Lentinula edodes (Italian Wikipedia)

Yamamoto Y, Shirono H, Kono K, Ohashi Y., Immunopotentiating activity of the water-soluble lignin rich fraction prepared from LEM--the extract of the solid culture medium of Lentinus edodes mycelia., in Biosci Biotechnol Biochem, vol. 61, n. 11, Nov 1997, pp. 1909–12, PMID 9404070.
Hatvani N, Antibacterial effect of the culture fluid of Lentinus edodes mycelium grown in submerged liquid culture., in Int J Antimicrob Agents, vol. 17, n. 1, gennaio 2001, pp. 71–4, DOI:10.1016/S0924-8579(00)00311-3, PMID 11137653.
Takehara M, Kuida K, Mori K, Antiviral activity of virus-like particles from Lentinus edodes (Shiitake), in Archives of Virology, vol. 59, n. 3, 1979, pp. 269–74, DOI:10.1007/BF01317423, PMID 222241.
Tochikura TS, Nakashima H, Yamamoto N, Antiviral agents with activity against human retroviruses., in J Acquir Immune Defic Syndr, vol. 2, n. 5, 1989, pp. 441–7, PMID 2477523.
Shimada S, Komamura K, Kumagai H, Sakurai H, Inhibitory activity of shiitake flavor against platelet aggregation^{[collegamento interrotto]}, in Biofactors, vol. 22, n. 1-4, 2004, pp. 177–9, DOI:10.1002/biof.5520220136, PMID 15630278.
Spierings EL, Fujii H, Sun B, Walshe T, A Phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers, in J. Nutr. Sci. Vitaminol., vol. 53, n. 6, dicembre 2007, pp. 536–9, PMID 18202543.
Ye SF, Wakame K, Ichimura K, Matsuzaki S, Amelioration by active hexose correlated compound of endocrine disturbances induced by oxidative stress in the rat, in Endocr Regul, vol. 38, n. 1, marzo 2004, pp. 7–13, PMID 15147233.
Ye SF, Ichimura K, Wakame K, Ohe M, Suppressive effects of Active Hexose Correlated Compound on the increased activity of hepatic and renal ornithine decarboxylase induced by oxidative stress, in Life Sci., vol. 74, n. 5, dicembre 2003, pp. 593–602, PMID 14623030.
Mach CM, Fugii H, Wakame K, Smith J, Evaluation of active hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy agents, in J Soc Integr Oncol, vol. 6, n. 3, 2008, pp. 105–9, PMID 19087767.
Nogusa S, Gerbino J, Ritz BW, Low-dose supplementation with active hexose correlated compound improves the immune response to acute influenza infection in C57BL/6 mice, in Nutr Res, vol. 29, n. 2, febbraio 2009, pp. 139–43, DOI:10.1016/j.nutres.2009.01.005, PMID 19285605.
Wang S, Welte T, Fang H, et al., Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice, in J. Nutr., vol. 139, n. 3, marzo 2009, pp. 598–602, DOI:10.3945/jn.108.100297, PMID 19141700.
Aviles H, O'Donnell P, Orshal J, Fujii H, Sun B, Sonnenfeld G, Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection, in Am. J. Surg., vol. 195, n. 4, aprile 2008, pp. 537–45, DOI:10.1016/j.amjsurg.2007.05.045, PMID 18304499.
Ritz BW, Supplementation with active hexose correlated compound increases survival following infectious challenge in mice, in Nutr. Rev., vol. 66, n. 9, settembre 2008, pp. 526–31, DOI:10.1111/j.1753-4887.2008.00085.x, PMID 18752476.
Aviles H, O'Donnell P, Sun B, Sonnenfeld G, Active hexose correlated compound (AHCC) enhances resistance to infection in a mouse model of surgical wound infection, in Surg Infect (Larchmt), vol. 7, n. 6, dicembre 2006, pp. 527–35, DOI:10.1089/sur.2006.7.527, PMID 17233570.
Ritz BW, Nogusa S, Ackerman EA, Gardner EM, Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection, in J. Nutr., vol. 136, n. 11, novembre 2006, pp. 2868–73, PMID 17056815.
Matsui Y, Uhara J, Satoi S, et al., Improved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study, in J. Hepatol., vol. 37, n. 1, luglio 2002, pp. 78–86, PMID 12076865.
Turner J, Chaudhary U, Dramatic prostate-specific antigen response with activated hemicellulose compound in metastatic castration-resistant prostate cancer, in Anticancer Drugs, vol. 20, n. 3, marzo 2009, pp. 215–6, DOI:10.1097/CAD.0b013e3283163c26, PMID 19104437.
Cowawintaweewat S, Manoromana S, Sriplung H, et al., Prognostic improvement of patients with advanced liver cancer after active hexose correlated compound (AHCC) treatment, in Asian Pac. J. Allergy Immunol., vol. 24, n. 1, marzo 2006, pp. 33–45, PMID 16913187.
Gao Y, Zhang D, Sun B, Fujii H, Kosuna K, Yin Z, Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses, in Cancer Immunol. Immunother., vol. 55, n. 10, ottobre 2006, pp. 1258–66, DOI:10.1007/s00262-005-0111-9, PMID 16362410.
Aviles H, Belay T, Vance M, Sun B, Sonnenfeld G, Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditions, in J. Appl. Physiol., vol. 97, n. 4, ottobre 2004, pp. 1437–44, DOI:10.1152/japplphysiol.00259.2004, PMID 15194672.
Kim H, Kacew S, Lee B, In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor), in Carcinogenesis, vol. 20, n. 8, 1999, pp. 1637–40, DOI:10.1093/carcin/20.8.1637, PMID 10426820.
Yang P, Liang M, Zhang Y, Shen B., Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC., in Adv Ther., vol. 25, n. 8, Aug 2008, pp. 787–94, DOI:10.1007/s12325-008-0079-x, PMID 18670743.
Nimura H, Mitsumori N, Takahashi N,, [S-1 combined with lentinan in patients with unresectable or recurrent gastric cancer], in Gan to Kagaku Ryoho., vol. 33, n. 1, Jun 2006, pp. 106–9, PMID 16897983.
Nakano H, Namatame K, Nemoto H, Motohashi H, Nishiyama K, Kumada K., A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group., in Hepatogastroenterology., vol. 46, n. 28, 1999, pp. 2662–8, PMID 10522061.
Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J, Individual Patient Based Meta-analysis of Lentinan for Unresectable/Recurrent Gastric Cancer, in Anticancer Res., vol. 29, n. 7, luglio 2009, pp. 2739–45, PMID 19596954.
Hazama S, Watanabe S, Ohashi M, et al., Efficacy of Orally Administered Superfine Dispersed Lentinan ({beta}-1,3-Glucan) for the Treatment of Advanced Colorectal Cancer, in Anticancer Res., vol. 29, n. 7, luglio 2009, pp. 2611–7, PMID 19596936.
Kataoka H, Shimura T, Mizoshita T, et al., Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life, in Hepatogastroenterology, vol. 56, n. 90, 2009, pp. 547–50, PMID 19579640.
Isoda N, Eguchi Y, Nukaya H, et al., Clinical efficacy of superfine dispersed lentinan (beta-1,3-glucan) in patients with hepatocellular carcinoma, in Hepatogastroenterology, vol. 56, n. 90, 2009, pp. 437–41, PMID 19579616.
Shimizu K, Watanabe S, Watanabe S, et al., Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer, in Hepatogastroenterology, vol. 56, n. 89, 2009, pp. 240–4, PMID 19453066.

pubmed.ncbi.nlm.nih.gov

(EN) P. S. Bisen, R. K. Baghel e B. S. Sanodiya, Lentinus edodes: a macrofungus with pharmacological activities, in Current Medicinal Chemistry, vol. 17, n. 22, 2010, pp. 2419–2430, DOI:10.2174/092986710791698495. URL consultato il 2 maggio 2026.
Xiaoshuang Dai, Joy M. Stanilka e Cheryl A. Rowe, Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults, in Journal of the American College of Nutrition, vol. 34, n. 6, 2015, pp. 478-487, DOI:10.1080/07315724.2014.950391. URL consultato il 14 novembre 2020.

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Hirasawa M, Shouji N, Neta T, Fukushima K, Takada K, Three kinds of antibacterial substances from Lentinus edodes (Berk.) Sing. (Shiitake, an edible mushroom)., in Int J Antimicrob Agents, vol. 11, n. 2, Feb 1999, pp. 151–7, DOI:10.1016/S0924-8579(98)00084-3, PMID =10221419.
Tsujinaka T, Yokota M, Kambayashi J, Ou MC, Kido Y, Mori T, Modification of septic processes by beta-glucan administration, in Eur Surg Res, vol. 22, n. 6, 1990, pp. 340–6, DOI:10.1159/000129120, PMID =2079094.
Hatvani N, Antibacterial effect of the culture fluid of Lentinus edodes mycelium grown in submerged liquid culture., in Int J Antimicrob Agents, vol. 17, n. 1, gennaio 2001, pp. 71–4, DOI:10.1016/S0924-8579(00)00311-3, PMID 11137653.
Takehara M, Kuida K, Mori K, Antiviral activity of virus-like particles from Lentinus edodes (Shiitake), in Archives of Virology, vol. 59, n. 3, 1979, pp. 269–74, DOI:10.1007/BF01317423, PMID 222241.
Suzuki H, Okubo A, Yamazaki S, Suzuki K, Mitsuya H, Toda S, Inhibition of the infectivity and cytopathic effect of human immunodeficiency virus by water-soluble lignin in an extract of the culture medium of Lentinus edodes mycelia (LEM)., in Biochem Biophys Res Commun, vol. 160, n. 1, 1989, pp. 367–73, DOI:10.1016/0006-291X(89)91665-3, PMID =2469420.
Sarkar S, Koga J, Whitley RJ, Chatterjee S, Antiviral effect of the extract of culture medium of Lentinus edodes mycelia on the replication of herpes simplex virus type 1, in Antiviral Res, vol. 20, n. 4, 1993, pp. 293–303, DOI:10.1016/0166-3542(93)90073-R, PMID =8387258.
Odani S, Tominaga K, Kondou S, Hori H, Koide T, Hara S, Isemura M, Tsunasawa S, The inhibitory properties and primary structure of a novel serine proteinase inhibitor from the fruiting body of the basidiomycete, Lentinus edodes, in Eur J Biochem., vol. 262, n. 3, 1999, pp. 915–23, DOI:10.1046/j.1432-1327.1999.00463.x, PMID =10411656.
Spierings EL, Fujii H, Sun B et al., A Phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers, in J Nutr Sci Vitaminol, vol. 53, 2007, pp. 536–539, DOI:10.3177/jnsv.53.536.
Nogusa S, Gerbino J, Ritz BW, Low-dose supplementation with active hexose correlated compound improves the immune response to acute influenza infection in C57BL/6 mice, in Nutr Res, vol. 29, n. 2, febbraio 2009, pp. 139–43, DOI:10.1016/j.nutres.2009.01.005, PMID 19285605.
Wang S, Welte T, Fang H, et al., Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice, in J. Nutr., vol. 139, n. 3, marzo 2009, pp. 598–602, DOI:10.3945/jn.108.100297, PMID 19141700.
Aviles H, O'Donnell P, Orshal J, Fujii H, Sun B, Sonnenfeld G, Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection, in Am. J. Surg., vol. 195, n. 4, aprile 2008, pp. 537–45, DOI:10.1016/j.amjsurg.2007.05.045, PMID 18304499.
Ritz BW, Supplementation with active hexose correlated compound increases survival following infectious challenge in mice, in Nutr. Rev., vol. 66, n. 9, settembre 2008, pp. 526–31, DOI:10.1111/j.1753-4887.2008.00085.x, PMID 18752476.
Aviles H, O'Donnell P, Sun B, Sonnenfeld G, Active hexose correlated compound (AHCC) enhances resistance to infection in a mouse model of surgical wound infection, in Surg Infect (Larchmt), vol. 7, n. 6, dicembre 2006, pp. 527–35, DOI:10.1089/sur.2006.7.527, PMID 17233570.
Turner J, Chaudhary U, Dramatic prostate-specific antigen response with activated hemicellulose compound in metastatic castration-resistant prostate cancer, in Anticancer Drugs, vol. 20, n. 3, marzo 2009, pp. 215–6, DOI:10.1097/CAD.0b013e3283163c26, PMID 19104437.
Terakawa N, Matsui Y, Satoi S et al., Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controlled study, in Nutr Cancer, vol. 60, 2008, pp. 643–51, DOI:10.1080/01635580801993280.
Gao Y, Zhang D, Sun B, Fujii H, Kosuna K, Yin Z, Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses, in Cancer Immunol. Immunother., vol. 55, n. 10, ottobre 2006, pp. 1258–66, DOI:10.1007/s00262-005-0111-9, PMID 16362410.
Aviles H, Belay T, Vance M, Sun B, Sonnenfeld G, Active hexose correlated compound enhances the immune function of mice in the hindlimb-unloading model of spaceflight conditions, in J. Appl. Physiol., vol. 97, n. 4, ottobre 2004, pp. 1437–44, DOI:10.1152/japplphysiol.00259.2004, PMID 15194672.
Kim H, Kacew S, Lee B, In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor), in Carcinogenesis, vol. 20, n. 8, 1999, pp. 1637–40, DOI:10.1093/carcin/20.8.1637, PMID 10426820.
Yang P, Liang M, Zhang Y, Shen B., Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC., in Adv Ther., vol. 25, n. 8, Aug 2008, pp. 787–94, DOI:10.1007/s12325-008-0079-x, PMID 18670743.

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Nicola Sitta, Paolo Davoli, Marco Floriani e Edoardo Suriano, Guida ragionata alla commestibilità dei funghi. Revisione critica della letteratura micotossicologica e biochimica. Analisi del consumo tradizionale e della casistica di intossicazioni in ambito italiano ed europeo. Valutazione degli aspetti di sicurezza alimentare. Regione Piemonte, 2021. (PDF), su regione.piemonte.it, p. 66.

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Alicia Di Rado, Can a mushroom help fight lung cancer?, ehope, vol. 7, n. 11, Duarte, California, City of Hope National Medical Center, 26 novembre 2008. URL consultato il 25 giugno 2009 (archiviato dall'url originale il 13 dicembre 2009).

Lentinula edodes (Italian Wikipedia)

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