesting that hypothalamic EC receptors are involved in energy balance and may be able to mediate food intake (Cota et al., 2003). ... The ECS works through many anorexigenic and orexigenic pathways where ghrelin, leptin, adiponectin, endogenous opioids, and corticotropin-releasing hormones are involved (Viveros et al., 2008).”
(2013) „Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far”. Front Neurosci7, 256. o. DOI:10.3389/fnins.2013.00256. PMID24391536. PMC3868890. „Direct CB1-HcrtR1 interaction was first proposed in 2003 (Hilairet et al., 2003). Indeed, a 100-fold increase in the potency of hypocretin-1 to activate the ERK signaling was observed when CB1 and HcrtR1 were co-expressed ... In this study, a higher potency of hypocretin-1 to regulate CB1-HcrtR1 heteromer compared with the HcrtR1-HcrtR1 homomer was reported (Ward et al., 2011b). These data provide unambiguous identification of CB1-HcrtR1 heteromerization, which has a substantial functional impact. ... The existence of a cross-talk between the hypocretinergic and endocannabinoid systems is strongly supported by their partially overlapping anatomical distribution and common role in several physiological and pathological processes. However, little is known about the mechanisms underlying this interaction.”
(2014) „OX1 and OX2 orexin/hypocretin receptor pharmacogenetics”. Front Neurosci8, 57. o. DOI:10.3389/fnins.2014.00057. PMID24834023. PMC4018553. „OX1–CB1 dimerization was suggested to strongly potentiate orexin receptor signaling, but a likely explanation for the signal potentiation is, instead, offered by the ability of OX1 receptor signaling to produce 2-arachidonoyl glycerol, a CB1 receptor ligand, and a subsequent co-signaling of the receptors (Haj-Dahmane and Shen, 2005; Turunen et al., 2012; Jäntti et al., 2013). However, this does not preclude dimerization.”
(2014) „Human orexin/hypocretin receptors form constitutive homo- and heteromeric complexes with each other and with human CB1 cannabinoid receptors”. Biochem. Biophys. Res. Commun.445 (2), 486–90. o. DOI:10.1016/j.bbrc.2014.02.026. PMID24530395. „Orexin receptor subtypes readily formed homo- and hetero(di)mers, as suggested by significant BRET signals. CB1 receptors formed homodimers, and they also heterodimerized with both orexin receptors. ... In conclusion, orexin receptors have a significant propensity to make homo- and heterodi-/oligomeric complexes. However, it is unclear whether this affects their signaling. As orexin receptors efficiently signal via endocannabinoid production to CB1 receptors, dimerization could be an effective way of forming signal complexes with optimal cannabinoid concentrations available for cannabinoid receptors.”
(2008. január 1.) „The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin”. Br. J. Pharmacol.153 (2), 199–215. o. DOI:10.1038/sj.bjp.0707442. PMID17828291. PMC2219532.
(2001. március 1.) „The neurobiology and evolution of cannabinoid signalling”. Philos. Trans. R. Soc. Lond., B, Biol. Sci.356 (1407), 381–408. o. DOI:10.1098/rstb.2000.0787. PMID11316486. PMC1088434.
(2011. december 1.) „Polymodal activation of the endocannabinoid system in the extended amygdala”. Nat. Neurosci.14 (12), 1542–7. o. DOI:10.1038/nn.2974. PMID22057189.
(2006) „Endocannabinoids in appetite control and the treatment of obesity”. CNS Neurol Disord Drug Targets5 (3), 272–92. o. DOI:10.2174/187152706777452272. PMID16787229.
(1998. december 1.) „Trick or treat from food endocannabinoids?”. Nature396 (6712), 636–7. o. DOI:10.1038/25267. PMID9872309.
(2001. április 1.) „Leptin-regulated endocannabinoids are involved in maintaining food intake”. Nature410 (6830), 822–5. o. DOI:10.1038/35071088. PMID11298451.
(2010. május 1.) „Endogenous cannabinoid signaling is essential for stress adaptation”. Proc. Natl. Acad. Sci. U.S.A.107 (20), 9406–11. o. DOI:10.1073/pnas.0914661107. PMID20439721.
(2011. december 1.) „Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses”. J. Immunol.187 (11), 5720–32. o. DOI:10.4049/jimmunol.1102195. PMID22048769. PMC3226756.
(2000) „Cannabinoids control spasticity and tremor in a multiple sclerosis model”. Nature404 (6773), 84–7. o. DOI:10.1038/35003583. PMID10716447.
(2006. augusztus 1.) „Changes in CB1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis mice”. Brain Res.1107 (1), 199–205. o. DOI:10.1016/j.brainres.2006.06.001. PMID16822488.
(2004. április 1.) „Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism”. Mol. Pharmacol.65 (4), 999–1007. o. DOI:10.1124/mol.65.4.999. PMID15044630.
(2000) „Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage”. Lancet355 (9212), 1326–9. o. DOI:10.1016/S0140-6736(00)02115-2. PMID10776746.
(1995) „The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling”. Proc. Natl. Acad. Sci. U.S.A.92 (21), 9460–4. o. DOI:10.1073/pnas.92.21.9460. PMID7568154. PMC40821.
(2002. június 1.) „An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors”. Proc. Natl. Acad. Sci. U.S.A.99 (12), 8400–5. o. DOI:10.1073/pnas.122196999. PMID12060783.
(1996) „Arousal-enhancing properties of the CB1 cannabinoid receptor antagonist SR 141716A in rats as assessed by electroencephalographic spectral and sleep-waking cycle analysis”. Life Sci.58 (6), PL103–10. o. DOI:10.1016/0024-3205(95)02319-4. PMID8569415.
(2011. január 1.) „The role of endocannabinoids in visceral hyposensitivity induced by rapid eye movement sleep deprivation in rats: regional differences”. Int. J. Mol. Med.27 (1), 119–26. o. DOI:10.3892/ijmm.2010.547. PMID21057766.
(2006. május 1.) „Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat”. Life Sci.79 (1), 30–7. o. DOI:10.1016/j.lfs.2005.12.028. PMID16434061.
(2011. augusztus 1.) „Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects”. British Journal of Pharmacology163 (7), 1344–1364. o. DOI:10.1111/j.1476-5381.2011.01238.x. PMID21749363. PMC3165946.
(2001. július 1.) „Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase”. Proc. Natl. Acad. Sci. U.S.A.98 (16), 9371–6. o. DOI:10.1073/pnas.161191698. JSTOR3056353. PMID11470906. PMC55427.
(2014) „The endocannabinoid system: helps to direct eating behavior and macronutrient metabolism”. Front Psychol5, 1506. o. DOI:10.3389/fpsyg.2014.01506. PMID25610411. PMC4285050. „CB1 is present in neurons of the enteric nervous system and in sensory terminals of vagal and spinal neurons in the gastrointestinal tract (Massa et al., 2005). Activation of CB1 is shown to modulate nutrient processing, such as gastric secretion, gastric emptying, and intestinal motility. ... CB1 is shown to co-localize with the food intake inhibiting neuropeptide, corticotrophin-releasing hormone, in the paraventricular nucleus of the hypothalamus, and with the two orexigenic peptides, melanin-concentrating hormone in the lateral hypothalamus and with pre-pro-orexin in the ventromedial hypothalamus (Inui, 1999; Horvath, 2003). CB1 knockout mice showed higher levels of CRH mRNA, suggesting that hypothalamic EC receptors are involved in energy balance and may be able to mediate food intake (Cota et al., 2003). ... The ECS works through many anorexigenic and orexigenic pathways where ghrelin, leptin, adiponectin, endogenous opioids, and corticotropin-releasing hormones are involved (Viveros et al., 2008).”
(2013) „Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far”. Front Neurosci7, 256. o. DOI:10.3389/fnins.2013.00256. PMID24391536. PMC3868890. „Direct CB1-HcrtR1 interaction was first proposed in 2003 (Hilairet et al., 2003). Indeed, a 100-fold increase in the potency of hypocretin-1 to activate the ERK signaling was observed when CB1 and HcrtR1 were co-expressed ... In this study, a higher potency of hypocretin-1 to regulate CB1-HcrtR1 heteromer compared with the HcrtR1-HcrtR1 homomer was reported (Ward et al., 2011b). These data provide unambiguous identification of CB1-HcrtR1 heteromerization, which has a substantial functional impact. ... The existence of a cross-talk between the hypocretinergic and endocannabinoid systems is strongly supported by their partially overlapping anatomical distribution and common role in several physiological and pathological processes. However, little is known about the mechanisms underlying this interaction.”
(2014) „OX1 and OX2 orexin/hypocretin receptor pharmacogenetics”. Front Neurosci8, 57. o. DOI:10.3389/fnins.2014.00057. PMID24834023. PMC4018553. „OX1–CB1 dimerization was suggested to strongly potentiate orexin receptor signaling, but a likely explanation for the signal potentiation is, instead, offered by the ability of OX1 receptor signaling to produce 2-arachidonoyl glycerol, a CB1 receptor ligand, and a subsequent co-signaling of the receptors (Haj-Dahmane and Shen, 2005; Turunen et al., 2012; Jäntti et al., 2013). However, this does not preclude dimerization.”
(2008. január 1.) „The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin”. Br. J. Pharmacol.153 (2), 199–215. o. DOI:10.1038/sj.bjp.0707442. PMID17828291. PMC2219532.
(2001. március 1.) „The neurobiology and evolution of cannabinoid signalling”. Philos. Trans. R. Soc. Lond., B, Biol. Sci.356 (1407), 381–408. o. DOI:10.1098/rstb.2000.0787. PMID11316486. PMC1088434.
(2011. december 1.) „Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses”. J. Immunol.187 (11), 5720–32. o. DOI:10.4049/jimmunol.1102195. PMID22048769. PMC3226756.
(1995) „The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling”. Proc. Natl. Acad. Sci. U.S.A.92 (21), 9460–4. o. DOI:10.1073/pnas.92.21.9460. PMID7568154. PMC40821.
