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Guo S, Kemphues K (1995). „par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed”. Cell81 (4), 611–20. o. DOI:10.1016/0092-8674(95)90082-9. PMID7758115.
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Macrae I, Zhou K, Li F, Repic A, Brooks A, Cande W, Adams P, Doudna J (2006). „Structural basis for double-stranded RNA processing by dicer”. Science311 (5758), 195–8. o. DOI:10.1126/science.1121638. PMID16410517.
Bernstein E, Caudy A, Hammond S, Hannon G (2001). „Role for a bidentate ribonuclease in the initiation step of RNA interference”. Nature409 (6818), 363–6. o. DOI:10.1038/35053110. PMID11201747.
Qiu S, Adema C, Lane T (2005). „A computational study of off-target effects of RNA interference”. Nucleic Acids Res33 (6), 1834–47. o. DOI:10.1093/nar/gki324. PMID15800213. PMC1072799.
Ahlquist P (2002). „RNA-dependent RNA polymerases, viruses, and RNA silencing”. Science296 (5571), 1270–3. o. DOI:10.1126/science.1069132. PMID12016304.
Parker G, Eckert D, Bass B (2006). „RDE-4 preferentially binds long dsRNA and its dimerization is necessary for cleavage of dsRNA to siRNA”. RNA12 (5), 807–18. o. DOI:10.1261/rna.2338706. PMID16603715. PMC1440910.
Liu Q, Rand T, Kalidas S, Du F, Kim H, Smith D, Wang X (2003). „R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway”. Science301 (5641), 1921–5. o. DOI:10.1126/science.1088710. PMID14512631.
Pak J, Fire A (2007). „Distinct populations of primary and secondary effectors during RNAi in C. elegans”. Science315 (5809), 241–4. o. DOI:10.1126/science.1132839. PMID17124291.
Sijen T, Steiner F, Thijssen K, Plasterk R (2007). „Secondary siRNAs result from unprimed RNA synthesis and form a distinct class”. Science315 (5809), 244–7. o. DOI:10.1126/science.1136699. PMID17158288.
Wang QL, Li ZH (2007). „The functions of microRNAs in plants”. Front. Biosci.12, 3975–82. o. DOI:10.2741/2364. PMID17485351. Zhao Y, Srivastava D (2007). „A developmental view of microRNA function”. Trends Biochem. Sci.32 (4), 189–97. o. DOI:10.1016/j.tibs.2007.02.006. PMID17350266.
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Okamura K, Ishizuka A, Siomi H, Siomi M (2004). „Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways”. Genes Dev18 (14), 1655–66. o. DOI:10.1101/gad.1210204. PMID15231716. PMC478188.
Lee Y, Nakahara K, Pham J, Kim K, He Z, Sontheimer E, Carthew R (2004). „Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways”. Cell117 (1), 69–81. o. DOI:10.1016/S0092-8674(04)00261-2. PMID15066283.
Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM (2005. február 1.). „Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs”. Nature433 (7027), 769–73. o. DOI:10.1038/nature03315. PMID15685193.
Selbach M, Schwanhäusser B, Thierfelder N, Fang Z, Khanin R, Rajewsky N (2008. szeptember 1.). „Widespread changes in protein synthesis induced by microRNAs”. Nature455 (7209), 58–63. o. DOI:10.1038/nature07228. PMID18668040.
Baek D, Villén J, Shin C, Camargo FD, Gygi SP, Bartel DP (2008. szeptember 1.). „The impact of microRNAs on protein output”. Nature455 (7209), 64–71. o. DOI:10.1038/nature07242. PMID18668037. PMC2745094.
Matranga C, Tomari Y, Shin C, Bartel D, Zamore P (2005). „Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes”. Cell123 (4), 607–20. o. DOI:10.1016/j.cell.2005.08.044. PMID16271386.
Leuschner P, Ameres S, Kueng S, Martinez J (2006). „Cleavage of the siRNA passenger strand during RISC assembly in human cells”. EMBO Rep7 (3), 314–20. o. DOI:10.1038/sj.embor.7400637. PMID16439995. PMC1456892.
Tomari Y, Matranga C, Haley B, Martinez N, Zamore P (2004). „A protein sensor for siRNA asymmetry”. Science306 (5700), 1377–80. o. DOI:10.1126/science.1102755. PMID15550672.
Sen G, Wehrman T, Blau H (2005). „mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavage”. Differentiation73 (6), 287–93. o. DOI:10.1111/j.1432-0436.2005.00029.x. PMID16138829.
Sen G, Blau H (2005). „Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies”. Nat Cell Biol7 (6), 633–6. o. DOI:10.1038/ncb1265. PMID15908945.
Jakymiw A, Lian S, Eystathioy T, Li S, Satoh M, Hamel J, Fritzler M, Chan E (2005). „Disruption of P bodies impairs mammalian RNA interference”. Nat Cell Biol7 (12), 1267–74. o. DOI:10.1038/ncb1334. PMID16284622.
Holmquist G, Ashley T (2006). „Chromosome organization and chromatin modification: influence on genome function and evolution”. Cytogenet Genome Res114 (2), 96–125. o. DOI:10.1159/000093326. PMID16825762.
Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal S, Moazed D (2004). „RNAi-mediated targeting of heterochromatin by the RITS complex”. Science303 (5658), 672–6. o. DOI:10.1126/science.1093686. PMID14704433. PMC3244756.
Volpe T, Kidner C, Hall I, Teng G, Grewal S, Martienssen R (2002). „Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi”. Science297 (5588), 1833–7. o. DOI:10.1126/science.1074973. PMID12193640.
Volpe T, Schramke V, Hamilton G, White S, Teng G, Martienssen R, Allshire R (2003). „RNA interference is required for normal centromere function in fission yeast”. Chromosome Res11 (2), 137–46. o. DOI:10.1023/A:1022815931524. PMID12733640.
Sugiyama T, Cam H, Verdel A, Moazed D, Grewal S (2005). „RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production”. Proc Natl Acad Sci USA102 (1), 152–7. o. DOI:10.1073/pnas.0407641102. PMID15615848. PMC544066.
DaRocha W, Otsu K, Teixeira S, Donelson J (2004). „Tests of cytoplasmic RNA interference (RNAi) and construction of a tetracycline-inducible T7 promoter system in Trypanosoma cruzi”. Mol Biochem Parasitol133 (2), 175–86. o. DOI:10.1016/j.molbiopara.2003.10.005. PMID14698430.
Robinson K, Beverley S (2003). „Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania”. Mol Biochem Parasitol128 (2), 217–28. o. DOI:10.1016/S0166-6851(03)00079-3. PMID12742588.
L. Aravind, Hidemi Watanabe, David J. Lipman, and Eugene V. Koonin (2000). „Lineage-specific loss and divergence of functionally linked genes in eukaryotes”. Proceedings of the National Academy of Sciences97 (21), 11319–11324. o. DOI:10.1073/pnas.200346997. PMID11016957. PMC17198.
Drinnenberg IA, Weinberg DE, Xie KT, Nower JP, Wolfe KH, Fink GR, Bartel DP (2009). „RNAi in Budding Yeast”. Science326 (5952), 544–50. o. DOI:10.1126/science.1176945. PMID19745116.
Morita T, Mochizuki Y, Aiba H (2006). „Translational repression is sufficient for gene silencing by bacterial small noncoding RNAs in the absence of mRNA destruction”. Proc Natl Acad Sci USA103 (13), 4858–63. o. DOI:10.1073/pnas.0509638103. PMID16549791. PMC1458760.
Lucy A, Guo H, Li W, Ding S (2000). „Suppression of post-transcriptional gene silencing by a plant viral protein localized in the nucleus”. EMBO J19 (7), 1672–80. o. DOI:10.1093/emboj/19.7.1672. PMID10747034. PMC310235.
Katiyar-Agarwal S, Morgan R, Dahlbeck D, Borsani O, Villegas A, Zhu J, Staskawicz B, Jin H (2006). „A pathogen-inducible endogenous siRNA in plant immunity”. Proc Natl Acad Sci USA103 (47), 18002–7. o. DOI:10.1073/pnas.0608258103. PMID17071740. PMC1693862.
Fritz J, Girardin S, Philpott D (2006). „Innate immune defense through RNA interference”. Sci STKE2006 (339), pe27. o. DOI:10.1126/stke.3392006pe27. PMID16772641.
Zambon R, Vakharia V, Wu L (2006). „RNAi is an antiviral immune response against a dsRNA virus in Drosophila melanogaster”. Cell Microbiol8 (5), 880–9. o. DOI:10.1111/j.1462-5822.2006.00688.x. PMID16611236.
Wang X, Aliyari R, Li W, Li H, Kim K, Carthew R, Atkinson P, Ding S (2006). „RNA Interference Directs Innate Immunity Against Viruses in Adult Drosophila”. Science312 (5772), 452–4. o. DOI:10.1126/science.1125694. PMID16556799. PMC1509097.
Lu R, Maduro M, Li F, Li H, Broitman-Maduro G, Li W, Ding S (2005). „Animal virus replication and RNAi-mediated antiviral silencing in C elegans”. Nature436 (7053), 1040–3. o. DOI:10.1038/nature03870. PMID16107851. PMC1388260.
Wilkins C, Dishongh R, Moore S, Whitt M, Chow M, Machaca K (2005). „RNA interference is an antiviral defence mechanism in Caenorhabditis elegans”. Nature436 (7053), 1044–7. o. DOI:10.1038/nature03957. PMID16107852.
Berkhout B, Haasnoot J (2006). „The interplay between virus infection and the cellular RNA interference machinery”. FEBS Lett580 (12), 2896–902. o. DOI:10.1016/j.febslet.2006.02.070. PMID16563388.
Schütz S, Sarnow P (2006). „Interaction of viruses with the mammalian RNA interference pathway”. Virology344 (1), 151–7. o. DOI:10.1016/j.virol.2005.09.034. PMID16364746.
(1993) „The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14”. Cell75 (5), 843–54. o. DOI:10.1016/0092-8674(93)90529-Y. PMID8252621.
(2007) „Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation”. Science318 (5858), 1931–1934. o. DOI:10.1126/science.1149460. PMID18048652.
(2005) „Absence of non-specific effects of RNA interference triggered by long double-stranded RNA in mouse oocytes”. Dev Biol286 (2), 464–71. o. DOI:10.1016/j.ydbio.2005.08.015. PMID16154556.
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(2002) „Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference”. Oncogene21 (39), 6041–8. o. DOI:10.1038/sj.onc.1205878. PMID12203116.
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Ecker JR, Davis RW (1986). „Inhibition of gene expression in plant cells by expression of antisense RNA”. Proc Natl Acad Sci USA83 (15), 5372–5376. o. DOI:10.1073/pnas.83.15.5372. PMID16593734. PMC386288.
Ratcliff F, Harrison B, Baulcombe D (1997). „A Similarity Between Viral Defense and Gene Silencing in Plants”. Science276 (5318), 1558–60. o. DOI:10.1126/science.276.5318.1558. PMID18610513.
Guo S, Kemphues K (1995). „par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed”. Cell81 (4), 611–20. o. DOI:10.1016/0092-8674(95)90082-9. PMID7758115.
Pal-Bhadra M, Bhadra U, Birchler J (1997). „Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent”. Cell90 (3), 479–90. o. DOI:10.1016/S0092-8674(00)80508-5. PMID9267028.
Fire A, Xu S, Montgomery M, Kostas S, Driver S, Mello C (1998). „Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans”. Nature391 (6669), 806–11. o. DOI:10.1038/35888. PMID9486653.
Macrae I, Zhou K, Li F, Repic A, Brooks A, Cande W, Adams P, Doudna J (2006). „Structural basis for double-stranded RNA processing by dicer”. Science311 (5758), 195–8. o. DOI:10.1126/science.1121638. PMID16410517.
Bernstein E, Caudy A, Hammond S, Hannon G (2001). „Role for a bidentate ribonuclease in the initiation step of RNA interference”. Nature409 (6818), 363–6. o. DOI:10.1038/35053110. PMID11201747.
Qiu S, Adema C, Lane T (2005). „A computational study of off-target effects of RNA interference”. Nucleic Acids Res33 (6), 1834–47. o. DOI:10.1093/nar/gki324. PMID15800213. PMC1072799.
Ahlquist P (2002). „RNA-dependent RNA polymerases, viruses, and RNA silencing”. Science296 (5571), 1270–3. o. DOI:10.1126/science.1069132. PMID12016304.
Parker G, Eckert D, Bass B (2006). „RDE-4 preferentially binds long dsRNA and its dimerization is necessary for cleavage of dsRNA to siRNA”. RNA12 (5), 807–18. o. DOI:10.1261/rna.2338706. PMID16603715. PMC1440910.
Liu Q, Rand T, Kalidas S, Du F, Kim H, Smith D, Wang X (2003). „R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway”. Science301 (5641), 1921–5. o. DOI:10.1126/science.1088710. PMID14512631.
Pak J, Fire A (2007). „Distinct populations of primary and secondary effectors during RNAi in C. elegans”. Science315 (5809), 241–4. o. DOI:10.1126/science.1132839. PMID17124291.
Sijen T, Steiner F, Thijssen K, Plasterk R (2007). „Secondary siRNAs result from unprimed RNA synthesis and form a distinct class”. Science315 (5809), 244–7. o. DOI:10.1126/science.1136699. PMID17158288.
Wang QL, Li ZH (2007). „The functions of microRNAs in plants”. Front. Biosci.12, 3975–82. o. DOI:10.2741/2364. PMID17485351. Zhao Y, Srivastava D (2007). „A developmental view of microRNA function”. Trends Biochem. Sci.32 (4), 189–97. o. DOI:10.1016/j.tibs.2007.02.006. PMID17350266.
Gregory R, Chendrimada T, Shiekhattar R (2006). „MicroRNA biogenesis: isolation and characterization of the microprocessor complex”. Methods Mol Biol342, 33–47. o. DOI:10.1385/1-59745-123-1:33. PMID16957365.
Pillai RS, Bhattacharyya SN, Filipowicz W (2007). „Repression of protein synthesis by miRNAs: how many mechanisms?”. Trends Cell Biol17 (3), 118–26. o. DOI:10.1016/j.tcb.2006.12.007. PMID17197185.
Okamura K, Ishizuka A, Siomi H, Siomi M (2004). „Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways”. Genes Dev18 (14), 1655–66. o. DOI:10.1101/gad.1210204. PMID15231716. PMC478188.
Lee Y, Nakahara K, Pham J, Kim K, He Z, Sontheimer E, Carthew R (2004). „Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways”. Cell117 (1), 69–81. o. DOI:10.1016/S0092-8674(04)00261-2. PMID15066283.
Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM (2005. február 1.). „Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs”. Nature433 (7027), 769–73. o. DOI:10.1038/nature03315. PMID15685193.
Selbach M, Schwanhäusser B, Thierfelder N, Fang Z, Khanin R, Rajewsky N (2008. szeptember 1.). „Widespread changes in protein synthesis induced by microRNAs”. Nature455 (7209), 58–63. o. DOI:10.1038/nature07228. PMID18668040.
Baek D, Villén J, Shin C, Camargo FD, Gygi SP, Bartel DP (2008. szeptember 1.). „The impact of microRNAs on protein output”. Nature455 (7209), 64–71. o. DOI:10.1038/nature07242. PMID18668037. PMC2745094.
Matranga C, Tomari Y, Shin C, Bartel D, Zamore P (2005). „Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes”. Cell123 (4), 607–20. o. DOI:10.1016/j.cell.2005.08.044. PMID16271386.
Leuschner P, Ameres S, Kueng S, Martinez J (2006). „Cleavage of the siRNA passenger strand during RISC assembly in human cells”. EMBO Rep7 (3), 314–20. o. DOI:10.1038/sj.embor.7400637. PMID16439995. PMC1456892.
Tomari Y, Matranga C, Haley B, Martinez N, Zamore P (2004). „A protein sensor for siRNA asymmetry”. Science306 (5700), 1377–80. o. DOI:10.1126/science.1102755. PMID15550672.
Sen G, Wehrman T, Blau H (2005). „mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavage”. Differentiation73 (6), 287–93. o. DOI:10.1111/j.1432-0436.2005.00029.x. PMID16138829.
Sen G, Blau H (2005). „Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies”. Nat Cell Biol7 (6), 633–6. o. DOI:10.1038/ncb1265. PMID15908945.
Jakymiw A, Lian S, Eystathioy T, Li S, Satoh M, Hamel J, Fritzler M, Chan E (2005). „Disruption of P bodies impairs mammalian RNA interference”. Nat Cell Biol7 (12), 1267–74. o. DOI:10.1038/ncb1334. PMID16284622.
Holmquist G, Ashley T (2006). „Chromosome organization and chromatin modification: influence on genome function and evolution”. Cytogenet Genome Res114 (2), 96–125. o. DOI:10.1159/000093326. PMID16825762.
Verdel A, Jia S, Gerber S, Sugiyama T, Gygi S, Grewal S, Moazed D (2004). „RNAi-mediated targeting of heterochromatin by the RITS complex”. Science303 (5658), 672–6. o. DOI:10.1126/science.1093686. PMID14704433. PMC3244756.
Volpe T, Kidner C, Hall I, Teng G, Grewal S, Martienssen R (2002). „Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi”. Science297 (5588), 1833–7. o. DOI:10.1126/science.1074973. PMID12193640.
Volpe T, Schramke V, Hamilton G, White S, Teng G, Martienssen R, Allshire R (2003). „RNA interference is required for normal centromere function in fission yeast”. Chromosome Res11 (2), 137–46. o. DOI:10.1023/A:1022815931524. PMID12733640.
Sugiyama T, Cam H, Verdel A, Moazed D, Grewal S (2005). „RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production”. Proc Natl Acad Sci USA102 (1), 152–7. o. DOI:10.1073/pnas.0407641102. PMID15615848. PMC544066.
DaRocha W, Otsu K, Teixeira S, Donelson J (2004). „Tests of cytoplasmic RNA interference (RNAi) and construction of a tetracycline-inducible T7 promoter system in Trypanosoma cruzi”. Mol Biochem Parasitol133 (2), 175–86. o. DOI:10.1016/j.molbiopara.2003.10.005. PMID14698430.
Robinson K, Beverley S (2003). „Improvements in transfection efficiency and tests of RNA interference (RNAi) approaches in the protozoan parasite Leishmania”. Mol Biochem Parasitol128 (2), 217–28. o. DOI:10.1016/S0166-6851(03)00079-3. PMID12742588.
L. Aravind, Hidemi Watanabe, David J. Lipman, and Eugene V. Koonin (2000). „Lineage-specific loss and divergence of functionally linked genes in eukaryotes”. Proceedings of the National Academy of Sciences97 (21), 11319–11324. o. DOI:10.1073/pnas.200346997. PMID11016957. PMC17198.
Drinnenberg IA, Weinberg DE, Xie KT, Nower JP, Wolfe KH, Fink GR, Bartel DP (2009). „RNAi in Budding Yeast”. Science326 (5952), 544–50. o. DOI:10.1126/science.1176945. PMID19745116.
Morita T, Mochizuki Y, Aiba H (2006). „Translational repression is sufficient for gene silencing by bacterial small noncoding RNAs in the absence of mRNA destruction”. Proc Natl Acad Sci USA103 (13), 4858–63. o. DOI:10.1073/pnas.0509638103. PMID16549791. PMC1458760.
Lucy A, Guo H, Li W, Ding S (2000). „Suppression of post-transcriptional gene silencing by a plant viral protein localized in the nucleus”. EMBO J19 (7), 1672–80. o. DOI:10.1093/emboj/19.7.1672. PMID10747034. PMC310235.
Katiyar-Agarwal S, Morgan R, Dahlbeck D, Borsani O, Villegas A, Zhu J, Staskawicz B, Jin H (2006). „A pathogen-inducible endogenous siRNA in plant immunity”. Proc Natl Acad Sci USA103 (47), 18002–7. o. DOI:10.1073/pnas.0608258103. PMID17071740. PMC1693862.
Fritz J, Girardin S, Philpott D (2006). „Innate immune defense through RNA interference”. Sci STKE2006 (339), pe27. o. DOI:10.1126/stke.3392006pe27. PMID16772641.
Zambon R, Vakharia V, Wu L (2006). „RNAi is an antiviral immune response against a dsRNA virus in Drosophila melanogaster”. Cell Microbiol8 (5), 880–9. o. DOI:10.1111/j.1462-5822.2006.00688.x. PMID16611236.
Wang X, Aliyari R, Li W, Li H, Kim K, Carthew R, Atkinson P, Ding S (2006). „RNA Interference Directs Innate Immunity Against Viruses in Adult Drosophila”. Science312 (5772), 452–4. o. DOI:10.1126/science.1125694. PMID16556799. PMC1509097.
Lu R, Maduro M, Li F, Li H, Broitman-Maduro G, Li W, Ding S (2005). „Animal virus replication and RNAi-mediated antiviral silencing in C elegans”. Nature436 (7053), 1040–3. o. DOI:10.1038/nature03870. PMID16107851. PMC1388260.
Wilkins C, Dishongh R, Moore S, Whitt M, Chow M, Machaca K (2005). „RNA interference is an antiviral defence mechanism in Caenorhabditis elegans”. Nature436 (7053), 1044–7. o. DOI:10.1038/nature03957. PMID16107852.
Berkhout B, Haasnoot J (2006). „The interplay between virus infection and the cellular RNA interference machinery”. FEBS Lett580 (12), 2896–902. o. DOI:10.1016/j.febslet.2006.02.070. PMID16563388.
Schütz S, Sarnow P (2006). „Interaction of viruses with the mammalian RNA interference pathway”. Virology344 (1), 151–7. o. DOI:10.1016/j.virol.2005.09.034. PMID16364746.
(1993) „The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14”. Cell75 (5), 843–54. o. DOI:10.1016/0092-8674(93)90529-Y. PMID8252621.
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