Have doctors found a drug to fight coronavirus? Two experts reveal how experimental antiviral remdesivir saved one woman who was in critical condition and helped 14 infected Diamond Princess passengers
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Gordon, C. J., Tchesnokov, E. P., Feng, J. Y., Porter, D. P., & Gotte, M. (2020). The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus. Journal of Biological Chemistry, jbc-AC120. doi:10.1074/jbc.AC120.013056PubMed
Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, et al. (2018). Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. mBio. 9(2). doi:10.1128/mBio.00221-18. PMC5844999.
Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, et al. (2017). Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Science Translational Medicine. 9 (396): eaal3653. doi:10.1126/scitranslmed.aal3653PMC5567817
Warren T., Jordan R., Lo M., Soloveva V., Ray A., Bannister R., Mackman R., Perron M., Stray K., Feng J., Xu Y., Wells J., Stuthman K., Welch L., Doerffler E., Zhang L., Chun K., Hui H., Neville S., Lew W., Park Y., Babusis D., Strickley R., Wong P., Swaminathan S., Lee W., Mayers D., Cihlar T., Bavari S. Nucleotide Prodrug GS-5734 Is a Broad-Spectrum Filovirus Inhibitor That Provides Complete Therapeutic Protection Against the Development of Ebola Virus Disease (EVD) in Infected Non-human Primates(անգլ.) // Open Forum Infectious Diseases : journal. — Т. 2. — № suppl 1. — С. LB–2. — doi:10.1093/ofid/ofv130.02
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Sheahan, T.P., Sims, A.C., Leist, S.R. et al. (2020). Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun 11, 222 https://doi.org/10.1038/s41467-019-13940-6
Gordon, C. J., Tchesnokov, E. P., Feng, J. Y., Porter, D. P., & Gotte, M. (2020). The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus. Journal of Biological Chemistry, jbc-AC120. doi:10.1074/jbc.AC120.013056PubMed
Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, et al. (2018). Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. mBio. 9(2). doi:10.1128/mBio.00221-18. PMC5844999.
Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, et al. (2017). Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Science Translational Medicine. 9 (396): eaal3653. doi:10.1126/scitranslmed.aal3653PMC5567817
